She was awarded with a postdoc fellow from the Ministry of Science at the Technical University of Catalonia in Biomaterials for bone tissue regeneration and since 2010 has been professor at this university. (ibecbarcelona.eu)
From 1999 onwards my research has been focused primarily on osteoblast biology and approaches to tissue engineer and model bone biology, pathology and repair. (nottingham.ac.uk)
My research interests focus mainly on stem cells (embryonic, 'adult' and fetal origins) and their applications in tissue engineering, particularly the osteoblast and bone tissue. (nottingham.ac.uk)
When the human body is unable to regenerate the lost bone tissue, surgeons come in and replace the missing bone using autografts, allografts, and synthetic grafts (artificial bone). (wikipedia.org)
Increased research and knowledge regarding the organization, structure of properties of collagen and hydroxyapatite have led to many developments in collagen-based scaffolds in bone tissue engineering. (wikipedia.org)
These findings are relevant to bone tissue engineering and regeneration because the IDPs from 45S5.2B BG may act as inexpensive inorganic angiogenic agents providing a convenient alternative to the application of conventional angiogenic growth factors. (rsc.org)
In this review, we introduce the broad application of β-TCP in tissue engineering and discuss the different approaches that β-TCP scaffolds are customized, including physical modification (e.g., pore size, porosity and roughness) and the incorporation of metal ions, other materials (e.g., bioactive glass) and stem cells (e.g., mesenchymal stem cells). (frontiersin.org)
The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
The growing importance of regenerative medicine and tissue engineering (TE) reflects the fact that bone metabolic and related diseases represent approximately 50% of all chronic diseases for people above the age of fifty. (encyclopedia.pub)
Alginate scaffolds, composed of cross-linked calcium ions, are actively being explored in the regeneration of skin, liver, and bone. (wikipedia.org)
As it has been established that boron (B) may perform functions in angiogenesis and osteogenesis, the controlled and localized release of B ions from bioactive glasses (BGs) is expected to provide a promising therapeutic alternative for regenerative medicine of vascularized tissues, such as bone. (rsc.org)
Tissues2
Artificial bones made of metal and ceramic tend to do poorly in terms of biocompatibility since it is difficult to blend into bone tissues. (wikipedia.org)
According to the National Ambulatory Medical Care Survey (NAMCS), in 2010, there were approximately 63 million visits to the orthopedic surgery department and about 3.5 million visits for fractures in the emergency departments in the U.S. Among the 6.5 million bone fracture or defect cases, approximately 887,679 people were hospitalized. (wikipedia.org)
Implant3
The structure of hydroxyapatite is very similar to that of the original bone, and collagen can act as molecular cables and further improve the biocompatibility of the implant. (wikipedia.org)
Hydroxyapatite is often used in artificial bone studies because it has the biocompatibility and osteoconductivity required for an effective, long-lasting bone implant, but is quite brittle, and further exhibits a dissolution rate of about 10 wt% per year, which is significantly slower than the growth rate of newly formed bone, necessitating measures to enhance its dissolution rate. (wikipedia.org)
In many cases, using one type of material limits the capabilities of an artificial bone implant, so composites are utilized. (wikipedia.org)
Resection2
Large segmental bone loss and bone resection due to trauma and/or the presence of tumors and cysts often results in a delay in healing or non-union. (frontiersin.org)
Bone defects or bone injuries caused by aging, traffic accidents, fractures, or bone tumor resection are among the serious problems in orthopedics because they cause major damage to health and lower the quality of life. (encyclopedia.pub)
Implants4
In the past, bone fractures were fixed by the methods of applying metal implants. (encyclopedia.pub)
There are several typical clinical indications for the use of biodegradable implants in orthopedics, which are mostly used for fractures stabilization, osteotomy procedures, bone grafts and fusions [ 6 ] [ 7 ] . (encyclopedia.pub)
It is believed that implants with roughened surfaces offer better bone anchoring and biomechanical stability. (com.pk)
11 Calcium phosphate-coated implants have been described in the literature which demonstrate early direct bone attachment to the hydroxyapatite surface and this occursas quickly as one month post-operatively. (com.pk)
Scaffolds2
Consequently, enhancing the adhesion of MSCs, augmenting the release of growth factors, and promoting angiogenic potential of biomaterial scaffolds after implantation are pivotal for successful bone regeneration. (frontiersin.org)
To create a favorable osteogenic environment, β-TCP scaffolds have been modified in a number of ways to boost bone healing, including modulating physical features (e.g., pore sizes, porosity and surface roughness), combining with ionic components, and the addition/delivery of growth factors. (frontiersin.org)
Tumor1
Large bone loss as a result of trauma, tumor removal, infection, and developmental congenital disorders, often leads to delayed healing or non-union, and remains a critical challenge for orthopedic surgeons. (frontiersin.org)
Scaffold1
Other composites suitable for use in artificial bone are those using alginate, a biopolymer known for its scaffold-forming properties. (wikipedia.org)
Osteoblast2
My first postdoctoral position was held jointly between Imperial College and the Royal London Hospital School of Medicine and Dentistry (with Professor Francis Hughes) looking at the roles of the nitric oxide and prostaglandin pathways in bone biology, specifically the osteoblast. (nottingham.ac.uk)
The cell responsible for bone resorption is osteoclast, while the cell responsible for bone formation is osteoblast. (wikipedia.org)
Diseases1
Prof. Elisabeth Engel got her PhD in 2003 in bone metabolism diseases in medical school. (ibecbarcelona.eu)
Significantly1
Curcumin has significantly higher glass transition temperature Tg (≈ 347 K) than the polymer matrix (≈274-277 K depending on the molecular weight), and dispersions displayed Tg's intermediate between those of the pure amorphous components, implying that curcumin acts as an effective antiplasticizer for PADAS. (ibecbarcelona.eu)
Collagen1
The two major components of bone are hydroxyapatite [Ca10(PO4)6(OH)2], and collagen fibers. (wikipedia.org)
Liver1
This study delves into specific impacts of mercury on fish, ranging from bone deformities to liver damage, developmental anomalies, neurotoxic effects, and disruptions in reproductive systems. (preprints.org)
Defects1
In the United States, more than 6.5 million bone defects and more than 3 million facial injury cases have been reported each year. (wikipedia.org)
Artificial bone4
Artificial bone refers to bone-like material created in a laboratory that can be used in bone grafts, to replace human bone that was lost due to severe fractures, disease, etc. (wikipedia.org)
When comparing artificial bone to autograft and allograft, it is less invasive and more biocompatible since it avoids the risk of unknown viral infections. (wikipedia.org)
Artificial bone was initially made of materials like metals and solid ceramics, which are strong enough to sustain the loading in bone. (wikipedia.org)
Thus, to better help those in need to live a more comfortable life, engineers have been developing new techniques to produce and design better artificial bone structure and material. (wikipedia.org)
Materials3
The rest of the bone is composed of materials including chondroitin sulfate, keratan sulfate and lipid. (wikipedia.org)
Materials suited for use in artificial bones need to be biocompatible, osteoconductive, and mechanically strong. (wikipedia.org)
These disadvantages can result in complications and the development of a bone substitute materials offers a potential alternative to overcome these shortcomings. (frontiersin.org)
Hydroxyapatite4
Hydroxyapatite, which is one of the most stable forms of calcium phosphate, makes up about 60 to 65 percent of the bone. (wikipedia.org)
Research on material types in bone grafting has been traditionally centered on producing composites of organic polysaccharides (chitin, chitosan, alginate) and minerals (hydroxyapatite). (wikipedia.org)
Even though many minerals can be adapted for bone composition, hydroxyapatite remains the dominant material, as its strength and the known Jager-Fratzl model of human bone provide a pre-existing framework for spacing and fabrication. (wikipedia.org)
By way of this review, a deeper understanding of the basic mechanisms of β-TCP for bone repair will be achieved which will aid in the optimization of strategies to promote bone repair and regeneration. (frontiersin.org)
Processes1
We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
Stability1
Internal fixation is required for reconstructive surgery on fractured bone to maintain the anatomic reduction in the fragments and provide stability during the healing process. (encyclopedia.pub)
Natural2
The attraction towards Ti and its alloys reside in their superior mechanical and tribological features, as compared to CaPs, which are renowned for their compositional and structural features similar to those of natural bones. (infim.ro)
In order to exploit the pharmacological potential of natural bioactive molecules with low watersolubility, such as curcumin, it is necessary to develop formulations, such as amorphous polymer dispersions, which allow a constant release rate and at the same time avoid possible toxicity effects of the crystalline form of the molecule under scrutiny. (ibecbarcelona.eu)
Damage1
In addition, mechanical damage of bone often occurs because of an accident, required surgery and so forth. (encyclopedia.pub)
Procedures1
More than 2.2 million bone graft procedures are performed worldwide per year. (wikipedia.org)