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IodineIodine RadioisotopesRadioisotopesZinc RadioisotopesIodine CompoundsRadioisotope Dilution TechniqueStrontium RadioisotopesKrypton RadioisotopesGoiter, EndemicIndium RadioisotopesGoiterSodium RadioisotopesRadionuclide ImagingRadioactivityBarium RadioisotopesYttrium RadioisotopesTin RadioisotopesCarbon RadioisotopesIron RadioisotopesCopper RadioisotopesThyroid GlandPhosphorus RadioisotopesPotassium IodideBeta ParticlesSodium Chloride, DietaryTechnetiumMercury RadioisotopesTechnetium Tc 99m Sulfur ColloidCesium IsotopesIsotope LabelingPovidone-IodineCerium RadioisotopesCobalt IsotopesDeficiency DiseasesHafniumGold RadioisotopesRadioimmunotherapyLead RadioisotopesDiagnostic Techniques, RadioisotopeAstatineZinc IsotopesSulfur RadioisotopesCadmium RadioisotopesRadiopharmaceuticalsIodidesIodophorsSoil Pollutants, RadioactiveLutetiumRheniumThyrotropinBromine RadioisotopesSamariumScintillation CountingSubdural EffusionCalcium IsotopesRadioactive WasteSerum Albumin, Radio-IodinatedCongenital HypothyroidismThyroxineRuthenium RadioisotopesThyroid Function TestsIodized OilRadiometric DatingThyroglobulinIodine IsotopesSelenium RadioisotopesAlpha ParticlesMethodsTissue DistributionHeterocyclic Compounds, 1-RingSodium Pertechnetate Tc 99mTungstenThyroid DiseasesIsotopesRadioisotope TeletherapyPentetic AcidHypothyroidismWhole-Body CountingSpectrometry, GammaIodoproteinsNuclear MedicineTechnetium Tc 99m PentetateRadiometryThyroid HormonesRosaniline DyesRadiation DosageTritiumHyperthyroidismNostoc communeIodide PeroxidaseCesium RadioisotopesPotassium RadioisotopesIodohippuric AcidPerchloratesCarbon IsotopesIntestinal AbsorptionDiiodotyrosineThyroid NeoplasmsSodium IodidePositron-Emission Tomography
HumansRadioactive iodine therapyBrachytherapyRadiotherapyTumorsRadiopharmaceuticalIodideTherapeuticUptakeIodidesMolybdenum-99StableAblationTechnetium-99mChemicallySynthesisDecayDeficiencyIodinationRadiationOccursNeutronSubstancesTumorXenonDiagnosisRadionuclideMiceReferencesIodateMedical RadioisotopesTraceMonoclonalTreatmentsMilkProducersCommonlyMETHODSHalogensTreatmentHalf-lifeCellsOfficialsDiscoveryAtmosphereEssentialProductionProvideTableFrenchMakes
Humans1
  • Did you know, for example, that iodine protects marine algae from oxidative damage (for example from the Sun), prevents some congenital abnormalities in humans, and has many industrial applications? (scienceinschool.org)
Radioactive iodine therapy3
Brachytherapy2
Radiotherapy1
  • For radiotherapy ablation of tissues that absorb iodine (such as the thyroid), or that absorb an iodine-containing radiopharmaceutical, the beta-emitter iodine-131 is the preferred isotope. (wikipedia.org)
Tumors1
  • Here we investigated the characteristics of the residualizing iodine label in SK-RC-52 RCC tumors. (snmjournals.org)
Radiopharmaceutical1
  • We are proud to be a leader in expanding the horizons of patient health by providing innovative solutions to ensure robust, reliable access to radioisotopes and radiopharmaceutical products that can make a positive difference in healthcare for people around the world. (businesswire.com)
Iodide6
  • The inner walls of the capsule are then rinsed with dilute NaOH solution to collect iodine as soluble iodide (I−) and hypoiodite (IO−), according to the standard disproportionation reaction of halogens in alkaline solutions. (wikipedia.org)
  • This radioactive iodine is used in the form of sodium iodide and because of the extremely small amounts used for imaging or destroying cells, RAI is safe to use in individuals who have had allergic reactions to seafood or X-ray contrast agents. (nrc.gov)
  • With the help of X-ray absorption spectroscopy, we now know that seaweeds accumulate iodine as iodide (I-), which acts as an antioxidant to protect them against oxidative damage caused by atmospheric ozone (O 3 ). (scienceinschool.org)
  • Iodine in the atmosphere originates mostly from biological and chemical processes in the ocean - such as the iodide antioxidant system in seaweeds. (scienceinschool.org)
  • In the ocean, iodine is mainly dissolved and exists as iodate (IO 3 - , oxidised form) and iodide (I - , reduced form). (scienceinschool.org)
  • Iodine, ingested in food and water as iodide, is actively concentrated by the thyroid and converted to organic iodine (organification) within follicular cells by thyroid peroxidase. (msdmanuals.com)
Therapeutic4
  • BUSINESS WIRE )-- NorthStar Medical Radioisotopes , LLC, a global innovator in the development, production and commercialization of radiopharmaceuticals used for therapeutic and medical imaging applications, today announced a corporate update highlighting progress across its key programs during the past twelve months, and indicating important upcoming milestones. (businesswire.com)
  • NorthStar is poised to be the first commercial-scale producer of therapeutic radioisotopes Cu-67 and non-carrier added (n.c.a. (businesswire.com)
  • Gamma radiation can be detected by the camera to determine radioactive iodine uptake and create an image of the thyroid gland during thyroid scintigraphy, whereas beta radiation yields the therapeutic effect by triggering thyroid follicular cell death. (acpinternist.org)
  • The beta particles emitted are used to kill, destroy, or ablate cells that use iodine and makes it a good therapeutic agent. (nrc.gov)
Uptake2
  • Because of the specificity of its uptake by the human body, radioactive isotopes of iodine can also be used to treat thyroid cancer . (wikipedia.org)
  • Atenolol was prescribed, and thyroid scintigraphy with determination of radioactive iodine uptake was ordered. (acpinternist.org)
Iodides1
Molybdenum-991
  • This process begins with radioisotope production, which involves using higher-energy elements like uranium and thorium to produce isotopes such as actinium-225 (Ac-225), Lead-212 (Pb-212), molybdenum-99 (Mo-99), iodine-131 (I-131). (mddionline.com)
Stable6
  • The thyroid gland uses iodine to produce thyroid hormones and cannot distinguish between radioactive iodine and stable (nonradioactive) iodine. (cdc.gov)
  • The other xenon radioisotopes decay either to stable xenon, or to various caesium isotopes, some of them radioactive (a.o., the long-lived 135Cs and 137Cs). (wikipedia.org)
  • These in vivo measurement techniques are commonly used to measure body burdens of iodine radioisotopes, but cannot be used to assess the stable isotope of iodine. (cdc.gov)
  • Instead, in vitro measurements provide an estimate of internally deposited iodine (both the stable and radioactive isotopes), utilizing techniques that measure iodine in body fluids, feces, or other human samples (Gautier 1983). (cdc.gov)
  • Stable Iodine, an essential trace element , is used by the thyroid gland to produce two thyroid hormones (T3 and T4). (nrc.gov)
  • In these cases, radioactive I-131 can be used to replace stable iodine and kill both the normal and abnormal thyroid cells regardless of where they are located. (nrc.gov)
Ablation1
  • A sample comprising 88 patients submitted to ablation with iodine 131 was included in the study. (bvsalud.org)
Technetium-99m1
  • of the 8,000,000 administrations per year of radioisotopes in the United States, some 90% utilize either iodine-131, cobalt-60 or technetium-99m. (orau.org)
Chemically1
  • The number of neutrons in the nucleus may vary and provide a number of different iodine atoms that chemically act the same but have different physical properties. (nrc.gov)
Synthesis4
  • As the heaviest essential mineral nutrient , iodine is required for the synthesis of thyroid hormones . (wikipedia.org)
  • Many iodine-containing compounds are frequently used as reagents in organic synthesis - mainly for iodination, oxidation and C - C bond formation. (scienceinschool.org)
  • Physiologically, iodine is an essential element, required for the synthesis of thyroid hormones - triiodotyronine and thyroxine - which regulate growth, development and cell metabolism. (scienceinschool.org)
  • PHARMACOLOGIC THERAPY  Two forms of pharmacotherapy are available for treating hyperthyroidism and controlling excessive thyroid activity:  (1) use of irradiation (exposure to radiation) by administration of the radioisotope 123I or 131I for destructive effects on the thyroid gland and  (2) Antithyroid medications that interfere with the synthesis of thyroid hormones and other agents that control manifestations of hyperthyroidism. (slideshare.net)
Decay1
  • Thereafter, the irradiated gas is allowed to decay for three or four days to eliminate short-lived unwanted radioisotopes, and to allow the newly created xenon-125 (half-life 17 hours) to decay to iodine-125. (wikipedia.org)
Deficiency2
  • [5] Iodine deficiency affects about two billion people and is the leading preventable cause of intellectual disabilities . (wikipedia.org)
  • The classic symptom of iodine deficiency is thyroid enlargement (goitre). (scienceinschool.org)
Iodination1
Radiation9
  • For more information about I-131, see the Public Health Statement by the Agency for Toxic Substances and Disease Registry at https://wwwn.cdc.gov/TSP/PHS/PHS.aspx?phsid=477&toxid=85 , or visit the Environmental Protection Agency at https://www.epa.gov/radiation/radionuclide-basics-iodine . (cdc.gov)
  • Iodine-125 can be used in scanning/imaging the thyroid, but iodine-123 is preferred for this purpose, due to better radiation penetration and shorter half-life (13 hours). (wikipedia.org)
  • There is some exposure to radiation from the radioisotope. (medlineplus.gov)
  • The radiation from this radioisotope is higher than from many others. (medlineplus.gov)
  • The in vivo measurement of these radioisotopes within the body is performed with various radiation detectors and associated electronic devices that are collectively known as in vivo thyroid monitors or whole body counters, depending on the body site of interest. (cdc.gov)
  • The radioisotope 131 I emits both gamma and beta radiation. (acpinternist.org)
  • The NRC staff developed the following information on radioactive iodine (RAI) treatment procedures so that patients will understand the reason for the procedures, the process, and how to reduce radiation exposure to others. (nrc.gov)
  • the transmutation reactions which led to the production of these radioisotopes were effected first with the 27-inch cyclotron, which later became the 37-inch cyclotron, in the old Radiation Laboratory, and finally with the 60-inch cyclotron in the Crocker Laboratory. (orau.org)
  • 1 'EXTREME' Radiation Water Filtration Straw filters radioisotopes from outdoor fresh-water drinking supplies. (nukepills.com)
Occurs1
  • Domestic production of radioisotopes occurs mainly at IPEN's IEA-R1 reactor, which has a maximum power of 5 megawatts (MW) and is located at the University of São Paulo (USP). (fapesp.br)
Neutron2
  • Iodine-125 itself has a neutron capture cross section of 900 barns, and consequently during a long irradiation, part of the 125I formed will be converted to 126I, a beta-emitter and positron-emitter with a half-life of 13.1 days, which is not medically useful. (wikipedia.org)
  • The RMB would be six times more powerful, at 30 MW, and in addition to producing radioisotopes for use in medicine, industry, and agriculture, would also be used to test nuclear materials and fuels and to generate neutron beams for research in various fields of science. (fapesp.br)
Substances1
  • Its production chain depends largely on imported radioisotopes-radioactive substances manufactured in nuclear reactors that serve as the raw material for radiopharmaceuticals. (fapesp.br)
Tumor1
  • To improve the residence time of the iodine label in the tumor, a new bivalent peptide was synthesized that is peptidase resistant and consists of 4 d -amino acids ( d -a.a. peptide). (snmjournals.org)
Xenon1
Diagnosis1
  • I became involved in the discovery of a number of radioisotopes that in subsequent years have found substantial applicants in the diagnosis and treatment of disease. (orau.org)
Radionuclide1
  • A radionuclide ( radioactive nuclide , radioisotope or radioactive isotope ) is a nuclide that has excess nuclear energy, making it unstable. (wikipedia.org)
Mice1
  • They found that absorption of the radioisotope in the thyroid was greatly impaired in mice lacking the KCNE2 gene. (sciencedaily.com)
References1
  • It includes information and links to medical and patient advocacy references about Iodine-131 (I-131) treatments. (nrc.gov)
Iodate1
  • Today, however, it is removed from natural iodine-containing brines in gas and oil fields in Japan and the USA, or from Chilean caliches (nitrate ores), which contain calcium iodate (Ca(IO 3 ) 2 ). (scienceinschool.org)
Medical Radioisotopes3
  • NorthStar's industry-leading reputation is grounded in technological innovation, successful execution and proven expertise, and we have made tremendous strides in advancing our portfolio over the past year," said Stephen Merrick, Chief Executive Officer of NorthStar Medical Radioisotopes. (businesswire.com)
  • Belgian Minister of Energy, Environment, and Sustainable Development Marie-Christine Marghem, who is responsible for IRE, said, "Despite the restrictions related to the health crisis, IRE has continued its efforts and has made it possible to collaborate in the implementation of our national strategy for the production of medical radioisotopes. (ans.org)
  • According to an April 20 communication from a Nuclear Medicine Europe (NMEu) emergency response team, organizations involved in the supply of Mo-99 and other medical radioisotopes, including research reactors, Mo-99 producers, Tc-99m generator manufacturers, and ground transportation, have reported regular operations. (ans.org)
Trace1
  • This goes some way to explaining why trace amounts of molecular iodine (I 2 ) can be detected in the atmosphere of coastal regions and why human iodine intake in these regions is dependent on seaweed abundance rather than proximity to the sea. (scienceinschool.org)
Monoclonal1
Treatments1
  • These agreements have the potential to bring novel new treatments to patients with cancer, using radioisotopes to selectively destroy a wide range of cancer cells. (businesswire.com)
Milk2
  • In addition, if dairy animals consume grass contaminated with I-131, the radioactive iodine will be incorporated into their milk. (cdc.gov)
  • Title : Field method for rapid collection of iodine 131 from milk Personal Author(s) : Porter, Charles R.;Carter, Melvin W. (cdc.gov)
Producers1
Commonly1
METHODS1
  • The purpose of this chapter is to describe the analytical methods that are available for detecting, measuring, and/or monitoring iodine and its radioisotopes, their metabolites, and other biomarkers of exposure and effect to iodine and its radioisotopes. (cdc.gov)
Halogens1
  • Iodine belongs to the halogens, and thus shares many of the typical characteristics of the elements in this group. (scienceinschool.org)
Treatment3
  • IRE said that the conversion process to LEU radioisotope production will soon include the manufacture of iodine-131, which is used in the treatment of thyroid cancer. (ans.org)
  • The U.S. Food and Drug Administration (FDA) has granted Cellectar's lead asset iopofosine I 131, a small-molecule Phospholipid Drug Conjugate™ (PDC) designed to provide targeted delivery of iodine-131 (radioisotope), Fast Track Designation for WM patients having received two or more prior treatment regimens, as well as relapsed (or refractory) multiple myeloma and relapsed (or refractory) diffuse large B-cell lymphoma (DLBCL). (cbs42.com)
  • Use of radioactive iodine is the most common treatment in elderly patients. (slideshare.net)
Half-life1
  • This is called the physical half-life of the radioisotope. (nrc.gov)
Cells1
  • Iodine, with its characteristic purple vapours, has myriad applications - from the familiar disinfectant to innovative solar cells. (scienceinschool.org)
Officials1
  • To be most effective, the first dose should be taken no later than 2-3 hours prior to potential exposure to radioactive iodine (as directed by public health officials). (nukepills.com)
Discovery1
Atmosphere1
Essential1
  • In 1811, iodine was discovered by French chemist Bernard Courtois , [8] [9] who was born to a manufacturer of saltpetre (an essential component of gunpowder ). (wikipedia.org)
Production1
  • Iodine is also used as a catalyst in the industrial production of acetic acid and some polymers . (wikipedia.org)
Provide1
  • The company's product pipeline includes lead asset iopofosine, a small-molecule PDC designed to provide targeted delivery of iodine-131 (radioisotope), proprietary preclinical PDC chemotherapeutic programs and multiple partnered PDC assets. (cbs42.com)
Table1
  • The recommended dietary intake of iodine for adults is 150 µg/day, which can be obtained from dairy products, seaweed and iodised table salt. (scienceinschool.org)
French1
  • Gay-Lussac went on to investigate the chemistry of iodine, and despite the war, the French chemists found ways to correspond with British chemists, notably Sir Humphry Davy. (scienceinschool.org)
Makes1