• These strategies involve rearrangements at the molecular level starting from transcription, regulation of mRNA processing, translation, and protein modification or its turnover. (intechopen.com)
  • Analysis of miRNAs involved in the regulation of MMP9 and its consequences to cell. (usp.br)
  • MicroRna expression profile involved in the regulation of genes associated with angiogenesis. (usp.br)
  • With the development of the gene expression profile, comparisons of differentially expressed genes that participate in the regulation of pathophysiological conditions in pathological tissue and normal tissue were available and convenient, and mRNAs gene expression profiles have been carried out in many diseases including TAD [ 6 ]. (hindawi.com)
  • Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression. (nih.gov)
  • RNA-Seq analysis revealed that more severe disease in line W was associated with significant up-regulation of pathways involved in inflammation, cytoskeletal regulation by Rho GTPases, nicotinic acetylcholine receptor signaling, and Wnt signaling in the bursa compared to line 15I. (imperial.ac.uk)
  • 0.01) and, when stimulated ex vivo with LPS, showed more rapid up-regulation of pro-inflammatory gene expression than those from line 15I birds. (imperial.ac.uk)
  • I was intrigued to learn more about the regulation of gene expression (protein synthesis) and how this is altered in disease conditions. (who.int)
  • After my master's degree, I was sure I wanted to pursue research as a career, and while selecting my PhD research topic I came across the field of epigenetics, which is the branch of molecular biology that deals with gene regulation. (who.int)
  • More specific to diatom biology, the understanding of silicon biochemistry in diatoms was enhanced by the discovery of genes involved in the uptake of silicic acid and proteins involved in vesicles for silica precipitation. (wikipedia.org)
  • Thus, stress response studies during these growth stages reveal novel differentially regulated genes or proteins with important functions in plant stress adaptation. (intechopen.com)
  • Odorant binding proteins (OBPs) are involved in either olfactory or nonolfactory cue sensation depending on their spatial and temporal expression. (bioone.org)
  • Expression of hepsin and pim-1 proteins was significantly correlated with measures of clinical outcome. (nature.com)
  • At each maturation stage, expression of proteins affects the commitment to move to the next stage and cellular functions, such as rearrangement and expression of Ig genes. (lu.se)
  • Defects in genes and proteins important for B cell maturation cause primary immunodeficiencies (see IDbase ). (lu.se)
  • Bioinformatic analysis of the proteomic phenotypes revealed shared Gene Ontology (GO) terms and signaling pathways within the clusters of co-expressed proteins (see Tables 1-2 ). (lu.se)
  • Signalling pathways and identified proteins involved. (lu.se)
  • This study aims at integrating two gene expression profile datasets and verifying hub genes and pathways involved in TAD as well as exploring potential molecular mechanisms. (hindawi.com)
  • The two expression profile datasets were integrated and we found out coexpression of differentially expressed genes (DEGs) using bioinformatics methods. (hindawi.com)
  • We analyse two comprehensive transcriptome datasets from human tissues and human-derived cell lines in terms of the expression profiles of the SLC and ABC families of membrane transporters. (biorxiv.org)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • Combining these new datasets with existing published gene expression and protein expression data have identified selected panels of novel biomarkers which have been evaluated on over 100 cervical cancer and pre-cancer cases using standard immunohistochemistry approaches. (europa.eu)
  • To analyze microarray datasets (34760 variables) and obtain functional implications of differential expression patterns, we used Linear Models for Microarray Data (limma) followed by Gene Set Enrichment Analysis (GSEA) using ClusterProfiler. (lu.se)
  • But even so, gene-expression profiling can be enormously valuable in finding biomarkers, highlighting druggable targets, revealing the metabolic pathways important in a biological process, and identifying subsets of a population that might respond to a certain therapy or be more susceptible to a certain clinical outcome. (genengnews.com)
  • 0.05), and these candidate genes could be used as potential diagnostic biomarkers and therapeutic targets of TAD. (hindawi.com)
  • Within the project using next generation sequencing technology and signal transduction pathway activity profiling technology, we have identified novel pathways and biomarkers implicated in cervical carcinogenesis. (europa.eu)
  • This study involves a comprehensive, multi-modal, and integrative assessment of biomarkers implicated in the pathophysiology of PTSD, including measuring differences in whole-blood gene expression and other blood biomarkers of key neurobiological systems, an approach critical to informing risk and resilience prediction algorithms for PTSD, and to develop novel psychopharmacologic approaches for the treatment of this disabling condition in disaster responders and other trauma survivors. (cdc.gov)
  • 3. Translational research - to identify predictive biomarkers for treatment decision - by immunohistochemistry, gene expression or sequencing. (lu.se)
  • Expression-profile analysis in Schwann cells identifies genes involved in myelination. (the-scientist.com)
  • Chromosomal abnormalities, HLA phenotypes, and polymorphisms of various genes have been associated with acne. (springer.com)
  • Characterisation of gene expression patterns in bladder cancer allows the identification of pathways involved in its pathogenesis, and may stimulate the development of novel therapies targeting these pathways. (urotoday.com)
  • Our findings shed further light on several important signalling pathways involved in lung adenocarcinoma, and suggest new molecular targets for treatment. (kb.se)
  • In this study, differentially expressed genes (DEGs) under drought and flooding conditions were investigated using Illumina RNA-Seq transcriptome profiling. (frontiersin.org)
  • Interestingly, both TGF-beta1 and SERPINE2 have been identified as candidate genes in COPD genetic linkage and association studies. (nih.gov)
  • We identified Tmem45b as one of 12 candidate genes that were specific to somatosensory ganglia and down-regulated by IB4 neuronal ablation. (iasp-pain.org)
  • We have used transcript profiling to explore the early transcriptional responses of mature C. albicans biofilms exposed to various antifungal agents. (who.int)
  • Disabling demyelinating neuropathies are associated with mutations in genes associated with regulating the process of myelination. (the-scientist.com)
  • Hara Levy, professor of physiology at the Human and Molecular Genetics Center of the Medical College of Wisconsin, studies cystic fibrosis (CF). Although CF is caused by mutations in the CF transmembrane conductance regulator gene, patients with identical genetic mutations in this gene can suffer variable levels of lung disease severity. (genengnews.com)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Genetic testing of OWRD patients and their family members can confirm the presence of mutations within implicated genes, most commonly the endoglin gene ( ENG ) in chromosome 9 or the activin receptorlike kinase type I (ALK-1) gene ( ALK1 ) in chromosome 12 (involved in HHT type 1 and type 2, respectively). (medscape.com)
  • DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. (kb.se)
  • These data provide evidence of somatic mutations in primary lung adenocarcinoma for several tumour suppressor genes involved in other cancers--including NF1, APC, RB1 and ATM--and for sequence changes in PTPRD as well as the frequently deleted gene LRP1B. (kb.se)
  • 6 ], the transforming growth factor beta 1 ( Tgfβ1 ) gene and several collagen genes were significantly downregulated in 8-week-old B6 mice scleras when compared with 3-week-old B6 mice scleras. (molvis.org)
  • In particular, with some exceptions such as olfactory receptors and genes involved in keratin production, transporter genes are significantly more heterogeneously expressed than are most non-transporter genes. (biorxiv.org)
  • these often differ significantly from the 'housekeeping' genes commonly used for normalisation in transcriptomics and qPCR studies. (biorxiv.org)
  • The expression of photosynthesis and chlorophyll synthesis related genes were significantly reduced under both types of stresses, which limit the metabolic processes and thus help prolong survival under extreme conditions. (frontiersin.org)
  • Our analysis identified 26 genes that are mutated at significantly high frequencies and thus are probably involved in carcinogenesis. (kb.se)
  • Expression profiling was carried out on samples of 7 benign, 7 LMP and 28 invasive (moderate and poorly differentiated) serous tumors and four whole normal ovaries using oligonucleotide microarrays representing over 21,000 genes. (biomedcentral.com)
  • Five genes that were differentially expressed between invasive and either benign or normal tissues were validated by real time PCR in an independent panel of 46 serous tumors (4 benign, 7 LMP, 35 invasive). (biomedcentral.com)
  • To identify genes associated with neoplastic progression in the serous subtype of ovarian tumors, we compared gene expression in tissues that exhibited the spectrum of tumor behavior, namely benign, low malignant potential (LMP) and invasive. (biomedcentral.com)
  • In order to clarify the molecular relationships among the spectrum of serous ovarian tumors, we compared gene expression profiles of 7 LMP and 28 invasive (moderate and poorly differentiated or Grade 2 and Grade 3) serous ovarian tumors with two different reference groups: 7 serous benign ovarian tumors and four normal whole ovary specimens. (biomedcentral.com)
  • ExperimentalDesign: We investigated ERh by immunohistochemistry in 353 stage II primary breast tumors from patients treated with 2 years adjuvant tamoxifen, and generated gene expres- sion profiles for a representative subset of 88 tumors. (lu.se)
  • Breast cancers are most often epithelial tumors involving the ducts or lobules. (msdmanuals.com)
  • Our findings are paving the way for the development of a gene therapy for cancer where the three molecules are delivered directly into tumors in patients eliciting a response independently of the tumor type. (lu.se)
  • Liver, muscle, and intestine tissue samples were taken to measure mRNA expression of key genes involved in glucose, lipid, and protein metabolism. (frontiersin.org)
  • The T. pseudonana genome revealed novel genes for intracellular trafficking and metabolism in diatoms. (wikipedia.org)
  • Tumor necrosis factor-alpha (TNF-alpha), a pivotal pro-inflammatory cytokine in RA may be involved in the development of the disturbed lipid metabolism. (researchgate.net)
  • however those involved in tissue morphology, metabolism and cell survival were also altered. (bmj.com)
  • Transcript profiles involved in the starch and sugar metabolism pathways were also affected under both stress conditions. (frontiersin.org)
  • Differential associations between plasma concentrations of insulin and glucose and intestinal expression of key genes involved in chylomicron metabolism. (harvard.edu)
  • Genes involved in extracellular matrix synthesis/degradation and apoptosis were among the up-regulated genes, whereas genes that participate in antiinflammatory responses were down-regulated. (nih.gov)
  • Results revealed distinct expression profiles where exposure to TGF-beta1 resulted in modulation of genes involved in extracellular matrix organization and cell adhesion by E2. (cdc.gov)
  • Microarray technology and next-generation sequencing methods have enabled us to see all of the genes expressed by a given cell type at any particular time, or under a particular circumstance. (genengnews.com)
  • In the present study, we use mRNA microarray to acquire differential expression profiles in human TAD tissues and non-TAD tissues. (hindawi.com)
  • Then we downloaded another microarray dataset GSE52093 [ 9 ] and screened out the coexpression of differentially expressed genes (DEGs) between TAD patients and non-TAD patients. (hindawi.com)
  • Thus, the integration of cDNA microarray, high-density tissue microarray, and linked clinical and pathology data is a powerful approach to molecular profiling of human cancer. (nature.com)
  • ITT, GTT, and MTT showed that CS rats were neither insulin resistant nor glucose intolerant, but mRNA expression of cholecystokinin (CCK) in the duodenum was higher and that of CPT1, PPARα, and PGC1α in liver were lower than in CR rats. (frontiersin.org)
  • In general, mRNA levels of ECM and collagen genes have been found to be downregulated in both the adult mouse sclera [ 6 ] and cornea [ 7 ] when compared with samples from an earlier developmental stage. (molvis.org)
  • These profiles measure mRNA, not protein, so further studies are needed to corroborate that any detected changes in gene expression actually have meaning in the life of the cell. (genengnews.com)
  • Using mRNA from total blood leukocytes, they found that a full one-quarter of the human genome exhibits changes in expression levels during the early stages of post-trauma (40-80 hours post-trauma). (genengnews.com)
  • mRNA from the specimens was profiled using Agilent's Functional ID v2.0 array (Agilent, Santa Clara, CA) containing 23,720 sequences. (nih.gov)
  • Specifically, Mason and his team found an increase in methylation, which involves slapping methyl groups onto stretches of DNA. (scientificamerican.com)
  • Previously published work on DNA methylation status in GWI was reanalyzed focusing specifically on the predicted shared targets indicating significant changes in DNA methylation of the associated genes. (cdc.gov)
  • These results were published in the article "Genome-wide DNA methylation profiling of esophageal squamous cell carcinoma from global high-incidence regions identifies crucial genes and potential cancer markers" in the journal Cancer Research . (who.int)
  • Expression of metalloproteinases and their tissue inhibitors in the detrusor muscle. (usp.br)
  • The results provide evidence that genes involved in tissue remodeling and repair are differentially regulated in the lungs of obstructed smokers and suggest that they are potential therapeutic targets. (nih.gov)
  • We assessed two of these genes-hepsin, a transmembrane serine protease, and pim-1, a serine/threonine kinase-at the protein level using tissue microarrays consisting of over 700 clinically stratified prostate-cancer specimens. (nature.com)
  • Molecular profiling of clinical tissue specimens: feasibility and applications. (nature.com)
  • DNA viruses such as herpesvirus and poxvirus have multiple genes, some of them host-derived, which interfere with effective innate or acquired immune responses. (imperial.ac.uk)
  • Given the uncertainty about the relationship between these different forms, we compared their patterns of gene expression. (biomedcentral.com)
  • This study was aimed at determining the differential gene expression patterns of OBP genes in the developmental stages (larval, pupal, teneral) and differentially starved adults of Glossina brevipalpis (Newstead) collected from Shimba Hills National Park, Kenya. (bioone.org)
  • To this end, we currently use several (conditional) knock-out mice and cell lines to study gene expression patterns, metabolic profiles, protein interactions, intracellular trafficking, and signaling pathways. (nih.gov)
  • Gene expression was related to forced expiratory flow between 25 and 75% of forced expiratory volume (FEF(25-75%) % predicted) revealing a signature gene set of 203 transcripts. (nih.gov)
  • Their analysis led to the identification of myelination-associated genes involved in lipid synthesis. (the-scientist.com)
  • However, cell wall synthesis related genes were up-regulated under drought stress and down-regulated under flooding stress. (frontiersin.org)
  • Using qRT-PCR, we confirmed that mHTT overexpression caused significant downregulation of key enzymes involved in neuropeptide synthesis, including histidine and dopa decarboxylases, compared to wtHTT overexpression. (lu.se)
  • Multiple biosynthetic pathways such as sterol synthesis were among the top shared processes, where both unique and shared genes constituted leading-edge subsets. (lu.se)
  • I was fascinated with topics such as the central dogma of molecular biology and protein synthesis, which are about the mechanisms of gene expression. (who.int)
  • Results of this work highlight ESR1 and E2 target genes as potential targets of MWNTs in the lung. (cdc.gov)
  • In this genomic age, one possible answer is that a cell can be defined by a profile of all of the genes it is expressing. (genengnews.com)
  • Two of these methods, signature-tagged mutagenesis and in vivo expression technology, do not directly measure gene expression and do not allow true genomic-scale analysis, but they have been devised to identify genes necessary for pathogens during real infections. (cdc.gov)
  • Genomic profiling also identifies genes associated with poor outcome in cases without molecular aberrations and specific genes that may be new therapeutic targets in adult ALL. (aacrjournals.org)
  • Over-expression of WNT7A in an ovarian cancer cell line led to increased migration and invasive capacity. (biomedcentral.com)
  • Using microarrays of complementary DNA, we examined gene-expression profiles of more than 50 normal and neoplastic prostate specimens and three common prostate-cancer cell lines. (nature.com)
  • Signature expression profiles of normal adjacent prostate (NAP), BPH, localized prostate cancer, and metastatic, hormone-refractory prostate cancer were determined. (nature.com)
  • Here we establish many associations between genes and prostate cancer. (nature.com)
  • Liotta, L. & Petricoin, E. Molecular profiling of human cancer. (nature.com)
  • Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. (nature.com)
  • Sub-groups of the cancer have been identified based on differences in gene expression profiles. (news-medical.net)
  • R-CHOP has even been reported to activate certain oncogenes (genes that can cause cancer) and favor a specific subset of cells also referred to as sub-clonal populations. (news-medical.net)
  • Genes associated with the classical complement pathway were downregulated in non-muscle invasive cancer. (urotoday.com)
  • The present study contributes to a growing body of work on gene expression signatures in bladder cancer. (urotoday.com)
  • Conclusion: Expression of ERh is an independent marker for favorable prognosis after adjuvant tamoxifen treatment in ERa-negative breast cancer patients and involves a gene expression program distinct from ERa. (lu.se)
  • Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)
  • Can tumor gene expression profiling improve outcomes in patients with breast cancer? (cdc.gov)
  • The research agen- role, from predicting how cancers sense, technology is both a cure for das of high-income countries (HICs) wil progress and evolve on the basis and a cause of global inequalities in and institutions that wish to indus- of their genetic profiles to optimizing cancer. (who.int)
  • Patients with rheumatoid arthritis (RA) frequently display an atherogenic lipid profile which has been linked with inflammation. (researchgate.net)
  • We investigated whether infliximab, an anti-TNF-alpha therapy, may modify the lipid profile. (researchgate.net)
  • Lipid profile and CRP were assayed at baseline and before infusion at weeks 6 and 30. (researchgate.net)
  • We will combine our mRNAs expression profile (6 TAD tissues versus 6 non-TAD tissues) and GSE52093 downloaded from the Gene Expression Omnibus (GEO) database. (hindawi.com)
  • The two mRNAs expression profiles contained 13 TAD aortic tissues and 11 non-TAD tissues. (hindawi.com)
  • The Gini index (coefficient) characterises inequalities of distributions, and is used in a novel way to describe the distribution of the expression of each transporter among the different tissues and cell lines. (biorxiv.org)
  • Similar trends hold true for the expression profiles of transporters in different cell lines, suggesting that cell lines exhibit largely similar transport behaviour to that of tissues. (biorxiv.org)
  • PCBP1 is both reasonably highly expressed and has a low Gini coefficient in both tissues and cell lines, and is an excellent novel housekeeping gene. (biorxiv.org)
  • Central to this investigation is an understanding of what gene products are required and expressed during a natural infection and how this expression changes over time (from initial colonization to causation of disease and spread of the pathogen to new hosts) and space (in different cells or tissues within the host). (cdc.gov)
  • A second group of methods, which includes DNA microarrays and proteomics, have advantages that overcome the limitations implicit in signature-tagged mutagenesis and in vivo expression technology, namely, the ability to directly measure expression (gene or protein) levels on a true genome-wide scale, but their application to analysis of bacterial pathogens during real infections is still in its infancy. (cdc.gov)
  • A surprising finding from the T. pseudonana genome was the presence of genes encoding enzymes for a complete urea cycle, which was unprecedented in a photosynthetic eukaryote. (wikipedia.org)
  • Overall, our analyses provide novel opportunities for the normalisation of genome-wide expression profiling data. (biorxiv.org)
  • Given that the basic genome of a differentiated organism is constant between cells (and we here ignore epigenomics), what mainly discriminates one cell type from another is its expression profile. (biorxiv.org)
  • Although analyses that give information on the expression of a few genes provide insight and have been responsible for a large proportion of the bacterial pathogenesis literature currently available, our ultimate goal is to understand expression changes across the whole genome. (cdc.gov)
  • The additional information generated by whole genome studies goes far beyond that derived by characterizing in isolation more genes and gene products, because analysis of the whole genome allows complete regulatory networks to be identified and characterized. (cdc.gov)
  • Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility. (nih.gov)
  • Gene expression of eye diseases should be studied as early as postnatal weeks 1-2 to ensure that any changes in gene expression pattern during disease development are detected. (molvis.org)
  • Interestingly, FLU-exposed biofilms showed no significant changes in gene expression over the course of the experiment. (who.int)
  • The aim of the present study was to investigate the mechanisms involved in these metabolic dysregulations. (frontiersin.org)
  • Despite the large economic and nutritional importance of tuber wound-healing, little is known about the induction of hormones that regulate molecular mechanisms and related genes controlling these processes and how they are expressed during the two major stages of wound-induced suberization, i.e. closing layer formation followed by wound periderm formation. (usda.gov)
  • The molecular mechanisms involved in the antifungal resistance of biofilms remain poorly understood. (who.int)
  • Thus, more basic research is needed on the chemical reactions involved in the antigen formation and the immunological mechanisms. (cdc.gov)
  • Immunohistochemistry confirmed expression of urokinase plasminogen activator (PLAU), urokinase plasminogen activator receptor (PLAUR), and thrombospondin (THBS1) by alveolar macrophages and airway epithelial cells. (nih.gov)
  • Osteopontin (OPN) expression was validated by immunohistochemistry. (urotoday.com)
  • The peroxisome proliferator- activated receptor gamma coactivator 1-alpha ( Ppargc1a ) gene was found to be involved in the networks generated using Ingenuity Pathway Studio (IPA) from the differentially expressed transcript cluster lists of week 2 versus 1, week 3 versus 2, week 6 versus 3, and week 8 versus 6. (molvis.org)
  • Multiple transcript variants encoding different isoforms have been found for this gene. (nih.gov)
  • The limitations and possibilities associated with expression profiling in intracellular amastigotes and promastigotes were assessed through a series of comparative experiments in which technical and biological parameters were scrutinized. (cambridge.org)
  • this is particularly a delicate task for intracellular amastigotes and for specific 'sensory' genes. (cambridge.org)
  • On the biological level, we demonstrate that gene expression levels fluctuate during in vitro development of both intracellular amastigotes and promastigotes. (cambridge.org)
  • Intracellular amastigote protocols need further refinement, but we describe a first generation tool for high-throughput comparative molecular characterization of patients' isolates, based on the changing expression profiles of promastigotes during in vitro differentiation. (cambridge.org)
  • To interpret their results they performed careful anchor gene correlation analysis (AGCA), using the expression of proliferative markers (Ki-67 antigen or PCNA ), inflammatory genes ( MCP -1 or interleukin 6) or myelination genes (such as PMP22 or MAG ), as anchor genes. (the-scientist.com)
  • Anaplastic large cell lymphomas (ALCLs) are distinguished from other lymphomas by their anaplastic cytology and constant membrane expression of the CD30 antigen (an activation marker for B or T cells). (medscape.com)
  • Further, B cell antigen receptor (BCR) activation induced proteome profiles were studied in anti-IgM stimulated Ramos cells in a time series. (lu.se)
  • The gene ontology and pathway enrichment of DEGs were performed by DAVID and Kyoto Encyclopedia of Genes and Genomes online analyses, respectively. (hindawi.com)
  • Traditional bioinformatics methods including gene ontology (GO) and pathways enrichment analyses of DEGs combined protein-protein interaction (PPI) network and cytohubber calculating software as well as Molecular Complex Detection (MCODE) analysis were used to analyze the key gene and pathway. (hindawi.com)
  • Recent genetic studies using ribosomal RNA gene sequences better distinguish and classify Thalassiosira species and metabolomics defines the organic compounds produced by Thalassiosira. (wikipedia.org)
  • Gene expression profiling is increasingly used in the field of infectious diseases for characterization of host, pathogen and the nature of their interaction. (cambridge.org)
  • The purpose of this study was to develop a robust, standardized method for comparative expression profiling and molecular characterization of Leishmania donovani clinical isolates. (cambridge.org)
  • Functional characterization and expression profile of microsomal FAD2 and FAD3 genes involved in linoleic and α-linolenic acid production in Leucas cephalotes . (bvsalud.org)
  • Differential protein expression was studied in eight human cell lines representing various maturation stages from early pre-B cell until terminally differentiated plasma cell (see Supplementary Table 1 ). (lu.se)
  • Supervised analysis of kinase genes revealed a high-level FLT3 expression in a subset of cases without molecular rearrangements. (aacrjournals.org)
  • Thoracic aortic dissection (TAD) is a catastrophic disease worldwide, but the pathogenic genes and pathways are largely unclear. (hindawi.com)
  • Zellweger spectrum disorder (ZSD) is a group of autosomal recessive disorders caused by biallelic pathogenic variants in any one of the 13 PEX genes essential for peroxisomal biogenesis. (stanford.edu)
  • Overexpression of the IGF-II/M6P receptor in mouse fibroblast cell lines differentially alters expression profiles of genes involved in Alzheimer's disease-related pathology. (nih.gov)
  • BEAS-2Bs were exposed to Mitsui MWNTs and estrogen receptor alpha (ESR1) gene expression was measured by qPCR. (cdc.gov)
  • his statistical challenge in this study was to correlate gene expression over multiple time points, in multiple patients, with multiple and different clinical presentations. (genengnews.com)
  • His innovation was to correlate the within-patient change in gene expression with the severity of the clinical outcome, rather than using absolute expression values as has traditionally been done. (genengnews.com)
  • We have validated this technology and plan to use it to correlate gene-expression status to disease status and pulmonary function," Dr. Levy said. (genengnews.com)
  • The observed mutational profiles correlate with clinical features, smoking status and DNA repair defects. (kb.se)
  • At the "Critical Assessment of Massive Data Analysis" conference held recently in Vienna, John Storey, from the Lewis-Sigler Institute for Integrative Genomics at Princeton University, gave a talk on dissecting the inflammatory complications in critically injured patients by within-patient gene-expression changes. (genengnews.com)
  • It took me a long time to appreciate just how extensively population heterogeneity and other unmeasured sources of variation introduce unwanted and systematic biases into the statistical analysis of gene-expression studies," Dr. Storey noted. (genengnews.com)
  • Five OBP genes, GbrOBP2 , GbrOBP6 , GbrOBP7 , GbrOBP8 , and GbrOBP13 , were selected for quantitative PCR expression analysis as representatives of the three OBP classes in Glossina spp. (bioone.org)
  • Bioinformatic and pathway analysis was performed using Ingenuity pathway analysis (IPA), with gene validation by real time PCR. (bmj.com)
  • Results Affymetrix analysis identified widespread changes in decidual gene expression following labour. (bmj.com)
  • Hypergeometric analysis was used to identify canonical pathways and curated networks having statistically significant enrichment of differentially expressed genes. (urotoday.com)
  • My work involves both benchwork experimentation and the analysis of the generated data using bioinformatics tools. (who.int)
  • In both these projects, I am coordinating the collaborations for project administration, which involves obtaining ethical clearances for project execution, collecting biospecimens and data, experimentation and molecular analysis, preparing manuscripts, and writing grant applications to support these projects. (who.int)
  • It was suggested that Tgfβ1 could possibly act as a signaling molecule in controlling collagen gene expression and modulate ECM during ocular growth. (molvis.org)
  • Genes identified as involved in the main biologic processes during postnatal scleral development were further confirmed using qPCR. (molvis.org)
  • The objective of this study was to determined content and, where possible, associated expression of genes limiting biosynthesis and catabolism of some of these hormones in potato tuber for coordination with established wound-healing processes. (usda.gov)
  • Of the genes involved in cell adhesion, Muc15 emerged as a potential target of E2 as Muc15 exhibited a statistically significant (p (cdc.gov)
  • Her research involves using transgenic animal models to understand how the physiological changes of pregnancy and lactation influence neuronal function and behavioural outcomes. (otago.ac.nz)
  • The current study aimed to characterise the inflammatory gene profile in the decidua during term labour. (bmj.com)
  • Researchers around the globe are harnessing gene-expression profiling studies in a variety of clinical settings to prevent and treat a number of diseases. (genengnews.com)
  • By measuring the change in expression within each patient, regardless of the patient's baseline values, this method leads more easily to a clinical translation of the results. (genengnews.com)
  • As usual, there was a vast array of PD research presented, covering topics that included clinical trials, epidemiology, non-pharmacologic interventions, non-motor symptoms, neuroimaging, gene- and cell-based therapies and more. (apdaparkinson.org)
  • The integrated advanced bioinformatics methods may provide a way to solve the disadvantages and identify the hub genes involved in TAD. (hindawi.com)
  • However, we now have a number of methods that allow identification of genes critical for survival in a host as well as methods that allow direct measurement of gene expression during interaction with a host. (cdc.gov)
  • This system regulates the expression of the genes involved in the degradation of toluene, benzene, and ethylbenzene through the toluene dioxygenase pathway. (nih.gov)
  • Space travel strongly affects the way genes are expressed, or turned on and off, preliminary results from NASA's ' Twins Study ' have revealed. (scientificamerican.com)
  • mainly involved in uptake, and ABC transporters (ABCs), mainly involved in efflux (e.g. (biorxiv.org)
  • This study has revealed the involvement of TFs, transporters, and photosynthetic genes, and has also given a glimpse of hormonal cross talk under the extreme water regimes, which will aid as an important resource for soybean crop improvement. (frontiersin.org)