• PPADS
  • The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS). (wikipedia.org)
  • P2X7 receptors are sensitive to pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) and relatively insensitive to suramin, but the suramin analog, NF279, is much more effective. (wikipedia.org)
  • inhibitor
  • antagonist: suramin) modulators, superoxide dismutase and a NADPH oxidase inhibitor (VAS2870), we evaluated the kinetics and balance of NO and ONOO - stimulated by nebivolol in human umbilical vein endothelial cells (HUVECs). (biomedcentral.com)
  • proteins
  • Once inside parasites, suramin combines with proteins, especially trypanosomal glycolytic enzymes to inhibit energy metabolism. (wikipedia.org)
  • a G protein-independent AT 1 R agonist) were used to determine the involvement of G proteins and AT 1A R trafficking in AngII-stimulated COX-2 protein expression in human embryonic kidney-293 cells stably expressing AT 1A /green fluorescent protein receptors and cultured vascular smooth muscle cells, respectively. (aspetjournals.org)
  • functional
  • Suramin contains six aromatic systems - four benzene rings, sandwiched by a pair of naphthalene moieties - plus four amide functional groups (in addition to the urea) and six sulfonic acid groups. (wikipedia.org)
  • This temporal modulation of KGF and KGFRs provides strong evidence for the functional involvement of KGF in human skin reepithelialization. (rupress.org)