Alternative sites for cell density regulation of the enzyme could rely on its sensitivity to sulfhydryl groups. (embl.de)
Methyl bromide, and possibly some other hydrocarbons, behave as alkylating agents and sulfhydryl enzyme inhibitors in mammalian tissues. (brainkart.com)
Antiulcerogenic1
SOIE could be used as a promising alternative antiulcerogenic compound to treat severe gastric lesions. (springeropen.com)
Tissues1
Mercury, in its various forms, has an affinity for the ubiquitous sulfhydryl groups in the tissues by forming covalent bonds. (statpearls.com)
Phosphate2
More than 95% of this activity is inhibited in assays where substrate has been added to a preincubated mixture of tissue with the non-neuropathic organophosphorus compound (OP) paraoxon (O,O'-diethyl p-nitrophenyl phosphate): residual activity includes soluble neuropathy target esterase (S-NTE) which, by definition, is considered resistant to long-term progressive (covalent) inhibition by paraoxon. (inrae.fr)
It uses active alkylating groups to interact with the amino groups, sulfhydryl groups, hydroxyl groups, phosphate groups and other nucleophilic groups in the protein and nucleic acid components of cells. (peroxidasessignaling.com)
Molecules2
In the human cell, antioxidant molecules include both nonenzymatic compounds such as glutathione (GSH), thioredoxin (Trx), ascorbate, α -tocopherol, β -carotene, and coenzyme Q10 and enzymes such as catalase, glutathione peroxidase, and superoxide dismutase (SOD) [ 8 ]. (hindawi.com)
Organic compounds are molecules that contain carbon bonded to another element such as hydrogen. (peroxidasessignaling.com)
Organic2
The organic forms of mercury can exist as short-chain, alkyl-mercury compounds (methylmercury and ethylmercury) or long-chain, aryl-mercury compounds (methoxyethyl mercury and phenylmercury). (statpearls.com)
Because microbial laccases have a broad substrate range, they can be used in biosensor technology to detect a wide range of organic compounds . (alquds.edu)
Biological activities2
Simple coumarins and analogues are a large class of compounds that have attracted their interest for a long time due to their biological activities: they have shown to be useful as antitumoural, anti-HIV agents and as CNS-active compounds. (benthamscience.com)
Terrestrial plants , fungi and actinobacteria have been the focus of many past bioprospecting programs, [12] but interest is growing in less explored ecosystems (e.g. seas and oceans) and organisms (e.g. myxobacteria , archaea ) as a means of identifying new compounds with novel biological activities . (alquds.edu)
Metabolism2
Cysteamine, a sulfhydryl compound, is an intermediate in the metabolism of coenzyme A to taurine in living organisms. (bvsalud.org)
The metabolism of 2,3,7,8-TCDD and related compounds is required for urinary and biliary excretion, and the rate of metabolism is thought to play a major role in regulating the rate of elimination (and detoxification) of these compounds (Van den Berg et al. (cdc.gov)
Renal1
Renal involvement is manifested by oliguria or anuria, haematuria and renal failure. (brainkart.com)
Structural2
The structural diversity found in this family of compounds led to the division into different categories, from simple coumarins to many other kinds of policyclic coumarins such as furocoumarins and pyranocoumarins. (benthamscience.com)
After the spectroscopic characterization of the late rhodopsin photoproducts, we analyzed truncated variants and revealed the involvement of the cytosolic N-terminus in the structural rearrangements upon photo-activation of the protein. (elifesciences.org)
Transport1
Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. (lookformedical.com)
Active1
Virtual screening approaches can roughly be divided into target structure-based screening (often referred to as docking) and screening using active compounds as templates (ligand-based virtual screening). (benthamscience.com)
Action3
Progressive hydroxylation of collagen over 48 h, as the inhibitory action of the compounds declined, was accompanied by a decreased loss of radiolabel from the uterine collagen. (embl.de)
The proposed mechanism of action consists in the formation of a toroidal pore with the involvement of the N-terminal domain [1]. (bvsalud.org)
An antineoplastic compound which also has antimetabolite action. (lookformedical.com)
Shown1
One of these compounds, 8-iso-PGF 2α , has recently been shown to be a specific, chemically stable, quantitative marker of oxidative stress in vivo. (biomedcentral.com)
Present1
The aim of the present study was to reveal the possible involvement of zinc-finger transcription factors Egr-1 & Sp-1 in the molecular mechanisms underlying gastric lesions caused by aspirin administration and stress. (ukrbiochemjournal.org)
Cell1
Using a fluorescent sulfhydryl probe as well as a sulfhydryl inhibitor, one observes a strong cell density response, supporting the hypothesis that cellular redox potential could alter protein stability. (embl.de)
Drug2
A site-directed labelling approach was used to attach thiol-reactive probes to cysteines introduced into transmembrane segment 6 (TM6) in order to perturb function and infer involvement of specific residues in drug binding and/or interdomain communication. (aston.ac.uk)
In the pharmaceutical industry, for example, almost one third of all small-molecule drugs approved by the U.S. Food and Drug Administration (FDA) between 1981 and 2014 were either natural products or compounds derived from natural products. (alquds.edu)
Study1
Twenty five from the 24 (74%) individuals allotted to the particular moderate-to-vigorous power team finished the actual treatment whilst Four in the Six (67%) participants in the stretches as well as sculpting involvement finished case study. (peptide-solubility.com)
Plants1
Earliest agronomist not considered Si as an essential element as N, P and K for plant growth because of non-availability of positive evidence to show Si involvement in any metabolic activities of plants (Datnoff et al. (researchsquare.com)
Glutathione4
It contains a sulfhydryl group that serves as an important branch in the formation of important biological compounds such as glutathione (GSH) and S-adenosylmethionine (SAM). (mthfrsupport.com.au)
The role of glutathione Even though involvement of genetic abnormalities in autism spectrum disorders (ASD) is well-accepted, recent studies point to an equal contribution by environmental factors, particularly environmental toxicants. (mthfrsupport.com.au)
In the present study, we ascertained the involvement of glutathione and certain sulfhydryl enzymes associated with signal transduction in mediating the effec. (uncg.edu)
Description: Glutathione helps protect cells from free radical damage as an antioxidant, but it can also covalently attach to proteins through its sulfhydryl moiety upon derivatization by reactive oxygen species (ROS). (muzeumamonitow.pl)
Enzymes1
Examples of damage caused by excessive concentration of various forms of oxygen and of free-radical activity include polysaccharide depolymerization (carbohydrate damage), oxidation and inactivation of sulfhydryl-containing enzymes (protein damage), and separation of DNA strands, cross-linkage, or base hydroxylation leading to mutations and inhibition of genes that are responsible for protein, nucleotide, and fatty acid synthesis (nucleic acid damage). (nih.gov)
Protein3
Additionally, the involvement of nitric oxide, non-protein sulfhydryl compounds (NP-SH), α-2 adrenergic receptors, and prostaglandins was investigated. (bvsalud.org)
Specific modification of protein sulfhydryl groups with α,β-unsaturated compounds. (nih.gov)
Protein S-glutathiolation and mixed disulfide formation as candidate mechanisms for protein regulation during intracellular oxidative stress have gained a renewed impetus in view of their involvements in redox regulation of signaling proteins. (nih.gov)
In addition to the dimeric soluble GSTs, other proteins have been identified as having a restricted ability to conjugate xenobiotics (foreign organic compounds) with GSH, notably the distantly related mitochondrial kappa GSTs and the trimeric microsomal GSTs of animals [ 4 , 5 ]. (biomedcentral.com)
Indirectly1
Most of the non-peptide tachykinin receptor antagonists described to date directly or indirectly arose out of large compound collection screening using a robust radioligand binding assay as the primary screen. (justia.com)
Biological1
Evidence also supports the involvement of tachykinin neuropeptides in a variety of biological activities including vasodilation, smooth muscle contraction, bronchoconstriction, immune system activation (inflammatory pain), and neurogenic inflammation. (justia.com)
Poorer2
[ 20 ] In a study involving approximately 120 Chinese patients with AML, two regulatory SNPs created two major haplotypes with lower mRNA level and poorer 2-year event-free survival associated with one compound genotype (-360CC/-201CC). (medscape.com)
Given that the virus‑induced neurological involvement is associated with a poorer prognosis, persistent neurological sequelae, and a more severe form of the disease, efforts have been made to introduce a biomarker to recognize neurological abnormalities early in the course of the disease. (ane.pl)
Groups1
The mechanism for tolerance is not fully understood, but it may involve depletion of tissue sulfhydryl groups, or scavenging of NO by superoxide anion and the subsequent production of peroxynitrite that may inhibit guanylyl cyclase. (kseldercare.com)
Specific1
This study aimed to ascertain if specific nutritive factors or related compounds influence heme oxygenase-1 expression. (uncg.edu)
Expression2
Antibiotics and toxic compounds induced the expression of ncgl0887 - atsR operon. (biomedcentral.com)
The TetR family of transcriptional factors are known to regulate expression of genes involved in bacterial efflux systems against antimicrobial compounds or drugs [ 4 ]. (biomedcentral.com)
Acts2
To our knowledge, this is the first report on a natural antitumor high-methoxyl homogalacturonan pectin from the H. rhamnoides berry-a compound that acts as a potential immunostimulant and anticancer adjuvant. (virginia.edu)
Symptomatic relief is also achieved by memantine, a compound that acts by blocking the functional dominance of the transmitter N-methyl-aspartate [ 14 ] . (encyclopedia.pub)
Role2
The metabolism of 2,3,7,8-TCDD and related compounds is required for urinary and biliary excretion, and the rate of metabolism is thought to play a major role in regulating the rate of elimination (and detoxification) of these compounds (Van den Berg et al. (cdc.gov)
However, to date, a detailed understanding of the physiological role of these compounds has been severely hampered by a lack of selective, high affinity, metabolically stable neurokinin receptor antagonists that possess both good bioavailability and CNS penetration. (justia.com)
Variety1
Oxidized and peroxidized compounds may be causally related to a variety of chronic diseases. (nih.gov)
Ability1
When the cellular level of toxic compounds increases, the repressor alters its DNA-binding ability and dissociates from the regulatory sequence, resulting in activation of antibiotic resistance of the bacterium. (biomedcentral.com)
Disease3
Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease. (nih.gov)
While the list of chronic diseases believed to have free radical or oxidant involvement is growing, in most cases it remains unclear whether this involvement is a cause or a result of the disease. (nih.gov)
Nevertheless, NFL assessment integrated with the evaluation of other neurodegenerative biomarkers and factors indicating disease prognosis could provide a more comprehensive estimate of disease prognosis and the extent of neurological involvement. (ane.pl)