Involved in endocytosis myeloid lymphoid leukemia protein. Medical search. Frequent questions

Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. (promab.com)

Dendritic cells display a large amount of MHC-peptide complexes at their surface and can increase the expression of costimulatory receptors and migrate to the lymph nodes, spleen, and other lymphoid tissues, where they activate specific T cells. (medscape.com)
Identification and Comparison of Differentiation-Related Proteins in Hepatocellular Carcinoma Tissues by Proteomics. (gzsys.org.cn)

MHC-I and MHC-II proteins are key components of the antigen presentation machinery responsible for neoantigen presentation to CD8 + and CD4 + T lymphocytes, respectively. (portlandpress.com)

The clinical manifestations of histiocytosis depend on the organs and systems involved, as well as their level of involvement. (medscape.com)
LCH can also involve multiple organs and systems, with clinically significant symptoms and consequences. (medscape.com)
[ 12 ] These cells can capture antigen and migrate to lymphoid organs, where they present the antigens to naive T cells. (medscape.com)
Mononuclear cells with pronounced phagocytic ability that are distributed extensively in lymphoid and other organs. (lookformedical.com)

Glycans, either alone or complexed with glycan-binding proteins, can deliver intracellular signals or control extracellular processes that promote initiation, execution and resolution of cell death programs. (nature.com)
Their expression in tumour cells is modulated by a complex interplay of genomic, transcriptomic and post translational factors involving multiple intracellular antigen processing pathways. (portlandpress.com)

2014). For example, clathrin assembly lymphoid myeloid leukemia protein (CALM) was shown to have a function in KIT signaling in mouse HSCs (Rai et al. (ucla-mls.com)
Clathrin assembly protein CALM plays a critical role in KIT signaling by regulating its cellular transport from early to late endosomes in hematopoietic cells. (ucla-mls.com)

After performing the trafficking protein colocalization experiment, we will gain insight to possible pathways for MYCT1. (ucla-mls.com)
Moreover, enrichment analysis suggested that ANLN functionally affected endocytosis, regulation of actin cytoskeleton, and oxytocin signaling pathways. (biomedcentral.com)
In hematological malignancies, exosome-mediated expulsion of a number of key proteins and micro RNAs, resulting in influence of major tumor-related pathways. (bbrc.in)
Although Wnt5a has been implicated in various pathological conditions, its role in cancer is ambiguous and might involve methyl modifications, distinct mRNA isoforms, as well as different downstream pathways. (cams.cn)
What pathways are this gene/protein implicaed in? (cancer-genetics.org)

In another recent study, G-protein-coupled receptor-associated sorting proteins (GPRASP1) and GPRASP2, were found to be negative regulators of HSC transplantation (Morales-Hernández et al, 2020). (ucla-mls.com)
Furthermore, there are several ways by which exosomes are taken up by recipient cells: receptor- or lipiddraft-mediated endocytosis, phagocytosis, macropinocytosis, or fusion with the plasma membrane of a target cell, For transportation, exosomes mainly originate from multivesicular bodies (MVB's) in the cells which are produced by the invagination of endosomal limiting membrane (Pfrieger et al . (bbrc.in)
The first signal may involve interaction between an MHC I-bound and/or MHC II-bound peptide on an APC with the T-cell receptor (TCRs) on the effector lymphocytes. (medscape.com)
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. (cancer-genetics.org)
Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. (cancer-genetics.org)

At the adherens junction in epithelia, the C-terminal domain of E-cadherin interacts, in a mutually exclusive manner, with β-catenin or γ-catenin (plakoglobin), which then interacts with α-catenin, an actin-binding protein. (oncotarget.com)
Anillin (ANLN) is an actin-binding protein that is essential for cell division and contributes to cell growth and migration. (biomedcentral.com)

2016). Thus, we will assess MYCT1 colocalization with Syntaxin 6, and other vesicular trafficking candidates such as, EEA1, Rab 5A, APPL1, which are associated with endosomes, Clathrin Heavy Chain (coating protein), Caveolin-1 (membrane protein associated with endocytosis), and GOPC (associated with Golgi). (ucla-mls.com)
Brentuximab vedotin [12] consists of the chimeric monoclonal antibody brentuximab (cAC10, which targets the cell-membrane protein CD30 ) linked with maleimide attachment groups, cathepsin -cleavable linkers ( valine - citrulline ), and para-aminobenzylcarbamate spacers to three to five units of the antimitotic agent monomethyl auristatin E (MMAE, reflected by the 'vedotin' in the drug's name). (mdwiki.org)
The protein encoded by this gene represents the beta subunit and is a type I membrane protein. (cancer-genetics.org)

METHODS: CD4- and CD25-positive cells were sorted from cultured T lymphocytes of a previously characterized experimental thymic tumor model composed of thymic nurse cells and abundant lymphoid stroma. (bvsalud.org)
Recently, it has been reported by many workers that the potential functions of exosomes contributed to various aspects of hematological tumorigenesis, particularly with a focus on the exosome-mediated tumor progression, metastasis, drug resistance and immune escape by altering the function of receiver cells via diverse exosomal cargoes including proteins, DNA, messenger RNAs (mRNAs), and microRNAs) (Whiteside and Boyiadzis, (2017). (bbrc.in)
They were nanoscale membrane vesicles that were generated by most types of cells, which can convey information in the tumor microenvironment by transferring cargos such as DNA, RNA, proteins and lipids, therefore they are critical to tumor progression [ 5 ]. (biomedcentral.com)

Scope includes mutations and abnormal protein expression. (cancer-genetics.org)

Cadherins are single-pass transmembrane glycoproteins that form homotypic interactions with cadherin proteins on neighboring cells and interact intracellularly with proteins of the catenin family [ 4 , 5 ]. (oncotarget.com)

Recent evidence suggests that plakoglobin may suppress tumorigenesis and metastasis by multiple mechanisms, including the suppression of oncogenic signaling, interactions with various proteins involved in tumorigenesis and metastasis, and the regulation of the expression of genes involved in these processes. (oncotarget.com)
INTRODUCTION Linear motifs (LMs) are short elements embedded within larger protein Rabbit polyclonal to ZFP161 sequence segments that operate as sites of regulation (1C5). (insulin-receptor.info)
They exert their biological functions by competitively binding to microRNAs (miRNAs) as miRNA sponges, promoting gene transcription and participating in the regulation of selective splicing, interacting with proteins and being translated into proteins. (biomedcentral.com)

Reverse transcription quantitative polymerase chain reaction and immunohistochemistry were used to determine ANLN mRNA and protein expression in colorectal cancer (CRC), gastric cancer (GC), and hepatocellular carcinoma (HCC) cell lines. (biomedcentral.com)

Thus, we asked if MYCT1 localizes in specific type of vesicles that can point to its function, how the deletion of the extracellular domain affects the potential localization of MYCT1 in trafficking vesicles, and what cellular programs MYCT1 may be involved in in HSCs. (ucla-mls.com)
We will also consider how the colocalization of MYCT1 with its extracellular domain deleted compares to the colocalization of the full-length MYCT1 and the selected proteins. (ucla-mls.com)
They can be found in telomeric proteins (6), in proteins of the extracellular matrix (7)and seemingly every macromolecular complex in between. (insulin-receptor.info)
Bennett J, Baumgarten SC, Stocco C. GATA4 and GATA6 Silencing in Ovarian Granulosa Cells Affects Levels of mRNAs Involved in Steroidogenesis, Extracellular Structure Organization, IGF-I Activity, and Apoptosis. (chicagobiomedicalconsortium.org)

This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP2 adaptors) complex found in clathrin coated vesicles. (wikipedia.org)
This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. (promab.com)
The mammalian genome comprises nuclear DNA (nDNA) derived from both parents and mitochondrial DNA (mtDNA) that is maternally inherited and encodes essential proteins required for oxidative phosphorylation. (regenerativemedicine.net)

AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene. (wikipedia.org)
What does this gene/protein do? (cancer-genetics.org)

It has been shown that Clathrin mediated endocytosis can regulate signaling programs essential for HSCs (Rai et al. (ucla-mls.com)
For example, Cirs-7 is derived from a highly conserved single exon, also known as antisense transcription of cerebellar degeneration-related protein 1 (CDR1as), which can regulate miR-7 through adsorption, thus reducing the inhibition of miR-7 on its target [ 19 ]. (biomedcentral.com)

For this purpose, NLRP3 homology model was built and the putative protein binding region of a non-covalent inhibitor MCC950 (used as a probe) was investigated using a combination of in silico techniques. (mdpi.com)

At least one of these genes, flavin-monooxygenase-2, is a well-conserved protein known to be involved in xenobiotic metabolism. (uw.edu)

2014). Given these findings, if we see colocalization between MYCT1 and any of our selected proteins, we can hypothesize its mechanistic role in hematopoietic cells according to the function of the proteins it colocalizes with. (ucla-mls.com)

The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. (wikipedia.org)

From Protein Complexes to Subunit Backbone Fragments: a Novel Approach to Native Mass Spectrometry. (chicagobiomedicalconsortium.org)

[ 15 ] The surface of the APC contains 2 peptide-binding proteins (ie, major histocompatability complex [MHC] classes I and II), which can stimulate cytotoxic T (T C ) cells, regulatory T (Treg) cells, and helper T (T H ) cells. (medscape.com)
However, useful advances are now being made in the bioinformatics tools that address the amazing modularity of eukaryotic regulatory proteins. (insulin-receptor.info)

The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. (cancer-genetics.org)

Previous results indicate that the HHV-8 viral transactivator ORF50 interacts synergistically with Tat protein in the transactivation of human immunodeficiency virus (HIV) long terminal repeat (LTR), leading to increased cell susceptibility to HIV infection. (ashpublications.org)

Improved understanding of the pathology of histiocytic disorders requires knowledge of the origins, biology, and physiology of the cells involved. (medscape.com)
Alvares K, Stern PH, Veis A. Dentin Phosphoprotein Binds Annexin 2 and is Involved in Calcium Transport in Rat kidney Ureteric Bud Cells. (chicagobiomedicalconsortium.org)
They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells. (lookformedical.com)
This class of personalized therapies involves collecting immune cells from an individual, engineering them to recognize and kill cancer cells, before culturing, and reintroducing them into the same individual. (technologynetworks.com)
Human epididymis protein 4 in association with Annexin II promotes invasion and metastasis of ovarian cancer cells. (gzsys.org.cn)
Understanding the mechanisms involved in preventing hair cell death may yield pharmacological advancements to protect sensory hair cells when these antibiotics are administered. (uw.edu)

GPRASP proteins are critical negative regulators of hematopoietic stem cell transplantation. (ucla-mls.com)
The protein is primarily expressed in the hematopoietic system. (cancer-genetics.org)

Autotaxin (ATX) is a secreted autocrine motility factor involved in the production of lysophosphatidic acid (LPA), a lipid mediator that promotes the progression of various cancers. (bvsalud.org)

Adaptor-related protein complex 2, alpha 1 has been shown to interact with DPYSL2 and NUMB. (wikipedia.org)
Using the links, experts can explore the motifs, proteins, complex structures and associated literature to evaluate whether candidate motifs might be worth experimental investigation. (insulin-receptor.info)
The main aim was to detect putative protein hot spots involved in the stabilization of protein-ligand complex. (mdpi.com)

With the histone of synthesis, the signaling glutamate is to introduce released well nuclear after protein. (evakoch.com)

Herein, we review the role of glycans and glycan-binding proteins as essential components of the cell death machinery during physiologic and pathologic settings. (nature.com)

The bioinformatics problem is simple to state: LMs are too short (and the information content too poor) to be statistically significant in protein sequence searches. (insulin-receptor.info)

Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition. (mdc-berlin.de)

The encoded protein is involved in endocytosis and may also play a role in the cell cycle. (promab.com)

A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. (mdpi.com)

Figure 2:Western blot analysis using SH3GL1 mAb against human SH3GL1 (AA: 12-119) recombinant protein. (promab.com)

How plakoglobin acts as a growth/metastasis inhibitory protein has remained, until recently, unclear. (oncotarget.com)

The use of alternative promoters results in multiple transcript variants encoding the same protein. (cancer-genetics.org)

Feel T Hypertens Last year 25:611-616 (Chemical) Last year American Record involving Blood pressure, Ltd.Target. (rotenoneinhibitor.com)

[ 3 , 4 ] This designation was changed to Langerhans cell histiocytosis based on the suggestion by Nezelof that the Langerhans cell represented the primary cell involved in the pathophysiology of the disease. (medscape.com)
with us one can be cytosol proteins, " badenova( 2009) is four primary photoreceptors, the most non-crossover-generating of which chloroplasts release, phosphorylated, and ready ataxia bacterial to a cascade of challenging glycoprotein GTPases. (evakoch.com)
Our review is targeted over the four primary subfamilies: Change/sucrose non-fermentable (SWI/SNF), imitation SWI (ISWI), chromodomain-helicase DNA-binding proteins (CHD), and INOsitol-requiring mutant 80 (INO80). (morainetownshipdems.org)

A good e-mail study had been provided for all active members of the actual Norwegian Affiliation involving Oral along with Maxillofacial Cosmetic surgeons (and Equates to Fifty-four) incorporated questions about complete BONJ instances seen in exercise and also option associated with drug supervision through The month of january 1st 2003 to Dec 31st '09. (rotenoneinhibitor.com)

Anatomy23

Organisms8

Diseases34

Chemicals and Drugs52

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes24

Information Science3

Acute myeloid1

Tissues2

Antigen presentation1

Organs4

Intracellular2

CALM2

Pathways5

Receptor5

Actin-binding2

Membrane protein3

Tumor3

Mutations1

Transmembrane1

Regulation3

MRNA1

Extracellular4

Encodes3

Gene2

Regulate2

Homology1

Genes1

Colocalization1

Vesicles1

Complexes1

Regulatory2

Subunit1

Interacts1

Cells6

Hematopoietic2

Cancers1

Complex3

Nuclear1

Essential1

Sequence1

Cancer1

Cell cycle1

Substantial1

Human1

Growth1

Multiple1

Blood1

Primary3

Members1