Investigate spinal cord ischemia. Medical search. Frequent questions

The present study was undertaken to study the effects of exogenous H2S on ischemia/reperfusion (I/R) injury of spinal cord and the underlying mechanisms. (biomedcentral.com)
Ischemia/reperfusion (I/R) injury of the spinal cord is a dynamic process that frequently occurs during a variety of clinical situations such as thoracoabdominal aortic surgery or spinal cord injury [ 1 ]. (biomedcentral.com)
Inhaled methane limits mitochondrial electron transport chain dysfunction and confers protection against mitochondrial dysfunction during experimental liver ischemia-reperfusion injury [ 11 ]. (hindawi.com)
It has been proved that inhalation of methane also modulates leukocyte activation, affects key events of ischemia-reperfusion-induced oxidative stress, and has anti-inflammatory effects against ischemia-reperfusion damage [ 12 ]. (hindawi.com)
Electrophysiological and neurochemical alterations in cardiospinal neural network in chronic MI will be compared with healthy hearts when subjected to additional cardiac stress (acute ischemia/reperfusion). (grantome.com)
To explicit cell apoptosis trend in PC12 oxygen-glucose-serum deprivation/restoration (OGSD/R) model and provide experimental bases for neural cell simulation in ischemia reperfusion injury in vitro . (oncotarget.com)
The apoptosis of PC12 reaches the highest at 1h after OGR, which may provide experimental bases for spinal cord ischemia reperfusion injury treatment. (oncotarget.com)
Reperfusion is the main treatment for patients with spinal cord injury. (oncotarget.com)
Hydrogen gas can reduce ROS and alleviate cerebral, myocardial, and hepatic ischemia/reperfusion injuries. (molecularhydrogenstudies.com)
The present study was designed to investigate the expression changes of PPAR-alpha, -beta, -gamma and NF-kappa B in the hippocampus of rats with global cerebral ischemia/reperfusion injury (GCIRI) after treatment with agonists or antagonists of PPAR-gamma. (biomedcentral.com)
Global cerebral ischemia/reperfusion injury (GCIRI) occurs in patients who are successfully resuscitated from various clinical conditions such as cardiac arrest, asphyxia and shock, which are frequently accompanied by inflammation and can lead to serious neuronal injury, and further to neurodegeneration and learning and memory impairment [ 12 ]. (biomedcentral.com)
Proinflammatory cytokines, such as interleukin (IL)-1β, IL-6 and tissue necrosis factor (TNF)-α, have been implicated as important mediators of injury following cerebral ischemia [ 13 ] and contribute to pathogenesis, exacerbating brain tissue damage following ischemia/reperfusion (I/R) injury [ 14 ]. (biomedcentral.com)
Ischaemia reperfusion injury (IR-injury) occurs when blood supply to a certain area of the body is blocked, and is subsequently followed by reperfusion. (ljmu.ac.uk)
Rapid reperfusion is mandatory, but unfortunately causes damage in addition to the damage induced by ischaemia alone. (ljmu.ac.uk)
While a prolonged period of ischaemia is harmful to the bodily tissue, short periods of ischaemia interspersed with short bouts of reperfusion have protective effects. (ljmu.ac.uk)
More specifically, acute exercise might possess the same protective effects against ischaemia-reperfusion injury as IPC. (ljmu.ac.uk)

Upregulation of HIF-1 expression may play a neuroprotective role in animal models of focal cerebral ischemia ( 6 ). (spandidos-publications.com)
Transplantation of these cells improves the clinical outcome in experimental models of cerebral ischemia and spinal cord injury. (edu.pl)
A model of global cerebral ischemia in C57 BL/6 mice. (riken.jp)
Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)

Aim: Previous studies have shown that carvedilol has a neuroprotective effect in animal models of brain ischemia and brain oxidative damage in vitro. (erbakan.edu.tr)
During secondary injury, toxic oxygen free radicals are produced from excitotoxicity, mitochondrial dysfunction and the oxidative stress resulting from ischemia. (scireproject.com)
The data suggest a heightened susceptibility of the developing brain to hypoxia-ischemia, oxidative stress and excitotoxicity that selectively targets nascent white matter. (johnshopkins.edu)

Specifically, the lab explores the structure and function of diaphragm muscle motor units that comprise phrenic motor neurons located in the cervical spinal cord and the group of muscle fibers they innervate. (mayo.edu)
Upper cervical spinal cord injury often results in complete or partial diaphragm muscle paralysis that may require ventilatory support and is associated with higher morbidity and mortality rates. (mayo.edu)
The efficacy of ultrasound-guided extracorporeal shockwave therapy in patients with cervical spondylosis and nuchal ligament calcification -(Tz-Yan Lin, Jing-Ting Chen, Yu-Yu Chen, Tien-Wen Chen , Chia-Ling Lee, Chia-Hsin Chen, Mao-Hsiung Huang) - We investigated the effects of extracorporeal shockwave therapy (ESWT) on the rehabilitation of cervical spondylosis with nuchal ligament (NL) calcification under X-ray and ultrasound guidance. (joinsoftwave.com)
That neck pain you've experienced for far too long is no longer a mystery - the cervical spinal stenosis diagnosis you received from your primary care physician or spine specialist has finally given the condition a name. (painneck.com)
Chances are, that is the very question you asked your doctor (or some variation) once you found out that the spinal cord or other neural openings in the cervical (neck) region of your spine were being restricted by some sort of anatomical abnormality. (painneck.com)
Results Cervical spine, lumbar spine, and spinal nerves and ganglia were accurately visualized with MRM. (bmj.com)
Apparent diffusion coefficients measurements are feasible in rat cervical spinal cord with intrathecal catheters. (bmj.com)
Disturbance of the normal free flow of CSF through the foramen magnum appears to be a major factor responsible for the formation of a syrinx in the cervical spinal cord (2, 16, 17). (marysfamilymedicine.org)

[ 19 ] IV iloprost therapy is probably most useful for slowing progressive tissue loss and reducing the need for amputation in patients with critical limb ischemia during the period when they first discontinue cigarette smoking. (medscape.com)

The aim of this study was to investigate whether ONO-5046, a specific inhibitor of neutrophil elastase that can attenuate tissue or organ injury in various pathologic conditions, could protect against ischemic spinal cord damage. (elsevierpure.com)
To investigate the mechanism by which ONO-5046 prevents ischemic spinal cord damage, we observed the immunoreactivity of CPP32 (caspase3), brain-derived neurotrophic factor, and phosphorylated extracellular signal-regulated kinase. (elsevierpure.com)
ONO-5046 may be a strong candidate for use as a therapeutic agent in the treatment of ischemic spinal cord injury. (elsevierpure.com)
Shock wave treatment protects from neuronal degeneration via a toll-like receptor 3 dependent mechanism: implications of a first-ever causal treatment for ischemic spinal cord injury - Paraplegia following spinal cord ischemia represents a devastating complication of both aortic surgery and endovascular aortic repair. (joinsoftwave.com)
Background: The healing of foot wounds in patients with diabetes mellitus is frequently complicated by critical limb threatening ischemia (neuro-ischemic diabetic foot syndrome, DFS). (mdpi.com)

Vascular endothelial growth factor (VEGF) has been investigated as a therapy for many disorders and injuries involving ischemia. (elsevierpure.com)
The plasmids were then injected into rat spinal cords with contusion injuries. (elsevierpure.com)
Extracorporeal shock wave therapy for complete cross-section of lesions at the level of the thoracic spine - (Protocol) Spinal cord injuries, fortunately, have a relatively low incidence. (joinsoftwave.com)
Thus, these findings suggest a potential role of MVIIC in preventing secondary injuries after spinal trauma. (biomedcentral.com)
A possible therapeutic effect of acetyl-L carnitine (ALCAR) on peripheral nerve injuries and the expression of Jun, the protein products of immediate-early genes(IEGs), in the spinal cord were investigated after. (koreamed.org)
The long-term survival and the possibility of functional rehabilitation of patients with spinal cord injuries has led to increased interest in treatment of these patients. (jortho.org)
Although corticosteroids have been shown to improve neurological recovery of patients with spinal cord injuries16, the primary treatment of patients with thoracolumbar injuries is surgical reduction, decompression, and stabilization. (jortho.org)
Overall gross function of patients with spinal cord injuries is assessed by the Frankel classification. (jortho.org)

GRP cells can be manipulated in vitro into OPCs and preOL for transplantation experiments with mouse PVL models and in vitro models of PVL-like insults including hypoxia-ischemia. (johnshopkins.edu)
Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)
We therefore investigated the impact of global brain hypoxia-ischemia on the thalamic circuit function in the somatosensory system of young rats. (cdc.gov)
Global brain hypoxia-ischemia during cardiac arrest has a long-term impact on processing and transfer of sensory information by thalamic circuitry. (cdc.gov)

The present study is aimed at investigating the anti-inflammatory, antioxidative, and antiapoptotic effects of methane on lipopolysaccharide- (LPS-) induced acute orchitis and its potential mechanisms. (hindawi.com)
Hyperbaric oxygen therapy is now an accepted adjunctive measure that has been shown to provide significant clinical improvement in patients with diabetic wounds, refractory osteomyelitis, acute limb ischemia, or necrotizing soft-tissue infection. (medscape.com)
Hawaiian physician Cherylee Chang, MD, describes symptoms of acute myelopathy in surfers likely due to ischaemia of the spinal cord. (painneck.com)

Mousavizadeh and colleagues produced a fascinating systematic review and meta-analysis investigating the relationship between the duration of hypothermic circulatory arrest (HCA) and the risk of developing complications including SCI and stroke. (authorea.com)
Neuromuscular electrical stimulation (NMES) can produce contractions of paralyzed muscles to improve function and reduce secondary complications for individuals with a spinal cord injury (SCI). (ualberta.ca)
To assess the occurrence and risk factors for complications following spinal cord injury during and after inpatient rehabilitation. (medicaljournals.se)
Multi-level random coefficient analyses revealed that complications were common following spinal cord injury. (medicaljournals.se)
Complications are common following spinal cord injury. (medicaljournals.se)
Spinal cord injury (SCI) is often followed by complications, which add to the detrimental effect that loss of motor, sensory and autonomic function have on a person's health, social participation and quality of life (1-4). (medicaljournals.se)
Previous studies have investigated complications following SCI and their risk factors. (medicaljournals.se)

MRI of the optic nerve demonstrated (1) pathologic signal enhancement on fat-suppressed, T1-weighted images after intravenous meglumine gadopentetate infusion and (2) a sawtooth pattern over 7 vertebral segments of the spinal cord on T2-weighted sagittal images. (medscape.com)

Results: ONO-5046 eased the functional deficits and increased the number of motor neurons after ischemia. (elsevierpure.com)
Dr. Sieck has also shown that the BDNF -TrkB signaling pathway is involved promoting neuroplasticity in synaptic input to phrenic motor neurons and recovery of function after spinal cord injury. (mayo.edu)

The goal of this proposal is to determine how the spinal cord processes cardiac afferent impulses during myocardial ischemia and to explain how neuromodulation therapies reduce ventricular arrhythmias, leading to their more effective and expansive use. (grantome.com)
In this proposal, it is hypothesized that unique cardiospinal neural networks integrate the cardiac afferent signals during myocardial ischemia (MI) and control sympathoexcitation, thereby modulating arrhythmogenesis. (grantome.com)
After a myocardial infarction or a heart attack, imbalances in the neural signaling/communication between the heart and the spinal cord are fundamental to the development of these abnormal heart rhythms. (grantome.com)
In this proposal, we will investigate the mechanisms by which neural signals from the heart affect its electrical function during myocardial ischemia or infarction and study the novel techniques that target these adverse neural events so that we can develop the most effective therapies for preventing sudden cardiac death. (grantome.com)

The signal transmitted by the brain is routed through 2 intermediate segments (the brainstem and the sacral spinal cord) prior to reaching the bladder. (medscape.com)
The American Spinal Injury Association (ASIA) defines a complete neurologic lesion as an absence of sensory and motor function below the level of injury including the lowest sacral segment2. (jortho.org)
Injury of the sacral cord (conus) and lumbar nerve roots within the neural canal, which usually results in an areflexic bladder, bowel, and lower limbs. (jortho.org)

Thus, we attempt to investigated the possible regulation role of H2S on spinal cord I/R injury in vitro or in vivo. (biomedcentral.com)
This study investigates problems associated with the use of in vivo MRM for spinal cord and peripheral nerve studies in the rat. (bmj.com)

The VEGF expression was detected in neurons and astrocytes of the spinal cord. (elsevierpure.com)
The N-methyl-D-aspartate (NMDA) receptor is a calcium channel that, when open, allows electrical signals to transfer between neurons in the spinal cord. (scireproject.com)

Methods: After induction of spinal ischemia, ONO-5046 or vehicle was injected intravenously. (elsevierpure.com)

Experimental data on vagal nerve and spinal cord stimulation suggest that each technique may reduce ventricular arrhythmias. (aerjournal.com)

However, there are major gaps in the understanding of regulation of cardiac excitability at the level of the spinal cord. (grantome.com)
Thus, modulation of cardiac afferent neural inputs to the spinal cord presents a novel target for suppression of excessive sympathetic reflex activation and cardiac arrhythmias. (grantome.com)
The proposed studies will evaluate novel mechanisms of regulation of cardiac excitability at the spinal level. (grantome.com)
Specific aims 1 is designed to provide a mechanistic understanding of the role of spinal cord processing of afferent cardiac neural inputs. (grantome.com)
The perivascular space changes in size during the cardiac cycle and is widest when spinal arteriole pressure is low. (marysfamilymedicine.org)

Compared to I/R injury groups, H 2 S pretreatment had reduced spinal cord infarct zone, improved hind motor function in rats. (biomedcentral.com)
Therefore, the present study aimed to investigate the potential toxic effects of MVIIC on organs and to evaluate clinical and blood profiles of rats submitted to spinal cord injury and treated with this marine toxin. (biomedcentral.com)
Rats were treated with placebo or MVIIC (at doses of 15, 30, 60 or 120 pmol) intralesionally following spinal cord injury. (biomedcentral.com)

The cephalad part of the spinal epidural space begins at the level of foramen magnum, where the periosteal and spinal layers of dura fuse together. (medscape.com)
Therefore when the heart beats and there is increase in volume of intracranial blood, CSF is displaced from the cranial to the spinal subarachnoid space through the foramen magnum thus avoiding a deleterious increase in intracranial pressure. (marysfamilymedicine.org)

For instance, clinical trials of vagal stimulation and spinal cord stimulation in the treatment of heart failure are currently underway, and renal denervation has been studied recently in the treatment of resistant hypertension. (aerjournal.com)
This review will attempt to provide a state-of-the-art on the potential antiarrhythmic efficacy of renal artery denervation, spinal cord stimulation and direct vagal stimulation. (aerjournal.com)

Single- or repetitive-pulse stimulation of the brain causes the spinal cord and peripheral muscles to produce neuroelectrical signals known as motor evoked potentials (MEPs). (medscape.com)
Myelopathy is a clinical diagnosis with localization of the neurological findings to the spinal cord, rather than the brain or the peripheral nervous system, and then to a particular segment of the spinal cord. (bvsalud.org)

MVIIC neuroprotective effects analyzed in in vitro models of brain and spinal cord ischemia suggest a potential role of this toxin in preventing injury after spinal cord trauma. (biomedcentral.com)
These findings suggest that MVIIC at 15, 30 and 60 pmol are safe for intralesional administration after spinal cord injury and could be further investigated in relation to its neuroprotective effects. (biomedcentral.com)

The present study aimed to investigate whether the protective effect of vitexin protects against sevoflurane-induced neuronal apoptosis and the underlying mechanisms of this protective effect. (spandidos-publications.com)
In the present study, authors aim to investigate whether hydrogen-rich saline can reduce neuropathic pain in a rat model of chronic constriction injury (CCI). (molecularhydrogenstudies.com)
Another study, published in the American Journal of Psychiatry , investigated the effects of CBD on smoking. (healthneu.com)
In a follow-up study, it was determined whether local IPC applied on the upper arm, or remote IPC applied on the legs, would lead to an improved maximum incremental arm crank exercise test in individuals with a complete spinal cord lesion. (ljmu.ac.uk)

While working for a biotech company later acquired by Elan Pharmaceuticals, she published the effects of ziconotide in a rat model of spinal cord ischemia. (wikipedia.org)
The effects of exogenous H2S on I/R injury were examined by using assessment of hind motor function, spinal cord infarct zone by Triphenyltetrazolium chloride (TTC) staining. (biomedcentral.com)
Despite evidence that some endogenous and synthetic cannabinoids interact with GABAA receptors, no-one has yet investigated the effects of CBD. (researchgate.net)

Although the phenomenon is still being investigated it does appear that the risk of so-called 'surfers' myelopathy' may be reduced simply by changing a common novice surfing habit. (painneck.com)
Myelopathy can be the result of primary intrinsic disorders of the spinal cord or from secondary conditions, which result in extrinsic compression of the spinal cord. (bvsalud.org)

The lumbosacral spinal cord houses neural networks that contribute to locomotion. (ualberta.ca)

abstract = "This is a protocol for derivation of glial restricted precursor (GRP) cells from the spinal cord of E13 mouse fetuses. (johnshopkins.edu)

Deep tissue injury (DTI) is a severe form of pressure ulcers resulting from ischemia and mechanical damage due to unrelieved pressure. (ualberta.ca)
During the period of ischaemia, tissue is damaged as a result of lack of oxygen. (ljmu.ac.uk)

A bony projection on either side of the vertebral body called the pedicle supports the arch that protects the spinal canal. (medscape.com)
CBD protects against pathological T-cell invasion after spinal cord injury in the laboratory. (healthneu.com)

For example, the long-term effect of indwelling intrathecal or plexus catheters can be studied in situ, and convective and diffusive forces within intrathecal, epidural, or nerve sheath spaces can be investigated. (bmj.com)

SCS and DRG stimulation, reduce sympathetic output through induction of GABA signaling pathways in the spinal cord, reducing ventricular excitability and arrhythmias after chronic MI. (grantome.com)

Normal voiding is essentially a spinal reflex modulated by the central nervous system (brain and spinal cord), which coordinates function of the bladder and urethra. (medscape.com)
The central nervous system is composed of the brain, brain stem, and the spinal cord. (medscape.com)
Although no evidence for miR-30c in spinal cord I/R injury, it has been proved to be a neural protector by targeting brain derived neurotrophic factoras well as neurotrophin signaling and axon guidance [ 10 ]. (biomedcentral.com)
Calcium channel blockers such as conotoxins have shown a great potential to reduce brain and spinal cord injury. (biomedcentral.com)
Syringomyelia is a disorder of CSF and therefore understanding the pathogenesis of this enigmatic disorder is dependent on understanding CSF flow dynamics, biochemistry and factors that influence its absorption and The majority of CSF is produced by the four choroid plexuses (one in each ventricle of the brain), which circulates through the ventricular system and the subarachnoid spaces of the brain and spinal cord (9, 10). (marysfamilymedicine.org)

Spinal neuromodulation therapies- spinal cord stimulation (SCS) and dorsal root ganglion (DRG) stimulation, show promise towards reducing VTs, but the mechanisms underlying the therapeutic benefits of these innovative approaches remain largely unknown. (grantome.com)

It is important to understand how rhythmic diaphragm muscle activity can be restored in patients with spinal cord injury. (mayo.edu)
Nevertheless, every effort should be made to improve distal arterial flow in patients with TAO, and autologous vein bypass of coexistent large-vessel atherosclerotic stenoses should be considered in patients with severe ischemia who have an acceptable distal target vessel. (medscape.com)
The annually increasing number of patients with spinal cord injury has become a major economic burden of the world due to lack of effective treatments by far. (oncotarget.com)
According to relevant reports by the United States, over 7 billion dollars are spent on the treatment and care of patients with spinal cord injury averaging 31.7 years of age with a peak age of onset at 15-25, who require long-term treatment and care [ 1 ]. (oncotarget.com)
It also has led to skin abscesses and an infection of the false vocal cord in patients receiving chemotherapy for hematologic malignancies and caused keratitis in a man with no significant medical history ( 2 , 4 , 6 ). (cdc.gov)

Our laboratory is currently investigating the role of oligodendrocyte progenitors in PVL and use cells at the GRP stage of development. (johnshopkins.edu)
Transcription factor expression and Notch-dependent regulation of neural progenitors in the adult rat spinal cord. (riken.jp)

In rat model of I/R injury, pretreatment of pre-miR-30c or 3-MA (an inhibitor for autophagy) can abrogated spinal cord protective effect of H2S. (biomedcentral.com)
However, the protective effect of H2S on I/R injury of spinal cord has not been described. (biomedcentral.com)
The next step is for the researchers to examine the individual clinical outcomes behind the cost savings, and to investigate the potentially protective properties of other commonly prescribed cardiovascular medications, including beta blockers and angiotensin-converting enzyme inhibitors. (vascularnews.com)

Syringomyelia is a condition characterised by fluid filed cavities (syrinxes or syringes) within the central spinal cord and the resulting damage produces clinical signs of pain and neurological deficits. (marysfamilymedicine.org)

The initial spinal cord trauma and subsequent ischemia produce an accumulation of glutamate around the injury site ( Amar & Levy 1999 ). (scireproject.com)

Howard and colleagues produced a fascinating systematic review and meta-analysis investigating the clinical outcomes of TEVAR for complicated and uncomplicated TBAD. (authorea.com)

Ischemia is arguably the biggest determinant of the degree of secondary injury, as it often extends beyond the spinal cord and negatively affects perfusion and oxygenation in surrounding tissues, causing permanent damage ( Amar & Levy 1999 ). (scireproject.com)

Spinal cord injury frequently causes paralysis of the limbs, even causes severe death. (oncotarget.com)

In this report, we constructed and evaluated a hypoxia-inducible VEGF expression system as a treatment for spinal cord injury (SCI). (elsevierpure.com)
[ 21 ] Hyperbaric oxygen therapy does, however, provide a promising alternative treatment option that is worth investigating on larger scales. (medscape.com)
We hypothesized that shock wave treatment also may have a beneficial effect on spinal cord ischemia. (joinsoftwave.com)
Spinal fracture classifications systems have been developed to aid in the understanding of fracture stability and help direct treatment. (jortho.org)

This chapter draws upon other specialities which have extensively investigated epigenetic mechanisms, such as learning and memory and oncology. (newmedia1.net)

These findings were confirmed at autopsy, during which pathologists grossly noted (1) a pronounced decrease of myelinated nerve fibers in the left optic nerve with thrombotic obstruction of the central retinal artery, (2) spongy degeneration in all levels of the spinal cord, and (3) patchy and moth-eaten patterns due to thromboses and endothelial proliferation in subarachnoid vessels. (medscape.com)

Real Time PCR also shows expression of GABAA and GABAB receptors is increased by SCS therapy in spinal cord during MI. (grantome.com)

Further, diffusion-weighted MRM, which measures an "apparent diffusion coefficient" (ADC), can be used to track the presence of ischemia, hypoperfusion, or cytotoxic edema. (bmj.com)
In groups 3 and 4, indwelling intrathecal catheters did not affect the spinal cord ADC, indicating normal blood flow and no cytotoxic edema. (bmj.com)

Anatomy18

Organisms2

Diseases26

Chemicals and Drugs2

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes7

Disciplines and Occupations1

Health Care3

Reperfusion16

Cerebral4

Oxidative3

Cervical8

Critical limb ischemia1

Ischemic5

Injuries8

Hypoxia-ischemia4

Acute3

Complications7

Pathologic1

Motor neurons2

Myocardial4

Sacral3

Vivo2

Neurons2

Methods1

Experimental1

Cardiac5

Rats3

Foramen magnum2

Renal2

Peripheral2

Neuroprotective2

Study4

Effects3

Myelopathy2

Neural networks1

Abstract1

Tissue2

Protects2

Epidural1

Arrhythmias1

Brain5

Therapeutic1

Patients5

Progenitors2

Protective3

Neurological1

Trauma1

Clinical outcomes1

Damage1

Severe1

Treatment4

Mechanisms1

Artery1

Receptors1

Edema2