• Matrix metalloproteinases (MMPs) are involved in the degradation of protein components of the extracellular matrix and thus play an important role in tumor invasion and metastasis. (biomedcentral.com)
  • Currently, four classes of proteinases are known as being capable of breaking down nearly all components of the extracellular matrix: serine proteinases, aspartatic proteases, cystein proteinases and matrix metalloproteinases (MMPs) [ 2 - 4 ]. (biomedcentral.com)
  • Previous studies showed that MMPs facilitate tumor invasion and metastasis in general. (biomedcentral.com)
  • MMPs are zinc dependent proteases which are capable of degrading one or more components of the extracellular matrix. (biomedcentral.com)
  • Additionally, the expression and activity of matrix metalloproteinases (MMPs) are increased in almost every type of human cancer, which may be associated with cell invasion, metastasis and angiogenesis. (spandidos-publications.com)
  • Some molecules are involved in several stages of the process of alveolar repair, for example matrix metalloproteinases (MMPs) 2 , among others. (bvsalud.org)
  • MMPs are an important family of metal-dependent endopeptidases and represent the major class of enzymes responsible for the degradation or resorption of all components of the extra-cellular matrix (ECM) 38 . (bvsalud.org)
  • however, in the corneal stroma, excessive infiltration of monocytes/macrophages is considered to be unfavorable because they secrete matrix metalloproteinases (MMPs) and other proteins undesirable for tissue healing. (medscape.com)
  • Matrix metalloproteinases (MMPs) are a group of structurally related endopeptidases that require a metal cofactor. (medscape.com)
  • Tumor invasion and metastasis define malignancy and are the principal causes of cancer associated death. (biomedcentral.com)
  • Degradation of the ECM facilitates invasion of tumor cells into the organ parenchyma, whereas degradation of the basement membrane is required for their entry into the blood stream as well as their metastasis to distant organs. (oncotarget.com)
  • Importantly, increasing numbers of novel reports suggest that the GFRα-mediated signaling pathway acts as an oncogenic promoter related to tumor proliferation, invasion, and metastasis as well as treatment resistance. (medsci.org)
  • CD44, the transmembrane receptor for hyaluronan, is implicated in tumor cell invasion and metastasis. (iiarjournals.org)
  • Despite advances in the early detection of breast cancer and the advent of novel targeted therapies, there is still a high failure rate, mainly due to tumor invasion and metastasis ( 2 , 3 ). (iiarjournals.org)
  • HA-bound CD44 triggers intracellular signaling that has been linked to diverse cellular functions, such as adhesion and invasion during tumor progression and metastasis ( 10 ). (iiarjournals.org)
  • Cancer invasion and metastasis are two major challenges for cancer treatment, and are usually the cause of an overall decrease in the long-term survival rates of cancer patients. (biomedcentral.com)
  • These findings have provided compelling evidence that G12 signaling is an important regulator of cancer cell invasion and metastasis. (biomedcentral.com)
  • Both the transforming ability and the impact on cell invasion and metastasis of G12 proteins appear to be dependent, at least in part, on their ability to engage Rho GTPases. (biomedcentral.com)
  • In addition, previous studies have shown that lysosomes may play important roles in cancer development and progression through the abovementioned biological processes and that the functional status and spatial distribution of lysosomes are closely related to cancer cell proliferation, energy metabolism, invasion and metastasis, immune escape and tumor-associated angiogenesis. (biomedcentral.com)
  • For that reason, it plays critical roles in glioma progression through induction of several genes implicated in many carcinogenic processes such as proliferation, angiogenesis, and invasion. (sagepub.com)
  • HL2401 inhibited proliferation and invasion of bladder and prostate cells along with disrupting endothelial sprouting in vitro . (thno.org)
  • In vitro assays confirmed that the two compounds, to varying extents, inhibited RA-FLS proliferation, migration, invasion, and NF-κB signaling. (frontiersin.org)
  • Prostaglandin E2 (PGE2) receptor 3 (EP3) regulates tumor cell proliferation, migration, and invasion in numerous cancers. (oncotarget.com)
  • Metalloproteinases are proteolytic enzymes responsible for the degradation of ECM proteins and the basal membrane of the vessels. (biomedcentral.com)
  • The substances that hamper angiogenesis are tissue inhibitors of metalloproteinases (TIMPs). (biomedcentral.com)
  • These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers. (spandidos-publications.com)
  • We have observed that transformation of cancer cells with oncogenic forms of RAS increases plasmin proteolytic activity by 2- to 4-fold concomitant with a 3-fold increase in cell invasion. (oncotarget.com)
  • While the plasminogen activator-plasminogen axis provides cells with a powerful fibrinolytic system, plasminogen-deleted animals use alternate proteolytic processes that allow fibrin invasion to proceed normally. (silverchair.com)
  • For example, neutrophils are short-lived and package active serine proteinases in azurophil (primary) granules and matrix metalloproteinases (MMP-8, MMP-9) in specific (secondary/tertiary) granules. (atsjournals.org)
  • Mignatti, P. and Rifkin, D.B. (1993) Biology and biochemistry of proteinases in tumor invasion. (scirp.org)
  • Biology and biochemistry of proteinases in tumor invasion. (biocancer.com)
  • Abruptions (decidual hemorrhage) produce excess thrombin which acts as autocrine/paracrine inducer of decidual cell expressed matrix metalloproteinases and of neutrophil chemoattractant and activator, interleukin-8. (scirp.org)
  • The finding that activation of G12 proteins promotes cancer cell migration and invasion has highlighted the need to understand the biologic processes underlying this phenomenon. (biomedcentral.com)
  • Zhang H, Wang Y, Chen T, Zhang Y, Xu R, Wang W, Cheng M, Chen Q. Aberrant Activation Of Hedgehog Signalling Promotes Cell Migration And Invasion Via Matrix Metalloproteinase-7 In Ovarian Cancer Cells. (jcancer.org)
  • MMP-7 facilitated the invasion and migration of ovarian tumour cells, indicating its key function in ovarian cancer progression. (jcancer.org)
  • Fibrinolytic enzymes and metalloproteinases are involved in various physiological and pathological processes that require tissue remodeling and cell migration. (czytelniamedyczna.pl)
  • Numerous studies have identified the GTPase Rho as a major mediator of G12 signaling via its ability to effect changes in cytoskeletal dynamics required for cell migration, invasion and engagement of the cellular transcriptional machinery [ 4 , 10 ]. (biomedcentral.com)
  • Fibrinolytic system may participate directly in tumor progression by plasmin activity, or indirectly via metalloproteinases regulation as well. (czytelniamedyczna.pl)
  • van Wart HE, Birkedal-Hansen H.. The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family. (biocancer.com)
  • Regulation of matrix metalloproteinase expression in tumor invasion. (biocancer.com)
  • Cancer cells that have acquired an invasive phenotype release proteases that attack and digest the protein component of the matrix that would restrict the movement of these malignant cells. (oncotarget.com)
  • Invasion processes are ubiquitous throughout cell biology and ecology. (nature.com)
  • Interestingly, we observed that EGFR ligand-induced CD44 and matrix metalloproteinase-9 (MMP-9) expression was reduced by silibinin treatment in a dose-dependent manner. (iiarjournals.org)
  • Molecular Cloning and Expression of Collagenase-3, a Novel Human Matrix Metalloproteinase Produced by Breast Carcinomas. (biocancer.com)
  • p53 down-regulates human matrix metalloproteinase-1 (collagenase-1) gene expression. (biocancer.com)
  • Koontongkaew S, Monthanapisut P, Saensuk T: Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression. (karger.com)
  • The results showed that formononetin downregulated the expression of the key pro-angiogenic factors, including vascular endothelial growth factor (VEGF) and matrix metalloproteinases. (spandidos-publications.com)
  • Furthermore, novel mechanistic investigations revealed that CXCL1 expression stimulated interleukin 6 (IL6) expression and repressed tissue inhibitor of metalloproteinase 4 (TIMP4). (thno.org)
  • We found that signaling through the Gα12 in MDA-MB-231 and MCF10A breast cancer cell lines enhances expression of interleukins (IL)-6 and −8, and matrix metalloproteinase (MMP)-2, and that these secreted factors play a role in G12-stimulated cell invasion. (biomedcentral.com)
  • Simon C, Goepfert H, Boyd D.. Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type IV collagenase secretion and in vitro invasion. (biocancer.com)
  • In cell biology, wound healing involves the invasion of fibroblasts into the wound space for tissue regeneration 7 . (nature.com)
  • Bowen disease (BD) is a squamous cell carcinoma in situ (SSCIS) with full-epidermal thickness dysplasia that has the potential for significant lateral spread before invasion. (medscape.com)
  • Cytogenetics and Cell Genetics, 69, 15-17. (scirp.org)
  • Nutricol embeds in the cell membrane and matrix. (life-enthusiast.com)
  • By coupling efficient chemical synthesis routes to multiple upfront in parallel phenotypic screens, we identify that KBU2046 inhibits cell motility and cell invasion in vitro. (nature.com)
  • Subsequent in vitro and in vivo studies have demonstrated the initial steps of cancer cell invasion and dissemination by disrupting the integrity of the myoepithelial belt that encircles the LECs [ 7 , 8 , 9 , 10 , 11 ]. (biomedcentral.com)
  • Of note, the effects of Ang II in facilitating cell apoptosis, increasing matrix metalloproteinase (MMP)-2 and MMP-9, reducing tissue inhibitor of MMP (TIMP)-1, and promoting switching from the contractile to synthetic phenotype in cultured VSMCs were enhanced by overexpression of PVT1 but attenuated by knockdown of PVT1 . (molcells.org)
  • MDA-MB-231 and MCF10A breast cancer cell lines were employed as a model system to explore the involvement of secreted factors in G12-stimulated cell invasion. (biomedcentral.com)
  • Factors secreted by cells expressing dominant-active Gα12 were identified by protein array, and their involvement in breast cancer cell invasion was assessed through both RNAi-mediated knockdown and antibody neutralization approaches. (biomedcentral.com)
  • Inhibition of IL-6 and IL-8, or MMP-2 activity significantly decreased Gα12-mediated cell invasion. (biomedcentral.com)
  • A hallmark feature of EMT is the downregulation of E-cadherin, a cell-cell adhesion molecule localized on the surface of epithelial cells [ 17 ]. (biomedcentral.com)
  • The aim of this study was to evaluate comparatively the effect of fluoride (F) on the activity of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) involved in process of alveolar bone repair. (bvsalud.org)
  • Nutricol reinforces membrane and matrix structures (halts damage that initiates inflammatory and spasmodic reactions). (life-enthusiast.com)
  • Cross-linked fibrin is deposited in tissues surrounding wounds, inflammatory sites, or tumors and serves not only as a supporting substratum for trafficking cells, but also as a structural barrier to invasion. (silverchair.com)
  • Structure of human pro-matrix metalloproteinase-2: activation mechanism revealed. (biocancer.com)
  • Nonetheless, MECs were also found to exhibit cancer-promoting effects and provoke tumour invasion and dissemination by displaying distinct cancer chemokines. (biomedcentral.com)
  • Hitherto the involvement of the MECs in mammary gland orchestration and morphogenesis [ 4 ] and in affording fortification against tumour progression and invasion [ 5 , 6 ] has re-established the attention in studying and characterizing the MECs. (biomedcentral.com)
  • Using fibroblasts recovered from wild-type or gene-deleted mice, invasion of three-dimensional fibrin gels proceeded in a matrix metalloproteinase (MMP)-dependent fashion. (silverchair.com)
  • Consistent with earlier studies supporting a singular role for the membrane-anchored MMP, MT1-MMP, in fibrin-invasive events, fibroblasts from MT1-MMP-null mice displayed an early defect in invasion. (silverchair.com)
  • Pertoft H. and Fries E. (1995) Inter-a-inhibitor is required for the formation of the hyaluronan-containing coat on fibroblasts and mesothelial cells. (lu.se)
  • Indeed, disruption of the MECs layer was reported to facilitate the invasion of the cancer cells to the surrounding stroma. (biomedcentral.com)
  • However, despite a well characterized role of Rho GTPases, the potential role of secreted factors in the capacity of G12 signaling to promote invasion of cancer cells is just beginning to be addressed. (biomedcentral.com)
  • Given the limited knowledge of the molecular mechanisms linked to the development of drug resistance in parasitic helminths [ 16 ], as well as the unavailability of effective vaccines, much attention is now directed towards the identification of novel targets for intervention [ 7 , 17 ]. (biomedcentral.com)
  • Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1. (biocancer.com)
  • 1, 7) Membrane and extra-cellular matrix damage leads to decreased ideal first-intention healing involving parenchyma. (life-enthusiast.com)
  • Some of these microorganisms such as Lactobacillus species reinforce the defense against invasion and colonization by opportunistic pathogens. (frontiersin.org)
  • Our integrated drug discovery strategy could be valuable in finding other multi-target bioactive compounds from complex matrices for treating multifactorial diseases. (frontiersin.org)