CatalysisModels, BiologicalComputer SimulationGene Expression Regulation, DevelopmentalMolecular Sequence DataSignal TransductionKineticsModels, MolecularBiocatalysisCatalytic DomainBinding SitesSubstrate SpecificityAmino Acid SequenceCrystallography, X-RayMutagenesis, Site-DirectedProtein ConformationModels, ChemicalEscherichia coliMutationProtein BindingProtein Structure, TertiaryHydrogen-Ion ConcentrationBase SequenceHydrolysisMolecular StructureSequence Homology, Amino AcidRNA, CatalyticStructure-Activity RelationshipRecombinant ProteinsHistidineOxidation-ReductionSequence AlignmentThermodynamicsStereoisomerismHydrogen BondingEnzymesAmino Acid SubstitutionAntibodies, CatalyticProtein Structure, SecondaryMetalsEnzyme StabilityBacterial ProteinsConserved SequenceMolecular ConformationAspartic AcidCloning, MolecularTime FactorsTemperatureMagnesiumProtonsNucleic Acid ConformationAdenosine TriphosphateCysteineLysineWaterProtein FoldingDNAEvolution, MolecularOxidoreductasesOxygenSpectrophotometryDimerizationProtein Structure, QuaternarySaccharomyces cerevisiaeBiological EvolutionAlgorithmsProton-Translocating ATPasesDNA PrimersManganesePhylogenyLigandsProteinsMagnetic Resonance SpectroscopyCrystallizationQuantum TheoryFlavinsModels, TheoreticalNADPEscherichia coli ProteinsArginineAmino Acid MotifsEnzyme ActivationCircular DichroismElectronsStatic ElectricitySpecies SpecificityPhosphatesZincPhenotypeMutagenesisAlkenesNADHemeCattleCyclizationPlantsElectron Spin Resonance SpectroscopyMolecular Dynamics SimulationBrainHydrogen