Intravenous administration intranasal. Medical search. Frequent questions

Comparing Intranasal Administration to Intramuscular Administration in Healthy Human Volunteers. (wikipedia.org)
Administration by intravenous, intramuscular, or intranasal routes. (e-lactancia.org)
With most users, peak opioid effects are reached in 10 minutes with the intravenous route, 10-15 minutes after nasal inhalation and 30-45 minutes with the intramuscular route [5]. (ems1.com)
Dosage forms for delivery of diazepam by other routes of administration, including intranasal, intramuscular, and transbuccal, are under investigation. (cureepilepsy.org)
To determine the effectiveness of intranasal (IN) naloxone compared with intramuscular (IM) naloxone for treatment of respiratory depression due to suspected opiate overdose in the prehospital setting. (mja.com.au)
Unlike Ketamine, which necessitates intravenous, intramuscular, or intranasal administration due to its limited oral bioavailability, in initial pre-clinical studies, Ketamir-2 appears to exhibit a more clinically desirable gastrointestinal absorption profile. (wkrn.com)
According to the route of administration, the efficacy was 28.6 to 100% (intrarectal) and 54 to 100% (intravenous) for diazepam, 82 to 100% (intravenous) for lorazepam, and 79% (intranasal), 93 to 100% (intramuscular) and 100% (intravenous) for midazolam. (nih.gov)

Oral, subcutaneous, and intranasal delivery are perhaps the most practical methods. (psychiatrist.com)
From the point of view of clinical practicability, subcutaneous, intranasal, and oral ketamine warrant further study. (psychiatrist.com)
Intravenous or subcutaneous kisspeptin administration has been shown to have significant potential to treat reproductive disorders. (endocrine-abstracts.org)
It is available in intranasal, subcutaneous, and oral formulations. (medscape.com)

This article presents a qualitative review and summary about what is known about ketamine dosing, rate of administration, route of administration, duration of treatment, and frequency of sessions. (psychiatrist.com)
There is likely to be a complex interaction between ketamine dose, session duration, route of administration, frequency of administration, and related practice. (psychiatrist.com)
3 The present article examines issues related to dosing, rate of administration, route of administration, duration of treatment, and frequency of sessions when ketamine is used in subanesthetic doses for the treatment of depression, especially treatment-resistant depression. (psychiatrist.com)
Ketamine was administered by the intravenous (IV) route in the doses of 0.1 and 0.5 mg/kg when its psychotomimetic and other effects were formally studied. (psychiatrist.com)
However, widespread off-label use of intravenous subanesthetic-dose ketamine for treatment-resistant depression has raised concerns about side effects, especially given its history as a drug of abuse. (nih.gov)
Most side effects peaked within an hour of ketamine administration and were gone within two hours. (nih.gov)
We did not see any serious, drug-related adverse events or increased ketamine cravings with a single-administration. (nih.gov)
To overcome the limitations associated with side effects and intravenous delivery, ongoing research efforts seek to develop a more practical rapid-acting antidepressant that works in the brain similarly to ketamine. (nih.gov)
Meanwhile, the U.S. Food and Drug Administration earlier this year approved an intranasal form of ketamine called esketamine, which can be administered to adults with treatment-resistant depression in a certified doctor's office or clinic. (nih.gov)
Because of its potential for misuse or illegal distribution, Ketamine is classified by the U.S. Drug Enforcement Administration (DEA) as a Schedule III substance, meaning that it is available legally only through a prescription, and its distribution and use are closely monitored. (wkrn.com)
Dr. Kaplin served as the Johns Hopkins site Principal Investigator for multi-center pivotal clinical trials, leading to the approval of an intranasal left-handed ketamine molecule called esketamine, brand name Spravato ®1 . (wkrn.com)
Intranasal dexmedetomidine and intravenous ketamine for procedural sedation in a child with alpha-mannosidosis: a magic bullet? (biomedcentral.com)
We administered intranasal dexmedetomidine (4 μg/kg) 45 min before intravenous cannulation, followed by one bolus of ketamine (1 mg/kg) for each procedure. (biomedcentral.com)
intranasal dexmedetomidine and intravenous ketamine could be a feasible option for MRI and lumbar puncture in children with alpha-mannosidosis needing sedation. (biomedcentral.com)
The strongest evidence of efficacy is for intranasal esketamine and intravenous ketamine. (medscape.com)
Evidence for long-term efficacy, safety, and tolerability of intravenous ketamine for patients with TRD is insufficient, the group notes. (medscape.com)

Early administration of oral oseltamivir increases the benefits of influenza treatment. (cdc.gov)
Desmopressin acetate tablets, for oral administration, contain either 0.1 or 0.2 mg desmopressin acetate, USP. (nih.gov)
The bioavailability of desmopressin acetate oral tablets is about 5% compared to intranasal desmopressin acetate, and about 0.16% compared to intravenous desmopressin acetate. (nih.gov)
The time to reach maximum plasma desmopressin acetate levels ranged from 0.9 to 1.5 hours following oral or intranasal administration, respectively. (nih.gov)
With respect to the mean values of total urine volume decrease and maximum urine osmolality increase from baseline, the 90% confidence limits estimated that the 0.4 mg and 0.2 mg oral dose produced between 95% and 110% and 84% to 99% of pharmacodynamic activity, respectively, when compared to the 0.01 mg intranasal dose. (nih.gov)
The oral route of administration (ROA) involves the application of the drug directly in to the mouth cavity, which will have a more direct effect on the target cells. (technavio.com)
OBJECTIVE: Diazepam, administered by the intravenous, oral, or rectal routes, is widely used for the management of acute seizures. (cureepilepsy.org)
Conclusions: Co-administration of ciprofloxacin with riluzole increases the systemic levels of riluzole and thereby the oral pharmacokinetic properties of riluzole while co-administration of grapefruit juice with riluzole has no significant effect. (researchgate.net)
Although, in clinical practice, IV administration of CIP is not recommended for routine use in the management of CRS, this route was herein chosen because oral bioavailability of CIP is only around 20% in rats (Hwang et al. (researchgate.net)
The preferred route of administration of a corticosteroid for the treatment of asthma is inhalation, which delivers the drug directly to the lung, where it acts locally and minimises the systemic side-effects associated with oral or parenteral administration. (ersjournals.com)
Oral route of administration held dominant position in the global allergic rhinitis treatment market in 2019, accounting for 48.4% share in terms of value, followed by Nasal and Intravenous, respectively. (medgadget.com)
Oral medication is easy to administer, and can be taken easily by the patients as compared to intranasal and intravenous medication. (medgadget.com)
Unlike Spravato, which must be monitored during treatment for two hours by trained clinicians, we believe that Ketamir-2's initial predicted favorable side effect profile and its oral availability may pave the way for Ketamir-2's target to achieve FDA approval for convenient home self-administration, a significant boon for patient-centric care. (wkrn.com)
Enteral' means any technique of administration in which the agent is absorbed through the gastrointestinal tract or oral mucosa (i.e., oral, rectal, sublingual). (virginia.gov)
The NSAID component of the drugs also restricted the routes of administration to oral ingestion. (palmpartners.com)
The past decade has seen clinical trials of transmucosal opioid formulations for breakthrough pain in cancer (BTPc), beginning with oral transmucosal fentanyl citrate (OTFC), followed by fentanyl buccal tablet and intranasal fentanyl spray, and most recently sublingual fentanyl tablet, fentanyl buccal soluble film, and fentanyl pectin nasal spray. (jnccn.org)
Although oral opioids have been used for historical reasons, evidence supports the use of intravenous morphine or transmucosal fentanyl for treating BTPc, regardless of the opioid being taken to manage background pain. (jnccn.org)

As reported by Medscape Medical News , the US Food and Drug Administration (FDA) approved esketamine nasal spray (Spravato) for TRD in March 2019. (medscape.com)
Intranasal esketamine demonstrates efficacy, safety, and tolerability for up to 1 year in adults with TRD. (medscape.com)

However, when intravenous administration is not available, rectal administration of a solution is a convenient method for diazepam, midazolam being the only one of these drugs that should be given intramuscularly. (nih.gov)
Emergency treatment for prolonged tonic-clonic seizures has long involved early administration of benzodiazepine drugs, for example, diazepam via the rectal route or lorazepam via intravenous route where available. (bestbets.org)

Until definitive studies comparing different doses, rates of administration, routes of administration, and other considerations are conducted, firm recommendations are not possible. (psychiatrist.com)
The levels of blockade were comparable across all routes of administration and a dose effect was observed for intravenous and intranasal cocaine but not for smoked cocaine. (erowid.org)
Classification:Routes of administration are usually classified by application location. (absoluteastronomy.com)
http://toxsci.oxfordjournals.org/ adverse-effect levels derived from clinical studies employing po sensitive pharmacological or toxicological end point by appro- and iv routes of administration and by applying default un- certainty factors or chemical-specific adjustment factors. (cdc.gov)

The company-funded trial involved administering SAGE-547 to a handful of patients with postpartum depression as an intravenous infusion over 48 hours. (the-scientist.com)
Here we administered diazepam by continuous intravenous infusion to obtain near-steady-state levels, which allowed an assessment of the minimal levels that elevate seizure threshold. (cureepilepsy.org)
Diazepam was administered to freely moving animals by continuous intravenous infusion via an indwelling jugular vein cannula. (cureepilepsy.org)

Here we assessed whether there were differences in the efficacy of cocaine to block the dopamine transporters (major target for cocaine's reinforcing effects), as a function of route of administration. (erowid.org)
Differences in the reinforcing effects of cocaine as a function of the route of administration are not due to differences in the efficacy of cocaine to block the dopamine transporters. (erowid.org)
The efficacy of the intranasal or buccal midazolam have been debated more recently and shown to be effective in seizure cessation, although intranasal administration has only demonstrated variable success and was found to be ineffective in children with concurrent upper respiratory tract infections (McIntyre et al. (bestbets.org)

Key findings: Co-administration of ciprofloxacin with riluzole caused significant increase in systemic exposure of riluzole (area under the curve, maximum plasma concentration and mean residence time were found to increase). (researchgate.net)

Bolus administration is safe and effective when the drug is administered intramuscularly or subcutaneously. (psychiatrist.com)
RESULTS: The pharmacokinetic parameters of diazepam following a single 80-?g/kg intravenous bolus injection were determined using a noncompartmental pharmacokinetic approach. (cureepilepsy.org)

A single dose, Open Label, Randomized Three Way Crossover, Bioavailability Study of 1.0 mg and 2.0 Intranasal Butorphanol Tartrate Compared to 2.0 mg. (wikipedia.org)
A single Dose, Randomized Two Period Crossover Pharmacokinetic Study of 2.0 mg Intranasal Hydromorphone Hydrochloride In Healthy Human Volunteers Using 10 mg/ml and 20 mg/ml Formulations. (wikipedia.org)
For intranasal use only, the recommended dose is 1 spray per nostril twice daily in adults and adolescents 12 years of age and older. (rxlist.com)
Methods: Pharmacokinetic parameters of riluzole were determined in Wistar rats after single-dose co-administration with ciprofloxacin and grapefruit juice. (researchgate.net)

Despite extensive research and very promising results, however, little is known about the pharmacokinetic characteristics of intranasal OXT application. (nature.com)
Co-administration of grapefruit juice with riluzole did not cause any significant difference in the pharmacokinetic parameters of riluzole. (researchgate.net)

METHODS: The thresholds for various behavioral seizure signs (myoclonic jerk, clonus, and tonus) were determined with the timed intravenous pentylenetetrazol seizure threshold test in rats. (cureepilepsy.org)

There are reports of an occasional change in response to the intranasal formulations of desmopressin acetate (Desmopressin Acetate Nasal Spray and Desmopressin Acetate Rhinal Tube). (nih.gov)

Increasingly, clinical studies have generated unprecedented interest in the therapeutic targets and potential benefits of intranasal OXT application for neuropsychiatric disorders characterised by social dysfunction, such as social anxiety, autism and schizophrenia 4 . (nature.com)
Presbyopia pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. (abnewswire.com)

Procedural sedation and analgesia (PSA) is the administration of a short-acting sedative-hypnotic or dissociative agent, with or without an analgesic, for patients undergoing anxiety-provoking and/or painful procedures. (msdmanuals.com)

It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. (researchandmarkets.com)
The route of administration influences the reinforcing effects of cocaine. (erowid.org)
Las Vegas, Nevada, United States) As per DelveInsight's assessment, globally, Presbyopia pipeline constitutes 12+ key companies continuously working towards developing 12+ Presbyopia treatment therapies, analysis of Clinical Trials, Therapies, Mechanism of Action, Route of Administration, and Developments analyzes DelveInsight. (abnewswire.com)
A route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. (absoluteastronomy.com)
Las Vegas, Nevada, United States) As per DelveInsight's assessment, globally, Influenza pipeline constitutes 120+ key companies continuously working towards developing 120+ Influenza treatment therapies, analysis of Clinical Trials, Therapies, Mechanism of Action, Route of Administration, and Developments analyzes DelveInsight. (coastalnewsnow.com)

As always, consult your veterinarian about proper and safe injection administration. (pbsanimalhealth.com)
Proper administration of injection products is important for both the safety of the animal as well as the safety of meat product consumers. (pbsanimalhealth.com)
Once again, consult your veterinarian about proper and safe injection administration. (pbsanimalhealth.com)

Intravenous Zanamivir in Hospitalized Patients With Influenza. (cdc.gov)

Finally, venous access may be troublesome, scaring and painful for these children, who often require repeated hospital admissions and procedures, so that a sedation sequence based on an intranasal premedication, facilitating cannulation without putting the patient at risk, may offer further advantages. (biomedcentral.com)

When OxyContin was released, abusers realized that they could crush the pill to release pure oxycodone (up to 80mg in one pill), which allowed larger doses and by additional routes of administrations such as intravenous and intranasal. (palmpartners.com)

A hollow, tubular medical device which is placed into a body part (such as a vein or urinary bladder) for the removal or administration of fluids. (infovets.com)

Positron emission tomography and [11C]cocaine, a dopamine transporter radioligand, were used to compare the levels of dopamine transporter blockade induced by intravenous, smoked and intranasal cocaine in 32 current cocaine abusers. (erowid.org)

There has been an unprecedented interest in the modulatory effects of intranasal oxytocin on human social cognition and behaviour, however as yet no study has actually demonstrated that this modality of administration increases concentrations of the peptide in the brain as well as blood in humans. (nature.com)

In one study, the pharmacodynamic characteristics of desmopressin acetate tablets and intranasal formulation were compared during an 8-hour dosing interval at steady state. (nih.gov)

Dymista (azelastine hydrochloride and fluticasone propionate) nasal spray is formulated as a white, uniform metered-spray suspension for intranasal administration. (rxlist.com)
After priming [see DOSAGE AND ADMINISTRATION ], each metered spray delivers a 0.137 mL mean volume of suspension containing 137 mcg of azelastine hydrochloride (equivalent to 125 mcg of azelastine base) and 50 mcg of fluticasone propionate. (rxlist.com)

The faster time course for the subjective effects for smoked than intravenous and for intravenous than for intranasal cocaine highlights the importance of the speed of cocaine's delivery into the brain on its reinforcing effects. (erowid.org)
However, intranasal administration could offer a novel non-invasive delivery route, which would be clinically preferable. (endocrine-abstracts.org)

Known by the generic name brexanolone, the drug sped through Phase 2 and Phase 3 trials before being approved by the US Food and Drug Administration (FDA) on March 19. (the-scientist.com)
Researchers who developed nitazenes obtained a patent, but nitazenes have never been approved for use by the Food and Drug Administration. (wtop.com)
For instance, in May 2019, Unichem Laboratories received tentative approval from the U.S. Food and Drug Administration for its generic copy of allergic rhinitis Johnson & Johnson Consumer Inc.'s Zyrtec-D 12 Hour used for treating allergic rhinitis. (medgadget.com)
The first combination product of a triptan and an NSAID was approved by the US Food and Drug Administration in April 2008. (medscape.com)
FDA U.S. Food and Drug Administration. (cdc.gov)

Glucagon intranasal is indicated for severe hypoglycemic reactions in adults and children (aged 4 years or older) with diabetes. (medscape.com)
But correct administration is important for minimizing tissue residue, lesions and reactions in your livestock. (pbsanimalhealth.com)

Often, another part of the research or testing use of animals is the effective administration of compounds to mice and rats. (jove.com)
In the present study, pharmacokinetics of CIP following IN and IV administration to rats was investigated and compared. (researchgate.net)

Intravenous Botorphanol Tartrate In Healthy Human Volunteers. (wikipedia.org)
Elevated OXT plasma concentrations peaking at 10-40 min after intranasal administration of OXT (30 IU) have been documented in three male volunteers 11 . (nature.com)

The NOAEL is of MK-0679, a leukotriene D4 receptor antagonist, was compared generally determined by the use of animal and/or human data following iv, po, intranasal (in), or intratracheal (it) administra- obtained following exposure to a drug via the traditional tion. (cdc.gov)
Following an intranasal VARV challenge that mimics the natural route for human smallpox transmission, the virus spread systemically within the humanized mouse before mortality (~ 13 days post infection), similar to the time from exposure to symptom onset for ordinary human smallpox. (cdc.gov)

Practice restraint before attempting compound administration, and practice administering substances to control animals before experimental animals. (jove.com)

The time to reach peak subjective was significantly faster for smoked (1.4+/-0.5 min) than for intravenous cocaine (3.1+/-0.9 min), which was faster than intranasal cocaine (14.6+/-8 min). (erowid.org)

Following administration of desmopressin acetate tablets, the onset of antidiuretic effect occurs at around 1 hour, and it reaches a maximum at about 4 to 7 hours based on the measurement of increased urine osmolality. (nih.gov)
Serum concentrations of dexmedetomidine were assayed at approximately 5 minutes, 15 minutes, 30 minutes, 1 hour and 4 hours after administration. (bvsalud.org)

Consequently, the most convincing animal studies of functional effects of OXT have therefore used intracerebroventricular or intracerebral administration routes. (nature.com)
We therefore sought to determine the effects of intranasal kisspeptin. (endocrine-abstracts.org)

SAMHSA, Substance Abuse and Mental Health Services Administration. (hivguidelines.org)
The Drug Enforcement Administration (DEA) has classified Adderall as a Schedule II controlled substance, which means it has a high potential for abuse and dependence . (withdrawal.net)
The goal of this article is to expose a viewer unfamiliar with these techniques to basic restraint and substance administration routes. (jove.com)

For equivalent levels of cocaine in plasma and DAT blockade, smoked cocaine induced significantly greater self reports of high than intranasal cocaine and showed a trend for a greater effect than intravenous cocaine. (erowid.org)

Glucagon may be useful when intravenous (IV) access for dextrose administration is problematic. (medscape.com)
This premedication allowed to perform a painless and fearless intravenous access. (biomedcentral.com)

This can occur naturally in the animal or can be induced using special drugs or fluid administration. (infovets.com)
The Drug Enforcement Administration classifies the 10 currently known nitazenes as Schedule 1 drugs, says Alex J. Krotulski, associate director of the Center for Forensic Science Research & Education in Willow Grove, Pennsylvania. (wtop.com)

Clinical experience with intravenous zanamivir under an emergency investigational new drug program in the United States. (cdc.gov)
In 1995, the Federal Drug Administration approved the manufacture of OxyContin, a time-release version of oxycodone. (palmpartners.com)
The drug quickly spread to Florida, well-known for having some of the most lax prescription laws in the U.S. Shady pain management operations, or "pill mills" began popping up all over the state, and users began travelling to Florida en-masse to get prescriptions. (palmpartners.com)

Moreover, it has been shown that insulin, melanocyte-stimulating hormone and vasopressin can all cross the BBB and increase cerebrospinal fluid (CSF) as well as blood concentrations within 15-30 min after intranasal administration 8 . (nature.com)

Anatomy20

Organisms27

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Disciplines and Occupations2

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