• To evaluate the safety of intravenous high-dose pulse methylprednisolone succinate (IVHDM) in the management of severe or refractory non-infectious pediatric uveitis. (dovepress.com)
  • The use of high-dose intravenous methylprednisolone for three days in conjunction with oral or intravenous cyclophosphamide is advised for aggressive disease. (medicinenet.com)
  • Methylprednisolone 100 mg intravenous or equivalent glucocorticoid is recommended 30 minutes prior to each infusion ( 2.5 ). (drugs.com)
  • Weibel et al performed a retrospective analysis of 34 pediatric patients with morphea who were treated with pulsed intravenous methylprednisolone/methotrexate, followed by an oral steroid taper and long-term (one to three years) maintenance therapy with methotrexate. (contemporarypediatrics.com)
  • Corticosteroids, plasma exchange, and intravenous immunoglobulin (IVIG) have been standard-of-care treatments for chronic inflammatory demyelinating polyneuropathy (CIDP) for more than 2 decades. (ahdbonline.com)
  • Most patients who developed these infections were taking concomitant immunosuppressants such as methotrexate or corticosteroids. (rxlist.com)
  • Although evidence-based literature about therapy is limited, various treatment options-including high-potency topical corticosteroids, topical calcipotriene, oral steroids, systemic methotrexate, and photochemotherapy-have been advocated. (contemporarypediatrics.com)
  • 3. Weibel L, Sampai MC, Visentin MT, et al: Evaluation of methotrexate and corticosteroids for the treatment of localized scleroderma (morphoea) in children. (contemporarypediatrics.com)
  • Adjuvant polychemotherapy (e.g. with 58% to 68%) for patients under the age of 50.1 Besides an cyclophosphamide, methotrexate and 5-fluorouracil (CMF)) or improvement in clinical outcome, these figures indicate that anthracycline-containing regimes, produce substantial reduc- a large proportion of the patients will never recur after the tion in recurrence and mortality. (lu.se)
  • Oral methotrexate is a low-dose chemotherapy medicine, normally used in combination with oral cyclophosphamide for the treatment of advanced breast or advanced ovarian cancer. (snec.com.sg)
  • In this article, we report three patients treated with immunosuppressive drugs and chemotherapy (vincristine, methotrexate) in whom cortical laminar necrosis developed. (ajnr.org)
  • All patients were treated with chemotherapy including intravenous high-dose methotrexate, rituximab and temozolomide and radiotherapy by the same oncologist. (thieme-connect.com)
  • Randomized phase II trial on primary chemotherapy with high-dose methotrexate and high-dose cytarabine with or without thiotepa, and with or without rituximab, followed by brain irradiation vs. high-dose chemotherapy supported by autologous stem cells transplantation for immunocompetent patients with newly diagnosed primary cns lymphoma. (clinicaltrialsregister.eu)
  • Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. (ox.ac.uk)
  • The dose for RA in combination with methotrexate is two-1,000 mg intravenous infusions separated by 2 weeks (one course) every 24 weeks or based on clinical evaluation, but not sooner than every 16 weeks. (drugs.com)
  • The follow up dose for adult patients with GPA and MPA who have achieved disease control with induction treatment, in combination with glucocorticoids is two 500 mg intravenous infusions separated by two weeks, followed by a 500 mg intravenous infusion every 6 months thereafter based on clinical evaluation ( 2.6 ). (drugs.com)
  • Intravenous immunoglobulin (IVIG) was used in 2 patients and plasmapharesis in 1 patient. (nih.gov)
  • Intravenous immunoglobulin (IVIG) has been used primarily for immune deficiency patients, and its greatest expansion is seen more and more in the treatment of autoimmune disorders, especially in neurology. (nursingcenter.com)
  • Intravenous immunoglobulin (IVIG) is a polymeric highly purified immunoglobulin fraction derived from large pools of up to 60,000 plasma donors. (nursingcenter.com)
  • The patients were defined as receiving active CIDP therapy (ie, IVIG, immunosuppressants, oral or intravenous steroids, or plasma exchange) or active surveillance. (ahdbonline.com)
  • High dose intravenous methotrexate with leucovorin rescue in rheumatoid arthritis. (cornell.edu)
  • Five patients with severe, treatment refractory rheumatoid arthritis were treated with high dose intravenous methotrexate (500 mg/m2) followed by leucovorin (50 mg/m2). (cornell.edu)
  • Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. (nih.gov)
  • Not all patients with rheumatoid arthritis can tolerate or respond to methotrexate, a standard treatment for this disease. (nih.gov)
  • We therefore investigated whether infliximab, a chimeric human-mouse anti-TNFalpha monoclonal antibody would provide additional clinical benefit to patients who had active rheumatoid arthritis despite receiving methotrexate. (nih.gov)
  • In an international double-blind placebo-controlled phase III clinical trial, 428 patients who had active rheumatoid arthritis, who had received continuous methotrexate for at least 3 months and at a stable dose for at least 4 weeks, were randomised to placebo (n=88) or one of four regimens of infliximab at weeks 0, 2, and 6. (nih.gov)
  • During 30 weeks, treatment with infliximab plus methotrexate was more efficacious than methotrexate alone in patients with active rheumatoid arthritis not previously responding to methotrexate. (nih.gov)
  • Remicade, Centocor, Malvern, PA) given alone or in combination with low-dose methotrexate (MTX) in rheumatoid arthritis (RA) patients. (ox.ac.uk)
  • The US Food and Drug Administration (FDA) has approved golimumab ( Simponi Aria , Janssen Biotech, Inc), intravenous (IV) formulation in combination with methotrexate, for the treatment of moderately to severely active rheumatoid arthritis (RA), the company has announced today. (medscape.com)
  • The approval follows a phase 3 international multicenter, randomized, double-blind, placebo-controlled (Golimumab, an Anti-TNF-alpha Monoclonal Antibody, Administered Intravenously, in Subjects with Active Rheumatoid Arthritis Despite Methotrexate Therapy [GO-FURTHER]) trial of 592 adults with active RA despite methotrexate (MTX) treatment. (medscape.com)
  • Rheumatoid Arthritis (RA) in combination with methotrexate in adult patients with moderately-to severely-active RA who have inadequate response to one or more TNF antagonist therapies ( 1.3 ). (drugs.com)
  • The pharmacokinetics of infliximab (IFX), an anti-TNF-α monoclonal antibody, is modified during methotrexate (MTX) coadministration in rheumatoid arthritis[1]. (page-meeting.org)
  • The Simponi Aria dose regimen is 2 mg/kg given as an intravenous infusion at weeks 0 and 4, then every 8 weeks thereafter, according to the company. (medscape.com)
  • Administer only as an intravenous infusion ( 2.1 ). (drugs.com)
  • While standardised concentrations for intravenous infusion and drug concentrations that avoid measurement of small volumes would ameliorate problems, further work is needed to establish accurate methods for handling small volumes during the administration of medicines to children and risk minimisation strategies to support staff involved are also necessary. (bmj.com)
  • 24 hours at the latest) after the beginning of methotrexate infusion. (janusinfo.se)
  • Forty-eight hours after the start of the methotrexate infusion, the residual methotrexate-level should be measured. (janusinfo.se)
  • The recommended adult intravenous dosage of ZOFRAN is three 0.15-mg/kg doses up to a maximum of 16 mg per dose [see CLINICAL PHARMACOLOGY ]. (globalrph.com)
  • For pediatric patients aged 6 months through 18 years, the intravenous dosage of ZOFRAN is three 0.15-mg/kg doses up to a maximum of 16 mg per dose [see Clinical Studies , CLINICAL PHARMACOLOGY ]. (globalrph.com)
  • The recommended adult intravenous dosage of ZOFRAN is 4 mg undiluted administered intravenously in not less than 30 seconds, preferably over 2 to 5 minutes, immediately before induction of anesthesia, or postoperatively if the patient did not receive prophylactic antiemetics and experiences nausea and/or vomiting occurring within 2 hours after surgery. (globalrph.com)
  • Since the calcium folinate rescue dosage regimen depends heavily on the posology and method of the intermediate- or high-dose methotrexate administration, the methotrexate protocol will dictate the dosage regimen of calcium folinate rescue. (janusinfo.se)
  • Dosage and duration of calcium folinate rescue primarily depend on the type and dosage of methotrexate therapy, the occurrence of toxicity symptoms, and the individual excretion capacity for methotrexate. (janusinfo.se)
  • We would recommend regular full blood counts in all patients receiving anti-TNF treatment, whether they are on concomitant methotrexate or not, and believe that guidelines need to be modified to take this into account. (bmj.com)
  • Methotrexate-induced lung disease, including acute or chronic interstitial pneumonitis, is a potentially dangerous lesion, which may occur acutely at any time during therapy and has been reported at low doses. (nih.gov)
  • Severe, occasionally fatal, skin reactions have been reported following single or multiple doses of methotrexate. (nih.gov)
  • Intraductal delivery of PLD resulted in much higher concentration in the breast compared to the circulation, whereas in the women with intravenous doses we saw relatively high concentrations in the blood but very little, if any, in the breast," she says. (futurity.org)
  • Calcium folinate rescue is necessary when methotrexate is given at doses exceeding 500 mg/m2 body surface and should be considered with doses of 100 mg - 500 mg/m2 body surface. (janusinfo.se)
  • Calcium folinate can be administered either by the intravenous route at a dose of 20 mg/m2 for 5 to 10 minutes every 6 hours for a total daily dose of 80 mg/m2 or by oral route with four doses of 20 mg/m2 administered at equal time intervals. (janusinfo.se)
  • high dose, intravenous methotrexate, or cytarabine and neurosurgery and Hodgkin's Lymphoma survivors don't receive any of them. (oncologytube.com)
  • The patients received either intravenous cA2 at 1, 3, or 10 mg/kg, with or without MTX 7.5 mg/week, or intravenous placebo plus MTX 7.5 mg/week at weeks 0, 2, 6, 10, and 14 and were followed up through week 26. (ox.ac.uk)
  • Therapeutic agents can be introduced into the body by several routes of administration with each having specific advantages and disadvantages (see Table I). For many drugs, including biologics and anticancer agents, the traditional route of administration is intravenous (IV). (pharmtech.com)
  • Our experience of rates of development of neutropenia in patients receiving other commonly prescribed DMARDs such as methotrexate and leflunomide is 12.5% and 14.9%, respectively. (bmj.com)
  • these patients are managed with supportive therapy, which includes analgesics, antinausea medications, intravenous fluids, and prevention and treatment of complications. (medscape.com)
  • Like other cytotoxic drugs, methotrexate may induce "tumor lysis syndrome" in patients with rapidly growing tumors. (nih.gov)
  • Tumor lysis syndrome: Administer aggressive intravenous hydration, anti-hyperuricemic agents, monitor renal function ( 5.5 ). (drugs.com)
  • In the animal portion of the new study, Sukumar's lab examined the intraductal effectiveness of four standard anticancer drugs, 5-fluorouracil (5FU), carboplatin, methotrexate and paclitaxel, all compared with PLD. (futurity.org)
  • 0.1 mL), for enteral and intravenous dosing, accounts for 25% of medicine manipulations within paediatric hospitals. (bmj.com)
  • Summary: We report three patients in whom neurologic symptoms and cortical laminar necrosis developed after immunosuppressive treatment (cyclosporin A and FK 506) and polychemotherapy (vincristine and methotrexate). (ajnr.org)
  • Such patients require especially careful monitoring for toxicity, and require dose reduction or, in some cases, discontinuation of methotrexate administration. (nih.gov)
  • Malignant lymphomas, which may regress following withdrawal of methotrexate, may occur in patients receiving low-dose methotrexate and, thus, may not require cytotoxic treatment. (nih.gov)
  • Discontinue methotrexate first and, if the lymphoma does not regress, appropriate treatment should be instituted. (nih.gov)
  • Contraceptive (birth control) measures are recommended for both men and women during treatment with Methotrexate. (snec.com.sg)
  • However, of those patients whose methotrexate was stopped, 44% developed a relapse between five and 32 months after discontinuation of the treatment, thus requiring additional treatment. (contemporarypediatrics.com)
  • Methotrexate can be considered a third-line treatment option. (easternpromotion.com)
  • In addition to calcium folinate administration, measures to ensure the prompt excretion of methotrexate (maintenance of high urine output and alkalinisation of urine) are integral parts of the calcium folinate rescue treatment. (janusinfo.se)
  • Addition of other therapeutics (cidofovir, brincidofovir, vaccinia immune globulin intravenous [VIGIV]) should be considered based on the clinical scenario. (cdc.gov)
  • Intravenous administration. (pharmtech.com)
  • refer to the applied intermediate or high dose methotrexate protocol for posology and method of administration of calcium folinate. (janusinfo.se)
  • Methotrexate elimination is reduced in patients with impaired renal functions, ascites, or pleural effusions. (nih.gov)
  • High dose methotrexate-leucovorin was associated with a significant reduction in DR antigen expression on peripheral Leu 2, Leu 3 and Leu 4 lymphocytes. (cornell.edu)
  • A comparison of 12 patients receiving PLD intraductally with three patients treated with PLD by the standard intravenous route also was revealing, Stearns said. (futurity.org)
  • Of these drugs, intraductal 5FU prevented the most cancers compared to no drug or to intravenous delivery. (futurity.org)
  • At that time-and at another hospital-she received intravenous gammaglobulin for presumed Kawasaki disease (she had right cervical lymphadenopathy, an erythematous rash, and chapped lips). (cancernetwork.com)
  • Man who underwent Roux-en-Y gastric bypass at age 26, subsequently diagnosed with Crohn's disease, involving jejunum, ileum and colon, at age 42 when he presented with large volume diarrhoea and rectal bleeding. (medscape.com)
  • Most cases were women, had Roux-en-Y surgery years prior to diagnosis and few IBD-related complications. (medscape.com)