• Fibrodysplasia ossificans progressiva (FOP) is a rare and disabling genetic condition characterized by congenital malformations of the great toes and progressive heterotopic ossification (HO) in specific anatomic patterns. (medscape.com)
  • Extensive heterotopic ossification on the back of a patient with fibrodysplasia ossificans progressiva. (medscape.com)
  • Fibrodysplasia ossificans progressiva is the most catastrophic disorder of heterotopic ossification in humans. (medscape.com)
  • Progressive postnatal heterotopic ossification in fibrodysplasia ossificans progressiva usually appears within the first decade of life as spontaneous or injury-induced exacerbations. (medscape.com)
  • blunt muscle trauma from bumps, bruises, falls) or influenza-like viral illnesses can trigger painful new flare-ups of fibrodysplasia ossificans progressiva, leading to progressive heterotopic ossification (HO). (medscape.com)
  • Two clinical features define classic fibrodysplasia ossificans progressiva: malformations of the great toes and progressive heterotopic ossification. (medscape.com)
  • Fibrodysplasia ossificans progressiva (FOP) is characterized by congenital bilateral hallux valgus malformations and early-onset heterotopic ossification, which may be spontaneous or precipitated by trauma including intramuscular vaccinations. (beds.ac.uk)
  • Currently, there are no effective medical treatment options to prevent the formation of heterotopic bones in fibrodysplasia ossificans progressiva (FOP). (biomedcentral.com)
  • Fibrodysplasia ossificans progressiva (FOP) (OMIM: 135100) is a severely disabling heritable disorder of connective tissue characterized by congenital malformations of the great toes and progressive heterotopic ossification in various extraskeletal sites. (biomedcentral.com)
  • Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disease characterized by progressive ossification of tendons, ligaments, fascia, and skeletal muscle. (ispub.com)
  • Painful, recurrent soft-tissue swellings (flare-ups) may precede localized heterotopic ossification. (beds.ac.uk)
  • The efficacy of Pex for preventing heterotopic ossifications was evaluated by the presence of flare-ups, measurements of serum bone markers, and changes in the total bone volume calculated by the three-dimensional computed tomography (3D-CT) images. (biomedcentral.com)
  • 3) Spontaneous flare-ups present as large, painful swellings resulting in heterotopic ossification. (ispub.com)
  • Note the severe kyphoscoliosis and the heterotopic calcifications present throughout her body. (ispub.com)
  • Ossification can occur either spontaneously or as a result of tissue trauma beginning in childhood. (ispub.com)
  • Also, trauma from needle placement can lead to further progression of their disease and lead to additional painful ossification. (ispub.com)
  • At this time our preoperative concerns included: difficulty obtaining an airway, difficulty with ventilation, difficulty with positioning and prevention of trauma or ossification, difficulty and risk vs. benefit of IV and arterial access, unknown surgical conditions and potential for increased length of surgery and bleeding. (ispub.com)
  • This new bone formation (known as "heterotopic ossification") eventually forms a secondary skeleton and progressively restricts the patient's ability to move. (wikipedia.org)
  • Attempts to remove heterotopic bones usually lead to explosive new bone formation. (biomedcentral.com)
  • Whitlockite had a potential of being a better bone substrate hydroxyapatite and tricalcium phosphate in spinal fusion with low risk of inducing ectopic ossification. (biomedcentral.com)
  • In group AT, both at 7 and 90 post-operative days, the main healing type was the presence of dense conjunctive tissue exhibiting bundles of collagen fibers disposed in beams permeating the remaining adipose tissue with rare heterotopic bone formation associated to fibrosis and different types of tissue necrosis. (bvsalud.org)
  • Serum levels of ALP and BAP appear to be promising biomarkers for monitoring the development of ectopic ossifications and efficacy of the therapy. (biomedcentral.com)
  • Also, the higher osteoinductivity of whitlockite raised concern of ectopic ossification, which was a complication of spinal fusion surgery that should be avoided. (biomedcentral.com)
  • In this study, we compared the osteoinductivity of whitlockite, hydroxyapatite, and tricalcium phosphate porous particles with SD rat spine posterolateral fusion model and investigated whether whitlockite could induce ectopic ossification with SD rat abdominal pouch model. (biomedcentral.com)
  • Herein, we describe seven cases of soft tissue hemorrhagic complications in the form of spontaneous intramuscular hematomas (SMHs) in patients after SCI undergoing rehabilitation. (bvsalud.org)
  • We could not prove the efficacy of oral Pex administration in the prevention of heterotopic ossifications in FOP. (biomedcentral.com)
  • Conclusions: Intramuscular hematomas are rare complications after SCI. (bvsalud.org)
  • Individuals with FOP will frequently have ossification of their temporomandibular joint (TMJ) resulting in jaw immobility. (ispub.com)
  • Regional anesthesia was to be avoided due to concerns of additional spinal ossification and inability to secure the airway in an emergency. (ispub.com)
  • At present, there is no definitive pharmacotherapy to prevent progressive heterotopic ossifications in FOP. (biomedcentral.com)
  • Specifically, ossification is typically first seen in the dorsal, axial, cranial and proximal regions of the body. (wikipedia.org)
  • Heterotopic ossification can occur at any location, but typically affects regions in close proximity to the axial skeleton in the early/mild stages, before progressing to the appendicular skeleton. (beds.ac.uk)
  • Problems with swallowing and speaking can occur with ossification affecting the jaw, head, and neck, and restriction of the airway and breathing may lead to thoracic insufficiency syndrome. (beds.ac.uk)
  • This can lead to restriction of movement as a result of ossification impacting joint mobility. (beds.ac.uk)
  • Myositis ossificans is a misnomer, although the term myositis ossificans circumscripta continues to be used to describe nonhereditary forms of heterotopic ossification. (medscape.com)
  • Additionally, a retrospective search in Pubmed database using the keywords "muscle metastasis", "muscle metastases", "intramuscular metastasis", "intramuscular metastases" and "metastases to the musculature" was performed. (biomedcentral.com)
  • By the drug repositioning strategy, we confirmed that perhexiline maleate (Pex) potentially ameliorates heterotopic ossification in model cells and mice. (biomedcentral.com)
  • Avoid intramuscular injections and arterial punctures. (nih.gov)
  • flare-ups of soft-tissue swelling may be prompted by injury, intramuscular injections, viral infection, or falls. (medscape.com)
  • As the extra-skeletal bone formation is accelerated by trauma (including intramuscular injections). (rarecare.world)
  • Avoid deep tissue trauma: including intramuscular (IM) injections, if possible. (rarecare.world)
  • Rapamycin, which we have previously shown to eliminate ectopic ossification in this model, also eliminates fibrosis without reducing osteogenic differentiation, suggesting clinical value for patients with FOP and with BMP implants. (jci.org)
  • The radiographic picture is completely unspecific, locking images of calcification or ossification. (jortho.org)
  • Fibrodysplasia ossificans progressiva (FOP) is characterized by congenital bilateral hallux valgus malformations and early-onset heterotopic ossification, which may be spontaneous or precipitated by trauma including intramuscular vaccinations. (nih.gov)
  • The diagnosis of FOP is established in a proband with heterotopic ossification, hallux valgus malformations, and/or a heterozygous pathogenic variant in ACVR1 identified by molecular genetic testing. (nih.gov)
  • However, prior work by Lu et al indicated a minimal contribution by Tie2-lineage cells to fracture repair, [ 11 ] suggesting important fundamental differences between heterotopic ossification and fracture healing. (medscape.com)
  • Open management of the fracture was challenging owning to the pervasive ossification and tendency for excessive bleeding. (biomedcentral.com)
  • Fibrodysplasia ossificans progressiva (FOP) is an extremely disabling connective tissue disorder characterized by progressive heterotopic ossification (HO). (medscape.com)
  • In isolated fibro-adipogenic progenitors from damaged muscle (cells at the origin of ossification), spinal cord injury induced a downregulation of osteo-suppressive miRNAs while osteogenic markers were overexpressed. (bvsalud.org)
  • when coupled with postnatal progressive heterotopic endochondral ossifications, this sign provide a convincing rationale for a clinical diagnosis of FOP. (biomedcentral.com)
  • Altogether, we highlighted an osteo-suppressive mechanism involving multiple miRNAs in response to muscle injury that prevents osteogenic commitment which is ablated by the neurologic lesion in heterotopic ossification pathogenesis. (bvsalud.org)
  • However, extensive heterotopic ossification (HO) secondary to this syndrome is extremely rare. (biomedcentral.com)
  • Ossification of chewing muscles may cause serious eating problems. (rarecare.world)
  • More research is needed on the effects of glucocorticoids on flare-up as well as other treatments to prevent ossification. (rarecare.world)
  • Amongst 15 FOP patients who received intramuscular COVID-19 vaccination. (fopfriends.co.uk)
  • 16. Intramuscular low-grade fibromyxoid sarcoma: a case report. (nih.gov)
  • This can lead to restriction of movement as a result of ossification impacting joint mobility. (nih.gov)