• proteins
  • Munc 18-1 has a vital regulatory role in preventing the formation of the binary complex between syntaxin 1a and SNAP-25 before the proteins reach their target destination of the plasma membrane. (bl.uk)
  • Interestingly, despite reducing the affinity of SNAP-25 for syntaxin 1a using mutagenesis, these proteins still co-cluster and interact on the plasma membrane. (bl.uk)
  • form
  • I show that munc 18-1 plays a vital role in binding to a closed-form of syntaxin 1a, keeping syntaxin 1a inactive and permitting its trafficking to the plasma membrane. (bl.uk)
  • Upon delivery to the plasma membrane that t-SNAREs have been shown to form cholesterol dependent clusters in several cell types of between 60-7509 nm. (bl.uk)