Intestinal role epithelium. Medical search. Frequent questions

Gastroesophageal reflux disease (GERD) probably plays a major role in the development of BE by inducing repeated mucosal damage. (jcancer.org)

Enemas with curcumin preserve the content of neutral and acidic mucins in the colonic epithelium without fecal stream. (scielo.br)
Accordingly, immunohistochemistry with specific antibodies shows that HMGCS2 is expressed mainly in differentiated cells of human colonic epithelium. (aacrjournals.org)
Colon cancer, which arises from the colonic epithelium, exhibits decreased hydroxymethylation and altered gene expression. (intechopen.com)
PCDH20 mRNA and protein expression is significantly downregulated in the colonic epithelium of Crohn's disease patients and mice with induced colitis compared with controls. (biomedcentral.com)
Before symptoms appear, Shigella first crosses the colonic epithelium via M cells where it is engulfed by macrophages that then undergo pyroptosis. (ku.edu)

The study thus introduces a novel immune response and a regulatory mechanism governing the entire system, demonstrating that MHCII in the epithelium, T cells producing granzymes, and the presence of SFB bacteria determine the rate of renewal of the intestinal epithelium. (cas.cz)
These observations suggest that GCC signaling may regulate the renewal of the intestinal epithelium by restricting the proliferating compartment and promoting the transition from proliferation to differentiation along the crypt to villus axis. (jefferson.edu)

It is widely accepted that chronic GERD leads to inflammation and ulceration of the esophageal squamous mucosa and that persistent and recurrent inflammation and ulceration may lead to columnar metaplasia and, ultimately, intestinal metaplasia. (jcancer.org)
The intestinal epithelium is part of the intestinal mucosa. (wikipedia.org)
The epithelium is composed of a single layer of cells, while the other two layers of the mucosa, the lamina propria and the muscularis mucosae, support and articulate the epithelial layer. (wikipedia.org)
Verificar se a aplicação de clisteres com extrato oleoso de curcumina preserva o conteúdo de mucinas nas glândulas da mucosa cólica sem trânsito intestinal. (scielo.br)
Trinta e seis ratos Wistar foram submetidos à derivação intestinal por colostomia proximal e fístula mucosa distal. (scielo.br)
Here we present an in vitro model that mimics the small intestinal mucosa and its interactions with intestinal pathogens in a relevant manner, containing the secreted mucus layer and the epithelial barrier in a 3D villus-like hydrogel scaffold. (ibecbarcelona.eu)
Thus, we demonstrated that our model faithfully mimics the key features of the intestinal mucosa necessary to study the interactions with intestinal pathogens. (ibecbarcelona.eu)
After release into the sub-mucosa, Shigella invades intestinal epithelial cells using its type III secretion system (T3SS). (ku.edu)
Gastric mucosa cells change to resemble intestinal mucosa-with goblet cells, endocrine (enterochromaffin or enterochromaffin-like) cells, and rudimentary villi-and may even assume functional (absorptive) characteristics. (msdmanuals.com)

In this study, the protective effect of a fermented wheat germ extract (FWGE) against LPS-induced inflammation and oxidative stress in IPEC-J2 porcine intestinal epithelial cells was studied. (hindawi.com)
Gut health and intestinal barrier integrity could be improved and maintained with proper selection of feed additives which prevent pathogen invasion and inflammation, furthermore stimulating growth of useful microorganisms. (hindawi.com)
Previously, we found that Lactobacillus rhamnosus CNCM I-3690 can protect intestinal barrier functions in mice inflammation model. (nature.com)
Intestinal lymphocytes (IL) are immune cells that can participate in inflammation through the generation of cytokines and by causing direct cellular injury. (uwaterloo.ca)
The role, however, of bLf in reducing inflammation by initiation of apoptosis or alteration of cytokine levels in IL has not been examined. (uwaterloo.ca)
Further, the exercise protocol resulted in oxidative stress, as measured by 8-iso prostaglandin F2α levels in plasma, but did not induce intestinal inflammation, evident by the absence of both tissue damage and infiltration of immune cells. (uwaterloo.ca)
Basic science: The research group is located in the Department of Physiology in the laboratory of Associate Professor Grant Butt and works on the role of epithelium in intestinal inflammation with the use of human organoids, animal models and cell cultures. (otago.ac.nz)
McCole explained that increased intestinal permeability - or leakiness - is a feature of ulcerative colitis and plays a critical role in promoting inflammation. (scienceblog.com)
His team tested tofacitinib in human intestinal epithelial cell lines, as well as in organoids, or colonoids, that were derived from primary human colonic stem cells isolated from human subjects - primarily patients undergoing elective colonoscopy for colon cancer screening - and found tofacitinib repaired inflammation-induced permeability defects in both. (scienceblog.com)
Finally, we demonstrate that pTregs and CD4IELs perform complementary roles in the regulation of intestinal inflammation. (uzh.ch)
The pattern of swelling, inflammation, ulcers, and fissures is similar to that of the lesions occurring in the intestinal tract. (medscape.com)

Moreover, siRNA-mediated knockdown of KLF5 blocked the expression of CDX2, MUC2 and villin, but transfection of a KLF5 expression vector into esophageal epithelial cells promoted their transdifferentiation into columnar-like cells, as demonstrated by increased expression of the intestinal markers CDX2, MUC2 and villin. (jcancer.org)
To securely contain the contents of the intestinal lumen, the cells of the epithelial layer are joined together by tight junctions, thus forming a contiguous and relatively impermeable membrane. (wikipedia.org)
Renewal relies on proliferative cells (stem cells) that reside at the crypt (base) of the intestinal glands (epithelial invaginations into the underlying connective tissue). (wikipedia.org)
Goblet cells secrete the mucus layer which protects the epithelium from the lumenal contents. (wikipedia.org)
Subsets of sensory intestinal epithelial cells synapse with nerves, and are known as neuropod cells. (wikipedia.org)
Important for the barrier function of intestinal epithelium, its cells are joined securely together by four types of junctions (cell junctions), which can be identified at the ultrastructural level: Gap junctions Desmosomes Adherens junctions Tight junctions Gap junctions bring the adjacent cells within 2 nanometers of each other. (wikipedia.org)
We previously reported that CD23/FcεRII (low-affinity IgE receptor) is expressed on human intestinal epithelial cells and is responsible for transepithelial transport of IgE. (mcmaster.ca)
Our results indicate that CD23 expression in these human intestinal epithelial cells is mediated through the p38 MAPK pathway and that inhibition of p38 MAPK consequently interferes with the transport of IgE and immune complexes across the intestinal epithelial barrier. (mcmaster.ca)
While dendritic cells are well known examples responsible for this function, earlier studies have detected the presence of MHCII molecules on the intestinal epithelial cells. (cas.cz)
Stem Cells are the Principal Intestinal Epithelial Responders to Bacterial Antigens. (mpg.de)
Consistent with the different origins of dorsal and ventral dermal cells, our results demonstrate both conserved and divergent roles ofβ-catenin/Wnt signaling in dermal development. (biologists.com)
Our findings show that all three cannabinoids induce autophagy in a dose-dependent manner in fully differentiated CaCo2 cells, a model of mature intestinal epithelium. (lancs.ac.uk)
Representative models of differentiated human intes- transmission are ingestion of contaminated food and water tinal epithelium can be established by growing cells in 3 and person-to-person contact ( 5 ). (cdc.gov)
TET1 plays a critical role in intestinal epithelial differentiation and development, and this is also correlated with increased hydroxymethylation in terminally differentiated epithelial cells. (intechopen.com)
In vitro characterization revealed that the strains tolerate gastric and bile challenges and display a great adhesion capacity to human intestinal cells. (frontiersin.org)
The apical junctional complex comprises tight junctions, adhesion junctions, and desmosomes, which seal adjacent cells, regulate paracellular transportation, and maintain intestinal barrier function, acting as a dynamic mechanical barrier [ 5 ]. (biomedcentral.com)
After successful intestinal colonization, this organism enters enterocytes, M cells and dendritic cells in the intestinal epithelium, subsequently reaching the submucosa and disseminating through the bloodstream. (news-medical.net)
In close agreement, induction of GCC signaling in mucosal sheets ex vivo and intestinal cells in vitro inhibited proliferation by activating cGMP-dependent protein kinase and delaying the cell cycle at the G1/S transition. (jefferson.edu)
T cell immunity is at the center of the disease contributing to the inflammatory process through the loss of tolerance to gluten and the differentiation of HLA-DQ2 or HLA-DQ8-restricted anti-gluten inflammatory CD4 + T cells secreting pro-inflammatory cytokines and to the killing of intestinal epithelial cells by cytotoxic intraepithelial CD8 + lymphocytes. (frontiersin.org)
formed by tissue-specific, post-translational processing of proglucagon by intestinal L-cells. (drugfuture.com)
Th17 cells are pro-inflammatory cells that play an important role in fighting invading pathogens. (asm.org)
The protective role of GB004 on barrier integrity was further supported by immunostaining experiments demonstrating that GB004 treatment protected epithelial cells from TNFa-induced cell apoptosis, improving both epithelial cell number and tight junction protein ZO-1 staining. (ecco-ibd.eu)
The intestinal barrier is made up of a layer of epithelial cells, preventing harmful pathogens and toxins from entering the system (i.e., leaky gut), and is critical for fluid and electrolyte secretion. (kemin.com)
Maturation and positioning of goblet cells and Paneth cells, the main cell lineage of the intestinal innate immune system, was severely disturbed. (uni-muenchen.de)
These results highlight the central function of E-cadherin in the maintenance of two components of the intestinal epithelial defense: E-cadherin is required for the proper function of the intestinal epithelial lining by providing mechanical integrity and is a prerequisite for the proper maturation of Paneth and goblet cells. (uni-muenchen.de)
The gastrointestinal epithelium is comprised of cells that have gaps between them, making them selectively permeable and providing a barrier that keeps out pathogens, toxins, and antigens from entering the gut, while allowing the absorption of nutrients. (scienceblog.com)
Within the intestine, pTregs are located primarily in the lamina propria, whereas intraepithelial CD4+ T cells (CD4IELs), which also exhibit anti-inflammatory properties and depend on similar environmental cues, reside in the epithelium. (uzh.ch)
The CCBE1 protein is involved in the maturation (differentiation) and movement (migration) of immature cells called lymphangioblasts that will eventually form the lining (epithelium) of lymphatic vessels. (medlineplus.gov)
Cells which lack ER expression at diagnosis arise from an ER compart- were harvested at 60 - 80% confluency and used as a reference in all hybrid- ment within the mammary epithelium or represent evolution from an izations. (lu.se)
Epigenetic Alteration of the Cancer-Related Gene TGFBI in B Cells Infected with Epstein-Barr Virus and Exposed to Aflatoxin B1: Potential Role in Burkitt Lymphoma Development. (who.int)

In this study, we describe a critical role for PCDH20 in maintaining intestinal homeostasis. (biomedcentral.com)

Understanding of the pathogenesis of human cate in a physiologically relevant 3-dimensional (3-D), organoid model of human small intestinal epithelium. (cdc.gov)
In vitro differentiation of small intestinal epithelium that nausea, vomiting, and watery diarrhea within 12-24 hours approaches physiologic functionality of the in vivo host of exposure and typically remain symptomatic for 1-2 may allow for the development of a pathogenesis model days ( 5 ). (cdc.gov)
We present cultured in the RWV bioreactors, with the rotation speed the results of our first attempts to infect a physiologically adjusted to maintain the cell aggregates in suspension dur- relevant 3-D small intestinal epithelium model (INT-407) ing the entire culture duration (18-20 rotations/min ini- with genogroup I and II human noroviruses. (cdc.gov)

Destruction of the intestinal epithelium is important because this is the site of nutrient absorption, part of our immune system and it has other biological functions that play a role in human health. (sciencedaily.com)
Researchers from the Jan Dobeš laboratory have made a significant discovery uncovering a novel immune response in the intestinal epithelium Furthermore, their study delineates a mechanism that controls this immune response. (cas.cz)
The human gut hosts a diverse array of bacteria that play vital roles in digestion, vitamin production, and even the training of our immune system. (cas.cz)
Epigenetic regulation of immune tolerance in intestinal epithelium. (mpg.de)
however, it also plays an active role in the maintenance of absorption, regulation of barrier function, and immune homeostasis [ 1 ]. (hindawi.com)
Coeliac disease (CeD) is a multifactorial intestinal immune-mediated disorder with autoimmune features that leads to inflammatory and destructive lesions in the proximal small intestine. (frontiersin.org)

The mucus layer that covers the colic epithelium represents the first line of defense against the aggression caused by antigens, virus, and bacteria in the intestinal lumen. (scielo.br)
Several bacteria, including pathogens and commensals, have been found to directly or indirectly modulate intestinal barrier function. (nature.com)
When the intestinal barrier is healthy, it allows selective paracellular transport of nutrients, regulating solute and water fluxes while preventing the entry of bacteria and toxins. (nature.com)
Different bacteria, including pathogens and commensals, can directly or indirectly modulate intestinal barrier function. (nature.com)
The expression of anti-bacterial cryptidins was reduced and mice showed a deficiency in clearing enteropathogenic bacteria from the intestinal lumen. (uni-muenchen.de)
Treatment of MHE targets the gut due to the role of intestinal ammonia-producing bacteria that has been indicated to be involved in MHE pathogenesis [ 3 ]. (termedia.pl)

However, when modelling in vitro the intestinal host-pathogen interactions, these two essential features, the intestinal mucus and the 3D topography are often not represented, thus limiting the relevance of the models. (ibecbarcelona.eu)

This family, which includes epidermal growth factor receptor (EGFR), plays a pivotal role in normal cell growth, lineage determination, repair, and functional differentiation. (medscape.com)
In mice, intestinal-specific Pcdh20 knockout causes defects in enterocyte proliferation and differentiation, while causing morphological abnormalities. (biomedcentral.com)
Intestinal-specific deletion of Pcdh20 damages epithelial cell proliferation and differentiation and causes morphological changes, including shortened crypts and microvilli. (biomedcentral.com)

Intestinal integrity is all about maintaining the strength of the intestinal barrier in order to maximize nutrient absorption within the bird. (kemin.com)

The effect of FWGE on the intestinal barrier integrity was determined by transepithelial electric resistance measurements and using a FD4 fluorescent tracer dye. (hindawi.com)
2 2 Gaudier E, Hoebler C. Physiological role of mucins in the colonic barrier integrity. (scielo.br)
By administering a selective ATF6 activator, the impairment of intestinal barrier integrity and dysregulation of CHOP/β-catenin/p-p120-catenin pathway was reversed in Pcdh20 -ablated mice with colitis and PCDH20 -deficient colonic cell lines. (biomedcentral.com)
PCDH20 is an essential factor in maintaining intestinal epithelial homeostasis and barrier integrity. (biomedcentral.com)
Destruction of intestinal barrier integrity is one of the first phases of CD pathogenesis [ 2 ], while its repair is the final, yet most important, phase of mucosal healing in CD treatment [ 3 ]. (biomedcentral.com)
This novel role in restricting the proliferating compartment and organizing the crypt-villus axis suggests that dysregulation of GCC, reflecting loss of endogenous ligands, might contribute to tumorigenesis by potentiating hyperproliferation which, in turn, may amplify disruption of genomic integrity. (jefferson.edu)
This previously unrecognized role of GCC as a tumor suppressor by restricting proliferation and maintaining genomic integrity suggests that receptor dysregulation reflecting ligand insufficiency is a key event during early colorectal tumorigenesis. (jefferson.edu)
For example, one research team found that omega-3s were support the removal of toxic substances from the intestinal wall by helping to flush them into the lymphatic channels that drain the intestinal tract-a process that may maintain intestinal health and integrity. (lifespa.com)
Lack of intestinal integrity is directly linked to frustrating health concerns like food intolerances and digestive imbalances. (lifespa.com)
In the human Repligut intestinal epithelium assay, GB004 significantly reduced cell death and improved barrier integrity in response to pro-inflammatory cytokines. (ecco-ibd.eu)

Villi and intestinal glands serve to increase the mucosal surface area tenfold. (wikipedia.org)
Underneath this mucus layer, the intestinal epithelium is organized into finger-like protrusions called villi and invaginations called crypts. (ibecbarcelona.eu)

Eventually, they undergo apoptosis and are shed off into the intestinal lumen. (wikipedia.org)

The intestinal epithelium is the single cell layer that form the luminal surface (lining) of both the small and large intestine (colon) of the gastrointestinal tract. (wikipedia.org)
The intestinal mucus lines the luminal surface of the intestinal epithelium. (ibecbarcelona.eu)

Intestinal villus) Microvilli covering the apical surface of the enterocytes increase the absorptive surface twentyfold. (wikipedia.org)
and 4) photomicrograph of intestinal villus (photograph courtesy of Alberti Lamberti, Ph.D., Temple University). (cdc.gov)
Here, the role of GCC in regulating normal enterocyte dynamics along the crypt-villus axis and the corruption of those mechanisms in tumorigenesis were explored. (jefferson.edu)

At the same time, the intestinal mucus accommodates the resident microbiota, providing nutrients and attachment sites, and therefore playing an essential role in the host-pathogen interactions and gut homeostasis. (ibecbarcelona.eu)
Recognized as gut-brain axis disorders by Rome IV criteria, FGIDs etiology is linked to altered gut-brain interaction, intestinal physiology, and microbiota. (frontiersin.org)
More than a century has passed since Tissier observed that gut microbiota from healthy breast fed infants were dominated by rods with a bifid shape (bifidobacteria) which were absent from formula fed infants suffering from diarrhoea, establishing the concept that they played a role in maintaining health. (hindawi.com)
Upon migration to the epithelium,Tregs lose Foxp3 and convert to CD4IELs in a microbiota-dependent manner, an effect attributed to the loss of the transcription factor ThPOK. (uzh.ch)

In 2004, Dmitry published a series of articles regarding the Wip1 phosphatase inhibition of tumorigenesis through p38 MAP kinase , and after establishing his lab in 2004 at IMCB in Singapore, he continued interrogating the role of Wip1 phosphatase in cancer but also in aging . (lifeboat.com)
He carried out his postdoctoral training at the National Cancer Institute, NIH in the USA, where he established a role of p38MAPK in negative regulation of tumorigenesis and the key role of phosphatase Wip1 as a potent human oncogene - both directions are now widely pursued in the cancer field. (lifeboat.com)
The significance of loss of GCC ligands early in intestinal tumorigenesis remains obscure because (patho)physiological roles of GCC signaling in intestine, beyond regulation of intestinal fluid and electrolyte homeostasis, are poorly defined. (jefferson.edu)
Guanylyl cyclase C (GCC), the intestinal receptor for the paracrine hormones guanylin and uroguanylin whose early loss characterizes transformation, has emerged as a component of developmental programs organizing spatiotemporal patterning along the crypt-surface axis whose loss promotes tumorigenesis through hyperproliferation and genetic instability. (jefferson.edu)

Impaired expression of E-cadherin in the small intestine and colon has been linked to a disturbed intestinal homeostasis and barrier function. (uni-muenchen.de)

The pronounced, but temporally different patterns of mRNA induction after ulceration suggest that the trefoil peptides may fulfil different and more immediate roles than the more 'traditional' healing proteins EGF and TGF alpha. (nih.gov)
SALSA proteins in the AF and intestinal samples were polymorphic and exhibited varying polypeptide compositions. (researchgate.net)
There are also reports that bLf can alter apoptotic proteins in the intestinal epithelium to favour cell death. (uwaterloo.ca)

Certain diseases and conditions are caused by functional defects in the intestinal epithelium. (wikipedia.org)
A research team led by biomedical scientists at the University of California, Riverside, has found that a drug approved by the FDA to treat rheumatoid arthritis and ulcerative colitis can repair permeability defects in the gut's epithelium. (scienceblog.com)
Specifically, it fixes intestinal epithelial permeability defects caused by 'interferon-gamma,' an inflammatory cytokine involved in autoimmune diseases such as ulcerative colitis and rheumatoid arthritis. (scienceblog.com)

Therefore, we investigated the role of Krüppel-like factor 5 (KLF5) signaling in the initiation of BE-associated metaplasia. (jcancer.org)
Intestinal metaplasia typically begins in the antrum in response to chronic mucosal injury and may extend to the body. (msdmanuals.com)
Intestinal metaplasia is classified histologically as complete (most common) or incomplete. (msdmanuals.com)
In incomplete metaplasia, the epithelium assumes a histologic appearance closer to that of the large intestine and frequently exhibits dysplasia. (msdmanuals.com)

Barrett's esophagus (BE) is an acquired condition in which normal squamous epithelium is replaced with metaplastic columnar epithelium as a consequence of gastroesophageal reflux disease. (jcancer.org)
Barrett's esophagus (BE), also defined as columnar-lined esophagus, is a metaplastic condition in which the normal non-keratinizing squamous epithelium of the esophagus is replaced by a columnar mucosal epithelium [ 1 , 2 ]. (jcancer.org)
pendent of those associated with cretory ducts, columnar epithelia the KRAS gene is more frequent- other key mechanistic characteris- lining the gastrointestinal tract and ly mutated in human cancer, which tics of IARC Group 1 carcinogens. (who.int)

The peptic ulcer (gastric and duodenal) using strongest evidence for the pathogenic role endoscopic examination at the endoscopic of H. pylori in peptic ulcer disease comes unit, Basra General Hospital, Iraq, by a spe- from treatment trials. (who.int)

Mitochondria plays a major role in cell signaling, growth and energy production, and for good health they need to function properly. (sciencedaily.com)
Using this novel high-throughput whole-genome assay, we could identity and quantify the activity of DNA regulatory elements (e.g. enhancers) that play critical roles in cell type specification and disease pathogenesis. (mpg.de)
FcRn expressed in endosomal compartment of intestinal epithelium, vascular endothelium and macrophages regulates the serum IgG levels by binding to the pinocytosed antibodies and recirculating them to cell surface without intracellular degradation. (academie-medecine.fr)
A key role for E-cadherin in intestinal homeostasis and Paneth cell maturation. (uni-muenchen.de)
Until now, the effects of tofacitinib on intestinal epithelial cell functions were largely unknown. (scienceblog.com)
Using intravital microscopy, we show distinct cell dynamics of intestinal Tregs and CD4IELs. (uzh.ch)

Whether patients with orofacial granulomatoses will subsequently develop intestinal manifestations of Crohn disease is uncertain, but histologic similarities between the oral lesions and the intestinal lesions are obvious. (medscape.com)

Specifically, the loss of PCDH20 impairs intestinal barrier function by unzipping adherens junctions in mice with colitis via targeting the ATF6/CHOP/β-catenin/p120-catenin axis. (biomedcentral.com)

Les IgIV intéragissent avec de nombreux composants du système immunitaire comme les récepteurs Fc, le complément, les cytokines, les lymphocytes T et B, les cellules dendritiques, les granulocytes et les cellules NK, ce qui explique en partie leurs effets anti-inflammatoires. (academie-medecine.fr)

In contrast, the intestinal SALSA was more enriched with the scavenger receptor cysteine-rich domains. (researchgate.net)
The most commonly lost gene products in colorectal carcinogenesis include guanylin and uroguanylin, the endogenous ligands for guanylyl cyclase C (GCC, GUCY2C), the intestinal receptor for diarrheagenic bacterial enterotoxins. (jefferson.edu)
In this study we examined the role of APN as a receptor. (uu.nl)

Intestinal barrier dysfunction plays a central role in the pathological onset of Crohn's disease. (biomedcentral.com)

The abnormal protein cannot play its role in the formation of the lymphatic vessel epithelium. (medlineplus.gov)

The intestinal barrier separates the self from the non-self and serves as the first line of defence against external threats such as toxins and pathogens. (nature.com)
Enteric infections, particularly those leading to diarrhea, can profoundly disrupt intestinal function and have a major impact on global mortality and morbidity rates.1 Globally, there are 1.7 billion cases of childhood diarrheal disease every year, which results in the death of approximately 525,000 children under the age of 5.2 Four pathogens were identified to be the key contributors to childhood diarrheal cases. (ku.edu)

Stomach Cancer Etiology of stomach cancer is multifactorial, but Helicobacter pylori plays a significant role. (msdmanuals.com)

Physiological roles of abundant extracellular chaperones. (mpg.de)

As part of its protective role, the intestinal epithelium forms an important component of the intestinal mucosal barrier. (wikipedia.org)

The virus infects the intestinal epithelium and causes villous atrophy, resulting in diarrhea and dehydration. (uu.nl)

The gut barrier plays an important role in human health. (nature.com)
The reported beneficial effects of probiotic consumption include improvement of intestinal health, amelioration of symptoms of lactose intolerance, and reduction of the risk of various other diseases, and several well-characterized strains of Lactobacilli and Bifidobacteria are available for human use [ 3 , 4 ]. (hindawi.com)
Nevertheless, despite the promising evidence, the role of probiotics in human health as well as the safety of their application should be further investigated as the current knowledge of the characteristics that are necessary for their functionality in the gut is not complete. (hindawi.com)
Together with the uniform over-expression of GCC in human tumors, and the standard of care in which hormone deficiencies are treated by replacement therapy, the role of GCC as a tumor suppressor underscores the potential of oral administration of GCC ligands for targeted prevention and therapy of colorectal cancer. (jefferson.edu)

We study the role of the lysosome in metabolic adaptation using subcellular omics approaches, functional genomics and innovative biochemical tools. (stanford.edu)

The trefoil peptides, rat spasmolytic polypeptide (rSP) and rat intestinal trefoil factor (rITF), along with epidermal growth factor (EGF) and transforming growth factor alpha (TGF alpha) were the molecules studied. (nih.gov)

Taken together, our data suggest that CNCM I-3690 restores impaired intestinal barrier functions via anti-inflammatory and cytoprotective responses. (nature.com)

In particular, a different abundance of peptides corresponding to functionally important structures was found in the AF and intestinal SALSA. (researchgate.net)

To genetically clarify the function of E-cadherin in intestinal homeostasis and maintenance of the epithelial defense line, the Cdh1 gene was conditionally inactivated in the mouse intestinal epithelium. (uni-muenchen.de)

Emerging data associates impaired autophagy, increased activity in the endocannabinoid system and upregulation of suppressor of cytokine signaling (SOCS)-3 protein expression during intestinal inflammatory states. (lancs.ac.uk)

Anatomy105

Organisms19

Diseases17

Chemicals and Drugs43

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes39

Disciplines and Occupations2

Information Science3

Inducing repeate1

Colonic Epithelium5

Renewal of the intestinal epithelium2

Mucosa9

Inflammation11

Cells30

Maintaining intestinal homeostasis1

Small intestinal3

Immune6

Bacteria6

Vitro1

Differentiation3

Absorption1

Integrity10

Villi2

Lumen1

Luminal surface2

Villus3

Microbiota4

Tumorigenesis4

Homeostasis and barrier1

Proteins3

Defects3

Metaplasia4

Columnar3

Gastric1

Cell6

Subsequently1

Colitis1

Lymphocytes1

Receptor3

Crohn's1

Lymphatic1

Pathogens2

Multifactorial1

Physiological1

Protective role1

Diarrhea1

Human4

Functional1

Polypeptide1

Anti-inflammatory1

Peptides1

Defense1

Protein expression1