• These changes in turn can lead to the development of left ventricular hypertrophy (LVH), coronary artery disease (CAD), various conduction system diseases, and systolic and diastolic dysfunction of the myocardium, complications that manifest clinically as angina or myocardial infarction, cardiac arrhythmias (especially atrial fibrillation), and congestive heart failure (CHF). (medscape.com)
  • Thus, hypertensive heart disease is a term applied generally to heart diseases, such as LVH (seen in the images below), coronary artery disease, cardiac arrhythmias, and CHF, that are caused by the direct or indirect effects of elevated BP. (medscape.com)
  • After the occlusion of the coronary artery, ventricular fibrillation and ventricular tachycardia can follow. (mesimedical.com)
  • The initial remodeling phase after a myocardial infarction results in repair of the necrotic area and myocardial scarring that may, to some extent, be considered beneficial since there is an improvement in or maintenance of LV function and cardiac output. (wikipedia.org)
  • After a myocardial infarction (MI), cardiac myocyte death can be triggered by necrosis, apoptosis, or autophagy, leading to thinning of the cardiac wall. (wikipedia.org)
  • Lindsey ML, Hall ME, Harmancey R, Ma Y. Adapting extracellular matrix proteomics for clinical studies on cardiac remodeling post-myocardial infarction. (pitt.edu)
  • Two-dimensional echocardiogram (parasternal long axis view) from a 70-year-old woman showing concentric left ventricular hypertrophy and left atrial enlargement. (medscape.com)
  • Kato S, Spinale FG, Tanaka R, Johnson W, Cooper Gt, Zile MR. Inhibition of collagen cross-linking: effects on fibrillar collagen and ventricular diastolic function. (pitt.edu)
  • The surviving cardiac myocytes either arrange in parallel or in series to each other, contributing to ventricular dilatation or ventricular hypertrophy, depending on the loading stress on the ventricular wall. (wikipedia.org)
  • Several etiologies with distinct mechanisms ultimately bring about signs of heart exhaustion such as reduced ejection fraction, reduced compliance and ventricular dilatation. (pitt.edu)
  • Besides, the cardiac interstitium which consisted of largely Type I and Type III collagen fibres are also involved in cardiac remodeling. (wikipedia.org)
  • Cardiac collagen is synthesized by fibroblasts and degraded by metalloproteinases. (wikipedia.org)
  • Collagen remodeling and cardiac dysfunction in patients with hypertrophic cardiomyopathy: the significance of type III and VI collagens. (pitt.edu)
  • Empagliflozin reduces body weight, improves glucose and lipid metabolism, alleviates obesity-induced cardiac ventricular wall thickening, and lowers cardiac tissue collagen. (biomedcentral.com)
  • After the insult occurs, a series of histopathological and structural changes occur in the left ventricular myocardium that lead to progressive decline in left ventricular performance. (wikipedia.org)
  • A short-axis cut through the ventricular myocardium shows subendocardial necrosis on the left ventricular aspect of the interventricular septum and in the anterior left ventricular wall (including the anterior papillary muscle of the mitral valve). (thoracickey.com)
  • The most common life-threatening arrhythmia is ventricular fibrillation, which is an erratic, disorganized firing of impulses from the ventricles (the heart's lower chambers). (onteenstoday.com)
  • Ultimately, ventricular remodeling may result in diminished contractile (systolic) function and reduced stroke volume. (wikipedia.org)
  • Recent studies in dogs, calves, and horses have shown that left and right ventricular systolic dysfunction, left ventricular diastolic dysfunction, and circulatory dysfunction can occur in sepsis, severe sepsis, and septic shock in animals. (bvsalud.org)
  • More specifically, AL amyloidosis can be classified as stage I, II or III based on cardiac biomarkers like Nt-proBNP and cardiac troponin. (onteenstoday.com)
  • Measurement of levels of the enzymes cardiac troponin T and I and creatine kinase MB isoenzyme shows good sensitivity and specificity for myocardial damage. (thoracickey.com)
  • NSTEMI does not show ST elevation , but there is an elevation of cardiac biomarkers (troponins) just like with STEMI. (mesimedical.com)
  • The term "reverse remodeling" in cardiology implies an improvement in ventricular mechanics and function following a remote injury or pathological process. (wikipedia.org)
  • Cardiac fibrosis is a process of pathological extracellular matrix (ECM) remodeling, leading to abnormalities in matrix composition and quality, as well as an impaired heart muscle function [4]. (onteenstoday.com)
  • Post MI, as fatty acid oxidation decreases, it leads to reduced energy supply for the cardiac myocytes, accumulation of fatty acids to toxic levels, and dysfunction of mitochondria. (wikipedia.org)
  • The term "sepsis-induced cardiomyopathy" (SIC) is used to describe transient cardiac dysfunction in septic patients. (bvsalud.org)
  • Echocardiographic variables have also shown that indices of left and right ventricular dysfunction and circulatory failure are valuable indicators of mortality in septic animals. (bvsalud.org)
  • The pathophysiologies of the various cardiac effects of hypertension differ and are described in this section. (medscape.com)
  • Elevated BP leads to adverse changes in cardiac structure and function in two ways: directly, by increased afterload, and indirectly, by associated neurohormonal and vascular changes. (medscape.com)
  • Methods Circulating (n = 179) and hepatic expression (n = 95) of ghrelin and LEAP-2 were measured in patients with severe obesity and available liver pathology analysis undergoing Roux-en-Y gastric bypass (RYGB). (unav.edu)
  • We examined the effect of obesity on serological markers and heart function in obese mice treated with or without empagliflozin and used proteomic techniques to investigate alterations in cardiac protein expression. (biomedcentral.com)
  • To investigate the mechanism of cardiac injury induced by obesity and the cardioprotective effect of empagliflozin, we employed proteomic techniques to examine cardiac protein expression in obese mice and the changes in protein expression after empagliflozin intervention. (biomedcentral.com)
  • Ventricular mass and volume increase, which together adversely affect cardiac function. (wikipedia.org)
  • We will examine a range of cardiac conditions, looking into their causes and symptoms and providing illustrations of how they can manifest on the ECG. (mesimedical.com)
  • Using proteomic techniques the impact of the sodium-glucose transport protein 2 inhibitor empagliflozin on cardiac protein expression in a mouse model was assessed under normal and high-fat diet (HFD) conditions. (biomedcentral.com)
  • Cardiac fibroblast: the renaissance cell. (pitt.edu)
  • In the absence of an effective regenerative approach, fibrosis may only be reversible if it is confined to the interstitium, and it is not associated with high levels of crosslinked ECM. (onteenstoday.com)
  • In C57BL/6 mice, HFD increased body weight, blood lipid, and glucose levels and was associated with structural damage to the heart. (biomedcentral.com)
  • Recent studies in several rodent models of cardiac fibrosis have documented reversal of fibrosis by treatment with relaxin peptide or virally mediated relaxin gene delivery. (onteenstoday.com)
  • My research focus in recent years has been to support the athlete cardiac pre-participation screening programme at LJMU, undertaking basic research and developing applied service research that has support two REF Impact Case Studies. (ljmu.ac.uk)
  • Besides, reduced expression of V1 myosin and L-type calcium channels on cardiac myocytes are also thought to cause cardiac remodeling. (wikipedia.org)
  • Myocardial fibrosis is a common postmortem finding among young individuals with sudden cardiac death. (onteenstoday.com)