• differentiate
  • We suggest that the specific spike timing of cholecystokinin interneurons and their sensitivity to endocannabinoids might contribute to differentiate subgroups of pyramidal cells forming neuronal assemblies, whereas parvalbumin interneurons contribute to synchronizing the entire network. (ox.ac.uk)
  • Interneurons differentiate from an electrophysiological, and a morphological point of view, as well as by the expression of molecular markers, and it remains debated if the combination of these features delineates separate classes, or if it defines a phenotypical continuum. (archives-ouvertes.fr)
  • characteristic
  • During theta oscillations, cholecystokinin-expressing interneurons fire with 8.8 +/- 3.3 Hz at a characteristic time on the ascending phase of theta waves (155 +/- 81 degrees), when place cells start firing in freely moving animals. (ox.ac.uk)
  • Mice
  • In the future, I will be determining the intrinsic firing characteristics of cortical interneurons in PGC-1alpha deficient mice as well as exploring environmental stimuli that cause PGC-1alpha expression to plummet and measuring long-term consequences of parvalbumin deficiency. (uab.edu)
  • found
  • During my first two years, I found that the transcriptional coactivator PGC-1alpha is required for the expression of the interneuron-specific calcium binding protein parvalbumin in the forebrain. (uab.edu)
  • Using unsupervised methods relying on electrophysiological and molecular properties, we showed that the classes of interneurons which were characterized in layer VI could be found again in our complete sample. (archives-ouvertes.fr)
  • second
  • A second family of interneurons, expressing cholecystokinin but not parvalbumin, is known to target the same domains of pyramidal cells as do the parvalbumin cells. (ox.ac.uk)