Other neurokinin subtypes and neurokinin receptors that interact with SP have been reported as well. (wikipedia.org)
It binds to tachykinin receptors [neurokinin-1 receptor (NK1R), NK2R, NK3R] that belong, like most neuropeptide receptors, to the family of seven-transmembrane, G protein-coupled receptors. (niepokorny.org)
Noteworthy, ligand-induced internalization of NK1 receptors into neurons in the dorsal horn can be triggered also by non-noxious somatosensory stimulation (Honor et al. (niepokorny.org)
Protease-activated receptors (PARs) and the neurokinin 1 receptor (NK1R) belong to the G protein-coupled receptor (GPCR) family. (scientificarchives.com)
Alterations of neurokinin receptors and interstitial cells of Cajal during and after jejunal inflammation induced by Nippostrongylus brasiliensis in the rat. (unifi.it)
In the late response phase (hours), the receptors are decreased too due to internalisation. (trc-p.nl)
NK1R5
The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). (wikipedia.org)
The authors concluded that intrathecal 15-µg SP-SAP reduced dorsal, but not ventral, neurokinin 1 receptor-positive (NK1r, the receptor for substance P) neurons at the spinal level of delivery with minimal side effects, whereas 150-µg SP-SAP resulted in motor neuron toxicity. (atsbio.com)
Throughout saline- and also CFA-treated rodents, neurokinin-1 receptor (NK1R) immunoreactivity has been localized to nerves in the RVM. (cdk-receptor.com)
To guage modifications in Subscription R discharge, the amount of RVM neurons in which shown NK1R internalization had been analyzed in saline-and CFA-treated rodents right after harmful temperature arousal from the back paws. (cdk-receptor.com)
Only CFA-treated subjects in which skilled poisonous high temperature arousal shown a significant surge in the volume of nerves showing NK1R internalization. (cdk-receptor.com)
GPCRs2
The Ser/Thr phosphorylation by GPCR kinases (GRKs) leads to the internalization of GPCRs [10, 11] and hampers GPCR signaling [12]. (massorrerjazzbar.com)
In some GPCRs, a tyrosine made up of motif in the cytoplasmic tail has been linked to the internalization of GPCRs. (massorrerjazzbar.com)
Substance6
Substance P and the closely related neurokinin A (NKA) are produced from a polyprotein precursor after alternative splicing of the preprotachykinin A gene. (wikipedia.org)
In 1983, Neurokinin A (previously known as substance K or neuromedin L) was isolated from porcine spinal cord and was also found to stimulate intestinal contraction. (wikipedia.org)
The substance P neurokinin 1 receptor (NK 1 R) regulates motility, secretion, inflammation and pain in the intestine. (nyu.edu)
Treatment with substance P resulted in the concentration-dependent internalisation of NK 1 R from the cell surface into endosome-like structures. (nyu.edu)
Intrathecal substance P-saporin in the dog: distribution, safety, and spinal neurokinin-1 receptor ablation. (atsbio.com)
This explains the failure of substance P/neurokinin-1 receptor antagonists and the success of blocking CGRP mechanisms for relieving the pain of acute migraine. (medlink.com)
Neurons1
Its receptor - the neurokinin type 1 - is distributed over cytoplasmic membranes of many cell types (neurons, glia, endothelia of capillaries and lymphatics, fibroblasts, stem cells, white blood cells) in many tissues and organs. (wikipedia.org)
Molecules1
Specifically, we found that human vascular endothelial cells (HUVECs) utilize CIE for internalization of unique cargo molecules and that in three-dimensional cultures CIE membranes are delivered to the newly formed lumen. (president2010.info)
Suggests1
This possibly suggests an internalization of neurokinin-1 (NK1). (wikipedia.org)
Cargo1
To take action, we performed an internalization assay where monoclonal antibodies against the main histocompatibility complex Course I molecule (MHCI) and fluorescently tagged transferrin (Tfn) had been put into the press to label and adhere to clathrin-independent and clathrin-mediated cargo substances, [6] respectively. (president2010.info)
Mechanism2
Binding of SP to NK-1R results in internalization by the clathrin-dependent mechanism to the acidified endosomes where the complex disassociates. (wikipedia.org)
According to this model, the vascular lumen is initiated in a single cell by the internalization of pinocytic vesicles through an undefined mechanism, which fuses to form an enlarged apical vacuole [32 after that,39]. (president2010.info)
Single1
Yellow staining for saporin after internalization of SP-SAP by this single spinal cord neuron. (atsbio.com)
Human1
Effect of otilonium bromide and ibodutant on the internalization of the NK(2) receptor in human colon. (unifi.it)
Receptor16
The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R). (wikipedia.org)
Its receptor - the neurokinin type 1 - is distributed over cytoplasmic membranes of many cell types (neurons, glia, endothelia of capillaries and lymphatics, fibroblasts, stem cells, white blood cells) in many tissues and organs. (wikipedia.org)
1. Functional consequences of alteration of N-linked glycosylation sites on the neurokinin 1 receptor. (nih.gov)
5. Dynamin and Rab5a-dependent trafficking and signaling of the neurokinin 1 receptor. (nih.gov)
6. Point mutation increases a form of the NK1 receptor with high affinity for neurokinin A and B and septide. (nih.gov)
8. Differences in the length of the carboxyl terminus mediate functional properties of neurokinin-1 receptor. (nih.gov)
9. Effect of peptidases on the ability of exogenous and endogenous neurokinins to produce neurokinin 1 receptor internalization in the rat spinal cord. (nih.gov)
The role of beta-arrestins in endocytosis of the neurokinin-1 receptor. (nih.gov)
13. Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R). (nih.gov)
17. Hepatoblastoma cells express truncated neurokinin-1 receptor and can be growth inhibited by aprepitant in vitro and in vivo. (nih.gov)
18. Relationship between neurokinin-1 receptor and substance P in the striatum: light and electron microscopic immunohistochemical study in the rat. (nih.gov)
Many neurons with cell bodies in laminae III or IV of the spinal dorsal horn possess the neurokinin 1 receptor and have dorsal dendrites that arborize in the superficial dorsal horn. (jneurosci.org)
Electron microscopy revealed that synapses were present at points of contact between substance P-immunoreactive boutons and dorsal dendrites of cells with the neurokinin 1 receptor. (jneurosci.org)
Some cells of this type belong to the spinothalamic tract, and we therefore examined neurons with cell bodies in laminae III or IV that possessed the neurokinin 1 receptor and were labeled retrogradely after thalamic injection of cholera toxin B subunit. (jneurosci.org)
NK1 receptor desensitization, β-arrestin recruitment and internalization are regulated by phosphorylation of carboxyl-terminal threonine344/serine347 (pT344/pS347-NK1).This nomenclature refers to the human NK1 receptor. (7tmantibodies.com)
We further discovered that FFAR2-mediated IAV internalization requires downstream signaling substances such as for example G protein-coupled receptor kinases (GRKs), -arrestin1, as well as the AP-2 complicated. (ap26113.com)
Endosomes1
Binding of SP to NK-1R results in internalization by the clathrin-dependent mechanism to the acidified endosomes where the complex disassociates. (wikipedia.org)
Spinal cord1
In 1983, Neurokinin A (previously known as substance K or neuromedin L) was isolated from porcine spinal cord and was also found to stimulate intestinal contraction. (wikipedia.org)
Cells1
enzymatic activity, as well as in vitro cytotoxicity and internalization into target cells. (thinkbeforeyouclickca.org)