Alpha subunitCytokineSynthesisInhibitorsReceptorGeneCell growthProductionReduceCytokinesReceptor is composedIdiopathic Nephrotic SyndromeEosinophilsStimulatesProteinColony-stimulGene is locatedInteractionsEosinophiliaHematopoieticImmuneInflammatorySubunitHumanDrugsCellsMiceCellShownFormMajorActivitiesCommon
Alpha subunit1
- IL-5 has been shown to interact with interleukin 5 receptor alpha subunit. (wikipedia.org)
Cytokine3
- IL-5 is a 115-amino acid (in human, 133 in the mouse) -long Th2 cytokine that is part of the hematopoietic family. (wikipedia.org)
- Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a homodimer. (wikipedia.org)
- Interleukin-23 ( IL-23 ) is a heterodimeric cytokine composed of an IL12B ( IL-12p40 ) subunit (that is shared with IL12 ) and the IL23A ( IL-23p19 ) subunit. (wikidoc.org)
Synthesis1
- 5-Aminosalicylic acid derivatives inhibit prostaglandin synthesis and reduce the inflammatory response to tissue injury. (medscape.com)
Inhibitors1
- The aim of this study was to systemically review the efficacy and safety of inhibitors of interleukin 6 (IL-6): clazakizumab, IL-12/23: ustekinumab, and IL-17A: secukinumab, brodalumab, and ixekizumab in psoriatic arthritis (PsA). (medscape.com)
Receptor2
- Through binding to the interleukin-5 receptor, interleukin 5 stimulates B cell growth and increases immunoglobulin secretion-primarily IgA. (wikipedia.org)
- The IL-5 receptor is composed of an α and a βc chain. (wikipedia.org)
Gene2
- The IL-5 gene is located on chromosome 11 in the mouse, and chromosome 5 in humans, in close proximity to the genes encoding IL-3, IL-4, and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are often co-expressed in Th2 cells. (wikipedia.org)
- Interleukin-6 is oedema, hypercholesterolaemia and gene- involved in inflammatory responses and im- ralized hyperlipidaemia [ 1 ]. (who.int)
Cell growth1
- Purification and partial sequence analysis of murine B cell growth factor II (interleukin 5). (umassmed.edu)
Production3
- In Hodgkin lymphoma, the typically-observed eosinophilia is thought to be attributable to an increased production of IL-5. (wikipedia.org)
- In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells from 30 non-splenectomized beta- thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. (who.int)
- Dans la présente étude, les taux de production des interleukines 12 et 13 (IL-12 et IL-13) ont été mesurés à l'aide de la méthode ELISA dans les surnageants de culture de cellules mononucléées de sang périphérique stimulées par des mitogènes chez 30 cas de bêta-thalassémie non splénectomisés présentant une surcharge martiale ainsi que chez 20 individus en bonne santé appariés pour l'âge et le sexe. (who.int)
Reduce1
- Mepolizumab is a monoclonal antibody antagonist IL-5 which can reduce excessive eosinophilia. (wikipedia.org)
Cytokines2
- Interleukin 33 is a member of the IL-1 family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g. (wikipedia.org)
- 4. Interleukins (ILs), a fascinating family of cytokines. (nih.gov)
Receptor is composed2
- The IL-5 receptor is composed of an α and a βc chain. (wikipedia.org)
- The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). (creativebiomart.net)
Idiopathic Nephrotic Syndrome1
- 18. Predictive Value of Serum Interleukins in Children with Idiopathic Nephrotic Syndrome. (nih.gov)
Eosinophils3
- IL-5 is also expressed by eosinophils and has been observed in the mast cells of asthmatic airways by immunohistochemistry. (wikipedia.org)
- IL-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma, wherein a large increase in the number of circulating, airway tissue, and induced sputum eosinophils have been observed. (wikipedia.org)
- Given that eosinophils are the primary IL-5Rα-expressing cells, it is not surprising that this cell type responds to IL-5. (wikipedia.org)
Stimulates2
- Through binding to the interleukin-5 receptor, interleukin 5 stimulates B cell growth and increases immunoglobulin secretion-primarily IgA. (wikipedia.org)
- Interleukin 3 stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells or, with the addition of IL-7, into lymphoid progenitor cells . (wikidoc.org)
Protein3
- Interleukin 33 ( IL-33 ) is a protein that in humans is encoded by the IL33 gene . (wikipedia.org)
- Interleukin 7 ( IL-7 ) is a protein [1] that in humans is encoded by the IL7 gene . (wikidoc.org)
- It is a 15,5 - 16 kDa protein [1] that regulates the activities of white blood cells (leukocytes, often lymphocytes ) that are responsible for immunity. (wikidoc.org)
Colony-stimul3
- The IL-5 gene is located on chromosome 11 in the mouse, and chromosome 5 in humans, in close proximity to the genes encoding IL-3, IL-4, and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are often co-expressed in Th2 cells. (wikipedia.org)
- In fact, IL-5 was originally discovered as an eosinophil colony-stimulating factor, is a major regulator of eosinophil accumulation in tissues, and can modulate eosinophil behavior at every stage from maturation to survival. (wikipedia.org)
- The α subunit is specific for the IL-5 molecule, whereas the βc subunit also recognised by interleukin 3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF). (wikipedia.org)
Gene is located1
- The human IL-3 gene is located on chromosome 5 , only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM-CSF. (wikidoc.org)
Interactions1
- 8. Modulating Interleukins and their Receptors Interactions with Small Chemicals Using In Silico Approach for Asthma. (nih.gov)
Eosinophilia3
- Mepolizumab is a monoclonal antibody antagonist IL-5 which can reduce excessive eosinophilia. (wikipedia.org)
- In Hodgkin lymphoma, the typically-observed eosinophilia is thought to be attributable to an increased production of IL-5. (wikipedia.org)
- Type 2 innate lymphoid cells (ILC2s) are a newly identified subset of immune cells that, along with Th2 cells, contribute to the pathogenesis of asthma by producing copious amounts of IL-5 and IL-13, which cause eosinophilia and airway hyperreactivity (AHR), a cardinal feature of asthma. (nih.gov)
Hematopoietic1
- He found a T cell derived factor that induced the synthesis of 20alpha-hydroxysteroid dehydrogenase in hematopoietic cells and termed it interleukin-3. (wikidoc.org)
Immune3
- The adaptive immune system consists of B lymphocytes (B cells) that secrete antibodies (a process known as humoral immunity) and T lymphocytes, which are also known as T cells (a process known as cell-mediated immunity), both of which are pathogen specific [ 3-5 ]. (nih.gov)
- as a result, a subsequent exposure to the same pathogen leads to a vigorous and rapid immune response [ 1 , 3 , 5 ]. (nih.gov)
- Consuming adequate amounts of several vitamins and minerals-including vitamin A, vitamin C, vitamin D, vitamin E, selenium, and zinc-is important for proper immune function, and clinical deficiencies of these nutrients weaken immunity and can increase susceptibility to infections [ 2 , 4 , 5 , 8-10 ]. (nih.gov)
Inflammatory3
- 14. Targeting interleukins for the treatment of inflammatory bowel disease-what lies beyond anti-TNF therapy? (nih.gov)
- 20. Increased levels of interleukins 8 and 10 as findings of canine inflammatory mammary cancer. (nih.gov)
- Interleukin-6 is oedema, hypercholesterolaemia and gene- involved in inflammatory responses and im- ralized hyperlipidaemia [ 1 ]. (who.int)
Subunit3
- IL-5 has been shown to interact with interleukin 5 receptor alpha subunit. (wikipedia.org)
- Glycosylation of the Asn196 residue of the Rα subunit appears to be essential for binding of IL-5. (wikipedia.org)
- Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. (creativebiomart.net)
Human1
- 11. Evolutionary divergence and functions of the human interleukin (IL) gene family. (nih.gov)
Drugs1
- Drugs that target IL-5 are mepolizumab and reslizumab. (wikipedia.org)
Cells2
- Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. (wikipedia.org)
- IL-5 and IL-13 ) from polarized Th 2 cells. (wikipedia.org)
Mice1
- Interleukin 3 originally was discovered by JN Ihle in mice. (wikidoc.org)
Cell1
- 16. Interleukins as Mediators of the Tumor Cell-Bone Cell Crosstalk during the Initiation of Breast Cancer Bone Metastasis. (nih.gov)
Shown1
- Interleukin 3 has been shown to interact with IL3RA . (wikidoc.org)
Form1
- Aldesleukin is a form of recombinant interleukin-2. (wikidoc.org)
Major1
- This graph shows the total number of publications written about "Interleukin-13" by people in Harvard Catalyst Profiles by year, and whether "Interleukin-13" was a major or minor topic of these publication. (harvard.edu)
Activities1
- 6. Antitumor Activities of Interleukin-12 in Melanoma. (nih.gov)
Common1
- IL-7 binds to the IL-7 receptor , a heterodimer consisting of Interleukin-7 receptor alpha and common gamma chain receptor . (wikidoc.org)