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  • CXCL8
  • IL-8 je preimenovan u CXCL8 od strane Subkomiteta za hemokinsku nomenklaturu koje je deo Internacionalne unije imunoloških udruženja , mada njegovo odobreni HUGO simbol gena ostaje IL8 . (wikipedia.org)
  • IL-8 is sometimes called CXCL8. (prospecbio.com)
  • Recombinant
  • FAK and ERK1/2 inhibitor also decreased IPDI-BEAS-2B-CM-, IPDI-HBEC-CM- and recombinant human IL-8-mediated BSMC proliferation and migration, whereas blocking Rnd3 using small interfering RNA failed to affect BSMC proliferation, suggesting that Rnd3 was only involved in the regulation of BSMC migration. (biomedsearch.com)
  • We also examined the effects of IL-8 on the expression of disease-progression genes by treating gastric carcinoma cell lines with recombinant IL-8. (aacrjournals.org)
  • mediator
  • It is believed that IL-8 acts as a proinflammatory mediator in conditions such as psoriasis and gingivitis. (prospecbio.com)
  • human
  • Like all of the Interleukin proteins, IL-8 modulates and controls the behavior of cells in the human body. (prospecbio.com)
  • Interleukin are responsible for the immune response, which has lead to the conclusion that well-functioning Interleukins are an essential component of human health. (prospecbio.com)
  • J. J. Oppenheim, K. Matsushima, C. G. Larsen, and A. O. Anderson, "Production of interleukin-8 by human dermal fibroblasts and keratinocytes in response to interleukin-1 or tumour necrosis factor," Immunology , vol. 68, no. 1, pp. 31-36, 1989. (hindawi.com)
  • Conclusions We propose that high circulating IL-8 in human alcoholic hepatitis may cause pathogenic overzealous neutrophil activation, and therapeutic blockade via pepducins merits clinical study. (bmj.com)
  • The expression of interleukin 8 (IL-8) by human gastric carcinomas directly correlates with tumor vascularity and disease progression. (aacrjournals.org)
  • exogenous
  • A minimum concentration of 250 pM of exogenous IL-8 could then be consistently detected in a salivary environment. (rsc.org)
  • induce
  • Furthermore, IL-8 then proceeds to induce phagocytosis when the cells it has influenced arrive at the infection site. (prospecbio.com)
  • blockade
  • We have now shown that blockade of the IL-8/IL-8R axis is effective at reverting the phenotype of the tumor cells towards a more epithelial one, decreasing stemness features, and significantly enhancing tumor sensitivity to chemotherapy, small-molecule targeted therapies, and immune-mediated lysis with NK and antigen-specific T cells in vitro. (aacrjournals.org)
  • tumor cells
  • Immunohistochemical staining of tumors revealed primary localization of IL-8 to individual tumor cells and demonstrated the capacity of tumor to elaborate IL-8. (rupress.org)
  • genomic
  • H. Zhang, G. H. Thorgaard, and S. S. Ristow, "Molecular cloning and genomic structure of an interleukin-8 receptor-like gene from homozygous clones of rainbow trout ( Oncorhynchus mykiss )," Fish and Shellfish Immunology , vol. 13, no. 3, pp. 251-258, 2002. (hindawi.com)
  • inflammatory
  • IL-8 has been found to encourage the response of immune cells to the site of an infection, and has a strong role to play in issues in the inflammatory and protective response of infected tissue. (prospecbio.com)
  • chemokines
  • 12 ] reported that MCP-1 and IL-8 are produced at much higher levels than other chemokines tested in RPE cells. (springer.com)
  • expression
  • CoQ10 intake for 12 weeks in PCOS women significantly improved gene expression of LDLR, PPAR-γ, IL-1, IL-8 and TNF-α. (greenmedinfo.com)
  • These findings indicate that berberine inhibited the expression of MCP-1 and IL-8 induced by LPS. (springer.com)
  • In the present study, we investigated the effects of berberine on MCP-1 and IL-8 expression in ARPE-19 cells stimulated with LPS. (springer.com)
  • responses
  • It is important to note that the addition of neutralizing antisera to IL-8 to these assays resulted in the marked and specific attenuation of these responses. (rupress.org)
  • In addition to the above, high levels of IL-8 have also been shown to impact positive responses in schizophrenic patients. (prospecbio.com)
  • antigen
  • Primarna funkcija IL-8 citokina je da regrutuje neutrofile da fagocitoziraju antigen koji je pobudio antigenski obrazac toll-sličnog receptora. (wikipedia.org)
  • A sandwich assay using two monoclonal antibodies, which recognize different epitopes on the antigen (IL-8), was used. (rsc.org)
  • pathogenesis
  • IL-8 is also believed to have a role in the pathogenesis of common viral respiratory tract disease bronchiolitis. (prospecbio.com)
  • Thus, MCP-1 and IL-8 may be involved in part in the pathogenesis of intraocular disorders. (springer.com)
  • promoter
  • Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. (wikipedia.org)
  • tissue
  • Increased quantities of IL-8 were detected in tumor tissue as compared with normal lung tissue. (rupress.org)
  • mast
  • Dok su neutrofilni granulociti primarna meta za IL-8, postoji relativno širok krug ćelija ( endotelne ćelije , makrofage , mast ćelije , keratinociti ) koje reaguju na ovaj hemokin. (wikipedia.org)