Interleukin 5. Medical search. Frequent questions

IL-5 is also expressed by eosinophils and has been observed in the mast cells of asthmatic airways by immunohistochemistry. (wikipedia.org)
IL-5 has long been associated with the cause of several allergic diseases including allergic rhinitis and asthma, wherein a large increase in the number of circulating, airway tissue, and induced sputum eosinophils have been observed. (wikipedia.org)
Given that eosinophils are the primary IL-5Rα-expressing cells, it is not surprising that this cell type responds to IL-5. (wikipedia.org)
In addition, WT mice but not IL-5-/- mice had raised levels of eosinophils in their peripheral blood between days 5 and 8 following infection. (strath.ac.uk)
This work has contributed to the development of new therapeutic strategies and drugs, such as a new class of drugs based on targeting eosinophils (e.g., anti-IL-5 humanized antibodies), which are now FDA approved for clinical usage. (cincinnatichildrens.org)
Interleukin-5 is produced by a number of cell types, and is responsible for the maturation and release of eosinophils in the bone marrow. (biomedcentral.com)
In humans, interleukin-5 is a very selective cytokine as a result of the restricted expression of the interleukin-5 receptor on eosinophils and basophils. (biomedcentral.com)
Eosinophils are a prominent feature in the pulmonary inflammation that is associated with allergic airway diseases, suggesting that inhibition of interleukin-5 is a viable treatment. (biomedcentral.com)
Further trials designed to measure eosinophil accumulation and lung function in asthmatic persons are currently underway, and will help to define the role of interleukin-5 and eosinophils in general in this disease. (biomedcentral.com)
IL-33 -mediated eosinophil production was indeed dependent on IL-5 as both airway and bone marrow eosinophils decreased in mice treated with anti- IL-5 in combination with IL-33 . (bvsalud.org)
Interleukin (IL)-5 has been shown to activate many signaling molecules in eosinophils, but their functional relevance remains unknown. (utmb.edu)
Interleukin 3 (IL-3) stimulates multipotent stem cells and differentiated hematopoietic progenitor cells, promoting their differentiation and proliferation into basophils, mast cells, type-1 and -2 dendritic cells, eosinophils and monocytes. (fujifilm.com)
IL-3 and GM-CSF act on other bone marrow-derived lineages, whereas the stimulatory activity of IL-5 appears to be limited to eosinophils and thus suggests it to be the dominant factor in eosinophil proliferation. (medscape.com)

Finally, a number of biologics that target CD4 + T cell differentiation into inflammatory subsets or their byproducts (i.e., cytokines) have shown efficacy in treating patients with IBD ( 5 - 7 ). (frontiersin.org)
Interleukin (IL)-12 and IL-23, cytokines induced during early stages of IBD, play important roles in differentiation of interferon (IFN)-γ/tumor necrosis factor (TNF)-producing Th1 cells as well as IL-17-producing Th17 cells. (frontiersin.org)
Th1 and Th2 responses are crucial in understanding the role of cytokines in the immune response to infectious agents [ 4 , 5 ]. (hindawi.com)
Multiple cytokines stimulate eosinophil production, including IL-3, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-5. (medscape.com)

In fact, IL-5 was originally discovered as an eosinophil colony-stimulating factor, is a major regulator of eosinophil accumulation in tissues, and can modulate eosinophil behavior at every stage from maturation to survival. (wikipedia.org)
White blood cell, eosinophil, CD4- and CD8-positive lymphocyte counts, and serum interleukin-5 (IL-5) and IgE levels were determined before, 2 and 4 weeks after switching to vitamin E-bonded dialyzers. (dadamo.com)
RESULTS: Eosinophil and CD4-positive lymphocyte counts and serum IL-5 were significantly (P = 0.003, 0.003 and 0.031, respectively) decreased after switching to vitamin E-bonded dialyzers. (dadamo.com)
Retinoic acid modulates IL-5 receptor expression and selectively inhibits eosinophil-basophil differentiation of hemopoietic progenitor cells. (dadamo.com)
BACKGROUND: IL-5 plays a central role in eosinophil and basophil differentiation, exerting its effects through the IL-5 receptor (IL-5Ralpha). (dadamo.com)
Therefore, exclusively inhibiting the actions of interleukin-5 can suppress at least one of the alleged causes of asthma, namely tissue damage due to eosinophil accumulation during pulmonary inflammation. (biomedcentral.com)
T helper type 2 (Th2) cells , type 2 innate lymphoid cells (ILC2s) and eosinophil progenitors have previously been described to produce interleukin-5 ( IL-5 ) in the airways upon allergen provocation or by direct administration of IL-33 . (bvsalud.org)
Eosinophilic airway inflammation is known to be associated with IL-5 -dependent eosinophil development in the bone marrow , however, the source of IL-5 remains unclear. (bvsalud.org)
Similar results were obtained by in vitro stimulation with IL-33 where ILC2s rapidly produced large amounts of IL-5 , which coincided with the induction of eosinophil hematopoiesis . (bvsalud.org)
Th1 cells that produce IL-2, IFN- γ , TNF- α, and TNF- β evoke cell-mediated immunity and phagocyte-dependent inflammation while Th2 cells that produce IL-5, IL-4, IL-6, IL-10, and IL-13 induce a strong antibody response that comprises the IgE class and eosinophil accumulation, but it inhibits several functions of phagocytic cells [ 7 ]. (hindawi.com)
Eosinophil (Eo) colonies were only formed by CD34 + ,CD33 - cells in response to IL-3, but scarcely formed by CD34 + cells in the presence of IL-5. (elsevierpure.com)
We have demonstrated that all three kinases are important for IL-5-induced suppression of eosinophil apoptosis. (utmb.edu)
The essential components of eosinophil migration into the lung, such as leukotriene (LT)D 4 , LTB 4 and IL-5, are generally considered chemotactic factors. (ersjournals.com)

IL-5 has been shown to interact with interleukin 5 receptor alpha subunit. (wikipedia.org)
Interleukin-5 Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Several isoforms of the interleukin-5 receptor alpha subunit exist due to multiple ALTERNATIVE SPLICING. (harvard.edu)
This graph shows the total number of publications written about "Interleukin-5 Receptor alpha Subunit" by people in Harvard Catalyst Profiles by year, and whether "Interleukin-5 Receptor alpha Subunit" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Interleukin-5 Receptor alpha Subunit" by people in Profiles. (harvard.edu)

The IL-5 gene is located on chromosome 11 in the mouse, and chromosome 5 in humans, in close proximity to the genes encoding IL-3, IL-4, and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are often co-expressed in Th2 cells. (wikipedia.org)
The role of interleukin-5 (IL-5) during Toxoplasma gondii infection was investigated by comparing disease progression in IL-5 gene deficient (IL-5-/-) mice and their wild-type (WT) counterparts on a C57BL/6 background. (strath.ac.uk)
The IL36RN gene provides instructions for making a protein called interleukin 36 receptor antagonist (IL-36Ra). (medlineplus.gov)
In the first part of this study it was shown that multiplex-PCR and the following fragment length analysis can verify gene variations within the 5" flanking region of the IL-10 gene of three geographically different cohorts. (uni-goettingen.de)
The results of the present study support the hypothesis that gene variations are associated with prognostic factors within the 5" flanking region of the IL-10 gene as well as could indicate the prognosis of aggressive NHL. (uni-goettingen.de)
The enzyme/prodrug strategy using cytosine deaminase (CD) and 5-fluorocytosine (5-FC) has been used for cancer gene therapy. (biomedcentral.com)
The results suggest that adenovirus-mediated IL-12 gene transfer combined with Ad.CD followed by 5-FC treatment may be useful for treating cancers. (biomedcentral.com)
Hypereosinophilic syndrome etiology can involve (1) primitive involvement of myeloid cells, essentially due to the occurrence of an interstitial chromosomal deletion on band 4q12 leading to the creation of the FIP1L1-PDGFRA fusion gene (F/P + variant), or (2) increased interleukin (IL)-5 production by a clonally expanded T-cell population (lymphocytic variant), most frequently characterized by a CD3 - CD4 + phenotype. (medscape.com)
Remarkably, retroviral gene transduction of T-bet into polarized Th2 and Tc2 primary T cells redirects them into Th1 and Tc1 cells, respectively, as evidenced by the simultaneous induction of IFNgamma and repression of IL-4 and IL-5. (nih.gov)
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. (nih.gov)
Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. (nih.gov)
This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. (antibodies-online.com)
Interleukin-6 is oedema, hypercholesterolaemia and gene- involved in inflammatory responses and im- ralized hyperlipidaemia [ 1 ]. (who.int)
The best-described aberration is the interstitial deletion on chromosome 4q12, resulting in fusion of the 5' portion of the FIP1L1 gene to the 3' portion of the PDGFRA gene. (medscape.com)

The α subunit is specific for the IL-5 molecule, whereas the βc subunit also recognised by interleukin 3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF). (wikipedia.org)
Glycosylation of the Asn196 residue of the Rα subunit appears to be essential for binding of IL-5. (wikipedia.org)
A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)
Interleukin-23 ( IL-23 ) is a heterodimeric cytokine composed of an IL12B ( IL-12p40 ) subunit (that is shared with IL12 ) and the IL23A ( IL-23p19 ) subunit. (wikidoc.org)
B29), and the -subunit of the E-mail: [email protected] interleukin (IL)-7 receptor [5, 6]. (lu.se)

The aim of this study was to systemically review the efficacy and safety of inhibitors of interleukin 6 (IL-6): clazakizumab, IL-12/23: ustekinumab, and IL-17A: secukinumab, brodalumab, and ixekizumab in psoriatic arthritis (PsA). (medscape.com)

[ 5 ] Specifically, a novel oncogenic mutation ( FIP1L1-PDGFRA ), which results in a constitutively activated platelet-derived growth factor receptor-alpha ( PDGFRA ), has been invariably associated with a primary eosinophilic disorder and results in clonal lines of pathologic cells. (medscape.com)
Although the mechanisms of eosinophilic accumulation remain to be elucidated, increasing evidence suggests the important roles of cytokine, chemokine and lipid mediators in the regulation of eosinophilic inflammation in various eosinophilic airway diseases 5 . (ersjournals.com)
Interleukin-5 is important for the development of eosinophilic rhinitis following toluene diisocyanate inhalation in mice. (cdc.gov)
[ 5 ] Eosinophilic angiocentric fibrosis may be viewed as its mucosal counterpart. (medscape.com)

Cell surface receptors that are specific for INTERLEUKIN-5. (childrensmercy.org)
Signaling from interleukin-5 receptors can occur through interaction of their cytoplasmic domains with SYNTENINS. (childrensmercy.org)

Mepolizumab is a monoclonal antibody antagonist IL-5 which can reduce excessive eosinophilia. (wikipedia.org)
Cinqair is part of a class of drugs called interleukin-5 antagonist monoclonal antibodies (IgG4 kappa). (medicalnewstoday.com)

We isolated total CD34 + cells, CD34 + ,CD33 + cells, and CD34 + ,CD33 - cells individually from normal human bone marrow cells by fluorescence-activated cell sorter (FACS), and examined the effects of granulocyte colony-stimulating factor (G-CSF), interleukin-3 (IL-3), and IL-5 on in vitro colony formation of these cells. (elsevierpure.com)

The present review addresses the data that relate interleukin-5 to pulmonary inflammation and function in animal models, and the use of neutralizing anti-interleukin-5 monoclonal antibodies for the treatment of asthma in humans. (biomedcentral.com)
T helper cells , ILC2s and CD34+ progenitors have been proposed to be involved in this process, therefore, we investigated whether these cells are taking part in eosinophilopoiesis by producing IL-5 locally in the bone marrow in IL-33 -driven inflammation . (bvsalud.org)
and 5) absence of severe respiratory illness (to concurrently received positive test results for SARS-CoV-2, exclude patients in which inflammation and organ dysfunc- the virus that causes COVID-19, by polymerase chain reaction tion might be attributable simply to tissue hypoxia). (cdc.gov)
[ 4 ] Psoriatic arthritis is associated with significant morbidity and mortality, [ 5 ] and its therapy is aimed at alleviating discomfort, controlling skin and joint inflammation, and retarding or preventing radiographic damage and functional impairment. (medscape.com)

Specifically, it is an interleukin-5 inhibitor . (medbroadcast.com)

SP600125 inhibited interleukin-1β-induced JNK activity and activator protein-1 activation, but it did not affect the activation of extracellular-regulated kinase, p38 mitogen-activated protein kinase, and nuclear factor-κB. (aspetjournals.org)

Interleukin (IL)-12, which is secreted by antigen-presenting cells, acts via signal transducer and activator of transcription (STAT)4 to promote the differentiation of naïve T cells into Th1 cells ( 9 - 11 ). (frontiersin.org)

The inhibition of tumor growth in mice treated with Ad.p35 plus Ad.p40 and Ad.CD, followed by injection of 5-FC, was significantly greater than that in mice treated with Ad.CD/5-FC, a mixture of Ad.p35 plus Ad.p40, or Ad.GFP (control). (biomedcentral.com)
Ad.CD/5-FC treatment significantly increased the antitumor effect of Ad.IL-12 in terms of tumor growth inhibition and mean animal survival time. (biomedcentral.com)

Serum interleukin (IL)-1, IL-6, tumour necrosis factor (TNF) and quantitative urinary -2-microglobulin (-2-m) excretion were estimated. (who.int)

However, peak serum IL-12 and IFN-gamma levels (at days 6 and 8, respectively) were significantly higher in IL-5-/- mice than in WT mice. (strath.ac.uk)
Description: A sandwich ELISA kit for detection of Interleukin 18 from Guinea pig in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (ibiomagazine.org)
The objective of this study was to evaluate the cytokine profiles of IL-4, IL-2, IL-10, IL-5, IFN- γ, and TNF in serum samples of infected school-aged children by using flow cytometry before and after treatment. (hindawi.com)
[ 5 ] Most laboratories that use the serum tryptase immunoassay use a reagent with a suppressor for these heterophilic antibodies. (medscape.com)

Bone marrow type 2 innate lymphoid cells: a local source of interleukin-5 in interleukin-33-driven eosinophilia. (bvsalud.org)
Importantly, IL-5 production as well as expression of the IL-33 receptor increased in ILC2s in the bone marrow under this treatment . (bvsalud.org)
In summary, we demonstrate for the first time that IL-33 acts directly on bone marrow ILC2s, making them an early source of IL-5 and part of a process that is central in IL-33 -driven eosinophilia . (bvsalud.org)

Find IL-5 Antibodies validated for a specific application such as WB, ELISA, FACS, IHC. (antibodies-online.com)
In this study production levels of interleukins (IL)-12 and IL-13 were measured by commercial ELISA in culture supernatants of mitogen-stimulated peripheral blood mononuclear cells from 30 non-splenectomized beta- thalassaemia cases with iron overload and 20 age- and sex-matched healthy individuals. (who.int)
Dans la présente étude, les taux de production des interleukines 12 et 13 (IL-12 et IL-13) ont été mesurés à l'aide de la méthode ELISA dans les surnageants de culture de cellules mononucléées de sang périphérique stimulées par des mitogènes chez 30 cas de bêta-thalassémie non splénectomisés présentant une surcharge martiale ainsi que chez 20 individus en bonne santé appariés pour l'âge et le sexe. (who.int)

High local interleukin 5 production in granuloma faciale (eosinophilicum): role of clonally expanded skin-specific CD4+ cells. (medscape.com)

Interleukin 5 (IL-5) is an interleukin produced by type-2 T helper cells and mast cells. (wikipedia.org)
At this time, splenocytes and mesenteric lymph node cells derived from IL-5-/- mice produced levels of IL-12, interferon-gamma (IFN-gamma), IL-4, IL-10, and nitric oxide (measured as nitrite) similar to those derived from WT mice when stimulated with Toxoplasma lysate antigen. (strath.ac.uk)
This specificity occurs because only those cells possess the interleukin-5 receptor. (biomedcentral.com)
A small but significant induction of IL-5 was also found in CD34+ progenitors but not in T helper cells . (bvsalud.org)
CD34 - ,CD33 + cells derived from CD34 + ,CD33 + cells by preincubation with G-CSF or IL-3 formed Eo colonies in the presence of IL-5 but not IL-3. (elsevierpure.com)
CD34 - ,CD33 + cells derived from CD34 + ,CD33 - cells by preincubation with IL-3 also formed Eo colonies by support of IL-5 as well as IL-3. (elsevierpure.com)
Additionally, in the OVA-induced asthma model, the number of immune cells in the bronchoalveolar lavage fluid, the concentration of OVA-specific IgE, the infiltration of inflammatory cells, the bronchial thickness and the levels of the inflammatory mediators interleukin-4 (IL-4), IL-13 and COX-2 were significantly lower in the OVA + SEAC‑treated group compared with the OVA + vehicle‑treated group. (spandidos-publications.com)
Katagiri K, Itami S, Hatano Y, Yamaguchi T, Takayasu S. In vivo expression of IL-4, IL-5, IL-13 and IFN-gamma mRNAs in peripheral blood mononuclear cells and effect of cyclosporin A in a patient with Kimura's disease. (medscape.com)
Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with Kimura disease. (medscape.com)

5-Aminosalicylic acid derivatives inhibit prostaglandin synthesis and reduce the inflammatory response to tissue injury. (medscape.com)
5, 6 We have also shown that repeated daily exposure to NO 2 (2 ppm for four hours/day for four successive days) can induce a decrement in FEV 1 that returns to baseline by day 4, but the acute inflammatory response characterised by PMN influx and activation still persists after the final exposure. (bmj.com)
Minority stress and inflammatory mediators: Covering moderates associations between perceived discrimination and salivary interleukin-6 in gay men. (bvsalud.org)

https://doi.org/10.1038/s41564-020-0770-5 extensão da UNICAMP (grant no. 2266/20). (cdc.gov)

Unlike other members of this cytokine family (namely interleukin 3 and GM-CSF), this glycoprotein in its active form is a homodimer. (wikipedia.org)

Liu Y, Zhang S, Li DW and Jiang SJ: Efficacy of anti-interleukin-5 therapy with mepolizumab in patients with asthma: a meta-analysis of randomized placebo-controlled trials. (spandidos-publications.com)

Through binding to the interleukin-5 receptor, interleukin 5 stimulates B cell growth and increases immunoglobulin secretion-primarily IgA. (wikipedia.org)

IL-5-/- mice infected orally with T. gondii were less susceptible to infection than WT mice as demonstrated by reduced mortality rates. (strath.ac.uk)
Consistent with this data, orally infected IL-5-/- mice had less severe pathological changes in their small intestines than WT mice at 8 days postinfection. (strath.ac.uk)
Oral administration of N omega-nitro-L-arginine methyl (from day 4 postinfection) increased mortality rates in both IL-5-/- and WT mice, indicating a protective role for nitric oxide during the early stages of oral T. gondii infection. (strath.ac.uk)
In comparison with oral infection, no difference in mortality was observed between IL-5-/- and WT mice following intraperitoneal infection with T. gondii, with all mice surviving until 35 days postinfection. (strath.ac.uk)

S2 Episode 5: The Future of Asthma Care: Glass Half Empty or Half Full? (medscape.com)

Drugs that target IL-5 are mepolizumab and reslizumab. (wikipedia.org)

Defective interleukin 2 production and responsiveness in human pulmonary tuberculosis. (rupress.org)

Secondary eosinophilia is a cytokine-derived (interleukin-5 [IL-5]) reactive phenomenon. (medscape.com)

IL-5 is a 115-amino acid (in human, 133 in the mouse) -long Th2 cytokine that is part of the hematopoietic family. (wikipedia.org)
Find IL-5 Antibodies for a variety of species such as anti-Human IL-5, anti-Mouse IL-5, anti-Rat IL-5. (antibodies-online.com)

Findings from this research have identified and elucidated the role of IL-5, the eotaxin subfamily of chemokines, IL-13, miR-21, proteases (e.g., calpain 14), anti-proteases (e.g. (cincinnatichildrens.org)
Interestingly, the responsiveness of ILC2s to IL-33 as well as IL-33 -induced eotaxin-2 /CCL24 were independent of the levels of IL-5 . (bvsalud.org)

SensoLyte® 520 MMP-3 Assay Kit uses a 5-FAM (fluorophore) and QXL520™ (quencher) labeled FRET peptide substrate for continuous measurement of the enzyme activities. (anaspec.com)
Upon the cleavage of the FRET peptide by MMP-3, the fluorescence of 5-FAM is recovered, and can be continuously monitored at excitation/emission = 490 nm/520 nm. (anaspec.com)
With superior fluorescence quantum yield and longer emission wavelength, 5-FAM/QXL520™ based FRET peptide is less interfered by the autofluorescence of test compounds and cellular components and provides better assay sensitivity. (anaspec.com)
Component A: MMP-3 substrate 5-FAM/QXL™520 FRET peptide Ex/Em=490 nm/520 nm upon cleavage: 60 µL Component B: 5-FAM-Pro-Leu-OH, fluorescence reference standard Ex/Em=490 nm/520 nm: 1 mM, 10 µL Component C: APMA, 4-aminophenylmercuric acetate (Caution: Organic mercury. (anaspec.com)

IL-5 expression is regulated by several transcription factors including GATA3. (wikipedia.org)

Anatomy46

Organisms10

Diseases10

Chemicals and Drugs131

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes33

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Alpha subunit5

Gene14

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Inhibitors1

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