• Receptors
  • In fact, the β-subunit of the IL-5 receptor is also found in IL-3 and GM-CSF receptors where it is associated with IL-3Rα and GM-CSFRα subunits respectively. (wikipedia.org)
  • The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). (wikipedia.org)
  • Other types of lymphoid malignancies have been associated with eosinophilia, as in lymphoblastic leukemia with a translocation between chromosomes 5 and 14 or alterations in the genes which encode platelet-derived growth factor receptors alpha or beta. (wikipedia.org)
  • recombinant
  • We performed a phase II clinical trial with intraperitoneal (IP) recombinant IL-2 administered in weekly infusions of 6 × 10 5 IU/m 2 . (springer.com)
  • Rosenberg SA, Lotze MT, Muul LM, Leitman S, Chang AE, Ettinghausen SE, Matory YL, Skibber JM, Shiloni E, Vetto JT et al (1985) Observations on the systemic administration of autologous lymphokine-activated killer cells and recombinant interleukin-2 to patients with metastatic cancer. (springer.com)
  • The biological activity of recombinant bovine IL-5 was measured in a cell proliferation assay using the human TF-1 cell line. (abcam.com)
  • colony-stimul
  • The α subunit is specific for the IL-5 molecule, whereas the βc subunit also recognised by interleukin 3 (IL3) and granulocyte-macrophage colony-stimulating factor (GM-CSF). (wikipedia.org)
  • In EG cytokines IL-3, IL-5 and granulocyte macrophage colony stimulating factor (GM-CSF) may be behind the recruitement and activation. (wikipedia.org)
  • binds
  • The IL-5 receptor (IL-5R) belongs to the type I cytokine receptor family and is a heterodimer composed of two polypeptide chains, one α subunit, which binds IL-5 and confers upon the receptor cytokine specificity, and one β subunit, which contains the signal transduction domains. (wikipedia.org)
  • In either case, the α-chain exclusively binds IL-5 and the intra-cellular portion of IL-5Rα is associated with Janus kinase (JAK) 2, a protein tyrosine-kinase essential in IL-5 signal transduction. (wikipedia.org)
  • tumor
  • Interleukin-2 (IL-2) is a T-cell growth factor believed to be important in anti-tumor immunity. (springer.com)
  • Solid epithelial cell tumors have been shown to cause both tissue and blood eosinophilia, with some reports indicating that this may be mediated by interleukin production by tumor cells, especially IL-5 or IL-3. (wikipedia.org)
  • asthma
  • Clinical trials have shown drugs targeting IL-5 or its receptor alpha subunit (IL-5Ra) to be a promising therapeutic approach to severe asthma, whose characteristics render standard therapy of little use: systemic corticosteroids only partially control the disease and have well-known adverse effects, and omalizumab is used for allergic subtypes. (frontiersin.org)
  • The Severe Asthma Research Program (SARP) study identified four asthma clusters based on age at onset, airflow limitation, comorbidities, and lung function ( 5 ). (frontiersin.org)
  • His identification of the cytokine Interleukin 13 and the subsequent unearthing of its central role in allergic asthma led to his discovery of type-2 innate lymphoid cells (ILC2). (wikipedia.org)
  • tyrosine
  • As with the IL-5Rα subunit, the β subunit's cytoplasmic domain is constitutively associated with JAK2, as well as LYN, another tyrosine kinase, which are both essential for IL-5 signal transduction. (wikipedia.org)
  • Furthermore, YM-90709 inhibited the IL-5-induced but not GM-CSF-induced tyrosine phosphorylation of Janus kinase 2 (JAK2) in eosinophilic HL-60 clone 15 cells. (medkoo.com)
  • Soluble
  • The soluble form does not lead to signal transduction and therefore has an antagonistic effect on IL-5 signaling. (wikipedia.org)
  • eosinophilia
  • In Hodgkin lymphoma, for instance, the typically-observed eosinophilia is thought to be attributable to an increased production of IL-5. (wikipedia.org)
  • Chemotherapy for Schistosomiasis in Ugandan Fishermen: Treatment Can Cause a Rapid Increase in Interleukin-5 Levels in Plasma but Decreased Levels of Eosinophilia and Worm-Specific Immunoglobulin E. (aber.ac.uk)
  • airway
  • Hakonarson, Whelan, Leiter, Kim, Chen, Campbell, Grunstein: T lymphocyte-mediated changes in airway smooth muscle responsiveness are attributed to induced autocrine release and actions of IL-5 and IL-1beta. (antikoerper-online.de)
  • Immune
  • Interleukin-2 (IL-2) is a lymphokine that plays a crucial role in the immune system, especially in the growth control of T lymphocytes. (eurekamag.com)
  • cell
  • Elias L, Hunt WC (2001) A literature analysis of prognostic factors for response and quality of response of patients with renal cell carcinoma to interleukin-2-based therapy. (springer.com)
  • In many clinical settings, however, studies on the T cell receptor and IL-5 are not available and therefore not routine parts of the diagnostic work-up or criteria for the disease. (wikipedia.org)
  • Hodgkin
  • This has also been shown to occur in Hodgkin lymphoma, in the form of IL-5 secreted by Reed-Sternberg cells. (wikipedia.org)
  • specific
  • Unlike the α-chain, the β-chain does not bind IL-5, is not specific to this cytokine, and is expressed on practically all leukocytes. (wikipedia.org)
  • 100 pg/ml) displayed reduced IL-5, IL-13, and IL-10 responses to SWA, and in contrast to the rest of the cohort, these high-IL-5 subjects displayed reduced levels of SWA-specific IgE in plasma 21 days posttreatment. (aber.ac.uk)
  • mast
  • Interleukin 5 (IL5) is an interleukin produced by type-2 T helper cells and mast cells. (wikipedia.org)
  • Similarly, ECP IL-5, GATA-3 mRNA expression and IgE-induced release of LTC4/D 4 /E 4 and PGD 2 from mast cells were significantly increased in patients with PER compared to patients with IAR. (wiley.com)
  • factor
  • Interleukin-4 (IL-4), IL-5, IL-10, IL-13, gamma interferon, and transforming growth factor levels were measured in the cultures and in plasma. (aber.ac.uk)