• cytokines
  • Many of the IL-3 activities depend upon co-stimulation with other cytokines. (acris-antibodies.com)
  • However, MMPs are also involved in controlling the availability of active forms of cytokines and growth factors-pro-tumor necrosis factor-α, interleukin (IL)-1β, insulin-like growth factor binding proteins, and FasL can be cleaved by MMPs ( 6 -9 ). (aacrjournals.org)
  • human
  • The human IL-3 gene is located on chromosome 5, only 9 kilobases from the GM-CSF gene, and its function is quite similar to GM-CSF. (wikipedia.org)
  • Ticks are blood-feeding ectoparasites that transmit a variety of pathogenic organisms, such as viruses, bacteria, protozoa, and helminths, many of which can cause various infectious disorders in human and animal hosts ( 1 - 3 ). (frontiersin.org)
  • Tick-borne diseases include viral encephalitis, sever fever with thrombocytopenia syndrome, Lyme disease, monocytic human ehrlichiosis, Rocky mountain spotted fever, and babesiosis ( 1 - 3 ). (frontiersin.org)
  • Receptor binding kinetics of human IL-3 variants with altered proliferative activity. (semanticscholar.org)
  • Use of combinatorial mutagenesis to select for multiply substituted human interleukin-3 variants with improved pharmacologic properties. (semanticscholar.org)
  • We thus decided to investigate the effect of simvastatin on the production of MMP-3 from cultured interleukin (IL)1 stimulated human chondrocytes. (mysciencework.com)
  • We investigated the effects of interleukin (IL)-10 on MMP-2 expression in CPTX-1532 human prostate tumor cells. (aacrjournals.org)
  • vivo
  • Both in vitro and in vivo studies have suggested that the addition of growth factors (G-CSF, GM-CSF) or interleukin-3 (IL-3) may potentiate the effect of r-EPO on dysplastic erythropoiesis. (haematologica.org)
  • Recently, microglial cells, the resident macrophages of the central nervous system (CNS) have been shown to proliferate in the presence of IL-3 both in vivo and in culture. (mysciencework.com)
  • mast
  • Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. (acris-antibodies.com)
  • Expression of interleukin-3 (IL3) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. (wikipedia.org)
  • transcription
  • Immunoblot assays of activating transcription factor (ATF) 3 immunoprecipitates with tyrosine specific antibodies revealed that IL-10 stimulated tyrosine phosphorylation of ATF3 to activate binding to the CREB domain and suppress MMP-2 expression. (aacrjournals.org)
  • tyrosine
  • While we demonstrate that the Gab-2 PH domain can bind PI(3,4,5)P3, it is dispensable for Gab-2 membrane localisation, tyrosine phosphorylation and signalsome formation. (sigmaaldrich.com)
  • cells
  • To investigate the role of the pleckstrin homology domain of Gab-2 in this process, epitope-tagged wild type Gab-2 (WTGab-2), Gab-2 lacking its PH domain (DeltaPHGab-2) and the Gab-2 PH domain alone (PHGab-2) were inducibly expressed in IL-3-dependent BaF/3 cells. (sigmaaldrich.com)
  • Il3 gene expression was highly upregulated at the second tick-feeding site, and adoptive transfer of interleukin-3 (IL-3)-sufficient but not IL-3-deficient CD4 + T cells conferred the basophil infiltration on T-cell-deficient mice, indicating that the CD4 + T-cell-derived IL-3 is essential for the basophil recruitment. (frontiersin.org)
  • Notably, IL-3 + resident CD4 + memory T cells were detected even before the second infestation in previously uninfested skin distant from the first tick-feeding site. (frontiersin.org)
  • Taken together, IL-3 produced locally by skin CD4 + memory T cells appears to play a crucial role in basophil recruitment to the second tick-feeding site. (frontiersin.org)
  • This is the first report identifying rat microglial cells themselves as a source of IL-3. (mysciencework.com)
  • IL-3 polypeptide was detected in both conditioned media (CM) and in microglial cells by Western blotting and immunoprecipitation. (mysciencework.com)
  • mRNAIL-3 was present in single microglial cells as revealed by in situ hybridization. (mysciencework.com)
  • It is concluded that IL-3 expression in ensuring the recruitment of enhanced numbers of immunocompetent cells at sites of lesion. (mysciencework.com)
  • optimal
  • The pleckstrin homology domain of Gab-2 is required for optimal interleukin-3 signalsome-mediated responses. (sigmaaldrich.com)
  • Future studies using combinations of IL-3 5 micrograms/kg/day and GM-CSF 3 micrograms/kg/day may help to define the optimal therapeutic regimen. (openrepository.com)
  • hematological
  • Since there was also no difference in hematological efficacy between the two routes of rhIL-3 administration, we conclude that the s.c. route of administration appears to have no disadvantages over the i.v. route and may facilitate its clinical application. (aacrjournals.org)
  • Phase I trial of subcutaneous interleukin 3 in patients with refractory malignancy: hematological, immunological, and pharmacodynamic findings. (semanticscholar.org)
  • responses
  • Overall, among 50 patients who completed the study, there were 3 erythroid responses (as determined by complete abolition of red-cell transfusions): 1 (4%) in the G-CSF + r-EPO and 2 (10.5%) in the GM-CSF + r-EPO treated groups. (haematologica.org)
  • cell
  • Monotherapy with IL-3 producted significant dose related increases in platelets and white cell counts. (openrepository.com)
  • Combinations of IL-3 and GM-CSF also produced increases in white cell counts, but these were no greater than would be expected following GM-CSF treatment alone. (openrepository.com)
  • erythroid
  • RESULTS: Ten patients were not evaluable for erythroid response because of relevant side effects related to GM-CSF or IL-3 administration. (haematologica.org)
  • effects
  • The aim of this study was to evaluate the effects of the combination of r-EPO with G-CSF, GM-CSF or IL-3 on the anemia of heavily transfusion-dependent MDS patients, previously unresponsive to r-EPO alone. (haematologica.org)
  • It inhibits chemical mediatory release of the slow-reacting substance of anaphylaxis (SRS-A) and may have antagonistic effects on interleukin-3. (drugbank.ca)
  • Complex
  • PKM2 is a cytosolic enzyme that is associated with other glycolytic enzymes, i.e., hexokinase, glyceraldehyde 3-P dehydrogenase, phosphoglycerate kinase, phosphoglyceromutase, enolase, and lactate dehydrogenase within a so-called glycolytic enzyme complex. (wikipedia.org)
  • patients
  • Patients received rhIL-3 by continuous i.v. infusion or once daily s.c. injection in Cycle 1 and the alternate route in Cycle 3. (aacrjournals.org)
  • Plasma rhIL-3 samples were obtained once daily on Days 1 to 6 and serially over a 24-h period on Day 7 for pharmacokinetic assessment of s.c. and i.v. administered rhIL-3 in 16 and 17 patients, respectively. (aacrjournals.org)
  • A significant increase in leukocyte count occurred in 96% of patients who received r-EPO + G-CSF, 78.9% of those treated with r-EPO + GM-CSF and 66% of subjects receiving r-EPO + IL-3. (haematologica.org)
  • INTERPRETATION AND CONCLUSIONS: Our results suggest that the combination of r-EPO with G-CSF, GM-CSF or IL-3, at least at the doses and schedules employed in the present study, has limited efficacy on the anemia of heavily transfusion-dependent MDS patients previously unresponsive to r-EPO alone. (haematologica.org)
  • IL-3 0.25, 0.5 or 5 micrograms/kg/day for 1, 4 or 7 days was given by continuous intravenous (i.v.) infusion to 35 patients with advanced malignancy. (openrepository.com)
  • 21 of the 35 patients also received sequential or overlapping treatment with continuous i.v. infusion of GM-CSF 1 or 3 micrograms/kg/day for up to 10 days. (openrepository.com)
  • There was a trend for platelets to increase more in patients receiving IL-3 and GM-CSF than those receiving IL-3 alone, but this did not reach statistical significance. (openrepository.com)
  • chromosome
  • This means there is a translocation between chromosome 9 and chromosome 22, with breaks happening in region (3), band (4), sub-band (1) of the long arm (q) of chromosome 9 and region (1), band (1), sub-band (2) of the long arm (q) of chromosome 22. (wikipedia.org)
  • Structures
  • As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1MRQ, 1Q13, and 1Q5M. (wikipedia.org)
  • known
  • The known substrates of MMPs include basement membrane and matrix components such as collagens, fibronectin, vitronectin, laminin, and tenascin ( 2 , 3 ). (aacrjournals.org)
  • high
  • suggested 3 diagnostic criteria which is still widely used: the presence of gastrointestinal symptoms, histological demonstration of eosinophilic infiltration in one or more areas of the gastrointestinal tract or presence of high eosinophil count in ascitic fluid (latter usually indicates subserosal variety), no evidence of parasitic or extraintestinal disease. (wikipedia.org)