• precursor
  • Molecular cloning of the Interleukin 1 Beta converting enzyme is generated by the proteolytic cleavage of an inactive precursor molecule. (wikipedia.org)
  • However, when mice with this genetic deletion have wild-type neural precursor cells injected into their hippocampus and these cells are allowed to mature into astrocytes containing the interleukin-1 receptors, the mice exhibit normal hippocampal-dependent memory function, and partial restoration of long-term potentiation. (wikipedia.org)
  • protein
  • The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19, and encodes a 23 kDa protein. (wikipedia.org)
  • The name "interleukin" was chosen in 1979, to replace the various different names used by different research groups to designate interleukin 1 (lymphocyte activating factor, mitogenic protein, T-cell replacing factor III, B-cell activating factor, B-cell differentiation factor, and "Heidikine") and interleukin 2 (TSF, etc. (wikipedia.org)
  • gp130
  • Signal transduction is initiated upon binding of IL-11 to IL-11Ralpha and gp130, facilitating the homodimerization of gp130 molecules. (wikipedia.org)
  • Osteoclastogenesis induced by IL-6 and IL-11 was inhibited by the addition of an anti-gp130 antibody but not by osteoprotegerin. (ox.ac.uk)
  • 2017
  • A number of studies reported IL-11 as a possible cancer progression marker suggesting that therapeutic targeting of IL-11 or IL11RA in humans may be beneficial, however as of 2017 clinically relevant IL-11 signalling antagonists were still under development. (wikipedia.org)
  • osteoclast
  • Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism. (ox.ac.uk)
  • In order to determine whether IL-6 and IL-11 could independently support human osteoclast formation, these factors were added to cultures of human peripheral blood mononuclear cells of the monocyte (CD14(+)) fraction in the presence of macrophage colony-stimulating factor (M-CSF). (ox.ac.uk)
  • These results indicate that IL-6 and IL-11, which are thought to play a role in several osteolytic bone disorders, are directly capable of inducing osteoclast formation by a RANKL-independent mechanism. (ox.ac.uk)
  • With colleagues, he discovered that BCC produce soluble factors increasing osteoclast activity, notably interleukin-11, the production of which is reduced by the cyclooxygenase inhibitor aspirin. (wikipedia.org)
  • STAT3
  • Reduced IL-11 production and STAT3 phosphorylation may contribute to unexplained infertility in some women. (sigmaaldrich.com)
  • endometrial
  • Endometrial IL-11, IL-11 receptor alpha (IL-11Ralpha), LIF and pSTAT3 in women with primary unexplained infertility was compared to normal fertile women during the implantation window. (sigmaaldrich.com)
  • This is the first demonstration of reduced endometrial pSTAT3 and IL-11 in some women with unexplained infertility. (sigmaaldrich.com)
  • human
  • IL-11 is a member of a family of human growth factors and is being produced in the bone marrow of healthy adults. (wikipedia.org)
  • immune
  • The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. (wikipedia.org)
  • cells
  • IL-11 has multiple effects on both hematopoietic and nonhematopoietic cells. (cellsciences.com)
  • Under these conditions, IL-6 and IL-11 induced the formation of multinucleated cells which were positive for TRAP, VNR, and calcitonin receptor and capable of lacunar resorption. (ox.ac.uk)
  • The majority of interleukins are synthesized by helper CD4 T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. (wikipedia.org)
  • The name is something of a relic, though (the term was coined by Dr Vern Paetkau, University of Victoria) it has since been found that interleukins are produced by a wide variety of body cells. (wikipedia.org)
  • These factors, which include interleukin 2 (IL2), are secreted by lectin- or antigen-stimulated T cells, and have various physiological effects. (wikipedia.org)