• precursor
  • Molecular cloning of the Interleukin 1 Beta converting enzyme is generated by the proteolytic cleavage of an inactive precursor molecule. (wikipedia.org)
  • However, when mice with this genetic deletion have wild-type neural precursor cells injected into their hippocampus and these cells are allowed to mature into astrocytes containing the interleukin-1 receptors, the mice exhibit normal hippocampal-dependent memory function, and partial restoration of long-term potentiation. (wikipedia.org)
  • protein
  • The human IL-11 gene , consisting of 5 exons and 4 introns , is located on chromosome 19 , and encodes a 23 kDa protein. (wikidoc.org)
  • The name "interleukin" was chosen in 1979, to replace the various different names used by different research groups to designate interleukin 1 (lymphocyte activating factor, mitogenic protein, T-cell replacing factor III, B-cell activating factor, B-cell differentiation factor, and "Heidikine") and interleukin 2 (TSF, etc. (wikipedia.org)
  • 2017
  • A number of studies reported IL-11 as a possible cancer progression marker suggesting that therapeutic targeting of IL-11 or IL11RA in humans may be beneficial, however as of 2017 clinically relevant IL-11 signalling antagonists were still under development. (wikidoc.org)
  • human
  • IL-11 is a member of a family of human growth factors and is being produced in the bone marrow of healthy adults. (wikipedia.org)
  • endometrial
  • Endometrial IL-11, IL-11 receptor alpha (IL-11Ralpha), LIF and pSTAT3 in women with primary unexplained infertility was compared to normal fertile women during the implantation window. (sigmaaldrich.com)
  • This is the first demonstration of reduced endometrial pSTAT3 and IL-11 in some women with unexplained infertility. (sigmaaldrich.com)
  • gp130
  • Signal transduction is initiated upon binding of IL-11 to IL-11Ralpha and gp130, facilitating the homodimerization of gp130 molecules. (wikidoc.org)
  • Osteoclastogenesis induced by IL-6 and IL-11 was inhibited by the addition of an anti-gp130 antibody but not by osteoprotegerin. (ox.ac.uk)
  • progression
  • Patients receive epoetin alfa subcutaneously on day 1 of weeks 1, 3, 5, 7, 9, and 11 in the absence of disease progression or unacceptable toxicity. (knowcancer.com)
  • adults
  • The purpose of this study is to determine the biologic efficacy and safety of rhIL-11 when given subcutaneously in adults with moderate or mild hemophilia A or Von Willebrand disease unresponsive to DDAVP. (clinicaltrials.gov)
  • Function
  • The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. (wikipedia.org)
  • cells
  • IL-11 has multiple effects on both hematopoietic and nonhematopoietic cells. (cellsciences.com)
  • Under these conditions, IL-6 and IL-11 induced the formation of multinucleated cells which were positive for TRAP, VNR, and calcitonin receptor and capable of lacunar resorption. (ox.ac.uk)
  • The majority of interleukins are synthesized by helper CD4 T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. (wikipedia.org)
  • The name is something of a relic, though (the term was coined by Dr Vern Paetkau, University of Victoria) it has since been found that interleukins are produced by a wide variety of body cells. (wikipedia.org)
  • These factors, which include interleukin 2 (IL2), are secreted by lectin- or antigen-stimulated T cells, and have various physiological effects. (wikipedia.org)
  • cell
  • The interleukin was N- or O-glycosylated at specific positions within the non-core region, and the functional consequences of these modifications were examined in cell-based as well as biophysical assays. (jimmunol.org)
  • minutes
  • 25 microgram/kg IL-11 by subcutaneous injection once daily for four days, followed by DDAVP 0.3 microgram/kg by intravenous infusion over 30 minutes on day 4, 30 minutes after IL-11. (clinicaltrials.gov)
  • miR10 reappears by stage 11 (320-440 minutes post-fertilisation), where it is found in the ventral nerve cord, posterior midgut and hindgut. (wikipedia.org)