Interacts tumor suppressor proteins. Medical search. Frequent questions

Furthermore, lncRNA-AK058003 acts as a tumor suppressor, suppressing hepatocellular carcinoma cell proliferation and metastasis in vitro and in vivo . (oncotarget.com)
This protein acts as a tumor suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. (medlineplus.gov)
In order to further examine the possibility that PTPRD acts as a tumor suppressor gene in neuroblastoma, we initially analyzed the levels of PTPRD mRNA transcripts in a set of 88 neuroblastoma tumors using the R2: microarray analysis and visualization platform ( http://r2.amc.nl ) (University of Amsterdam). (biomedcentral.com)
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. (caslab.com)
Gaur et al suggest FLCN acts as a tumor suppressor by negatively regulating rRNA synthesis. (medscape.com)

Meanwhile, the DOC-2/DAB2 interacting protein DAB2IP was previously identified as a member of the Ras-GTPase activating protein family, and functions as a tumor suppressor in cancer progression 7 , 8 . (nature.com)
ARTS (Sept4_i2) is a mitochondrial pro-apoptotic protein that functions as a tumor suppressor. (huji.ac.il)

HPV types relies on the role of their major oncoproteins E6 and E7, which bind, inactivate and degrade the two major cellular tumor-suppressor gene products, p53 and the retinoblastoma tumor-suppressor protein (pRb), respectively. (srce.hr)
It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. (anticorps-enligne.fr)

This study aimed to evaluate the expression levels of miR-34a and 11 of its bioinformatically selected target genes and proteins to test their potential dysregulation in RCC. (hindawi.com)
Briefly, miRNAs are expected to account for 1-5% of the human genome and to interfere with at least 30% of the protein-coding genes ( 4 , 5 ). (frontiersin.org)
have uncovered a key tumor suppressor among those genes frequently lost on chromosome 20. (elifesciences.org)
p53 and BRCA are the well-known tumor suppressor proteins, that regulate downstream genes in response to numerous cellular stress and are frequently mutated in human cancer. (substack.com)
Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS . (lookformedical.com)
The Nrf2-signaling pathway mediates multiple avenues of cytoprotection by activating the transcription of more than 200 genes that are crucial in the metabolism of drugs and toxins, protection against oxidative stress and inflammation, as well as playing an integral role in stability of proteins and in the removal of damaged proteins via proteasomal degradation or autophagy. (dundee.ac.uk)
Sometimes the increased risk is due to a single gene and sometimes it is due to several genes interacting together. (msdmanuals.com)
These genes produce proteins that regulate growth and alter cell division and other basic cell properties. (msdmanuals.com)
Tumor suppressor genes normally suppress the development of cancers by coding for proteins that repair damaged DNA or suppress the growth of cancerous cells. (msdmanuals.com)

Her focus of research is the role of estrogen and thyroid hormones in colon cancer progression and their effects on inflammatory components of the tumor microenvironment, in a big female cohort. (lu.se)

ARTS binds and inhibits XIAP (X-linked Inhibitor of Apoptosis protein) by interacting with its Bir3 domain. (huji.ac.il)
Moreover, Debcl and Drp1 can interact and Buffy inhibits this interaction. (sdbonline.org)
This gene encodes a tumor suppressor protein that inhibits DNA synthesis and oncogenic transformation through association with the retinoblastoma 1 protein. (utsouthwestern.edu)

Phosphorylation of the Mdm2 oncoprotein by the c-Abl tyrosine kinase regulates p53 tumor suppression and the radiosensitivity of mice. (umassmed.edu)
Protein tyrosine phosphatase receptor delta (PTPRD) is a member of a large family of protein tyrosine phosphatases which negatively regulate tyrosine phosphorylation. (biomedcentral.com)
The phosphoinositide 3-kinase (PI3K)/RAC seine/threonine-protein kinase (AKT)/mechanistic target of rapamycin (mTOR) signaling pathway is a promising therapeutic target owing to its frequent dysregulation in HCC and the critical functions it has in regulating cell survival, proliferation, apoptosis, migration and angiogenesis through phosphorylation of distinct protein substrates ( 6 , 7 ). (spandidos-publications.com)
Overexpression of DAB2IP's rat homolog DIP, but not its mutant defective in Ras GTPase activating protein activity, reverses miR431 's effect on promoting invasion, Erk phosphorylation, and epithelial-mesenchymal transition of PNETs. (quanterix.com)
PHOSPHORYLATION of IRF-3 causes the protein to be translocated from the CYTOPLASM to CELL NUCLEUS where it binds DNA , and activates transcription. (lookformedical.com)
This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. (creative-biolabs.com)

As a molecular mechanism, we demonstrate that PTPRD interacts with aurora kinase A (AURKA), an oncogenic protein that is over-expressed in multiple forms of cancer, including neuroblastoma. (biomedcentral.com)
This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)
This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. (cancerindex.org)
These complexes interact with 5'-AMP-activated protein kinase (AMPK) that is part of the mechanistic target of rapamycin (mTOR) pathway, which is involved in cellular energy, cytokinesis, cell motility, cellular adhesion, and nutrient sensing. (medscape.com)
The RAC serine/threonine-protein kinase (AKT) family of serine/threonine protein kinases, particularly the AKT1 isoform, has been identified abnormally expressed in hepatocellular carcinoma (HCC) cells, and is highly associated with cell behavior, including proliferation, survival, metabolism, and tumorigenesis. (spandidos-publications.com)
The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene.The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. (novusbio.com)
The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. (novusbio.com)
In the early embryo, a myosin II-dependent contraction of the cortical meshwork asymmetrically distributes the highly conserved PDZ proteins PAR-3 and PAR-6, as well as an atypical protein kinase C (PKC-3), to the anterior. (biologists.com)
The PAR proteins include the PDZ domain-containing PAR-3 and PAR-6, the atypical protein kinase PKC-3, the serine/threonine kinase PAR-1 and, in nematodes, the putative ubiquitin E3 ligase PAR-2. (biologists.com)

Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
The first miRNA was discovered in 1993 by Lee, Freinbaum and Ambros ( 6 , 7 ), and since then an increasing load of literature data have pointed that they can act as both tumor suppressors and oncogenes ( 1 - 3 ). (frontiersin.org)

Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. (genetex.com)
Antibody-mediated blockade of BTNL2 attenuates tumour progression in multiple in vivo murine tumour models, resulting in prolonged survival of tumour-bearing mice. (bvsalud.org)
53BP2, a p53-interacting protein, enhances p53 transactivation, impedes cell cycle progression, and promotes apoptosis through unknown mechanisms. (ox.ac.uk)
The role of cell cycle checkpoint proteins is to integrate internal and external factors to determine whether the cell is prepared for progression of the cell cycle. (ptgcn.com)
These mediators and their receptors are enriched in colon cancer cells and colon cancer tissues, which demonstrate there, contribute to tumor development and progression. (lu.se)

What pathways are this gene/protein implicaed in? (cancerindex.org)
Two powerful tumour suppressor pathways, controlled by the p53 and retinoblastoma (pRB) proteins, are important for establishing and maintaining the senescence growth arrest. (nature.com)
These pathways respond to somewhat different stimuli but interact and cooperate to control the senescence response. (nature.com)
Both, E6 and E7 co-operate to induce transformation of epithelial cells by interacting with numerous host cell proteins affecting many essential cellular pathways. (srce.hr)
The Warburg phenotype constitutes a metabolic signature of 70-80% of human cancers, which results from the interplay between the normoxic/hypoxic activation of the transcription factor hypoxia-inducible factor-1 (HIF-1), oncogene activation, loss of function of tumour suppressors, altered signalling pathways and interaction with components of the tumour microenvironment (TME), sometimes working in concert with epigenetic mechanisms. (substack.com)
She is investigating two different ligands and their receptive G-protein coupled receptors WNT5A/Frizzle and cysteinyl leukotriene C4/CysLTR2 signaling pathways which both upregulates 15-PGDH and induce re-differentiation of colon cancer cells. (lu.se)
Associations between tumor hypoxia and aggressively malignant phenotypes are observed across a range of cancers, focusing attention on molecular dissection of these pathways and how they contribute to tumorigenesis. (lu.se)

1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)
In addition to this there is evidence that some tumour inhibitory agents (1,25-dihydroxycholecalciferol and transforming growth factor (TGF)-β) may up-regulate the expression of COM-1 and result in cell growth arrest ( 11 , 12 ). (iiarjournals.org)

Collectively, lncRNA-AK058003 can reduce the expression of mRNA stabilizing protein HuR and act as a precursor of miR-15a to suppress γ-synuclein-mediated cell proliferation and the metastasis of hepatocellular carcinoma. (oncotarget.com)
COM-1, candidate of metastasis-1, otherwise known as p8, is a primarily nuclear protein initially discovered within the last decade by the differential display of cDNA from breast cancer metastases within the brains of athymic nude rats. (iiarjournals.org)
Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. (anticorps-enligne.fr)

In uveal melanomas, expression of this protein is silenced in rapidly metastasizing and metastatic tumor cells but has normal expression in slowly metastasizing or nonmetastasizing tumor cells. (modellab.cn)

Clinical and morphologic review of 60 hereditary renal tumors from 30 hereditary renal cell carcinoma syndrome patients: lessons from a contemporary single institution series. (medscape.com)
Clear cell renal cell carcinoma (ccRCC) is characterized by a loss of the tumor suppressor gene VHL, and hence this tumor type is characterized by constitutive activation of the hypoxic response. (lu.se)

Mechanistically, BTNL2 interacts with local Î³Î´ T cell populations to promote IL-17A production in the tumour microenvironment. (bvsalud.org)
The tumor microenvironment in the context of colon cancer and with a focus on the inflammatory mediators leukotriene D 4 (LTD 4 ) and prostaglandins (PGE 2 ) and their respective receptors. (lu.se)
Our aim is to generate solid support for novel and complementary treatments of colon cancer patients that focus on the inflammatory component of the tumor microenvironment. (lu.se)
I am interested in colon cancer, one of the most common cancers in the world, and specifically how the microenvironment and cancer interact with one another. (lu.se)
We investigate how the lack of these receptors affects tumour growth and the surrounding tumour microenvironment in different colon cancer models. (lu.se)
It´s still not clear what role the infiltration of neutrophils in colorectal cancer have and how many types of neutrophils exist that interact with cancer and its effect on CRC microenvironment. (lu.se)
Her focus is to target the tumor microenvironment for developing new and effective therapeutic strategies. (lu.se)

This may include oncomir (oncogenic miRNA) inhibition, or tumor suppressor-miRNA replacement therapies [ 6 , 9 ]. (hindawi.com)
lncRNA-AK058003 can reduce mRNA stabilizing protein HuR, which results in the inhibition of the expression of γ-synuclein. (oncotarget.com)
Impact of TMPRSS2 Expression, Mutation Prognostics, and Small Molecule (CD, AD, TQ, and TQFL12) Inhibition on Pan-Cancer Tumors and Susceptibility to SARS-CoV-2. (cdc.gov)

Schwannomin, a member of the 4.1 family of proteins, which are known to link the cytoskeleton to the plasma membrane, has little known function other than its ability to suppress tumor growth. (wustl.edu)
William Kaelin, Jr. was in 1995 engaged in the study of the von Hippel-Lindau tumor suppressor gene, and after isolation of the first full-length clone of the gene showed that it could suppress tumor growth in VHL mutant tumorigenic cell lines. (nobelprize.org)

As a member of the BCL2 protein family, BAK1 functions as a pro-apoptotic regulator involved in a wide variety of cellular activities. (wikipedia.org)
Abdul Hamid, N, Brown, C & Gaston, K 2009, ' The regulation of cell proliferation by the papillomavirus early proteins ', Cellular and Molecular Life Sciences , vol. 66 (10), pp. 1700 - 1717. (bris.ac.uk)
Campisi, J. Cellular senescence as a tumor-suppressor mechanism. (nature.com)
This protein is believed to be involved in several important cellular functions involving protein production. (medlineplus.gov)
577Role of Cellular Proteins in RV Replication. (vdocuments.net)
Mitochondrial porin , also known as the voltage-dependent anion channel (VDAC), is a multi-functional channel protein that shuttles metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions. (sdbonline.org)
This suggests that UV damage activates cellular factors that can relieve the p53-mediated suppression of 53BP2 protein. (ox.ac.uk)

Its ability to ubiquitinate p53 is regulated by TUMOR SUPPRESSOR PROTEIN P14ARF. (umassmed.edu)

This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. (caslab.com)
The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. (anticorps-enligne.fr)

We are investigating how Pbx and Meis proteins contribute to the specificity of Hox function in development and how disruption of their activities leads to neoplasia. (stanford.edu)

Proto-Oncogene Proteins c-mdm2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
This graph shows the total number of publications written about "Proto-Oncogene Proteins c-mdm2" by people in this website by year, and whether "Proto-Oncogene Proteins c-mdm2" was a major or minor topic of these publications. (umassmed.edu)
Below are the most recent publications written about "Proto-Oncogene Proteins c-mdm2" by people in Profiles. (umassmed.edu)

A Ras GTPase activating protein tumor suppressor, DAB2 interacting protein ( DAB2IP ), was discovered as an miR431 target. (quanterix.com)
In this study, we demonstrated that the loss of DOC-2/DAB2 interacting protein (DAB2IP) is responsible for TMZ-resistance in GBM through ATG9B. (nature.com)

Most of the MEN1 gene mutations that cause multiple endocrine neoplasia type 1 lead to the production of an abnormally short, inactive version of menin or an unstable protein that is rapidly broken down. (medlineplus.gov)
RBM8A gene mutations that cause TAR syndrome reduce the amount of RNA-binding motif protein 8A in cells. (medlineplus.gov)
People with either an RBM8A gene mutation and a chromosome 1 deletion or with two gene mutations have a decreased amount of RNA-binding motif protein 8A. (medlineplus.gov)
Suppressor gene mutations, inherited from a parent, may underlie a certain percentage of cases of breast cancer, usually occurring at a young age and in multiple family members. (msdmanuals.com)

Western Blot: ROR alpha/NR1F1 Antibody [NBP1-52813] - Western blot analysis of RORa expression in NP tissues isolated from three rats showed positive expression of the protein. (novusbio.com)
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. (lookformedical.com)
Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. (cusabio.com)
Importantly, we find that a monoclonal antibody against BTNL2 attenuates colorectal tumorigenesis in mice and that the mBTNL2-Fc recombinant protein has a therapeutic effect in a dextran sulfate sodium (DSS)-induced colitis model. (bvsalud.org)

The viral E2 protein regulates transcription of E6 and E7 and thereby has an indirect effect on cell proliferation. (bris.ac.uk)

Sager, R. Senescence as a mode of tumor suppression. (nature.com)
[ 42 ] Another study by Nahorski et al demonstrated tumor suppression by the interaction of p0071 (plakophilin-4, a potential novel folliculin-interacting protein) and the regulation of RhoA. (medscape.com)

It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. (wikipedia.org)
The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)

S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein p53 and BRCA: an in silico study. (cdc.gov)
Here, we have investigated the interaction of S2 subunit to tumor suppressor and cell cycle-related proteins. (substack.com)
HADDOCK 2.2 software was used to analyze the interaction and found that S2 subunit of SARS-nCov-2 strongly interacts with p53 and BRCA-1/2 proteins. (substack.com)

Aberrant splicing of the 5' UTR also has been noted in neuroblastoma cell lines and primary tumors, which could potentially cause destabilization of the mRNA sequence [ 10 ]. (biomedcentral.com)
These functions include helping to transport molecules called messenger RNA (mRNA), which serve as the genetic blueprint for making proteins. (medlineplus.gov)
RNA-binding motif protein 8A likely carries mRNA molecules from the nucleus to areas of the cell where proteins are assembled. (medlineplus.gov)
It may also be involved in controlling how the instructions in mRNA molecules are used to build proteins and in destroying mRNA that is defective or not needed. (medlineplus.gov)
Materials and Methods: The expression of COM-1 mRNA was examined using a quantitative polymerase chain reaction (PCR) technique together with immunohistochemistry to examine expression and distribution of the COM-1 protein in human colorectal carcinoma and matched normal colorectal mucosa. (iiarjournals.org)

Many of the mutations in the MEN1 gene that are associated with familial isolated hyperparathyroidism change single protein building blocks (amino acids) in the menin protein. (medlineplus.gov)
As a result of these mutations, one copy of the MEN1 gene in each cell makes no functional protein. (medlineplus.gov)
Scope includes mutations and abnormal protein expression. (cancerindex.org)

A hydrophobic groove formed along the C-terminal of α2 to the N-terminal of α5, and some residues from α8, binds the BH3 domain of other BCL-2 proteins in its active form. (wikipedia.org)
MDM2 binds a subset of peptide motifs corresponding to real proteins with a range of allosteric responses to MDM2 ligands. (ed.ac.uk)
PNC-27 is a synthesised anti-cancer protein that binds HDM-2 and blocks it from interacting with the tumour suppressor protein p53. (pharmagrade.store)

Mutation of the APC gene occurs in a high percentage of colorectal tumors and is a central event driving tumor initiation in the large intestine. (duke.edu)
Here, we present evidence that butyrophilin-like protein 2 (BTNL2) is required for colorectal IL-22 production, and BTNL2 knockout mice show decreased colonic tumorigenesis and more severe colitis phenotypes than control mice due to defective production of IL-22. (bvsalud.org)

This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. (genetex.com)

abstract = "The neurofibromatosis 2 tumor suppressor protein schwannomin/merlin is commonly mutated in schwannomas and meningiomas. (wustl.edu)
abstract = "Linear motifs mediate protein-protein interactions (PPI) that allow expansion of a target protein interactome at a systems level. (ed.ac.uk)

The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
Cyclin-dependent kinases and tumor suppressor proteins are stimulators and modulators of cell division. (ptgcn.com)

Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. (rndsystems.com)
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. (rndsystems.com)
This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag. (cusabio.com)

is a protein that consists of 403-amino acids. (proteopedia.org)
Mouse IGSF4A cDNA encodes 445 amino acids including a signal peptide, three Ig-like domains (a V-type, a divergent C1-type and an I-type), a transmembrane domain and a cytoplasmic domain with protein 4.1 and PDZ domain binding sites. (rndsystems.com)
The breast and ovarian cancer susceptibility gene BRCAl has been recently cloned and revealed an open reading frame of 1863 amino acids, but a lack of significant homology to any known protein in the database has led to few clues about its functions. (um.es)

FLNC has two known binding partners, FLNC-interacting protein 1 (FNIP1) and FLNC-interacting protein 2 (FN1P2). (medscape.com)
In recent studies, renal and pulmonary tumors in Birt-Hogg-Dubé syndrome appear to follow the two-hit tumorigenesis theory relating to the interaction of folliculin with the FLCN-interacting protein 1 (FNIP1) and FLCN-interacting protein 2 (FNIP2). (medscape.com)

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. (genetex.com)
Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor. (medlineplus.gov)

The protein encoded by RORA is a member of the NR1 subfamily of nuclear hormone receptors. (novusbio.com)
The APC protein performs multiple tumor suppressor functions including negative regulation of the canonical WNT signaling pathway by both cytoplasmic and nuclear mechanisms. (duke.edu)
Normal tissues demonstrated strong nuclear and peri-nuclear staining for COM-1 on immunohistochemistry (IHC) and in tumour tissues, the level of staining was found to be much greater, with a greater degree of cytoplasmic staining and little nuclear staining. (iiarjournals.org)
Nrf2 interacts with other important cell regulators such as tumor suppressor protein 53 (p53) and nuclear factor-kappa beta (NF-kappa B) and through their combined interactions is the guardian of healthspan, protecting against many age-related diseases including cancer and neurodegeneration. (dundee.ac.uk)

The molecular mechanism, however, by which PTPRD renders a tumor suppressor effect in neuroblastoma is unknown. (biomedcentral.com)
PTPRD has a tumor suppressor function in neuroblastoma through AURKA dephosphorylation and destabilization and a downstream destabilization of MYCN protein, representing a novel mechanism for the function of PTPRD in neuroblastoma. (biomedcentral.com)
However, the overall response rate to these treatments is low, suggesting that immune checkpoint activation is not the only mechanism leading to dysfunctional anti-tumour immunity. (bvsalud.org)

One difference from PTEN compared to other know Protein Tyrosine Phosphatases (PTPs) is the location of two Lys residues in the center of the Walker Loop. (proteopedia.org)
Ectopic up-regulation of PTPRD in neuroblastoma dephosphorylates tyrosine residues in AURKA resulting in a destabilization of this protein culminating in interfering with one of AURKA's primary functions in neuroblastoma, the stabilization of MYCN protein, the gene of which is amplified in approximately 25 to 30% of high risk neuroblastoma. (biomedcentral.com)
Protein tyrosine phosphatase receptor delta ( PTPRD ) is an important regulator of axon growth and guidance and is highly expressed in the central nervous system where it functions as a transmembrane homophilic neuronal cell adhesion molecule [ 1 ]. (biomedcentral.com)

This illustration shows the dynamic interactions of anti-cancer drug EGCG with the transactivation domain (TAD) of tumor suppressor protein p53. (umass.edu)

The inactive form of BAK1 is maintained by the protein's interactions with VDAC2, Mtx2, and other anti-apoptotic members of the BCL2 protein family. (wikipedia.org)
It has been previously shown that rbf1 pro-apoptotic activity depends on its ability to decrease the level of anti-apoptotic proteins such as the Bcl-2 family protein Buffy. (sdbonline.org)

Neuroblastoma is a major childhood cancer arising from precursor cells of the sympathetic nervous system which is known to acquire deletions and alterations in the expression patterns of PTPRD , indicating a potential tumor suppressor function for this gene. (biomedcentral.com)
Neuroblastoma is derived from primitive cells of the sympathetic nervous system, and is the most common extracranial solid tumor in children accounting for 15% of all childhood cancer deaths [ 13 ]. (biomedcentral.com)
We further demonstrate that PTPRD has a tumor suppressor function in neuroblastoma through dephosphorylating and destabilizing AURKA, leading to a downstream decrease of MYCN protein. (biomedcentral.com)
Differential Expression of Multiple Disease-Related Protein Groups Induced by Valproic Acid in Human SH-SY5Y Neuroblastoma Cells. (anticorps-enligne.fr)

Therapeutic blockade of the immune checkpoint proteins programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte antigen 4 (CTLA4) has transformed cancer treatment. (bvsalud.org)
B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)
We have also defined as a novel ccRCC specific biomarker, SLC6A3, and explore the diagnostic and therapeutic potential of this protein. (lu.se)

The encoded protein also interacts with a complex of other cell cycle regulators to repress cell cycle-dependent gene expression in non-dividing cells. (utsouthwestern.edu)

PTEN is a dual phosphatase and tumor suppressor protein that interacts with LKB-1. (proteopedia.org)
PTEN works with tumor suppressing for cancers, such as breast and prostate cancer. (proteopedia.org)
PTEN's relevance is that without the PTEN suppressing tumors, you would have a higher increased odds of having multiple cancers, including but not limited to Breast and Prostate cancer. (proteopedia.org)
Crystal Structure of the PTEN Tumor Suppressor: Implications for Its Phosphoinositide Phosphatase Activity and Membrane Association. (proteopedia.org)
This was demonstrated by the somatic PTEN deletion in parotid tumors in addition to the germline loss of FLCN , thereby following a model of compound heterozygosity, instead of the classic two-hit mutation. (medscape.com)

Pradella et al suggest that FLCN may not always follow a classic two-hit model of tumorigenesis and may alternatively be a noncanonical tumor suppressor gene. (medscape.com)

However, prior to these integration events, E2 can interact directly with the E6 and E7 proteins and modulate their activities. (bris.ac.uk)

One example is the conserved Drosophila tumor-suppressor protein Lethal giant larvae (Lgl). (biologists.com)
Glioblastoma multiforme (GBM) is the most prevalent primary malignant brain tumor and, remains one of the most lethal cancers, with a median survival of only 15 months upon diagnosis 1 . (nature.com)

The key role of checkpoint proteins is to detect DNA damage and send a signal to delay cell cycle advance until the damaged chromosomes are repaired (Figure 1). (ptgcn.com)

AMHERST, Mass. - Jianhan Chen , a University of Massachusetts Amherst chemistry and biochemistry and molecular biology professor, has received a five-year, $2 million National Institutes of Health (NIH) grant to support research in his computational biophysics lab aimed at better understanding the role of intrinsically disordered proteins (IDPs) in biology and human disease. (umass.edu)

The passage of a cell through the cell cycle is controlled by proteins in the cytoplasm. (ptgcn.com)
This protein may have a role in cell-cycle control by interacting with the Cdk1/cyclinB1 complex. (modellab.cn)

The main goal of RT consists in delivering a precise dose of radiation in a target volume, such as tumor, promoting the tumor cells eradication with as minimal damage as possible in surrounding normal tissues ( 13 ). (frontiersin.org)
In tumour tissues, 43.6% of samples expressed COM-1, at a level of 98.9 copies of COM-1 transcript per sample (p=0.012). (iiarjournals.org)
In prostate tissues, we have shown that cancer tissues have significantly reduced expression of COM-1 protein compared to normal prostate tissue whereas prostate cancer cell lines widely expressed COM-1. (iiarjournals.org)
We have observed that no studies have examined the expression of COM-1 in tumours of the lower gastrointestinal tract and as such have set out to examine quantitatively the expression of COM-1 in carcinomas and matched normal tissues of the colon and rectum and to examine the localisation of COM-1 protein within the tissues. (iiarjournals.org)
This gene encodes a tumor suppressor protein that is ubiquitously expressed in normal tissues. (modellab.cn)
[ 35 ] Expression of the Birt-Hogg-Dubé syndrome protein has been widespread in a variety of tissues, including the kidneys, lungs, and skin. (medscape.com)
Solid tumors are consistently less well-oxygenated than the normal tissues from which they arise. (lu.se)

Occupational exposure limits with proteins such as topoisomerase inhibitors, and mitotic and meiotic spindle poisons. (cdc.gov)

Without normal menin function, cells likely divide too frequently, leading to the formation of tumors involving the parathyroid glands. (medlineplus.gov)
Until relatively recently, it was thought that proteins needed to adopt a well-defined structure to perform their biological function. (umass.edu)
But about two decades ago, Chen explains, IDPs were recognized as a new class of proteins that rely on a lack of stable structures to function. (umass.edu)
Our goal is really trying to combine simulation and experiments in collaboration with other labs to tease out what are the hidden features of these disordered proteins that are crucial to their function," Chen says. (umass.edu)
Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. (cusabio.com)
MDM2 is a multi-functional protein with over one hundred known binding partners not stratified by hierarchy or function. (ed.ac.uk)
Cancer is more likely when DNA damage impairs tumor suppressor gene function, allowing affected cells to multiply continuously. (msdmanuals.com)

The modified cells are able to expand more robustly than normal cells, and this dominance induced by downregulation of the tumor suppressor increases the risk of malignancy. (elifesciences.org)
It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. (lookformedical.com)

Anatomy17

Organisms8

Diseases31

Chemicals and Drugs96

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes75

Disciplines and Occupations1

Information Science3

Health Care1

Acts as a tumor5

Functions as a tumor suppressor2

Retinoblastoma tumor-suppressor protein2

Genes9

Components of the tumor microenvironment1

Inhibits3

Phosphorylation6

Kinase9

Oncogenes2

Progression5

Pathways7

Regulate2

Metastasis3

Nonmetastasizing tumor cells1

Renal cell carc2

Microenvironment7

Inhibition3

Suppress tumor growth2

Cellular7

P14ARF1

Histone deacetylase2

Specificity1

Proto-Oncogene3

DAB22

Gene mutations4

Antibody4

Regulates1

Suppression2

Mitochondrial3

Subunit3

MRNA5

Mutations3

Binds3

Colorectal2

Expression of this gene1

Abstract2

Kinases2

Recombinant protein3

Amino Acids3

FNIP12

Highly conserved2

Nuclear4

Mechanism3

Tyrosine3

Transactivation1

Anti-apoptotic2

Neuroblastoma4

Therapeutic3

Regulators1

PTEN5

Tumorigenesis1

Modulate1

Lethal2

Checkpoint proteins1

Intrinsically disordered1

Cell cycle2

Tissues7

Inhibitors1

Function7

Increases2