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  • Nested pharmacokinetic studies will evaluate anti-tuberculosis drug concentrations, providing model-based predictions for optimal dosing, and measure antiretroviral exposures in order to describe the drug-drug interactions in a subset of HIV-infected children. (biomedcentral.com)
  • Ethambutol is used with other medications to treat tuberculosis (TB). (healthwarehouse.com)
  • Ethambutol is utilized to treat tuberculosis (TB). (llclinic.com)
  • Avoid administering aluminum hydroxide containing antacids for at least 4 hr following ethambutol dose. (medscape.com)
  • 95% CI, 1.19-5.45) in patients with TB who received more than 60 defined daily doses (DDDs) of ethambutol, and the effect was dose-dependent. (psychiatrist.com)
  • PTB patients had a higher risk of incident depressive disorder, particular in those with an ethambutol dose of more than 60 DDDs. (psychiatrist.com)
  • Ethambutol can be found in fixed dose combinations. (llclinic.com)
  • There is the potential for significant drug interactions and overlapping toxicities in patients receiving medications for treatment or prevention of opportunistic infections (OIs). (hiv.gov)
  • Table 5 provides clinicians with information regarding known or suspected drug interactions between drugs commonly used for treatment or prevention of HIV-associated OIs and treatment of HIV infection. (hiv.gov)
  • It is difficult to predict the interaction potential when three or more drugs with similar metabolic pathways are co-administered and there is substantial inter-patient variability in the magnitude of these interactions. (hiv.gov)
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  • At the same time it also avoids interactions with antiretroviral drugs, improving treatment for the millions of HIV-TB co-infected patients. (citizen-news.org)
  • Ethambutol interferes with RNA synthesis, causing suppression of Mycobacteria multiplication. (medicscientist.com)
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  • Protein structure and interaction modelling are used to understand the functional effects of putative mutations and provide insight into the molecular mechanisms leading to resistance. (biomedcentral.com)
  • Unfortunately, at the current time there's limited data that can be found on the clinical importance of low-level ethambutol resistance. (llclinic.com)
  • Therefore, there is a critical need to expand our understanding of the interaction between the microorganism and xenobiotics and various mechanisms of resistance presented by Mtb , identify new anti-TB chemical matter, expand our knowledge of microorganism and host interaction, and establish molecular targets for host-directed therapy. (nature.com)
  • In addition, the effect of identified candidate mutations on protein stability and interactions was assessed quantitatively with well-established computational methods. (biomedcentral.com)
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  • Patients that are too young or that are otherwise not able to comprehend this warning shouldn't receive ethambutol. (llclinic.com)
  • Regimens for TB have been developed for patients, depending on their HIV status, the prevalence of multidrug-resistant disease in the community, drug allergies, and drug interactions. (unboundmedicine.com)
  • RÉSUMÉ Nous avons comparé l'efficacité de deux schémas thérapeutiques de la tuberculose à bacilles résistant à l'isoniazide chez 42 patients fréquentant un centre spécialisé dans le traitement de la tuberculose en République islamique d'Iran. (who.int)
  • Les patients ont été répartis en deux groupes thérapeutiques : 26 ont reçu le traitement HRZE standard de 6 mois et 16 ont reçu un traitement RZE modifié pendant 6 mois. (who.int)
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  • In particular, protease inhibitors and non-nucleoside reverse transcriptase inhibitors affect the CYP450 or other transporter systems and may be associated with clinically significant drug interactions. (hiv.gov)
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  • Please see Adult OI guidelines for information about drug interactions, including warnings about interactions between boceprevir and HIV protease inhibitors. (hiv.gov)
  • Abstract: Drug-drug interaction due to enzymatic inhibition is the focus of this research. (tufts.edu)
  • Two different projects to address separate questions of drug-drug interaction were carried out applying the in vitro approaches. (tufts.edu)
  • When possible, alternative agents with less drug interaction potential or use of therapeutic drug monitoring should be considered. (hiv.gov)
  • Ethambutol can lead to vision problems that might be considered a sign that you must stop taking the medicine. (llclinic.com)
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  • Ask your pharmacist any questions you might have relating to Ethambutol, particularly when it's new to you. (llclinic.com)
  • The integrase inhibitor raltegravir is metabolized by UGT1A1 and may be a suitable option when trying to minimize interactions with other drug classes. (hiv.gov)
  • Ethambutol is an antibiotic and works by stopping the growth of bacteria. (healthwarehouse.com)
  • Drug interaction information is generally obtained from studies involving healthy adult volunteers. (hiv.gov)