Interactions characterization drug carriers. Medical search. Frequent questions

We developed a surface proteomicsmethod for a rapid and systematic analysis of the interphasebetween the nanoparticle protein corona and the targeting cellsthat could implement the rapid prototyping of nanomedicines.Native nanoparticles entering in a protein-rich liquid mediaquickly form a macromolecular structure called protein corona.This protein structure defines the physical interaction betweennanoparticles and target cells. (diva-portal.org)
Paper I: deals with the simplification of functional characterization for nanoparticles intended for use in biomedicine. (diva-portal.org)
This could be beneficial in predicting the interactions between nanoparticles and a biological entity like the cell or a receptor protein and provide initial valuable information related to targeting, uptake and safety. (diva-portal.org)
Nanoparticles in contact with and to the body interact with the ligand bound to the drug. (chemistryexamhero.com)
Moreover, nanoparticles with higher micellar drug densities react with the drug on the ligand through the interaction with cytoplasmic proteins. (chemistryexamhero.com)
Several publications have been discussed concerning the possibilities of nanosafety technique in drug delivery carriers, demonstrating the efficient and significant use of nanoparticles. (chemistryexamhero.com)
Usually the paper about the safety of the nanoparticles has to be cited or articles published, especially the ones named as publication concerning nanomaterials in the field of electrochemical drug delivery are lacking for the use of nanomaterials, so the paper does not intend for the actual selection of authors to cite, so the decision is being difficult. (chemistryexamhero.com)
Recently more focus has been put to the development of innovative drug-delivery systems that includes liposomes and solid lipid nanoparticles (SLNs). (scialert.net)
Solid lipid nanoparticles (SLN) containing stabilized lipid dispersions have been designed as an alternative colloidal drug delivery system to polymer nanoparticles, emulsions and liposomes. (scialert.net)
My scientific activities revolve around the rational design and synthesis of inorganic and hybrid nanoparticles and bio-based nanocomposites and the study of their structural-functional properties, including the better understanding of nano/bio/interactions. (icmab.es)
SLN or solid lipid nanoparticles were suggested as advantageous alternatives to liposomes and other colloidal carriers for hydrophobic drug delivery, yet with limited loading capabilities and diminished tunable release profiles, especially for hydrophilic proteins and peptides. (uandes.cl)
Future Advances in Diagnosis and Drug Delivery in Interventional Radiology Using MR Imaging-Steered Theranostic Iron Oxide Nanoparticles. (polymtl.ca)
We work on polymer-based therapeutics and surface engineering of nanoparticles with stealth and targeting "nanoshells" and the application of advanced surface characterisation techniques, such as X-ray photon electron spectroscopy (XPS), to determine amount and arrangement on the outmost 10 nm surface that is a predominant factor in determining biological interactions. (au.dk)
This study focuses on the preparation and characterization of biopolymeric alginate and chitosan nanoparticles for encapsulating the antidepressant drug Venlafaxine XR and analyzing it as an effective drug carrier and delivery system. (ijpsr.com)
It was observed that strong electrostatic interaction exists in the nanoparticles. (ijpsr.com)
Drug delivery to inflamed colon by nanoparticles: Comparison of different strategies. (innovareacademics.in)
Lai SK, Wang YY, Hanes J. Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues. (innovareacademics.in)
Chitosan nanoparticles as a nasal drug delivery for memantine hydrochloride. (innovareacademics.in)
Kovachev P. Functionalization and Polymer Coating - Strategies to improve Drug Delivery from Mesoporous Silica Nanoparticles. (rjptonline.org)

Pristine NPs have shown a huge similarity to nanofibers in terms of their specific physicochemical characterizations. (chemistryexamhero.com)
In most cases (conventional dosage forms), only a small amount of administered dose reaches the target site, while the majority of the drug distributes throughout the rest of the body in accordance with its physicochemical and biochemical properties. (ijpsr.com)

Physical stabilization resulted from the reinforcement of intermolecular interactions in binary or ternary systems due to the synergetic effect of PVP. (intechopen.com)
The exploration still largely relies on serendipitous, because the construction requires a perfectly stable equilibrium among a series of complicated and meticulous balances, including amphipathicity, intermolecular interactions, chirality, and spatial molecular arrangement 20 . (nature.com)
Quan-tum mechanical pha-se involves exact com-putation of mo-le-cular properties relevant to drug - na-no--car-rier intermolecular interactions. (vi-seem.eu)
The research program is focused on intermolecular interactions and their manifestations in a liquid environment. (lu.se)
The theoretical basis for the description of intermolecular interactions and their consequences are treated using both quantum chemical calculations and statistical mechanical simulations. (lu.se)

Furthermore, the NMR-based structural characterization and molecular dynamics calculations revealed that the TEG interacts with bases in the G-quartet and loop via CH-pi and lone pair-pi interactions. (cobiss.net)
NMR structural study of the interaction between a small-molecule optical probe (DAOTA-M2) and a G-quadruplex from the promoter region of the c-myc oncogene revealed that they interact at 1:2 binding stoichiometry. (cobiss.net)
Self-assembling natural drug hydrogels formed without structural modification and able to act as carriers are of interest for biomedical applications. (nature.com)
Therefore,in our application, we de-ve-lop and implement new, ro-bust com-putational modeling appro-a-c-hes to stu-dy the structural and vibrational spectroscopic properties of different API`s as well as to investigate the physics and chemistry of in-ter-ac-tions between drug mo---lecules and their potential carriers, un-der realistic conditions encountered in bio-lo-gical systems. (vi-seem.eu)
Up to now, we have successfully im-p-le-men-ted our hybrid computational appro-ach to study the structural and vibrational spe-ctroscopic properties of hydrophilic drug irinotecane. (vi-seem.eu)
Recent observations raise the hypothesis that not only the drug/chemical, but also parts of the haptenated protein or peptides may constitute the important structural determinants for antigen recognition by the TCR. (frontiersin.org)
To the best of our knowledge, this is the first report depicting the formation and characterization of polyelectrolyte multi-layers on SLN and analyzing structural properties of core-shell colloids on a gold surface by QCM-D tool. (uandes.cl)
Investigators are exploiting the tremendous structural diversity of polypeptides and their biophysical properties to develop novel drug carriers. (pharmtech.com)
This study also describes the structural characterisation of the novel folatecyclodextrin conjugate using a range of techniques including electronic, vibrational, NMR, MALDI-MS and ESI-MS spectroscopies, all of which provided evidence that the folate moiety was bound to the cyclodextrin through an amide linkage. (tudublin.ie)
Structural characterization of 16 FabG-inhibitor complexes by X-ray crystallography revealed that the compounds bind at a novel allosteric site located at the FabG subunit-subunit interface. (dundee.ac.uk)

Current understanding of interactions between nanoparticle s and the immune system. (cdc.gov)
However, there are several other nanoparticle formats which have demonstrated to be promising as delivery systems for RNA and other drugs. (fleming.events)

The addition of polyvinylpyrrolidone (PVP K30), a low molecular weight molecule, into the binary solid dispersion (Ibuprofen/β-cyclodextrin), leads to a 1.5-2 folds increase in the drug intrinsic dissolution rate only after 10 min. (intechopen.com)
In fact, PVP acted as a stabilizing agent for various amorphous drug molecules by minimizing their molecular mobility. (intechopen.com)
Afterward, the FLTP method is applied in extracting the highly representative descriptors of PSSM, and the combinations of FLTP descriptors and drug molecular fingerprints are regarded as the complete features of drug-target pairs. (imrpress.com)
Molecular characterization of these benign yet rapidly proliferating tumors has been limited to evaluating a few mutations in few genes. (frontiersin.org)
but molecular and cellular characterization has been limited. (frontiersin.org)
Molecular modeling ap-proach is of substantial importance in the course of efficient design and development of conventional dosage forms as well as novel micro/nano carrier systemsforactive pharma-ceu-ti-cal ingredients - API(from in-silico to industrial level scaling). (vi-seem.eu)
molecular tools which without undesired interaction at other sites target a specific drug receptor. (tudublin.ie)
Transporters on the plasma membrane of tumor cells are promising molecular "Trojan horses" to deliver drugs and imaging agents into cancer cells. (aspetjournals.org)
This thesis focuses on the molecular interaction profiles of hSERTand hDATby using different computational methods. (univie.ac.at)
The computational part comprised characterization of the substituents with molecular descriptors, induced-fit docking, and a solvent analysis in the ligand binding pocket. (univie.ac.at)
Molecular dynamics simulations of the outward-occluded and outward-open transporter conformations, important molecular features of these states werecompared by monitoring the extra-and intracellular gating residues, permeationpathway solvation, and the protein-ligand interactions in the central binding site. (univie.ac.at)

2021) Emerging Roles of the Human Solute Carrier 22 Family . (guidetopharmacology.org)

Amorphous ternary solid dispersion has become one of the strategies commonly used for improving the solubility and bioavailability of poorly water soluble drugs. (intechopen.com)
This made it possible to overcome several challenges for drug formulations (e.g., solubility and bioavailability weakness, physical instability under stress conditions, complexation efficiency of cyclodextrin molecules). (intechopen.com)
We have shown that PVP enhanced physical stability of amorphous indomethacin under stress conditions (at RH: 75% and T = 40°C for three months), leading to the improvement of drug aqueous solubility by suppressing kaolin adsorption effect. (intechopen.com)
Cefdinir is a poorly- water-soluble drug, it belongs to Biopharmaceutical Classification System class IV, which shows that it may have limited therapeutic effects due to its low solubility and poor bioavailability. (setpublisher.com)
Poor oral bioavailability of BCS class 4 drug is due to poor aqueous solubility and poor permeability across intestine. (omicsonline.org)
Two factors govern the total oral absorption of drug i.e. drug's solubility and permeability across intestine. (omicsonline.org)
ENGLISH ABSTRACT: The delivery of many anti-inflammatory and anti-cancer drugs is hindered due to their low solubility in water, leading to poor bioavailability and therapeutic efficacy. (sun.ac.za)
Upon loading sparingly soluble drugs, an improvement in their solubility was found, most likely by amorphization, obtained after crystallization of the problem substance in the delicate pores of these specific carriers. (rjptonline.org)

All these factors must be considered when the cellular uptake of potential drug carriers is considered. (bvsalud.org)
The crosslinkers play a prime role for secondary interactions with biological tissues along with the participation of hydrophilic groups for water uptake [ 7 ] . (encyclopedia.pub)
Novel mucus-penetrating liposomes as a potential oral drug delivery system: Preparation, in vitro characterization, and enhanced cellular uptake. (innovareacademics.in)
In passive mechanism, diffusion of drug through close junctions of epithelial cells occurs depending on its size and charge while in active transport, uptake of drug is mediated by carrier i.e. active proteins [ 3 - 5 ]. (omicsonline.org)
Hence, a major goal in cancer drug development and therapy is to increase tumor-specific drug uptake while reducing uptake into normal tissues to minimize toxicities. (aspetjournals.org)

I am a materials scientist working in the preparation, characterization and new uses of functional nanomaterials. (icmab.es)
Preparation and pharmaceutical characterization of amorphous cefdinir using spray-drying and SAS-process. (setpublisher.com)

The surface proteins compose thefirst line of interaction between this macromolecular structureand the cell surface of a target cell. (diva-portal.org)
These biochemical processes seem to favor the ability to render the interaction with cytoplasmic proteins more diffusible, such as PI3+⁇⁲ molecules in the case of nanovectors of this kind. (chemistryexamhero.com)
The higher binding probabilities of these labeled carriers for nanovectors depend upon the extent of recognition by the targeting proteins. (chemistryexamhero.com)

These observations may also suggest that in the case of drug/chemical allergy, the T-cell repertoire results from particular properties of certain TCR to recognize hapten-modified peptides without need for previous thymic selection. (frontiersin.org)

The presence of intrinsic lactose fines in the formulation influences its performance and their role and interactions between the lactose carrier and the micronized drug is still not fully understood. (herts.ac.uk)
Sawant KK, Patel MH, Patel K. Cefdinir nanosuspension for improved oral bioavailability by media milling technique: formulation, characterization and in vitro-in vivo evaluations. (setpublisher.com)

Additionally, these biological materials from drug carriers require complex syntheses and are relatively expensive 12 , which create great obstacles for effective clinical application. (nature.com)
The group works on the development of advanced drug delivery technology for therapeutic intervention of diseases with a focus on understanding biological barriers required for optimal design of nanoscale carriers. (au.dk)

Subsequently, rhein hydrogels alleviate neuroinflammation with a long-lasting effect and little cytotoxicity compared to the equivalent free-drug in vitro. (nature.com)
Mathematical modeling of in vitro dissolution data indicated the best fitting with Korsmeyer-Peppas model and the drug release kinetics primarily as Fickian diffusion. (setpublisher.com)

These results suggest that numerous cellular co-solutes likely affect DNA function through interactions, which were previously overlooked. (cobiss.net)
Retinoschisin is a secreted protein found throughout the retina and is involved in intercellular adhesion, retinal cellular organization, cell-cell interactions within the inner nuclear layer, as well as synaptic connection between photoreceptors and bipolar cells. (medscape.com)

2020 Feature in the exhibit Científiques Catalanes 2.0 2017 Anna Roig, ALBUS: Albumin Award Program from Grifols Scientific Awards UAB Best PhD thesis award to six thesis that I have supervised or co supervised (Lluis Casas, Martí Gich, Elena Taboada, Elisa Carenza, Nerea Murillo, Laura González Moragas) 2015 Elisa Carenza, I Prize Dr. Ramon Ríos, Fundación Foltra 2014 'Los Nuevos Materiales en el Aula' I Prize Reach.Out! (icmab.es)

Understanding and exploiting transport across mucosal surfaces is being used as treatment strategy for inflammatory bowel disease (IBD) by designing nanocarriers that disassemble on interaction with the mucus barrier to release anti-inflammatory nucleic acid therapeutics. (au.dk)

Polyionic hydrocolloids for the intestinal delivery of protein drugs: Alginate and chitosan - A review. (innovareacademics.in)

3-Oxo-acyl-acyl carrier protein (ACP) reductase (FabG) plays a key role in the bacterial fatty acid synthesis II system in pathogenic microorganisms, which has been recognized as a potential drug target. (dundee.ac.uk)
The synthesis of some types of silicate carriers is a method for improving the loading of the particles with active substances is confirmed. (rjptonline.org)

Inverse gas chromatography is a physical characterization analytical technique that is used in the analysis of the surfaces of solids. (wikipedia.org)
As such, there has been look at more info interest in the development of nanomaterials that will enhance the physical properties of drug delivery carriers in the body. (chemistryexamhero.com)
Comparative study was carried out using Pluronic as solid dispersion and beta cyclodextrin as inclusion complexation in different drug to polymer ratios through physical mix, kneading, solvent evaporation and spray drying technique. (omicsonline.org)
Tablets were formulated of selected batches and evaluated for drug release and physical parameters. (sld.cu)

Lactose is a common excipient in Dry Powder Inhaler (DPI) formulations, used as a carrier for the micronized drug particles. (herts.ac.uk)
One use this link approach that has garnered interest is the use have a peek at these guys nanochannels as they enable delivery drug particles to the site of absorption, which can be important even without the use of drug material. (chemistryexamhero.com)
Polymer nano particles bind efficiently to the drug and disperse the drug proficiently into the system. (ijpsr.com)
The mesoporous silica particles (MSNs) have been investigated as potential drug delivery carriers. (rjptonline.org)
9. Popova T. Tzankov B. Voycheva C. Yoncheva K. Lambov N. Development of advanced drug delivery systems with bicalutamide based on mesoporous silica particles. (rjptonline.org)

This enhanced pharmacokinetic properties and bioavailability of these drug molecules (1.49 to 15-folds increase in plasma drug concentration). (intechopen.com)
An improved understanding of guest‑host interactions is central to establishing pathways to control the binding/release of drug molecules from MOFs as carriers. (stfc.ac.uk)
Other approaches such as FTIR spectroscopy and X‑ray diffraction have been used previously to elucidate the chemical interactions of drug molecules in MOF systems. (stfc.ac.uk)
They make it possible to create bonds or interactions between the drug molecules and the carrier. (rjptonline.org)

Solid-state characterization may indicate a change in crystallinity of cefdinir into an amorphous state. (setpublisher.com)

This study focused on cellulose nanocrystals (CNC) and nanofibres (CNF), as potential drug delivery systems (DDSs) for slow-release of the model hydrophobic drug, quercetin. (sun.ac.za)

Perland and Fredriksson, 2017 ) or the pharmaceutical drug substrates of these transporters, and one clue to this may be to understand their differential tissue distribution. (biorxiv.org)
Yin J, Wang J. (2016) Renal drug transporters and their significance in drug-drug interactions. (guidetopharmacology.org)
It has been reported that solute carrier (SLC) and the ATP-binding cassette (ABC) transporter super families are the major class of membrane transporters [ 14 , 17 ]. (omicsonline.org)
Both transporters belong to the solute carrier 6 protein family and share high sequence identity, the same protein fold and transport mechanism. (univie.ac.at)
Numerous compound classes have been identified to interact with these transporters, whichare used in therapeutic settings or abused as illicit drugs. (univie.ac.at)

Thus, we proposed formulating core-shell nanocapsules: coating SLN cores with alternate layers of natural polyelectrolytes via the layer-by-layer self-assembly approach based on electrostatic interactions. (uandes.cl)
Electrostatic interactions enable and limit polymer adsorption. (pharmtech.com)

pH M -SDs of cefdinir were prepared at different drug-to-carrier ratios by the spray-drying technique. (setpublisher.com)

Guided by the EU principles of innovative doctoral training, the ESRs will be educated in the context of a close interaction between academia, research institutes, commercial enterprises and unique large-scale research infrastructures to be able to tackle the interdisciplinary approaches needed to bring nanotechnology to the market place and to educate the workforce that will help solve the European Societal Challenges and the UN Sustainable Development Goals. (lu.se)
Approaches for characterization of the systems are presented. (fleming.events)

Therefore, developing a drug delivery system that optimizes the pharmaceutical action of a drug while reducing its toxic side effects in vivo is a challenging task. (ijpsr.com)
Now that lipidic drug delivery systems can be designed to be highly responsive in vivo , they have advanced beyond being simple, inert drug carriers. (fleming.events)

What are the uses of nanomaterials in drug delivery carriers? (chemistryexamhero.com)
Home - Pay Someone To Take My Inorganic Chemistry Exam - What are the uses of nanomaterials in drug delivery carriers? (chemistryexamhero.com)
So, nanoscale applications can potentially realize the improved applicability in real time in the detectionWhat are the uses of nanomaterials in drug delivery carriers? (chemistryexamhero.com)
However, in the meantime more and more complex nanochannels incorporating carrier material are being produced, as wellWhat are the uses of nanomaterials in drug delivery carriers? (chemistryexamhero.com)

2. Popova T. Voycheva Ch. Tzankov B. Study on the influence of technological factors on drug loading of poorly water-soluble drug on MCM-41 mesoporous carrier. (rjptonline.org)

Multi-functional oil in water nanoemulsions (O/W NEs) are an ideal carrier for drug delivery thanks to their ability to dissolve hydrophobic drugs and natural substances like curcumin and coenzyme Q10 (CoQ10), and protect their cargo from hydrolysis and enzymatic degradation under physiological conditions. (unina.it)
Cross-linking mass spectrometry uncovers protein interactions and functional assemblies in synaptic vesicle membranes. (ugr.es)

The identification of DTIs has turned into a focal point of pharmaceutical science to support screening the drug candidates and solving the problems of etiologies. (imrpress.com)
One of the most important goals of pharmaceutical science is local izing the pharmacological activity of the drug at the site of action. (tudublin.ie)
Relevant of mutagenicity and clastogenici- angiosarcomas of the liver, which carcinogens discussed in this chap- ty, including the induction of sister are rare tumours, were identified in ter do not include pharmaceutical chromatid exchange (SCE), chro- humans, rats, and mice exposed to drugs classified in Group 1, which mosomal aberrations (CA), and mi- vinyl chloride. (who.int)

However, clinical researchers continually find that the involvement of drug carriers may lead to poor biocompatibility and biodegradability, low loading efficacy, and potential side effects. (nature.com)
Pertinent concerns in the development of a biomaterial for drug delivery include biocompatibility, efficiency of drug loading, and timescale of drug release. (pharmtech.com)
Nanocellulose (NC) in particular is of special interest as a drug carrier, due to its inherent biocompatibility, biodegradability, and low toxicity. (sun.ac.za)

Ibuprofen, Probucol, Gliclazid, Fenofibrate, Ibrutinib and Naproxen) and this was correlated to the synergy of multiple factors (hydrophilicity enhancement, particle size reduction, drug-carrier interactions, anti-plasticizing effect and complexation efficiency). (intechopen.com)
The effect of surfactant and drug concentration on particle size (Z), polydispersity index (PdI), zeta potential (ζ) and binding efficiency (BE) was investigated by response surface methodology (RSM), an empirical modelling technique in parametric optimisation. (sun.ac.za)

the purpose of this research was to formulate taste masked complexes of cefuroxime axetil and to evaluate them for taste, drug loading and characterized by FTIR, XRD. (sld.cu)
complexation technique is used to prepare complexes of drug where ion exchange resins such as Indion ® 214, Indion ® 234 and Indion ® 414 were used with a drug-resin ratio of 1:0.5, 1:1, 1:2. (sld.cu)

These nanofoil fillers typically make up 30-60% of all drug delivery polymer formulations, but provide a similar anisotropic porosity to the core particle. (chemistryexamhero.com)
Namely, during the preformulation studies proper characterization of API, selected excipients/polymer sand their interactions are essential for efficient development of the new drug product. (vi-seem.eu)

Present work was undertaken to increase oral bioavailability of BCS class 4 drug i.e. (omicsonline.org)

Thanks to high binding affinity with biotin, streptavidin was used as linker to conjugate the synthetized peptide to the entire systems, using a decoration strategy, while keeping nano-carrier stability. (unina.it)

Various carriers have been developed for local or systemic delivery of small-molecule drugs and biologics. (pharmtech.com)

NPS are purchased as alternatives to traditional illicit drugs of abuse and are manufactured to circumvent laws regulating the sale and use of controlled substances. (jneurosci.org)

means that to understand drug distributions we must understand transporter distributions. (biorxiv.org)
Finally, a serotonin-bound homology model of the human serotonin transporter was built in an outward-occluded conformation, a key intermediate in the physiological transport cycle, where the substrate interactions can be optimally studied. (univie.ac.at)

Design and interaction of block polymers which self assemble (micelle phase diagrams, peptide gels and DNA). (jsswarriorsupport.com)

A particular focus was accorded to compare the ternary and binary system including Ibuprofen and highlighting the contribution of thermal and spectral characterization techniques. (intechopen.com)
Any Literature I are public studies over the techniques is 5 carriers. (andrewlost.com)
Optical characterisation techniques (Raman spectroscopy, X-ray photoemission spectroscopy, etc. (jsswarriorsupport.com)

The solid dispersions were investigated by dissolution studies at different pH media, drug release kinetics were studied, and their solid-state characterizations were performed by FTIR spectrophotometer, Scanning electron microscopy (SEM), Differential scanning calorimetry (DSC), and Powder X-ray diffraction (PXRD). (setpublisher.com)
According to these observations, pH M -SD in the presence of an alkalizer for a poorly water-soluble acidic drug, cefdinir, appeared to be efficacious for enhancing its dissolution rate. (setpublisher.com)
8. Tzankov B. Voycheva C. Aluani D. Yordanov Y. Avramova K. Tzankova V. Spassova I. Kovacheva D. Yoncheva K. Improvement of dissolution of poorly soluble glimepiride by loading on two types of mesoporous silica carriers. (rjptonline.org)

Measuring how the retention time changes as a function of probe molecule chemistry, probe molecule size, probe molecule concentration, column temperature, or carrier gas flow rate can elucidate a wide range of physico-chemical properties of the solid under investigation. (wikipedia.org)

Due to its high surface area and convenient functionalization, graphene oxide has many potential applications in biomedicine, especially as a drug carrier. (bvsalud.org)

Chhayani RL, Chhayani RB, Patel D, Borkhataria CH. Development and characterization of self- microemulsifying drug delivery system for improvement of bioavailability of Cefdinir. (setpublisher.com)
Pérez-Pariente J. A new property of MCM-41: drug delivery system. (rjptonline.org)

Current drug treatments restore the lost dopamine, while initially efficacious, the beneficial effects wear off resulting in severe side effects. (lu.se)

NC is naturally hydrophilic and anionic, and was therefore first modified with the cationic surfactant, cetyltrimethylammonium bromide (CTAB), in order to facilitate effective drug binding through hydrophobic interaction. (sun.ac.za)

Polyvinylpyrrolidone (PVP) has proven to be a highly versatile material, as evidenced by its long history as multifunctional biomaterial with a wide range of high-performance applications (e.g., tissue engineering, drug delivery systems, and ophthalmologic applications). (intechopen.com)

The strikingly improved biochemical technologies have dramatically promoted the process of therapeutic drug discovery. (imrpress.com)

Onco Immunology, Antibody Engineering, Drug Discovery. (edu.in)

The efficacy of many drugs is often limited by their potential to reach the site of therapeutic action. (ijpsr.com)
Hence, search for new lead molecule/bioactive and rational delivery of the existing drug (for better therapeutic effect) to the site of action is the need of the hour. (hindawi.com)

Most studies have focused on the identification of memory T cells that recognize drugs/chemicals and the insights obtained have led to the development of allergy diagnostic tests ( 7 - 21 ). (frontiersin.org)
Identification and characterization of proteases and amylases producing Bacillus licheniformis strain EMBS026 by 16S rRNA Gene Sequencing. (edu.in)

Characterization of PROPPIN-Phosphoinositide Binding by Stopped-Flow Fluorescence Spectroscopy , in Phosphoinositides: Methods and Protocols , R.J. Botelho, Editor. (ugr.es)
Therefore, there is a need to find new specific biomarkers, which will enable the development and deployment of innovative methods for early diagnosis and effective treatment with new drugs that have improved pharmacological properties. (pu-technocentre.eu)

Anatomy2

Organisms2

Diseases1

Chemicals and Drugs36

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes18

Disciplines and Occupations5

Technology, Industry, Agriculture16

Health Care3

Nanoparticles19

Physicochemical2

Intermolecular interactions5

Structural10

Nanoparticle2

Molecular11

20211

Solubility8

Uptake5

Preparation2

Proteins3

Peptides1

Formulation2

Biological2

Vitro2

Cellular2

20201

Nanocarriers1

Chitosan1

Synthesis2

Physical4

Particles5

Molecules4

Amorphous1

Hydrophobic drug1

Transporters5

Electrostatic2

Spray-drying te1

Approaches2

Vivo2

Nanomaterials4

Water-soluble drug1

Functional2

Pharmaceutical3

Biocompatibility3

Particle size2

Complexes2

Polymer2

Oral bioavailability1

Nano-carrier1

Small-molecule1

Illicit drugs1

Transporter2

Polymers1

Techniques3

Dissolution3

Elucidate1

Biomedicine1

Delivery system2

Dopamine1

Hydrophilic1

Biomaterial1

Biochemical1

Immunology1

Therapeutic2

Identification2

Methods2