Interactions cell 1 heparin syndecan 1. Medical search. Frequent questions

Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E." J. Lipid Res. (wikipedia.org)
Partial primary structure of the 48- and 90-kilodalton core proteins of cell surface-associated heparan sulfate proteoglycans of lung fibroblasts. (wikipedia.org)
More specifically, these core proteins carry three to five heparan sulfate and chondroitin sulfate chains, i.e. they are proteoglycans, which allow for interaction with a large variety of ligands including fibroblast growth factors, vascular endothelial growth factor, transforming growth factor -beta, fibronectin and antithrombin -1. (leonieclaire.com)
Heparan sulfate (HS) proteoglycans are expressed on cell surfaces and in the extracellular matrix, and take part in developmental, regenerative, as well as pathological processes. (exbio.cz)
N-sulfated heparan sulfate proteoglycans are located in specific microdomains in the plasma membrane, independent on those formed around N-acetyl-rich heparan sulfate, and play different role in the cell signaling. (exbio.cz)
The liver clears triglyceride-rich lipoproteins (TRL) via LDL receptor (LDLR), LDLR-related protein-1 (LRP-1), and heparan sulfate proteoglycans (HSPGs), mostly syndecan-1. (rug.nl)
This growth factor also stimulates production of collagens, proteoglycans, elastin, fibronectin, tenascin and thrombospondin, diminishes production of extracellularly active neutral endoproteinases belonging to the matrix metalloproteinase (MMP) and serine proteinase families, and stimulates production of endogenous MMP inhibitors (tissue inhibitor of metallo-proteinase [TIMP]) and serpins (plasminogen activator inhibitor-1). (biomedcentral.com)
Heparan sulfate proteoglycans and heparin regulate melanoma cell functions. (uoc.gr)
The sulfated saccharide domains provide numerous docking sites for protein ligands and are abundantly expressed at cell surfaces and in the extracellular matrix as part of proteoglycans (PGs). (silverchair.com)
This review will summarize our current state of knowledge of the structure, biochemical properties and functions of syndecans, a family of transmembrane heparan sulphate proteoglycans. (scienceopen.com)
Among glycans that play a critical role in stromal tumor cell interactions are glycosaminoglycans (GAGs) attached to proteoglycans (PGs). (biomedcentral.com)
Thereby, LMWH induced sensitization by transcriptional reprogramming of A2780cis cells via not yet elucidated mechanisms that depend on cellular proteoglycans. (oncotarget.com)
1. Nikitovic D, Tsatsakis AM, Karamanos NK, Tzanakakis G. The effects of genistein on the synthesis and distribution of glycosaminoglycans/ proteoglycans by two osteosarcoma cell lines depends on tyrosine kinase and the estrogen receptor density. (aristsatsakis.com)

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. (wikipedia.org)
CD138 is a heparin sulphate proteoglycan that controls tumor cell survival, growth, adhesion and bone cell differentiation in MM (2). (leonieclaire.com)
Syndecan-1-positive plasma cells and proteoglycan-rich non-haematopoietic cells displayed specific, heparin-sensitive binding to APRIL. (cancer-ecosystem.com)
Importantly, cell-associated and tumor microenvironment glycosaminoglycans (GAGs)/proteoglycan (PG) content and distribution are markedly altered during tumor pathogenesis and progression. (hindawi.com)
Free glycosaminoglycans (GAGs) and proteoglycan- (PG-) containing GAGs, key effectors of cell surface, pericellular and extracellular microenvironments, perform multiple functions in cancer by virtue of their coded structure and their ability to interact with both ligands and receptors that regulate cancer growth [ 1 - 4 ]. (hindawi.com)
Parathyroid hormone affects the fibroblast growth factor / proteoglycan signaling axis to regulate osteosarcoma cell migration. (uoc.gr)
Proteoglycan (PG) coreceptors carry heparan sulfate (HS) chains that mediate interactions with growth factors, morphogens, and receptors. (silverchair.com)
This study was performed to identify the carrier proteoglycan (PG) and the sulfotransferase gene involved in synthesis of the surface P-selectin-reactive CS-GAGs in human breast cancer cells with high metastatic capacity, as well as to determine a direct role for CS-GAGs in metastatic spread. (biomedcentral.com)
Transient transfection of the human breast cancer cell line MDA-MB-231 with the siRNAs for carbohydrate (chondroitin 4) sulfotransferase-11 ( CHST11 ) and chondroitin sulfate proteoglycan 4 ( CSPG4 ) was used to investigate the involvement of these genes in expression of surface P-selectin ligands. (biomedcentral.com)
The carrier proteoglycan CSPG4 was highly expressed on the aggressive breast cancer cell lines and contributed to the P-selectin binding and CS-A expression. (biomedcentral.com)

Interaction of hepatocyte growth factor with heparan sulfate. (wikipedia.org)
Re-expression of glucuronyl C5-epimerase in the mutant MEF cells increases heparan sulfate epimerization but has no influence on the Golgi localization and enzymatic activity of 2-O-sulfotransferase. (uu.se)
Syndecans are thought to function predominantly as coreceptors for other receptors such as integrins, members of the fibroblast growth factor family, vascular endothelial cell growth factor, and transforming growth factor β, which need heparin sulfate for signaling. (leonieclaire.com)
What is the difference between heparin and heparan sulfate? (leonieclaire.com)
The mouse monoclonal antibody HepSS-1 (also known as HepSS1) recognizes N-sulfated heparan sulfate (extracellular antigen) present in many species. (exbio.cz)
Separation of EA.hy926 cells (red-filled) from EA.hy926 cells treated with heparinase (1 hour, 1 UI per ml of cell suspension) stained using anti-N-sulfated heparan sulfate (HepSS-1) PE antibody (concentration in sample 10 μg/ml). (exbio.cz)
Kure S, Yoshie O: A syngeneic monoclonal antibody to murine Meth-A sarcoma (HepSS-1) recognizes heparan sulfate glycosaminoglycan (HS-GAG): cell density and transformation dependent alteration in cell surface HS-GAG defined by HepSS-1. (exbio.cz)
Lipscombe RJ, Nakhoul AM, Sanderson CJ, Coombe DR: Interleukin-5 binds to heparin/heparan sulfate. (exbio.cz)
Chung JS, Shiue LH, Duvic M, Pandya A, Cruz PD Jr, Ariizumi K: Sézary syndrome cells overexpress syndecan-4 bearing distinct heparan sulfate moieties that suppress T-cell activation by binding DC-HIL and trapping TGF-beta on the cell surface. (exbio.cz)
The binding of heparan sulfate/heparin-linked syndecans (SDCs) to LG45 modules was influenced by their core proteins. (bvsalud.org)
Glycosaminoglycans (GAGs) comprise a class of linear, negatively charged polysaccharides composed of repeating disaccharide units of acetylated hexosamines (N-acetyl-galactosamine in the case of chondroitin sulphate and dermatan sulfate or N-acetyl-glucosamine in the case of heparin sulphate and heparin) and mainly of uronic acids (d-glucuronic acid or l-iduronic acid) being sulfated at various positions. (hindawi.com)
hyaluronan (HA), chondroitin sulfate (CS) and dermatan sulfate (DS), heparin and heparan sulphate (HS), and keratan sulfate (KS). (hindawi.com)
Some cytokines act as competence rather than progression factors, some lack secretory signals, and some must be processed and released from the pericellular matrix or basement membranes (eg transforming growth factor beta [TGF-β ] binding to chondroitin or the keratan sulfate of biglycan, decorin and fibromodulin, or basic fibroblast growth factor and platelet derived growth factor binding to the heparin sulfate of glypican, perlecan and syndecan). (biomedcentral.com)
Heparan sulfate: decoding a dynamic multifunctional cell regulator. (research.com)
Interactions of heparin/heparan sulfate with proteins: appraisal of structural factors and experimental approaches. (research.com)
Almost every type of animal cell has the capacity to synthesize heparan sulfate (HS). (silverchair.com)
We have previously demonstrated that chondroitin sulfate glycosaminoglycans (CS-GAGs) on breast cancer cells function as P-selectin ligands. (biomedcentral.com)

The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. (wikipedia.org)
Syndecans are transmembrane proteins, whereas glypicans are attached to the cell surface via a GPI anchor. (leonieclaire.com)
Syndecans are transmembrane proteins with an N-terminal signal sequence and an ectodomain-containing consensus sequences for heparin-binding extracellular ligands including growth factors, extracellular matrix proteins, cell adhesion molecules, among others. (leonieclaire.com)
By interaction with extracellular matrix components, growth factors, enzymes, and their inhibitors, they regulate and influence tissue distribution of the cells and biological activities of the proteins. (exbio.cz)
The GCX, which is major constituent of the ESL, forms a luminal mesh that provides endothelial cells with a framework to bind plasma proteins and soluble GAGs. (biomedcentral.com)
We reveal the potential to exploit interactions of sPLA 2 s with other proteins in medical terms, for the development of original diagnostic and therapeutic procedures. (ijbs.com)
The spiral of Ca2+ in H+ requirements is prescribed to routes which are phosphorylated proteins and frequently listen Ca2+ audiences in absent XH2A( as 1 TGN). (erik-mill.de)
Because this diversity appears to be strictly regulated, it is currently believed to enable selective interaction with proteins in a topologically and temporally controlled manner ( Esko and Lindahl, 2001 ). (silverchair.com)
Principal functions of the syndecan core proteins are to target the heparan sulphate chains to the appropriate plasma-membrane compartment and to interact with components of the actin-based cytoskeleton. (scienceopen.com)
Evidence for the presence of the cellular entry sites of the virus, the ACE2/TMPRSS2 proteins, has been reported in non-chemosensory cells in the rodent's nose and mouth, missing a direct correlation between the symptoms reported in patients and the observed direct viral infection in human sensory cells. (cov19longhaulfoundation.org)
The target cells of the virus share a molecular signature: the concomitant cellular expression of the angiotensin-converting enzyme 2 (ACE2) and of its facilitating transmembrane serine protease 2 (TMPRSS2), which plays a crucial role for the interaction of viral spike proteins with the host cell 11 - 13 . (cov19longhaulfoundation.org)

Fragments of the GCX, such as syndecan-1 and/or hyaluronan (HA), have been examined, and their validity is now being examined. (biomedcentral.com)
Role of receptor for hyaluronan mediated motility (RHAMM) in low molecular weight hyaluronan (LMWHA) mediated fibrosarcoma cell adhesion. (uoc.gr)
Hyaluronan/RHAMM interactions in mesenchymal tumor pathogenesis: role of growth factors. (uoc.gr)
At each point, blood was collected for hyaluronan, syndecan-1, vascular cell adhesion molecule (VCAM-1), and von Willebrand factor (vWF), and a PBR measurement was performed. (scienceopen.com)

Regulation of Syndecan Expression Syndecan-1 is expressed predominantly in epithelial and mesenchymal tissues, syndecan-2 in cells of mesenchymal origin and neuronal and epithelial cells, and syndecan-3 almost exclusively in neuronal and musculoskeletal tissue, whereas syndecan-4 is found in virtually every cell type. (leonieclaire.com)

The TACI intracellular domain interacts with TRAF-2, TRAF-5 and TRAF-6 and activates NF-B and JNK.25 BAFF, but not APRIL, binds a third receptor named BAFF-R or BR3.31C33 BAFF-R was first identified in A/WySnJ mice that are deficient in B cells and present a mutated gene, (B-cell maturation deficiency) in comparison with the parental A/J mice. (cancer-ecosystem.com)
Li Q, Cao Z, Zhao S. The Emerging Portrait of Glial Cell Line-derived Neurotrophic Factor Family Receptor Alpha (GFRα) in Cancers. (medsci.org)
Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. (medsci.org)
The GDNF family ligands (GFLs) function through a glycosyl-phosphatidylinositol-(GPI) anchored coreceptor, GDNF family receptor alpha (GFRα), and rearranged during transfection (RET), a well-known receptor tyrosine kinase involved in kidney development, spermatogonial stem cell maintenance, and the development and maintenance of the sympathetic, parasympathetic, and enteric nervous systems [ 1 , 2 ]. (medsci.org)
Based on whether it cooperates with the second receptor RET, GFRα has also been widely linked to the mechanisms that contribute to cell growth, differentiation and migration and tissue maturation. (medsci.org)
Receptor for hyaluronic acid-mediated motility (RHAMM) regulates HT1080 fibrosarcoma cell proliferation via a b-catenin/c-myc signaling axis. (uoc.gr)
adiponectin receptor 1 [Source:HGNC Sym. (gsea-msigdb.org)
RT-PCR and Southern analyses revealed that all six RCC cell lines expressed ET(A) receptor mRNA, while 3/6 cell lines also expressed ET(B) mRNA. (jsce-ip.com)
Using the interaction of recombinant hCD40 ligand with HEK-Blue sensor cells expressing the CD40 receptor as example, we show that such an assay can be developed based on BCIP/NBT (5-bromo-4-chloro-3-indolyl phosphate/nitroblue tetrazolium chloride) as substrate. (envite.org)
In summary, the virus could target cells involved in tissue regulation such as the supporting cells of the olfactory receptor neurons and the regenerative basal cells but also, specifically, the chemosensory cells of both gustatory and olfactory systems. (cov19longhaulfoundation.org)

Dysregulated cell proliferation underlies all forms of oncogenesis. (wisc.edu)
Cell Proliferation 43: 9-18, 2010. (uoc.gr)
Syndecans have been proposed to play a role in a variety of cellular functions, including cell proliferation and cell-matrix and cell-cell adhesion. (scienceopen.com)

How do Syndecan and Glypican attach to the membrane? (leonieclaire.com)
Glypican-3 (GPC3) is upregulated in A2780cis cells in response to LMWH treatment, probably as counter-regulation to sustain the high Wnt activity against LMWH. (oncotarget.com)

Syndecans bind a variety of extracellular ligands via their covalently attached heparan sulphate chains. (scienceopen.com)

both ligands induce NF-B activation in GSK 2334470 these cells.24 Binding of BAFF to TACI also stimulates NF-B activation in B-lymphoma cells, whereas a soluble form of TACI inhibits this induction and also the production of immunoglobulin M (IgM) by peripheral B lymphocytes. (cancer-ecosystem.com)
Low molecular weight heparin inhibits melanoma cell adhesion and migration through a PKCa/JNK signaling pathway inducing actin cytoskeleton changes. (uoc.gr)
NO in turn inhibits ET-1 expression. (jsce-ip.com)

Endothelial cells are sentinels lining the innermost layer of blood vessel that gatekeep micro- and macro-vascular health by sensing pathogen/danger signals and secreting vasoactive molecules. (nature.com)
Taken together, the concerted actions of above factors lead to dysfunctional status of the vascular endothelium (endothelial dysfunction) (Fig. 1 ) [ 14 ]. (nature.com)
These include, but are not limited to, (1) preventing hyperacute rejection, (2) preventing acute vascular rejection, (3) facilitating immune accommodation, (4) inducing immune tolerance, (5) preventing the transmission of viruses from xenografts into humans, and (6) addressing the ethical issues surrounding animal sources for xenografts and the appropriate selection of recipients (given that xenotransplantation remains experimental). (medscape.com)
Over the past decade, insight has been gained into the role of the glycocalyx in vascular physiology and pathology, including mechanotransduction, hemostasis, signaling, and blood cell-vessel wall interactions. (scienceopen.com)
Tissue factor (TF) is the initiator of the coagulation cascade, constitutively expressed in subendothelial cells such as vascular smooth muscle cells and initiating rapid coagulation when the vascular vessel is damaged. (go.jp)
Bluo-Gal staining of kidney sections revealed intracellular blue particles as indicators of prepro-ET-1 promoter activity in tubular and vascular endothelium and glomerular cells. (jsce-ip.com)
Cell-type specific evaluation revealed an increase of 136+/-51% in tubular (P=0.001) and 105+/-41% in glomerular cells (P=0.046), but no significant increase in vascular endothelium . (jsce-ip.com)

The membrane expression of BAFF persists during differentiation in macrophages but decreases during maturation in dendritic cells. (cancer-ecosystem.com)
We subsequently discuss how β-TCP can regulate osteogenic processes to aid bone repair/healing, namely osteogenic differentiation of mesenchymal stem cells, formation of blood vessels, release of angiogenic growth factors, and blood clot formation. (frontiersin.org)
The glial cell line-derived neurotrophic factors (GDNFs), a family of neurotrophic factors, were initially thought to be able to regulate the growth, survival, and differentiation of neural-derived cell types. (medsci.org)
Lumican is positively correlated with human osteosarcoma cell differentiation and negatively with their growth. (uoc.gr)
with the conditioned medium from Oct4-overexpressing lung cancer cells were used to investigate M2 TAM differentiation. (nos-nop.org)

Placental syndecan-1 and sulphated glycosaminoglycans are decreased in preeclampsia. (mdx.ac.uk)

molecules by B-CLL cells, their regulation, transduction pathways and their effects on leukaemic cells. (cancer-ecosystem.com)
It will discuss the expression of these molecules by B-CLL cells, their regulation, transduction pathways and their effects on leukaemic cells. (cancer-ecosystem.com)
The higher expression of gremlin 1 and HIF1a genes after exposure to dragonfly larvae indicated an in vivo hypoxic reaction, while down-regulation of syndecan-2 may indicate impairment of angiogenesis. (biomedcentral.com)
Regulation at the protein level includes modulation of its cell surface expression, cathepsin L-mediated processing, cellular uptake, secretion, and cytoplasmic vs. nuclear localization. (pafr-signal.com)
The functional repertoire of heparanase is further expanded by its regulation of syndecan clustering and shedding. (pafr-signal.com)
Q2986 Kesanakurti,D., Chetty,C., Maddirela,D.R., Gujrati,M., Rao,J.S. Essential role of cooperative NF-kappaB and Stat3 recruitment to ICAM-1 intronic consensus elements in the regulation of radiation-induced invasion and migration in glioma. (alzet.com)

Using phosphoproteomic approaches, they are mapping downstream effectors of TFG-NTRK1 and TFG-ALK that simultaneously drive cell transformation and regulate vesicle secretion. (wisc.edu)

Syndecan-2 is a protein that in humans is encoded by the SDC2 gene. (wikipedia.org)
GRP75-driven, cell-cycle-dependent macropinocytosis of Tat/pDNA-Ca2+ nanoparticles underlies distinct gene therapy effect in ovarian cancer. (uu.se)
We are studying the novel, RNA-based pathways and virus-host interactions underlying replication, gene expression and evolution by positive-strand RNA viruses, the largest class of viruses. (wisc.edu)
In his research, Jeremy E. Turnbull performs multidisciplinary study on Cell biology and Gene. (research.com)
Gene and Cell biology are two areas of study in which he engages in interdisciplinary work. (research.com)
The gene encodes for 3'-phospoadenosine 5'-phosphosulfate (PAPS) synthase 1 (PAPSS1), a dual function enzyme comprising an ATP sulfurylase and a kinase domain. (oncotarget.com)
The CHST11 gene was highly expressed in aggressive breast cancer cells but significantly less so in less aggressive breast cancer cell lines. (biomedcentral.com)
Cell surface P-selectin binding depends on CHST11 gene expression. (biomedcentral.com)
We established transgenic mice carrying a lacZ reporter gene under control of the human prepro-ET-1 gene promoter sequence (8 kb of 5′ sequences). (jsce-ip.com)
Here, mapping the gene and protein expression of ACE2/TMPRSS2 in the mouse olfactory and gustatory cells, we precisely identify the virus target cells to be of basal and sensory origin and reveal the age-dependent appearance of viral entry-sites. (cov19longhaulfoundation.org)

Jeremy E. Turnbull integrates Glycosaminoglycan and Heparin in his studies. (research.com)
He combines Heparin and Glycosaminoglycan in his research. (research.com)
In his works, Jeremy E. Turnbull conducts interdisciplinary research on Glycosaminoglycan and Heparin. (research.com)
Jeremy E. Turnbull undertakes multidisciplinary studies into Heparin and Glycosaminoglycan in his work. (research.com)

Disruption of innate defense responses by endoglycosidase HPSE promotes cell survival. (uu.se)
Insulin-like growth factor-II and heparin are anti-apoptotic survival factors in human villous cytotrophoblast. (mdx.ac.uk)
Such defects are often associated with changes in cellular signal transduction pathways, such as the Ras-Raf-MEK-ERK kinase cascade, which promotes cell survival and growth. (wisc.edu)
These results suggest that sulfonation reactions are important for cancer cell survival. (oncotarget.com)

Cell-associated and tumor microenvironment GAG content and distribution is markedly altered during tumor pathogenesis and progression [ 11 , 12 ]. (hindawi.com)
Further variety of the pathogenesis of heparin on food or eRF3 activation novo increases characterised for the unidentified blood, since responses between foreign mitochondria and the vacuolar agonist bind Generally previously often endocytosed. (erik-mill.de)
In the past several decades, numerous studies have been conducted to understand the pathogenesis of IF/TA and multiple factors and mechanisms have been demonstrated to be involved in the progress of the IF/TA, including immunosuppressive drug toxicity, antibody-mediated injury, and epithelial-mesenchymal transition (EMT) (Figure 1 ). (biomedcentral.com)

This PG family consists of four members: syndecan-1,44 syndecan-2/fibroglycan, 45 syndecan-3/N-syndecan, 46 and syndecan-4/amphiglycan/ryudocan, 47,48 all of which are expressed in the CNS. (leonieclaire.com)

Syndecan is the family name of membrane-intercalated HSPGs. (leonieclaire.com)

IGF-I regulates HT1080 fibrosarcoma cell migration through a syndecan-2/Erk/ezrin signaling axis. (uoc.gr)

Implications of Heparanase on Heparin Synthesis and Metabolism in Mast Cells. (uu.se)
Other profibrotic, collagen synthesis stimulating cytokines include endothelin, interleukin (IL)-1 and mast cell tryptase. (biomedcentral.com)
Interaction of SLIT1 with a mitosis IV fibrillogenesis COL4A5 regulates caspase-dependent for turn of SLIT1 to the atom synthesis of the first methyl( Xiao et al. (erik-mill.de)
We found that (1) arsenite stimulated TF synthesis and activated the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway in HASMCs, (2) sulforaphane, an Nrf2 activator, also stimulated TF synthesis in HASMCs, and (3) arsenite-induced upregulation of TF synthesis was prevented by Nrf2 knockdown in HASMCs. (go.jp)

The fundamental mechanism of interstitial fibrosis is the imbalance of extracellular matrix metabolism and abnormal accumulation via interaction of various inflammatory cytokines. (biomedcentral.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Endothelin-1 (ET-1) is a potent vasoconstrictor that has been shown to significantly impact many benign and malignant tissues by signaling through its two cognate receptors: ET(A) and ET(B). As ET-1 has a role in both normal and diseased kidney, we initiated studies to investigate endothelin axis expression and function in renal cell carcinoma (RCC). (jsce-ip.com)
ET-1 protein was estimated from the tissues by enzyme-linked immunosorbent assay. (jsce-ip.com)
Therefore, we propose that damage to and subsequent release of mtDNA elicits a protective signalling response that enhances nDNA repair in cells and tissues, suggesting that mtDNA is a genotoxic stress sentinel. (regenerativemedicine.net)

Tumor-associated glycans play a significant role in promoting aggressive and metastatic behavior of malignant cells [ 1 - 5 ], participating in cell-cell and cell-extracellular matrix interactions that promote tumor cell adhesion and migration. (biomedcentral.com)

Inhibition of Tumor-Host Cell Interactions Using Synthetic Heparin Mimetics. (uu.se)
PAPSS1 inhibition in combination with low-dose (IC 10 ) cisplatin resulted in increased DNA damage, apoptosis and G1/S cell cycle arrest. (oncotarget.com)
At the IC 10 of cisplatin (i.e. the dose of cisplatin that would cause 10% cell death), PAPSS1 inhibition reduced long-term viability of some cancer cells by 99% compared to non-targeting controls. (oncotarget.com)

What kind of ligands does a syndecan carry? (leonieclaire.com)

The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. (wikipedia.org)

Particularly, we have found that Wnt signaling dysregulates mammary stem cells, and that this precedes the formation of differentiated, bilineal tumors. (wisc.edu)
In this review, we introduce the broad application of β-TCP in tissue engineering and discuss the different approaches that β-TCP scaffolds are customized, including physical modification (e.g., pore size, porosity and roughness) and the incorporation of metal ions, other materials (e.g., bioactive glass) and stem cells (e.g., mesenchymal stem cells). (frontiersin.org)
The main challenge for large bone defect repair and regeneration remains the inadequate recruitment of mesenchymal stem cells (MSCs), reduced vascularization, and decreased growth factors stimulation within the scaffold construct to support cell viability and tissue growth. (frontiersin.org)
Aggressive, transformed or transfected mesenchymal cells containing proto-oncogenes can act in the absence of lymphocytes, but whether these cells represent regressed fibroblasts, chondrocytes or bone marrow stem cells is unclear. (biomedcentral.com)
We have demonstrated that human embryonic stem cells (hESC) - derived microenvironment provide a niche which enables the growth of important subsets of ovarian cancer stem cells, which evade growth in conventional systems. (pafr-signal.com)

Cell type and tissue specific alterations in fine GAG structure, which are strictly predetermined [ 8 - 10 ], allow these molecules to modulate with high specificity different cellular processes [ 7 ]. (hindawi.com)
Bluo-Gal staining of tissue sections revealed intracellular blue particles as indicators of prepro-ET-1 promoter activity. (jsce-ip.com)
Total RNA was extracted from tissue samples, and reverse transcriptase-polymerase chain reaction was performed for ET-1, ETA, and ETB. (jsce-ip.com)

Syndecans: multifunctional cell-surface co-receptors. (scienceopen.com)

The purpose of this review is to provide a latest summary of biomarkers associated with endothelial cell activation in COVID-19 and offer mechanistic insights into the molecular basis of endothelial activation/dysfunction in macro- and micro-vasculature of COVID-19 patients. (nature.com)
Our studies integrate molecular genetics, genomics, biochemistry and cell biology to address fundamental questions in virus replication and virus-cell interactions. (wisc.edu)
Low molecular weight heparin (LMWH), the guideline based drug for prophylaxis and treatment of cancer-associated thrombosis, was recently shown to sensitize cisplatin resistant A2780cis human ovarian cancer cells for cisplatin cytotoxicity upon 24 h pretreatment with 50 μg × mL -1 of the LMWH tinzaparin in vitro , equivalent to a therapeutic dosage. (oncotarget.com)
Here we aim to illuminate the underlying molecular mechanisms of LMWH in sensitizing A2780cis cells for cisplatin. (oncotarget.com)
According to clinical guidelines for antithrombotic prophylaxis or treatment of patients in oncology, low molecular weight heparin (LMWH) is the drug of choice [ 2 ]. (oncotarget.com)
These data provided evidence that HPV-positive tumors may be more sensitive to chemotherapy and molecular inhibitors that specifically target cell cycle. (moffitt.org)
In the present study, we investigated the effect of arsenite on the expression of TF in human aortic smooth muscle cells (HASMCs) and the underlying molecular mechanisms. (go.jp)

Heparanase also augments cell adhesion and signaling cascades leading to enhanced phosphorylation of selected protein kinases and increased transcription of genes associated with aggressive tumor progression. (pafr-signal.com)

Heparin is distinct from HS in that it is produced primarily by mast cells, whereas, HS is produced by all cell types. (leonieclaire.com)

A cell adhesion assay showed that HEK293 cells could readily adhere to the LG45 modules of α3-5 chains through a combination of SDCs and integrins. (bvsalud.org)
Using TCF/LEF luciferase promotor assay (Top/Flash) we show that resistant A2780cis cells possess a threefold higher Wnt signaling activity compared to A2780 cells. (oncotarget.com)

In addition, mtDNA stress in TFAM-deficient mouse melanoma cells produces tumours that are more resistant to doxorubicin in vivo. (regenerativemedicine.net)

SEAP (secreted embryonic alkaline phosphatase) has been suggested as versatile reporter protein inter alia for cell ligand interaction. (envite.org)

the substrate used for sulfonation reactions in cells. (oncotarget.com)
SEAP activity measurement in reporter cell-based assays using BCIP / NBT as substrate. (envite.org)

J. Cell Biol. (wikipedia.org)
Eur J Obstet Gynecol Reprod Biol:163(1):11-6. (mdx.ac.uk)
Int J Biochem Cell Biol 43(6): 928-35, 2011. (uoc.gr)
J Cell Biol (2006) 174 (3): 323-327. (silverchair.com)

The axonemal site of NOTCH1 and the collagen Ligand-binding WD40 cell of 40kDa are different benefits of pumps in accumulation epithelial Endoplasmic development - T-ALL( Welcker and Clurman 2008). (evakoch.com)
2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)

Specifically, these extracellular matrix (ECM) components critically modulate the tumor cell "motile phenotype" affecting their adhesive/migratory abilities which are directly correlated to the metastatic cascade [ 5 , 6 ]. (hindawi.com)
The main function of syndecans appears to be to modulate the ligand-dependent activation of primary signalling receptors at the cell surface. (scienceopen.com)

Interaction of SLIT2 with DAG1( matrix) phosphorylates distinct for enhanced release of SLIT2 at the backbone blood( Wright et al. (erik-mill.de)

1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)
2000). In *Correspondence to: Perrine Barraud, Department of Veterinary Medi- contrast, several cell surface markers have been used to cine, Neurosciences, Madingley Road, Cambridge CB3 OES, United enrich for NSCs in the rodent CNS. (lu.se)

Urate crystals induce macrophage PAF-AH secretion which is differentially regulated by TGFb-1 and hydrocortisone. (mdx.ac.uk)
CONCLUSIONS: Together, these data demonstrate a direct binding interaction between Angpt-2 and VWF that persists after secretion. (imperial.ac.uk)

MMPs now comprise a group of 18 different enzymes in man, including the classic fibroblast collagenase MMP-1 (collagenase-1), the mesenchymal form of MMP-8 (collagenase-2) and MMP-13 (collagenase-3). (biomedcentral.com)
Fibroblasts produce TIMPs (1-4), which were previously called human fibroblast collagenase inhibitors. (biomedcentral.com)
The expression of ET-1 and its receptors was also examined in gingival fibroblast cells treated with CsA. (jsce-ip.com)

IL-6, interestingly, does not seem to stimulate the production of collagenase, but is a potent inducer of TIMP-1. (biomedcentral.com)

TIMP-1 is induced by inflammatory cytokines IL-1 and TNF-α, but also by TGF-β, progesterone and estrogen. (biomedcentral.com)
Lumican affects tumor cell functions, tumor-ECM interactions, angiogenesis and inflammatory response. (uoc.gr)
The inflammatory factors in the conditioned medium of Oct4-overexpressing A549 cells were examined using human JTC-801 inflammation antibody arrays. (nos-nop.org)
Genomic genes with the Rev: RNA cation and Ran: GTP and has been to begin with Statistics coalescing missing of the RRE-Rev-CRM1-RanGTP pair to the AIM2 tunnel and the lipid of the export across the inflammatory interaction evolution. (evakoch.com)

We have previously shown that VWF itself regulates angiogenesis, raising the hypothesis that some of the angiogenic activity of VWF may be mediated by its interaction with Angpt-2. (imperial.ac.uk)

Emerging techniques using the analysis of circulating tumor cells show promising results in predicting and identifying the early stages of breast cancer metastasis in patients. (iiarjournals.org)
An emerging method to detect metastasis is the analysis of circulating tumor cells (CTCs), which has shown promise in filling the gaps left by other diagnostic methods. (iiarjournals.org)
CTCs are tumor cells originating from primary sites or metastases that circulate in the patients' bloodstream and are very rarely found in healthy individuals ( 9 , 10 ) ( Figure 1 ). (iiarjournals.org)
Morphological-based isolation separates CTCs according to size discrepancies, using isolation by size of epithelial tumor cells (ISET) or according to density, using density-gradient separation ( 4 ). (iiarjournals.org)
This method uses either epithelial cell-specific markers which are generally expressed in all tumor cells, or tumor markers expressed by specific types of cancer ( 13 ). (iiarjournals.org)
Circulating tumor cells in the blood stream. (iiarjournals.org)
The consecutive stages of cancer growth and dissemination are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)
The consecutive steps of tumor growth, local invasion, intravasation, extravasation, and invasion of anatomically distant sites are obligatorily perpetrated through specific interactions of the tumor cells with their microenvironment. (hindawi.com)

Specifically the research showed that the most significantly deregulated genes in the HPV-positive tumors are cell cycle regulators. (moffitt.org)
A lead compound (non-anticoagulant glycol-split heparin), highly effective 4-Aminobutyrate aminotransferase against myeloma tumors, was selected toward a clinical trial in cancer patients. (pafr-signal.com)

Conclusions Progressive CKD induces hepatic HS elongation, leading to increased interaction with PCSK9. (rug.nl)
However, cells overexpressing full-length ADAMTS6 lack heparan sulphate and focal adhesions, whilst depletion of ADAMTS6 induces a prominent glycocalyx. (nos-nop.org)

4] Porcine skin has been grafted onto burn patients,[5] and pig neuronal cells have been transplanted into patients with Parkinson (Parkinson's) disease and Huntington (Huntington's) disease. (medscape.com)

A model for an interaction with extracellular matrix. (exbio.cz)
GAGs bound into PGs are located to the extracellular matrix, basal membrane, and cell surface [ 7 ]. (hindawi.com)
Functional analyses indicated that some of the genes induced by dragonfly larvae caused an increase in laminins necessary for cell adhesion in the extracellular matrix. (biomedcentral.com)

Malignant tumor diseases induce an upregulation of blood coagulation by a functional interlinkage that has first been described more than 150 years ago, referred to as Trousseau syndrome [ 1 ]. (oncotarget.com)
GMPs may efficiently induce regulatory T cell advancement also. (nos-nop.org)
induce focal adhesions, bind heparin and syndecan-4. (nos-nop.org)

Background: A major clinical feature of severe coronavirus diease 2019 (COVID-19) is microvascular thrombosis linked to endothelial cell activation. (imperial.ac.uk)

2017 Dec 7;8(1):1973. (exbio.cz)

Anatomy26

Organisms11

Diseases18

Chemicals and Drugs110

Analytical, Diagnostic and Therapeutic Techniques and Equipment42

Phenomena and Processes50

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science4

Health Care4

Proteoglycans13

Proteoglycan10

Sulfate17

Proteins11

Hyaluronan4

Epithelial cells1

Receptor10

Proliferation3

Glypican2

Extracellular ligands1

Inhibits3

Vascular7

Differentiation5

Glycosaminoglycans1

Regulation6

Regulate1

Gene10

Glycosaminoglycan4

Survival4

Pathogenesis3

Fibroglycan1

HSPGs1

Ezrin1

Synthesis4

Metabolism1

Tissues4

Migration1

Inhibition3

Ligands1

Mediate1

Stem cells5

Tissue3

Multifunctional1

Molecular7

Heparanase1

Mast Cells1

Assay2

Melanoma1

Ligand interaction1

Substrate2

Biol4

NOTCH12

Modulate2

Distinct1

20002

Secretion2

Fibroblast3

Potent1

Inflammatory4

Angiogenesis1

Tumor cells8

Tumors2

Induces2

Neuronal1

Matrix3

Induce3

Endothelial cell activation1

20171