CorticosteroidsMetabolismOsteoporosisEndogenousMineralocorticoidCortisolReceptor-interacGenomicAdrenal InsufficiencyGene expressionTranscriptionalRegulationProteinCortisoneReceptorsResistanceSteroidInflammatoryMechanismsSecretionDexamethasoneCyclophosphamideGenesInflammationRepressionNR3C1WidelyDrug-drug interactionsNorepinephrineSerumPrednisoneAdequateAlterationsIntestinalEnvironment interactionsExposurePredictMedicationsCalciumTreatmentAbsenceResponseAirwayTherapyEffectsHumanDrugsLigands
Corticosteroids7
- Glucocorticoid is a compound that belongs to the family of compounds called corticosteroids (steroids). (news-medical.net)
- Since the start of the COVID-19 pandemic, a class of corticosteroids called glucocorticoids (GCs) have become established as one of the main treatment options, especially for severe cases, thanks to their anti-inflammatory and immunosuppressant action. (news-medical.net)
- Dexamethasone and other corticosteroids are agonists, while mifepristone and ketoconazole are antagonists of the GR. Anabolic steroids also prevent cortisol from binding to the glucocorticoid receptor. (wikipedia.org)
- In this review article, recent advances into the understanding of cellular mechanisms and the clinical implications of the interaction of inhaled corticosteroids and the airway vasculature in asthma are reviewed. (ersjournals.com)
- and 3) the interactions of corticosteroids and airway blood vessels by which inflammatory changes of the airway vasculature can be reversed in patients with asthma. (ersjournals.com)
- Evidence indicates that exposure to glucocorticoids (a class of corticosteroids) increases the risk of bone loss and fractures, and corticosteroids are the leading cause of secondary osteoporosis. (dsm.com)
- Corticosteroids, glucocorticoid (e.g. (transplantliving.org)
Metabolism9
- Glucocorticoids affect metabolism and have anti-inflammatory and immunosuppressive effects. (news-medical.net)
- Mounting evidence suggests that stress, along with the associated hormonal and neurochemical mediators (particularly glucocorticoids), induces changes in glutamate release, transmission and metabolism in cortical and limbic brain areas, thereby influencing cognitive and emotional processing and behaviour. (nature.com)
- Recent studies have shed light on the mechanisms by which stress and glucocorticoids affect glutamate transmission, including effects on glutamate release, glutamate receptors and glutamate clearance and metabolism. (nature.com)
- 2 Fodor L, Ahnefeld FW, Fazekas AT: Studies on the glucocorticoid control of zinc metabolism, Infusionsther Klin Ernahr, 1975, 2(3):210-3. (naturalnews.com)
- Endogenous glucocorticoid (GC) production and metabolism have been implicated based upon parallels with Cushing s syndrome. (endocrine-abstracts.org)
- The interaction between GC metabolism and insulin sensitivity in the context of significant weight loss has not been explored. (endocrine-abstracts.org)
- The role of endogenous glucocorticoid (GC) production and metabolism in the pathogenesis of obesity, insulin resistance and type 2 diabetes remains unclear. (endocrine-abstracts.org)
- Dysregulation of the enzymes that control local tissue steroid metabolism has been implicated in the pathogenesis of obesity and insulin resistant states, however longitudinal changes in glucocorticoid metabolism over time have not been investigated. (endocrine-abstracts.org)
- This study was designed to evaluate the role of pre-receptor glucocorticoid metabolism in the development of insulin resistance and obesity. (endocrine-abstracts.org)
Osteoporosis2
- 1 Hachulla E, Cortet B: Prevention of glucocorticoid-induced osteoporosis, Rev Med Interne, 1998, 19(7): 492-500. (naturalnews.com)
- Supplementation with calcium and vitamin D3 has a significant effect on reducing the risk of hip and nonvertebral fractures 9 , consistent with guidelines for the prevention and treatment of glucocorticoid-induced osteoporosis 10 . (dsm.com)
Endogenous3
- The endogenous glucocorticoid hormone cortisol diffuses through the cell membrane into the cytoplasm and binds to the glucocorticoid receptor (GR) resulting in release of the heat shock proteins. (wikipedia.org)
- Glucocorticoids (GCs) are widely prescribed therapeutics for the treatment of inflammatory diseases, and endogenous GCs play a key role in immune regulation. (frontiersin.org)
- The most relevant hormones for the neuroendocrine axis are the adrenocorticotropic hormone (ACTH) and ß-endorphins, which stimulate the secretion of various endogenous substances, such as glucocorticoids, produced in the adrenal cortex, and noradrenaline and adrenaline, produced in the adrenal medulla and nerve endings 5-7 . (bvsalud.org)
Mineralocorticoid4
- 24 h urinary glucocorticoid and mineralocorticoid metabolites were measured by gas chroma. (endocrine-abstracts.org)
- After appropriate diagnostic studies are performed or after the results are known, glucocorticoid therapy, mineralocorticoid therapy, or both may be started. (medscape.com)
- The goal of therapy for adrenal hyperplasia is the replacement of glucocorticoid and mineralocorticoid to prevent signs of adrenal insufficiency and to prevent the accumulation of precursor hormones that cause virilization. (medscape.com)
- Primary adrenal insufficiency is treated with glucocorticoid and mineralocorticoid replacement therapy. (medscape.com)
Cortisol3
- The glucocorticoid receptor (GR or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. (wikipedia.org)
- Un test de ANOVA mostró diferencias marginales de efecto moderado en los niveles de cortisol en hijos de madres con DPP comparados con grupo de control. (bvsalud.org)
- Suponiendo que los hijos de madres con DPP tienen niveles de cortisol ligeramente elevados al nacer, no se observaron estas diferencias en otros momentos. (bvsalud.org)
Receptor-interac2
- To provide insight into the molecular mechanisms of their activity and selectivity, we determined the crystal structures of the ERalpha ligand-binding domain (LBD) and a peptide from the glucocorticoid receptor-interacting protein 1 (GRIP1) coactivator complexed with the ligands OBCP-3M, OBCP-2M, and OBCP-1M. (rcsb.org)
- Finally, the mutant receptor hGRαV575G demonstrated impaired interaction with the LXXLL motif of the glucocorticoid receptor-interacting protein 1 coactivator in vitro and in computer-based structural simulation via its defective activation function-2 (AF-2) domain. (qxmd.com)
Genomic2
- We assessed the impact of genomic differences following glucocorticoid administration by examining the transcriptional profile of human induced pluripotent stem cell (hiPSC)-derived glutamatergic neurons and live cultured peripheral blood mononuclear cells from combat veterans with PTSD ( n =5) and without PTSD ( n =5). (biorxiv.org)
- Mostafa MM, Bansal A, Michi AN, Sasse SK, Proud D, Gerber AN , Newton R. Genomic determinants implicated in the glucocorticoid-mediated induction of KLF9 in pulmonary epithelial cells. (nationaljewish.org)
Adrenal Insufficiency1
- In the growing child with adrenal insufficiency, long-term glucocorticoid replacement must be balanced to prevent symptoms of adrenal insufficiency while still allowing the child to grow at a normal rate and prevent symptoms of glucocorticoid excess. (medscape.com)
Gene expression1
- Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression. (reprocell.com)
Transcriptional2
- Gβ2 was associated with GR/glucocorticoid response elements (GREs) in vivo and suppressed activation function-2-directed transcriptional activity of the GR. We conclude that the Gβγ complex interacts with the GR and suppresses its transcriptional activity by associating with the transcriptional complex formed on GR-responsive promoters. (rupress.org)
- We observed that BCL2L13 and PMAIP1 genes get upregulated upon PLK1 inhibition, probably through transcriptional regulation by FOXOs in interaction with β-catenin. (lu.se)
Regulation4
- Acute stress increases glutamate release, membrane trafficking of AMPA and NMDA receptors, and potentially glutamate clearance in the prefrontal cortex through various mechanisms that involve glucocorticoid regulation. (nature.com)
- When glucocorticoids bind to GR, its primary mechanism of action is the regulation of gene transcription. (wikipedia.org)
- Here, we proposed a new perspective of intestinal microbiota - neural mitochondria interaction as a communicating channel from gut to brain, which could help to extend the vision of gut-brain axis regulation and provide additional research directions on treatment and prevention of responsive neurological disorders. (frontiersin.org)
- Although glucocorticoid receptors (GRs) in the hippocampus play a vital role in the regulation of physiological and behavioural responses to stress, the regulation of receptor expression remains unclear. (karger.com)
Protein4
- SGK-1 protein levels in spinal astrocytes are increased in response to glucocorticoid stimuli and enhanced ATP release by opening the pannexin-1 hemichannels. (nature.com)
- The natural mutant receptor hGRαV575G causes primary generalized glucocorticoid resistance by affecting multiple steps in the glucocorticoid signaling cascade, including the affinity for the ligand, the time required for nuclear translocation, and the interaction with the glucocorticoid-interacting protein-1 coactivator. (qxmd.com)
- Here, we report that the guanine nucleotide-binding protein (G protein)-coupled receptor-activated WD-repeat Gβ interacts with the glucocorticoid receptor (GR), comigrates with it into the nucleus and suppresses GR-induced transactivation of the glucocorticoid-responsive genes. (rupress.org)
- FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
Cortisone1
- Glucocorticoids -such as cortisone- are among the most widely used anti-inflammatory drugs, and are used to treat asthma, psoriasis, organ transplantation and even COVID-19. (news-medical.net)
Receptors3
- Diurnal enhancement of pain hypersensitivity is mediated by glucocorticoid-induced enhancement of the extracellular release of ATP in the spinal cord, which stimulates purinergic receptors on microglia in the dorsal horn. (nature.com)
- Temporal elevations in glucocorticoid levels enhance the extracellular release of ATP in the spinal cord, which stimulates purinergic receptors on microglia in the dorsal horn. (nature.com)
- Extracellular stimuli that activate cell surface receptors modulate glucocorticoid actions via as yet unclear mechanisms. (rupress.org)
Resistance5
- The GR is abnormal in familial glucocorticoid resistance. (wikipedia.org)
- A novel point mutation of the human glucocorticoid receptor gene causes primary generalized glucocorticoid resistance through impaired interaction with the LXXLL motif of the p160 coactivators: dissociation of the transactivating and transreppressive activities. (qxmd.com)
- Primary generalized glucocorticoid resistance is a rare genetic disorder characterized by generalized, partial, target-tissue insensitivity to glucocorticoids. (qxmd.com)
- Glucocorticoid and cytokine crosstalk: Feedback, feedforward, and co-regulatory interactions determine repression or resistance. (nationaljewish.org)
- To understand the mechanisms of resistance to glucocorticoids, such as dexamethasone, we generated dexamethasone-resistant B-ALL cell lines in paper I. One such resistant cell line was found to possess increased FLT3 expression levels with FLT3-ITD and FLT3-R845G mutations that led to the activation of oncogenic RTK signaling. (lu.se)
Steroid1
- New research being presented at this year's European Congress on Obesity (ECO) in Dublin, Ireland (17-20 May) suggests that glucocorticoid levels (a class of steroid hormones secreted as a response to stress) present in the hair of individuals may indicate which of them are more likely to suffer from cardiovascular diseases (CVD) in the future. (news-medical.net)
Inflammatory2
- Glucocorticoids (GCs) represent the most effective anti-inflammatory drugs in the therapy of inflammatory lung diseases. (frontiersin.org)
- Nascent transcript analysis of glucocorticoid crosstalk with TNF defines primary and cooperative inflammatory repression. (nationaljewish.org)
Mechanisms2
- The objective of the study was to present three new cases caused by a novel mutation in the hGR gene and to delineate the molecular mechanisms through which the mutant receptor impairs glucocorticoid signal transduction. (qxmd.com)
- Therefore, considering the common ancestries, similar mechanisms, similar goals, and similar structures between gut microbiota and mitochondria ( Franco-Obregon and Gilbert, 2017 ), is it possible that neural mitochondria are direct targets of intestinal microflora and function as key mediators regulating gut-brain interaction? (frontiersin.org)
Secretion1
- To determine the pathological relevance of the diurnal secretion of adrenal glucocorticoids in neuropathic hypersensitivity, we investigated the influence of adrenalectomy on the threshold of mechanical allodynia in nerve-injured mice. (nature.com)
Dexamethasone1
- These forms of glucocorticoid have the advantage of half-lives longer than those of hydrocortisone, permitting twice-daily or even once-daily dosing (dexamethasone), which often aids compliance. (medscape.com)
Cyclophosphamide1
- Patients could be taking stable doses of medications for RA or connective tissue disease at baseline, except azathioprine, cyclosporine, mycophenolate mofetil (Cellcept), tacrolimus, rituximab (Rituxan), cyclophosphamide, or oral glucocorticoids in dosages above 20 mg/day. (medpagetoday.com)
Genes2
- Interactions between variation in candidate genes and environmental factors in the etiology of schizophrenia and bipolar disorder: a systematic review. (medline.ru)
- This research has shown that variation in a number of studied candidate genes, in interaction with child maltreatment, is associated with or predicts various psychopathological outcomes, including internalizing and externalizing problems. (psychologicalscience.org)
Inflammation1
- Secreted glucocorticoids regulate leukocyte-endothelial interactions in inflammation. (google.no)
Repression1
- Altonsy MO, Mostafa MM, Gerber AN , Newton R. Long-acting beta2-agonists promote glucocorticoid-mediated repression of NF-kappaB by enhancing expression of the feedback regulator TNFAIP3. (nationaljewish.org)
NR3C11
- FSS did not affect GR binding to a putative negative glucocorticoid response element within the Nr3c1 gene. (karger.com)
Widely2
- The interaction of GCs with macrophages in the immunosuppressive resolution phase upon prolonged TLR activation is widely unknown. (frontiersin.org)
- Glucocorticoids are widely used along with the chemotherapeutic regimens for treating ALL patients. (lu.se)
Drug-drug interactions4
- Tablets is used due to the risk of adverse effects or loss of efficacy due to drug-drug interactions (see also sections 4.4. (who.int)
- Based on how the drug is broken down in your body and metabolized, there are some potential drug-drug interactions, though no formal drug studies have been conducted. (positivelyaware.com)
- b Ritonavir-boosted nirmatrelvir has significant drug-drug interactions. (cdc.gov)
- Clinicians should carefully review a patient's concomitant medications and evaluate potential drug-drug interactions. (cdc.gov)
Norepinephrine1
- recent advances have demonstrated interactions with norepinephrine and serotonin at the neural level. (wikipedia.org)
Serum3
- We identify serum- and glucocorticoid-inducible kinase-1 (SGK-1) as the key molecule responsible for the glucocorticoid-enhanced release of ATP from astrocytes. (nature.com)
- Serum- and glucocorticoid-inducible kinase-1 (SGK-1) mediates the glucocorticoid-enhanced release of ATP from astrocytes by opening the pannexin-1 hemichannels. (nature.com)
- Reduction of serum-1,25-dihydroxyvitamin-D, in children receiving glucocorticoids. (naturalnews.com)
Prednisone2
- These theoretically potential interactions can affect people on glucocorticoid (such as prednisone) therapy and may require an increased prednisone dose. (positivelyaware.com)
- The problem is that there is a drug-test interaction with cosyntropin and prednisone. (rxeconsult.com)
Adequate2
- Appropriate responsiveness of the stress system to stressors is a crucial prerequisite for a sense of well-being, adequate performance of tasks, and positive social interactions. (nih.gov)
- Adequate glucocorticoid replacement should prevent excessive concentrations of ACTH from stimulating the adrenal glands to produce abnormal concentrations of adrenal androgens that result in further virilization. (medscape.com)
Alterations2
- Here, we report that mechanical pain hypersensitivity in sciatic nerve-injured mice shows pronounced diurnal alterations, which critically depend on diurnal variations in glucocorticoids from the adrenal glands. (nature.com)
- Alterations of glucocorticoid actions by other drugs and disease states. (naturalnews.com)
Intestinal1
- Therefore, it is necessary to rationalize the interactions of intestinal microbiota with neural mitochondria. (frontiersin.org)
Environment interactions1
- The developmental timing and duration of maltreatment also have been shown to play important roles in gene-environment interactions. (psychologicalscience.org)
Exposure2
- Gestational exposure to air pollution alters cortical volume, microglial morphology, and microglia-neuron interactions in a sex-specific manner. (medline.ru)
- of genetic, environmental, and behavioral interactions in adult- exposure to the causal agent and treatment with inhaled glucocorti- onset asthma (8). (cdc.gov)
Predict1
- The response to glucocorticoids can predict long-term remission outcome. (lu.se)
Medications1
- Of these patients, 21% were taking biologic medications, more than half were receiving disease-modifying antirheumatic drugs (DMARDs), and 73% were taking glucocorticoids in dosages below 20 mg/day. (medpagetoday.com)
Calcium1
- 1 Gennari C, Differential effect of glucocorticoids on calcium absorption and bone mass, Br J Rheumatol, 1993, 32 (suppl 2):11-4. (naturalnews.com)
Treatment1
- Therefore, the knowledge of these possible interactions is fundamental for the implementation of a nutritional treatment in the presence of a pharmacological therapy. (mdpi.com)
Absence1
- The dose of glucocorticoid is adjusted by clinically evaluating the patient (for an absence of symptoms of glucocorticoid deficiency and normal growth) and by periodically measuring the concentrations of precursor hormones. (medscape.com)
Response1
- In central nervous system structures, the glucocorticoid receptor is gaining interest as a novel representative of neuroendocrine integration, functioning as a major component of endocrine influence - specifically the stress response - upon the brain. (wikipedia.org)
Airway2
- Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle Hypertrophy. (nationaljewish.org)
- Glucocorticoid and TNF signaling converge at A20 (TNFAIP3) to repress airway smooth muscle cytokine expression. (nationaljewish.org)
Therapy2
- Effects of glucocorticoid aerosol therapy on Acinetobacter baumannii isolation during invasive mechanical ventilation among prespecified patient subgroups, China. (cdc.gov)
- Other important aspects discussed are side effects of glucocortiocid replacement therapy and interactions with other drugs. (medscape.com)
Effects1
- Further, additive interaction effects linked smoking and 3-HPMA levels. (cdc.gov)
Human1
- The molecular basis of the condition has been ascribed to inactivating mutations in the human glucocorticoid receptor (hGR) gene. (qxmd.com)
Drugs1
- DSM recently hosted a webinar detailing the consequences of vitamin D3 drug interactions and how the administration of vitamin D3 can improve the pharmacological action of some drugs. (dsm.com)
Ligands1
- A comparison of these structures with existing ER structures suggests that the ERbeta selectivity of OBCP ligands can be attributed to a combination of their interactions with Met-336 in ERbeta and Met-421 in ERalpha. (rcsb.org)