Potential for drug interactions should be considered when selecting ART for patients with human immunodeficiency virus (HIV) infection. (medscape.com)
Drug interactions with antiretrovirals are commonly caused by the inhibition or induction of hepatic drug metabolism. (medscape.com)
Protease inhibitors in combination with other drugs may require dose adjustments or should be avoided because of these potential drug interactions. (medscape.com)
Drug interactions can change how medicines work or increase risk for side effects. (cigna.com)
Drug-drug interactions can lead to changes in systemic exposure (e.g., maximum concentration (Cmax), area under the concentration time curve (AUC), average steady state concentration (Cpss)) potentially resulting in adverse reactions (higher drug exposure) or loss of efficacy (lower drug exposure). (fda.gov)
Thus, these enzymes and systems are often implicated in drug-drug interactions because of their effect on a drug's pharmacokinetics (e.g., drug exposure). (fda.gov)
These examples were evaluated and compiled by FDA as an optional resource for healthcare professionals to consult when reviewing information in the DRUG INTERACTIONS section of the approved U.S. Prescribing Information (PI) in clinical practice. (fda.gov)
This website contains examples of drugs with CYP enzyme-based and transporter-based interactions but does not include drugs with other mechanisms leading to drug interactions (such as certain interactions affecting drug absorption (e.g., chelating agents, resin-based binders, interactions, and drugs that change gut pH), interactions affecting drug plasma protein binding, or pharmacodynamic interactions). (fda.gov)
There is the possibility of negative drug interactions between itraconazole EDTA nasal spray and other Rx or OTC medications, including avanafil / cisapride / eliglustat / irinotecan / isavuconazonium / methadone / naloxegol / ranolazine / ticagrelor / lurasidone / pimozide / lomitapide / lovastatin / simvastatin / dihydroergotamine / ergonovine / ergotamine / methylergonovine / eplerenone / felodipine / ivabradine / nisoldipine / disopyramide / dofetilide / dronedarone / triazolam. (canadapharmacy.com)
Due to system maintenance, the drug interactions feature you are attempting to access is temporarily unavailable. (medscape.com)
Also tell your doctor if you take any medications that increase your risk for these heart problems or low levels of minerals (see also Drug Interactions section). (imedix.com)
See CONTRAINDICATIONS , WARNINGS , PRECAUTIONS: Drug Interactions , ADVERSE REACTIONS: Post-marketing Experience , and CLINICAL PHARMACOLOGY: Special Populations for more information. (guidelinecentral.com)
Pimozide (sold under the brand name Orap) is an antipsychotic drug of the diphenylbutylpiperidine class. (wikipedia.org)
Thioridazine (Mellaril), moxifloxacin (Avelox), pimozide (Orap), quinidine (Quinidex), dofetilide (Tikosyn), sotalol (Betapace), and sparfloxacin (Zagam) should not be taken with Geodon due to increased risk of serious disturbances in the heart rhythm. (umc-cares.org)
Cisapride1
Biaxin may interact with cisapride, pimozide, ergot medicines and result in life-threatening heart rhythm disorders. (pharm-europe.com)
Fluconazole1
Tacrolimus There have been published reports that an interaction exists when fluconazole is administered concomitantly with tacrolimus. (ultimateunderground.com)
Hypersensitivity2
It is also contraindicated in individuals being cotreated with selective serotonin reuptake inhibitors (SSRI) or in those with a known hypersensitivity to pimozide or other diphenylbutyl-piperidine derivatives. (wikipedia.org)
APONVIE is contraindicated in patients with a history of hypersensitivity to aprepitant or any component of the product, and in patients taking pimozide. (heronconnect.com)
Tourette's2
In 1985 pimozide was approved by the FDA for marketing as an orphan drug for the treatment of Tourette's syndrome. (wikipedia.org)
Pimozide is used to suppress the motor and phonic tics associated with Tourette's disorder. (health32.com)
Antipsychotics2
A 2013 systematic review compared pimozide with other antipsychotics for schizophrenia or related psychoses: It is contraindicated in individuals with either acquired, congenital or a family history of QT interval prolongation. (wikipedia.org)
Similarly to other typical antipsychotics pimozide has a high affinity for the dopamine D2 receptor and this likely results in its sexual (due to prolactin hypersecretion) and extrapyramidal side effects as well as its therapeutic efficacy against the positive symptoms of schizophrenia. (wikipedia.org)
Irregular heartbeats1
A dangerous interaction, possibly resulting in irregular heartbeats and/or death may occur if pimozide is taken with any of the medicines listed above. (health32.com)
Reactions1
Increased pimozide levels may cause serious or life-threatening reactions, such as QT prolongation. (heronconnect.com)
Interact1
Pimozide can interact with grapefruit products, and the interaction may have dangerous effects. (health32.com)
Dosage1
You may not be able to take pimozide, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. (health32.com)
Concomitantly1
Pimozide: Do not use concomitantly ( 4.2 ). (nih.gov)
Drowsiness2
Pimozide may cause dizziness or drowsiness. (health32.com)
Alcohol may increase drowsiness and dizziness while taking pimozide. (health32.com)
Drugs2
To refine your search for interacting examples of drugs* in CYP-based metabolic- and transporter system-based drug interaction classes, use the filters (in the box below) and/or the search box (located below the filters and above the table of examples). (fda.gov)
Most often, the result of an interaction is a decrease in the effectiveness of one of the drugs. (antidepressantstore.online)
Dizziness1
Very common (>10% frequency) side effects include: Akinesia Constipation Dizziness Dry mouth Hyperhidrosis Nocturia Somnolence Speech disorder Pimozide overdose presents with severe extrapyramidal symptoms, hypotension, sedation, QT interval prolongation and ventricular arrhythmias including torsades de pointes. (wikipedia.org)
Indications1
Pimozide is used in its oral preparation in schizophrenia and chronic psychosis (on-label indications in Europe only), Tourette syndrome, and resistant tics (Europe, United States and Canada). (wikipedia.org)
Increases2
Pimozide increases the risk of heat stroke. (health32.com)
Either increases toxicity of the other by unspecified interaction mechanism. (medscape.com)
Harmful1
Pimozide is in the FDA pregnancy category C. This means that it is not known whether pimozide will be harmful to an unborn baby. (health32.com)
Occur1
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. (mayoclinic.org)
Efficacy1
The use of pimozide for the treatment of delusional parasitosis is based primarily on data from case series/reports that demonstrate some efficacy in the majority of patients. (wikipedia.org)
Medication2
Pimozide is an antipsychotic medication. (health32.com)
Pimozide may also be used for purposes other than those listed in this medication guide. (health32.com)
Side1
However, patients who experience negative side-effects with the first line medications are typically given pimozide. (wikipedia.org)
Patients2
In one case a series of 33 patients with delusional parasitosis (median age, 60 years), pimozide was prescribed for 24 patients, 18 of whom took the drug. (wikipedia.org)
Of those patients receiving pimozide, 61% (11/18) experienced improvement in or full remission of symptoms. (wikipedia.org)
Treatment3
Pimozide has been used in the treatment of delusional disorder and paranoid personality disorder. (wikipedia.org)
Gastric lavage, establishment of a patent airway and, if necessary, mechanically assisted respiration is the recommended treatment for pimozide overdose. (wikipedia.org)
Do not consume grapefruit or grapefruit juice during treatment with pimozide. (health32.com)
Effect2
[ 1 , 2 ] Failure to recognize these interactions may lead to loss of therapeutic effect or excess toxicity. (medscape.com)
AP, DIN_AA and PB induce hypothermia in rabbits, p-Chlorophenylalanine and pimozide antagonize this effect of AP. (erowid.org)
Days1
Cardiac monitoring should be continued for at least 4 days due to the long half-life of pimozide. (wikipedia.org)
Site1
The interaction analysis showed that the catalytic site residues including His51, Asp75, Ser135 and other non-catalytic residues such as Asp129, Asp83, and Asp79 contribute substantial interactions. (bvsalud.org)
Potential1
The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. (mayoclinic.org)
Systems1
Agents which stimulate DA receptors may influence secondarily 5-HT neurons and thus the interaction between dopaminergic and serotoninergic systems would exist. (erowid.org)