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  • gene
  • Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. (uniprot.org)
  • This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and, thus, plays a role in the stimulation of hypoxia-induced genes such as VEGF. (wikipedia.org)
  • proteins
  • CRIF1 interacts with LSU proteins, some of which surround the exit tunnel of the mitoribosome, and also interacts with nascent OXPHOS polypeptides and the mitochondrial-specific chaperone Tid1. (wikipedia.org)
  • Syndecans interact with fibronectin on the cell surface, cytoskeletal and signaling proteins inside the cell to modulate the function of integrin in cell-matrix adhesion. (wikipedia.org)
  • Matrix molecules, growth factors, and enzymes) Chondroitin sulfate chain Transmembrane domain - self-association C1 domain - actin-association cytoskeleton Variable domain - syndecan-specific C2 domain - attach to PDZ proteins Syndecans normally form homodimers or multimers. (wikipedia.org)
  • genes
  • The motifs discovered were used to detect transcription factor binding sites in the 5' regulatory regions of all human genes (according to the UCSC hg18 assembly). (jbsdonline.com)
  • Gadd45b is required for activity-induced DNA demethylation of specific promoters and expression of corresponding genes necessary for adult neurogenesis, including brain-derived neurotrophic factor and fibroblast growth factor. (wikipedia.org)
  • novel
  • Using novel methods for single cell whole genome sequencing able to detect rare mutations, and unique mouse models, we will define how age and diet, two major risk factors for common sporadic intestinal cancer, alter the mutational load and spectrum of intestinal stem cells. (grantome.com)
  • demonstrate
  • We demonstrate that binding sites for a pair of interacting TFs can be found at distances that are dramatically nonrandom and depend both on selected TFs and a relative orientation of their binding sites. (jbsdonline.com)
  • HUMAN
  • We make use of aging mice and a unique nutritionally driven model of sporadic colon and intestinal tumors in wild-type mice that recapitulates the stochastic development of sporadic colon cancer (1-2 tumors in 25% of the mice following exposure to major human dietary risk factors for 2/3 of the host lifespan). (grantome.com)
  • Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium. (nih.gov)
  • project
  • Given this, studies of C cycling need to capture the spatial and temporal variance of biotic and abiotic factors and their interactions to project the likely impacts of environmental change. (springer.com)