• gene
  • Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. (uniprot.org)
  • Enhancement of rice whole-cell extracts with recombinant transcription factors thus provides a powerful tool for the in vitro determination of plant gene regulation mechanisms. (plantcell.org)
  • Transient transfection of plasmids containing a reporter gene under the control of GalNAc-T3 indicated that several transcriptional elements are involved in response to sodium butyrate, with the nuclear respiratory factor-1 (NRF-1)-binding motif located between −88 and −77nt being the most important. (biochemj.org)
  • This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and, thus, plays a role in the stimulation of hypoxia-induced genes such as VEGF. (wikipedia.org)
  • nuclear
  • The p300 interaction with transcription factors is managed by one or more of p300 domains: the nuclear receptor interaction domain (RID), the KIX domain (CREB and MYB interaction domain), the cysteine/histidine regions (TAZ1/CH1 and TAZ2/CH3) and the interferon response binding domain (IBiD). (wikipedia.org)
  • Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. (wikipedia.org)
  • demonstrate
  • We demonstrate that binding sites for a pair of interacting TFs can be found at distances that are dramatically nonrandom and depend both on selected TFs and a relative orientation of their binding sites. (jbsdonline.com)
  • We also demonstrate a physical interaction between OsTBP2 and RF2a, a rice bZIP transcription factor that bound to the box II cis element of the promoter of Rice tungro bacilliform virus , resulting in enhanced transcription from the viral promoter. (plantcell.org)
  • interaction
  • Because these components are likely to be present simultaneously in the atherosclerotic milieu, we investigated whether oxLDL interacts with FGF-1 and whether this interaction affects FGF-1 functioning. (ahajournals.org)
  • family
  • updated cancer risk factor and family cancer history information was collected from all cases and controls at the time of blood collection by telephone interview. (aacrjournals.org)
  • vascular
  • 1,3 ⇓ OxLDL induces a number of cytokines and growth factors in vascular cells, exerts mitogenic effects at low concentrations and cytotoxic effects at high concentrations, and are also implicated in the progression of the plaque to vulnerable, highly thrombogenic atheroma. (ahajournals.org)
  • cells
  • We previously reported that HIF-1 is upregulated and required for transforming growth factor (TGF)-β induction of collagen in renal tubular cells. (sigmaaldrich.com)