• gene
  • Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. (uniprot.org)
  • This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and, thus, plays a role in the stimulation of hypoxia-induced genes such as VEGF. (wikipedia.org)
  • nuclear
  • The p300 interaction with transcription factors is managed by one or more of p300 domains: the nuclear receptor interaction domain (RID), the KIX domain (CREB and MYB interaction domain), the cysteine/histidine regions (TAZ1/CH1 and TAZ2/CH3) and the interferon response binding domain (IBiD). (wikipedia.org)
  • Characterization of MyD118, Gadd45, and proliferating cell nuclear antigen (PCNA) interacting domains. (wikipedia.org)
  • demonstrate
  • We demonstrate that binding sites for a pair of interacting TFs can be found at distances that are dramatically nonrandom and depend both on selected TFs and a relative orientation of their binding sites. (jbsdonline.com)
  • interaction
  • Because these components are likely to be present simultaneously in the atherosclerotic milieu, we investigated whether oxLDL interacts with FGF-1 and whether this interaction affects FGF-1 functioning. (ahajournals.org)
  • HUMAN
  • We make use of aging mice and a unique nutritionally driven model of sporadic colon and intestinal tumors in wild-type mice that recapitulates the stochastic development of sporadic colon cancer (1-2 tumors in 25% of the mice following exposure to major human dietary risk factors for 2/3 of the host lifespan). (grantome.com)
  • family
  • updated cancer risk factor and family cancer history information was collected from all cases and controls at the time of blood collection by telephone interview. (aacrjournals.org)
  • risk
  • Age and diet are the two most clearly recognized risk factors for common sporadic colon cancer, responsible for >90% of cases in developed countries. (grantome.com)
  • Using novel methods for single cell whole genome sequencing able to detect rare mutations, and unique mouse models, we will define how age and diet, two major risk factors for common sporadic intestinal cancer, alter the mutational load and spectrum of intestinal stem cells. (grantome.com)
  • Risk factors include obesity and eating red meat. (wikipedia.org)
  • Some risk factors associated with the development of uterine fibroids are modifiable. (wikipedia.org)
  • vascular
  • 1,3 ⇓ OxLDL induces a number of cytokines and growth factors in vascular cells, exerts mitogenic effects at low concentrations and cytotoxic effects at high concentrations, and are also implicated in the progression of the plaque to vulnerable, highly thrombogenic atheroma. (ahajournals.org)