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  • In such patients, care must to be taken to select the safest drug from the necessary class of medication. (medscape.com)
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  • Only 2 reviews have attempted to distinguish between the effectiveness of antihypertensive therapies used as first-line agents. (cmaj.ca)
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  • Therapy with carbidopa, given with or without levodopa or carbidopa-levodopa combination products, is started, dosage adjustment of the antihypertensive drug may be required. (medscape.com)
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  • In both the drug-drug and the drug-no treatment comparison trials, thiazides were significantly better at reducing systolic blood pressure than the other drug classes. (cmaj.ca)
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  • The review by Psaty and colleagues [8] had a number of deficiencies: drug-drug comparison trials were not included, trials were misclassified to drug therapy groups, and data on the effects of lowering blood pressure were not included. (cmaj.ca)
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