Interact microtubules. Medical search. Frequent questions

Centrosomes nucleate the formation of the microtubule cytoskeleton in interphase cells and form the poles of the mitotic spindle during cell division. (elifesciences.org)
In an mutant trichomes, the organization of the actin cytoskeleton is normal but the distribution of microtubules is aberrant. (nih.gov)
A role of AN in the control of the microtubule cytoskeleton is further supported by the finding that AN genetically and physically interacts with ZWICHEL, a kinesin motor molecule involved in trichome branching. (nih.gov)
Our data suggest that CtBP/BARS-like protein function in plants is directly associated with the microtubule cytoskeleton. (nih.gov)
The cytoskeleton is typically divided into three distinct components: microtubules, intermediate filaments and actin[ 4 , 5 ]. (biorxiv.org)
We focus on the microtubule cytoskeleton - the dynamic network of protein fibers that pulls the chromosomes apart at mitosis, acts as "railroad tracks" for intracellular transport, and organizes the cytoplasm. (nd.edu)
APC also interacts with the actin cytoskeleton to regulate cell polarity. (ku.edu)
Plant cytoskeleton consists of two major networks of protein polymers, actin microfilaments (AFs) and microtubules (MTs). (cas.cz)
The chemi- appear to interact with the structural elements of the cell, cal analysis was assessed at DATA CHEM Laboratories using plasma- with apparent binding to the cytoskeleton [Porter et al. (cdc.gov)

Kinetochores are protein complexes on the chromosomes, whose function as linkers between spindle microtubules and chromosomes is crucial for proper cell division. (nature.com)
We show that kinetochores on homologous chromosomes move together, microtubules are dynamic and pivot around the spindle pole, and the average capture time is 3-4 minutes. (nature.com)
Our theory describes paired kinetochores on homologous chromosomes as a single object, as well as angular movement of microtubules and their dynamics. (nature.com)
In order to distribute the genetic material equally, the cell forms a spindle, a precise micro-machine made of microtubules (MTs) to which all chromosomes have to be correctly targeted. (nature.com)
Simultaneous to this process, the opposite ends of the filaments extend towards the cell centre, where they interact with chromosomes. (sciencedaily.com)
When the spindle is finally assembled, the microtubules pull the chromosomes to opposite poles and initiate the physical division of the cell. (sciencedaily.com)
This is an important cellular event because when the kinetochore is not tethered to microtubule-ends, the growth and shrinkage of microtubule-ends can not push or pull chromosomes. (qmul.ac.uk)
b) how microtubules impart adequate forces to pull apart chromosomes into two equal sets. (qmul.ac.uk)
How do other parts of the cell (organelles, chromosomes, the cell cortex) interact with microtubules? (nd.edu)
Microtubules play a crucial role in segregating chromosomes from one cell to another during cell mitosis and division. (databasefootball.com)
From the knowledge gained through pioneering studies in both simple and complex model organisms such as these, we now know that microtubules interact with chromosomes during the entire cell cycle, not just during cell division. (databasefootball.com)

On the other hand, microtubules are metastable polymers made of α- and β-tubulin, alternating between growing and shrinking phases, a phenomenon known as dynamic instability. (wikipedia.org)
The scientists have demonstrated that the protein γ-tubulin localizes at the starting points of the microtubule filaments and is relatively stably associated with these structures. (sciencedaily.com)
Using a version of γ-tubulin that carries a fluorescent label activated by laser light, the researchers were able to follow the movement of the starting points of microtubules within mitotic spindles by filming dividing human cells. (sciencedaily.com)
Microtubules, the cytoskeletal component with the widest cross-section at about 25nm in diameter, are hollow tubes consisting of repeated α - and β -tubulin sub-units[ 6 ]. (biorxiv.org)
SIRT2 colocalizes and interacts in vivo with HDAC6, another tubulin deacetylase. (nih.gov)
At that time, there were only two known types of tubulins that make up microtubules: alpha and beta tubulin, and alpha and beta tubulins are just the building blocks that create microtubule filaments. (databasefootball.com)
By using genetic screening on the common fungal model species Aspergillus nidulans , Dr. Oakley and his team targeted a gene that fit their screening criteria: one that seemed to interact with beta-tubulin. (databasefootball.com)
As an unknown tubulin gene, this gene had never been studied, so Dr. Oakley's team set out to isolate and understand why this particular gene was important for microtubules. (databasefootball.com)
They were surprised to discover that this gene, which they named Gamma tubulin , was the foundation of microtubule formation. (databasefootball.com)
In cells, tubulin molecules arrange themselves into tube-like structures, the microtubule filaments. (psi.ch)
Thus tubulin performs diverse functions in the cell and in doing so interacts with numerous other substances. (psi.ch)
APC is implicated in spindle formation by direct interactions with tubulin and microtubule-binding protein EB1. (ku.edu)
The microtubule protein tubulin regulates adenylyl cyclase and phospholipase Cβ 1 (PLCβ 1 ) signaling via transactivation of the G-protein subunits Gαs, Gαi1, and Gαq. (jneurosci.org)
In SK-N-SH cells, carbachol induced a rapid and transient translocation of tubulin to the plasma membrane, microtubule reorganization, and a change in cell shape as demonstrated by confocal immunofluorescence microscopy. (jneurosci.org)

The kinetochore assembles on the centromere and links the chromosome to microtubule polymers from the mitotic spindle during mitosis and meiosis. (wikipedia.org)
MTs interact with a chromosome via the kinetochore (KC), a large protein complex located at the centromere. (nature.com)
When a cell divides into two, its microtubules must properly capture each chromosome at specialised multi-protein structures called kinetochores. (qmul.ac.uk)
15-30 months: The student will choose mutant phenotypes from year-1 for live-cell analysis for analysing changes in microtubule-mediated pulling of kinetochore and chromosome-microtubule attachment status. (qmul.ac.uk)
Microtubule filaments composed of tubulins are now known to play an active role in chromosome separation. (databasefootball.com)

Other proteins in the kinetochore adhere it to the microtubules (MTs) of the mitotic spindle. (wikipedia.org)
The mechanisms that facilitate kinetochore capture by microtubules are still unclear. (nature.com)
This analysis has already yielded some important insights: For example, the Dam1 complex, a specialized microtubule-binding component of the budding yeast kinetochore oligomerizes to form a ring around microtubules in vitro ( Figure 2 ). (uni-due.de)
Our investigations into kinetochore assembly have led to the identification of a conserved receptor molecule for the microtubule-binding Ndc80 complex. (uni-due.de)
To analyze this process we have reconstituted dynamic microtubules in vitro and visualized the interaction of individual kinetochore components using total internal reflection fluorescence (TIRF) microscopy (Movie 1) . (uni-due.de)
This technique allows the observation of individual kinetochore complexes and microtubule-binding proteins with single-molecule sensitivity to reveal their mode of interaction with dynamic plus-ends. (uni-due.de)
1-15 months: The student will generate mutants of outer-kinetochore proteins that interact with microtubules. (qmul.ac.uk)

Other proteins, such as Mad2, monitor the microtubule attachment as well as the tension between sister kinetochores and activate the spindle checkpoint to arrest the cell cycle when either of these is absent. (wikipedia.org)
For the experimentally measured parameters, the model reproduces the measured capture kinetics and shows that the paired configuration of kinetochores accelerates capture, whereas microtubule pivoting and dynamics have a smaller contribution. (nature.com)
A defining feature of kinetochores is their ability to interact with microtubule plus-ends through multiple rounds of polymerization and depolymerization. (uni-due.de)
Therefore, to understand how aneuploidy arises, we should understand how kinetochores are captured by microtubules. (qmul.ac.uk)
Recent high-resolution microscopy work in the Draviam group showed that kinetochores are first captured along microtubule walls and then brought to microtubule-ends. (qmul.ac.uk)

Eg5 is localized at the centrosomes, spindle microtubules, and intracellular bridge. (biolegend.com)

The in vivo visualization and monitoring of the starting points of microtubules -- filaments responsible for organizing the mitotic spindle -- provides novel insight into the dynamic architecture of this structure. (sciencedaily.com)
The findings will also contribute to understanding how the mitotic spindle is perturbed by drugs that target microtubules and that are used in chemotherapy. (sciencedaily.com)
The researchers describe for the first time where most microtubules form inside the mitotic spindle, how they develop, and how their starting points are transported -- with the help of three motor proteins -- to opposite poles of the spindle, where they attach. (sciencedaily.com)
Our results are the first to tubes (SWCNT) suggest the potential to interact report disruption of the mitotic spindle by with critical biological structures. (cdc.gov)
The nanotube bundles are similar to the potential of nanotubes to induce genetic damage size of microtubules that form the mitotic spindle in normal lung cells, cultured primary and immor- and may be incorporated into the mitotic spindle talized human airway epithelial cells were apparatus. (cdc.gov)

Eg5 (also known as kinesin-like protein KIF11, kinesin-related motor protein Eg5, kinesin-like spindle protein HKSP, and thyroid receptor interacting protein 5 (TRIP5)) is a 119 kD kinesin-like protein family, BimC subfamily. (biolegend.com)

The microtubules and actin filaments within the phragmoplast serve to guide vesicles with cell wall material to the growing cell plate. (sciforums.com)
Unlike the globular units of microtubules and actin filaments, intermediate filaments are themselves constructed from filamentous sub-units, and confer strength as well as stress resistance to the cell[ 10 ]. (biorxiv.org)
But a pertinent question remains: how do tubulins organize themselves into microtubule filaments? (databasefootball.com)
Model organisms were once again critical in answering the question of how tubulins are organized into microtubule filaments in 1989 in the lab of Dr. Berl Oakley. (databasefootball.com)
Dr. Oakley was interested in identifying proteins which associate with microtubules in the cytoplasm, particularly during the breakdown of microtubule filaments. (databasefootball.com)
We also present evidence for interactions between APC and IFs, independent of actin filaments and microtubules. (ku.edu)
Actin filaments and microtubules play important biological functions in mammalian cells, such as mitosis, cytokinesis, cell signaling, intracellular transport, and cell motility. (go.jp)

They are also involved in the assembly and function of microtubule-based structures such as CILIA and CENTRIOLES. (bvsalud.org)

This protein interacts with microtubules and regulates the activity of a variety of proteins that are involved in their function. (medlineplus.gov)
The encoded protein plays a role in cell-cycle progression and spindle organization, regulates cytokinesis, interacts with Nephrocystin 8 and is required for cilia formation. (nih.gov)

In addition, they affect non-dividing cells such as neurons, in which microtubules also have important functions. (sciencedaily.com)
Talk to me again when you've read Kandel and can explain what quantum fluxes in microtubules adds to our understanding of how neurons work, because none of the stuff you've said or linked to on TT shows any understanding of the basics. (freethoughtblogs.com)

Here, we report that AQP5 promotes microtubule assembly and helps maintain the assembled microtubule steady state levels with slower turnover dynamics in cells . (plos.org)
These findings indicate that AQP5-mediated regulation of microtubule dynamics modulates airway epithelial barrier properties and epithelial function. (plos.org)
To answer these questions we use a combination of biochemistry, molecular biology, quantitative microscopy, and (in collaboration with applied mathematician Mark Alber) computational models of microtubule dynamics. (nd.edu)

The GAP activity of Tum is required for cytokinesis: in its absence cytokinesis fails early even though Tum is present on microtubules at the cell equator where the furrow should form. (biologists.com)

In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. (nih.gov)

In plants, microtubules retain a role in cell division but also guide cell wall development through their relationship with wall-building enzyme complexes in the plasma membrane[ 9 ]. (biorxiv.org)

To identify proteins interacting with alpha A-crystallin (CRYAA) and to investigate the potential role that these protein interactions play in the function of CRYAA using a human proteome (HuProt) microarray. (molvis.org)
Besides the more or less indirect cooperation between AFs and MTs, their direct interactions through specific physically interacting proteins has been well described in yeast, nematodes, insect and animal cells. (cas.cz)

At that time scientists were using the term "mitotic figures" to describe microtubules because they were observed during metaphase of mitosis. (databasefootball.com)

In contrast, overexpression of AQP5 increased assembly of microtubules, with evidence of increased MT stability, and promoted the formation of long straight microtubules in the apical domain of the epithelial cells. (plos.org)
Fernandes, G. F. and Goodson, H. V. "Overexpression of the Microtubule-Binding Protein CLIP-170 Induces a Plus TIP Network Superstructure Consistent with a Biomolecular Condensate" 2021 PLOS One , 16 (12), e0260401. (nd.edu)

Therefore, small molecules that interact with these cytoskeletons are expected to be useful not only as antitumor agents, but also as tools for understanding a wide variety of the cellular functions of cytoskeletons. (go.jp)

The TRIP11 gene provides instructions for making a protein known as Golgi microtubule-associated protein 210 (GMAP-210). (medlineplus.gov)
PAFAH1B1 gene mutations cause PAF levels to be reduced and impair the normal function of microtubules. (medlineplus.gov)
Caffeine intake interacts with Asian gene variants in Parkinson's disease: a study in 4488 subjects. (cdc.gov)

Negative stain electron microscopy of Dam1 complex decorating microtubules. (uni-due.de)
Single Cik1-Kar3 Kinesin-14 motor proteins (red) moving along taxol-stabilized microtubules (blue), visualized by TIRF microscopy. (uni-due.de)

Here, we report that a human ortholog of Sir2p, sirtuin type 2 (SIRT2), is a predominantly cytoplasmic protein that colocalizes with microtubules. (nih.gov)

We hope not only to provide a mechanistic understanding of this process but also to explore more generally the type of features that allow translocation of molecules along microtubules. (uni-due.de)

These microtubules function as the "skeleton" of cells which give cells their shape and maintain their integrity. (databasefootball.com)

We propose that procentriole assembly requires PLK4 to phosphorylate STIL in two different regions: phosphorylation of residues in the STAN motif allow STIL to bind SAS6 and initiate cartwheel assembly, while phosphorylation of S428 promotes the binding of STIL to CPAP, linking the cartwheel to microtubules of the centriole wall. (elifesciences.org)

By performing cell biological and biochemical experiments using human cells, Moyer and Holland show that PLK4 interacts with a protein called STIL that is found in the central part of the centriole. (elifesciences.org)
Jonasson, E. M. and Goodson, H. V. "The CLIP-170 N-Terminal Domain Binds Directly to both F-Actin and Microtubules in a Mutually Exclusive Manner" 2022 Journal of Biological Chemistry , 298 (5), 101820. (nd.edu)
Microtubules also enable many biological processes, such as protein transport within cells and cell to cell communication. (databasefootball.com)
Based on this research, you might understand how important microtubules are for normal biological processes. (databasefootball.com)

It would mean that if the microtubules in your visual cortex could be replaced with functional equivalents you would be blind but you would not notice you were blind and you would behave as if you had normal vision. (extropy.org)

Here, I describe our recent research into anti-actin and anti-microtubule natural products. (go.jp)

Here we summarize recent advances in our knowledge about the candidate proteins or protein complexes that interact with both AFs and MTs and their role in fundamental cellular and developmental processes. (cas.cz)

Although the positioning signal is likely to be transmitted via the anaphase microtubule array to the cell cortex, exactly how the microtubule array determines the site of contractile ring formation remains unresolved. (biologists.com)
These data support a model in which Tum/RacGAP, via its interaction with Pbl, provides a critical link between the anaphase microtubule spindle and cytokinetic furrow formation in Drosophila cells. (biologists.com)

GMAP-210, A cis-Golgi network-associated protein, is a minus end microtubule-binding protein. (medlineplus.gov)

Is consciousness to be found in quantum processes in microtubules? (sciforums.com)

Disruption of the Pebble-interacting domain leaves Tum localised to the cell equator on cortically associated microtubules, again with no evidence of furrowing. (biologists.com)

Quantum effects in microtubules are going to be inconsequential relative to ion fluxes and chemical changes in membrane properties and channels, and there is no explained mechanism to regulate quantum effects. (freethoughtblogs.com)

The abnormal PAFAH1B1 protein is less able to interact with microtubules and to attach (bind) to other subunits to form the PAFAH1B complex, both of which are needed for neuronal migration. (medlineplus.gov)

Brain hypometabolism in non-demented microtubule-associated protein tau H1 carriers with Parkinson's disease. (cdc.gov)

MTs have to get in close proximity to the KCs in order to be able to interact with them, but the mechanisms that facilitate this process are still under debate 1 . (nature.com)
A large number of compounds have been reported as anti-microtubule or anti-actin agents, but only a few compounds have been clarified as to their binding sites on target molecules and their inhibition mechanisms. (go.jp)

In line with this notion, mitochondria are highly dynamic organelles that undergo fission and fusion and move into the cell along the microtubules to generate the mitochondrial network [ 6 ]. (hindawi.com)

A better understanding of the differences in spindle organisation between cancer and healthy cells and how they respond to microtubule-targeted drugs is essential in order to optimise treatments, for example by identifying more specific drugs or new targets. (sciencedaily.com)

The growing plus-ends of microtubules are decorated with EB1 (green). (uni-due.de)
Topics of particular interest include microtubule plus-end tracking proteins (+TIPs), a network of diverse proteins that dynamically track growing microtubule plus ends, as well as the disease-associated proteins Tau (Alzheimer's) and stathmin (cancer). (nd.edu)

For more than 10 years we have been able to track only the growing ends of microtubules but not the starting points. (sciencedaily.com)
CSPP1 stabilizes growing microtubule ends and damaged lattices from the luminal side. (nih.gov)

Note unidirectional, processive runs of individual motor molecules along the microtubules. (uni-due.de)

CRYAA interacted with these proteins to maintain their solubility and decrease the accumulation of denatured target proteins. (molvis.org)

Junior scientists and graduate students will interact with the field leaders, through oral presentations, poster sessions, and late-breaking talks selected from submitted abstracts. (grc.org)

One-hundred and twenty-seven of 17,225 human full-length proteins were identified that interact with CRYAA. (molvis.org)

At this level the action potentials for electric and chemical responses (comfort, discomfort) are generated and action potentials are a result of the microtubule data processing system. (sciforums.com)

Anatomy36

Organisms18

Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes35

Technology, Industry, Agriculture4

Information Science5

Health Care1

Cytoskeleton9

Chromosomes11

Tubulin14

Chromosome5

Kinetochore7

Kinetochores5

Spindle microtubules1

Mitotic spindle5

Thyroid receptor-interac1

Filaments7

Structures1

Regulates2

Neurons2

Dynamics3

Cytokinesis1

Meiosis1

Plasma membrane1

Interactions2

Metaphase1

Overexpression2

Functions1

Gene3

Microscopy2

Cytoplasmic1

Translocation1

Function1

Assembly1

Biological4

Functional1

Describe1

Complexes1

Formation2

Minus1

Processes1

Disruption1

Quantum1

Form1

Brain1

Mechanisms2

Generate1

Cells1

Plus-ends2

Ends2

Motor1

Maintain1

Scientists1

HUMAN1

Result1