Integrity tissue scaffolds. Medical search. Frequent questions

Scaffolds have been utilized in tissue regeneration to facilitate the formation and maturation of new tissues or organs where a balance between temporary mechanical support and mass transport (degradation and cell growth) is ideally achieved. (hindawi.com)
One of the most attractive subjects in tissue engineering is the development of a scaffold, a three-dimensional porous solid structure that plays a key role in assisting tissue regeneration [ 1 ]. (hindawi.com)
Its degradation rate should match the rate of new tissue regeneration in order to maintain the structural integrity and to provide a smooth transition of the load transfer from the scaffold to the tissue [ 3 ]. (hindawi.com)
Biodegradability can be imparted into polymers through molecular design with a controlled rate in concert with tissue regeneration [ 18 - 21 ]. (hindawi.com)
The incorporation of osteoinductive factors into scaffolds is usually required to promote sufficient bone regeneration (Egri & Eczacioglu, 2017 ). (springeropen.com)
Specific growth factors play important roles in the regeneration process of different tissues. (springeropen.com)
Strategies to bone tissue engineering have focused on the use of synthetic or natural degradable materials as scaffolds for cell transplantation to guide bone regeneration. (manchester.ac.uk)
The integration of multiscale micro- and macroenvironment has been demonstrated as a critical role in designing biomimetic scaffolds for peripheral nerve tissue regeneration. (desktopmetal.com)
However, due to the inherent complexity of nerve tissues, bioprinting scaffolds that can appropriately promote the regeneration of damaged tissues is still challenging. (desktopmetal.com)
This paper presents our study on bioprinting Schwann cell-laden scaffolds from low-viscosity hydrogel compositions including RGD modified alginate, hyaluronic acid and fibrin, with a focus on investigating the printability of hydrogel compositions and characterizing the functions of printed scaffolds for potential use in nerve tissue regeneration. (desktopmetal.com)
Epimorphic regeneration is a process by which damaged tissues or severed body parts are restored to the original. (eurekaselect.com)
Epimorphic regeneration and retrodifferentiation both have the capacity to recreate and reconstruct tissue with precise positional integration of cells in such a way that will enable us to heal without scars and to understand how to maintain tissue integrity and architecture in the face of a hostile environment. (eurekaselect.com)
Restoration of nerve tissue remains highly challenging, mainly due to the limited regeneration capacity of the nervous system and the development of fibrosis. (yjxinhua.com)
The combination of inductive scaffold materials with stem cells might optimize the approaches for bone regeneration. (bvsalud.org)
The development of new biomaterials for tissue engineering provides a scientific basis for the creation of scaffolds that could provide appropriate regeneration and tissue repair 14 . (bvsalud.org)
The high regeneration potential has aroused a great interest in the scientific community 3 , due to its many clinical applications in cell therapy or tissue engineering. (bvsalud.org)
The tissues that used to be discarded may now serve as a basis for scientific research and clinical use in tissue regeneration and treatment of many diseases 23 . (bvsalud.org)
Tissue regeneration is needed to re-establish homeostasis of the ocular surface and to preserve vision. (unibs.it)
The thickness measurements at the end of processing suggest ultra-thin DCD obtained could represent a promising scaffold for regeneration of conjunctival tissue. (unibs.it)
Bioactive scaffolds designed for bone repair and regeneration have emerged as one of the fastest-growing applications in the field of biomaterials. (boydbiomedical.com)
By incorporating bioactive molecules and growth factors, these scaffolds can stimulate cell proliferation and differentiation, accelerate the healing process, and enhance bone regeneration. (boydbiomedical.com)
Applications for bioresorbable implants include orthopedics, cardiovascular interventions, and tissue engineering, where they provide temporary support while facilitating tissue regeneration. (boydbiomedical.com)

For instance, PLA could be combined with PGA to form poly(lactic- co -glycolic acid) (PLGA), which has degradation rate tailored with the tissue healing period and has been shown to support osteoblast cells attachment and growth in vitro and in vivo [ 22 - 24 ]. (hindawi.com)
Evaluation of the efficacy of proposed agents in an in vitro model is convenient and allows assessment of the mechanical properties of the bone-tendon interface as well as the effect on fibroblast proliferation and collagen content of the tissue. (researchgate.net)
We hypothesize that the hydrolytic degradation of composite PLGA/CaO 2 3-dimensional (3D) scaffolds would result in a measurable in vitro release of CaO 2 over 28 days. (confex.com)
In vitro, scaffold size is limited to a few hundred microns because of lack of a vascular system, thus cells rely solely on oxygen diffusion. (umd.edu)
Binding of MHC class II antigens on leukocytes with the monoclonal antibody CR3/43 appears to emulate stress and injury in human tissue in vitro, similar to limb amputation in salamander. (eurekaselect.com)
Nobel Prize winner Alexis Carrel performed numerous experiments clearly showing that tissue explants, including connective tissue and heart tissue, could be cultured in vitro preserving their characteristics for prolonged periods of time [ 2 ] supporting the notion that entire organs could be cultured in vitro. (intechopen.com)
MSCs have great therapeutic potential in tissue engineering, they can be expanded in vitro, and combined with scaffolds they can be inserted into wounds to promote healing and tissue replacement. (bvsalud.org)

It is found within the dermal/epidermal junction, placental tissues, as well as in association with tissues containing type I collagen. (wikipedia.org)
Collagen proteins are often associated with the strengthening and support of many tissues including skin, bones, muscles, and ligaments. (wikipedia.org)
There are some studies that suggest that Type V collagen is responsible for the formation of other collagen fibrils in different tissues within the body. (wikipedia.org)
Collagen V overexpression has been found in cancer, granulation tissue, inflammation and atherosclerosis. (wikipedia.org)
48,49 In addition, cyclic mechanical strain enhances the function and development of engineered tissues by improving the production of collagen and elastin. (researchgate.net)
Collagen is a critical protein that acts as the backbone of our connective tissues, providing essential support and strength throughout the body. (abundanceandhealth.co.uk)
When it comes to the ACL joint, collagen plays a pivotal role in maintaining its integrity and functionality. (abundanceandhealth.co.uk)
Imagine collagen as a robust scaffold that holds the ACL together. (abundanceandhealth.co.uk)
In this study, using a micro electro mechanical systems process and soft lithography, fifteen negative molds, with different dimensions and aspect ratios in grid- and pillar-type configurations, were designed and fabricated to create three-dimensional micropatterns and replicated onto fish-scale type I collagen scaffolds treated with chemical crosslinking. (tissueandcells.com)
With the help of rheological test, the collagen scaffold manufactured in this study was confirmed to be an ideal gel and have visco-elastic features. (tissueandcells.com)
As this three-dimensional microstructure is valuable for maintaining epithelial integrity, our micropatterned collagen scaffolds can be used not only intraorally but extraorally as a graft material for human use. (tissueandcells.com)
Collagen refers to a collection of proteins found in the tendon and ligament, as well as the connective tissue layer of the skin dermis, dentin, and cartilage, that are composed of white, fairly inelastic fibres with high tensile strength. (vedantu.com)
Collagen provides strength by forming a scaffold-like structure. (vedantu.com)
Furthermore, collagen is an important component of connective tissue, responsible for keeping skin firm and supple. (senzuhealth.com)
Collagen also helps protect the body from inflammation and the breakdown of connective tissue, which can lead to wrinkles and other signs of aging. (senzuhealth.com)
The benefits of collagen are manifold: it is an important nutrient and an essential amino acid that helps to maintain skin integrity, firmness, and suppleness. (senzuhealth.com)
Collagen also helps in reducing bone resorption (breakdown of bone tissue) and in preventing the development of osteoporosis. (senzuhealth.com)
Additionally, collagen helps to form the connective tissue around the joints, which helps to provide additional stability. (senzuhealth.com)
Collagen helps in the formation of a lattice-like structure around the wound that acts as a scaffold for wound healing. (senzuhealth.com)

These premixed hydrogels retained high bioactivity and tissue-specificity due to their containing dECM-Gs. (desktopmetal.com)
PEG-penetrated chitosan-alginate co-polysaccharide-based partially and fully cross-linked hydrogels as ECM mimic for tissue engineering applications. (docksci.com)
Specifically, we employ biosynthetic hydrogels composed of conjugated poly(ethylene glycol) (PEG) and fibrinogen protein (PEG-Fb) to create engineered breast and colorectal cancer tissue microspheres for 3D culture, tumorigenic characterization, and examination of potential for high-throughput screening (HTS). (nsf.gov)
To ensure structural integrity and enhance biocompatibility, the electrospun nanofibers were crosslinked to form hydrogels. (unh.edu)
developed a method for printing cellularised scaffolds from thermosensitive hydrogels. (slideshare.net)
This includes bioactive scaffolds, bioresorbable implants, injectable hydrogels, "organ-on-a-chip" organ models, and self-healing biomaterials. (boydbiomedical.com)

With further optimization in topologically ordered porosity design exploiting material property and fabrication technique, porous biodegradable metals could be the potential materials for making hard tissue scaffolds. (hindawi.com)
Sufficient porosity is needed to accommodate cell proliferation and differentiation, which will eventually enhance tissue formation [ 2 , 3 ]. (hindawi.com)
Zhang and Ma have developed [ 25 ] a highly porous biodegradable polymer/apatite composite scaffold (95% porosity) through a thermally induced phase separation technique, which resulted in significant improvement in mechanical properties compared to polymer-only scaffold. (hindawi.com)
In this study, a series of zonal-structured scaffolds were fabricated via 3D printing with controlled porosity to support each layer of the OC unit along with a graded scaffold intended to enable the formation of the OC interface. (programmaster.org)
Moreover, this technique allows the control of the scaffolds' architecture and porosity. (upc.edu)
After the paraffin spheres were dissolved and removed by cyclohexane, PLGA scaffold with controlled pore size, good interconnectivity and high porosity was obtained with apatite left on the pore surface uniformly throughout the whole scaffold. (manchester.ac.uk)
Porosity, which determines the rate at which tissue, will grow and encapsulate the implant. (swicofil.com)

The field of tissue engineering is constantly evolving as it aims to develop bioengineered and functional tissues and organs for repair or replacement. (mdpi.com)
Due to their large surface area and ability to interact with proteins and peptides, graphene oxides offer valuable physiochemical and biological features for biomedical applications and have been successfully employed for optimizing scaffold architectures for a wide range of organs, from the skin to cardiac tissue. (mdpi.com)
Biomedical implants are used to aid or replace damaged tissues or organs. (swicofil.com)
The ECM component of the tissues forms an insoluble scaffold, which determines the shape and dimension of the organs (Cox and Erler 2011). (docksci.com)
Tissue engineering is the science that combines the principles of biology and engineering techniques in order to obtain biological substitutes for regenerating, replacing, modifying, repairing or restoring the function of organs and tissues. (bvsalud.org)
Development of functional tissues and organs requires the ability to achieve large full-scale scaffolds that mimic human organs. (unh.edu)

Within the caveolae, the caveolin-3 protein acts as a scaffold to organize other molecules that are important for cell signaling and maintenance of the cell structure. (medlineplus.gov)

Polymers have been widely chosen as tissue scaffolding material having a good combination of biodegradability, biocompatibility, and porous structure. (hindawi.com)
Biodegradable polymers have been widely used and accepted as the most suitable materials for scaffolds due to their degradability, biocompatibility, and ease of processability [ 9 - 11 ]. (hindawi.com)
Decellularized extracellular matrix hydrogel (dECM-G) has demonstrated its significant tissue-specificity, high biocompatibility, and versatile utilities in tissue engineering. (desktopmetal.com)
Polypyrrole (PPy) was deposited on PLCL and PLGA scaffolds to enhance biocompatibility for nerve recovery. (desktopmetal.com)
Gelatin is a natural biopolymer which is widely exploited in the fabrication of scaffolds due to its high biodegradability, biocompatibility and great cell adhesion12,13. (yjxinhua.com)

Self-setting calcium phosphate inks, which harden at low temperature, allow obtaining nanostructured scaffolds with biomimetic properties and enhanced bioactivity. (upc.edu)
Different hydrothermal treatments for the consolidation of DIW scaffolds fabricated with an a-tricalcium phosphate /pluronic F127 ink were explored, comparing them with a biomimetic treatment. (upc.edu)
Biomimetic and hydrothermally treated scaffolds supported the adhesion and proliferation of rat mesenchymal stem cells, indicating a good suitability for bone tissue engineering applications. (upc.edu)
The present work introduces a new method to harden biomimetic hydroxyapatite 3D-plotted scaffolds which avoids high-temperature sintering. (upc.edu)
While it remains a remarkable challenge for developing a biomimetic multiscale scaffold for enhancing 3D neuronal maturation and outgrowth. (desktopmetal.com)

In this study, the capabilities of composite poly(lactic- co -glycolic acid) (PLGA) and calcium peroxide (CaO 2 ) sintered microsphere scaffolds were investigated as an alternative to current bone repair strategies. (confex.com)
Scaffold Fabrication: 0%, 0.5%, and 1% 85:15 PLGA/CaO 2 microspheres were fabricated via the single emulsion technique. (confex.com)
However, 1% PLGA/CaO 2 scaffolds released a significantly greater amount of calcium ions over time. (confex.com)
acid) (PLGA) scaffold. (manchester.ac.uk)
To improve this efficiency, 3D electrospun scaffolds (3D/E) of poly(l-lactide-co-ε-caprolactone) (PLCL) and poly(l-lactide-co-glycolide) (PLGA) were designed and fabricated by the combination of 3D printing and electrospinning techniques, resulting in an ideal porous architecture for NGCs. (desktopmetal.com)
The designed pore architecture of these "PLCL-3D/E" and "PLGA-3D/E" scaffolds exhibited a combination of nano- and microscale structures. (desktopmetal.com)

Extracellular matrix scaffolds derived from porcine small intestinal submucosa (SIS-ECM) have been shown to promote the formation of site-specific tissue in a number of preclinical animal studies. (researchgate.net)
Introduction The cells in a tissue are held together by colloidal extracellular matrix (ECM), which is gel like in consistency. (docksci.com)
Histology confirmed successful removal of epithelial cells and integrity of the extracellular matrix. (unibs.it)
These bioactive cues can trigger specific cellular responses, including the production of extracellular matrix and the mineralization of new bone tissue. (boydbiomedical.com)
Fibrosis is a dynamic process of abnormal connective tissue formation as a result of excessive wound healing and extracellular matrix deposition. (omicsonline.org)

Ideally, a scaffold must be porous, bioactive, and biodegradable and possess adequate mechanical properties suited to the biological site. (hindawi.com)
These scaffolds should be biocompatible, biodegradable and porous and support the normal proliferation and functioning of the cells seeded on to it (Gnanaprakasam Thankam et al. (docksci.com)
Tamaddon M, Samizadeh S, Wang L, Blunn G, Liu C. Intrinsic Osteoinductivity of Porous Titanium Scaffold for Bone Tissue Engineering. (scielo.br)

In the current study, novel polyethylene glycol interpenetrated cross-linked hydrogel scaffold based on a co-polysaccharide (PIAC) synthesized from two marine heteropolysaccharides, alginate and chitosan, was designed. (docksci.com)

The current promising fabrication technique for making scaffolds, such as computation-aided solid free-form method, can be easily applied to metals. (hindawi.com)
Traditional fabrication methods are often met with limitations in replicating the unique structure of the OC tissue. (programmaster.org)
3D bioprinting techniques have been attracting attention for tissue scaffold fabrication in nerve tissue engineering applications. (desktopmetal.com)
With advancements in materials science and fabrication techniques, these biomaterial scaffolds hold great promise for addressing the increasing prevalence of bone-related disorders and an increase in orthopedic interventions as the population ages. (boydbiomedical.com)

Abstract The emerging strategy of tissue engineering for the management of end-stage organ failure and associated complications mainly relies on ECM mimicking scaffolds for neo-tissue genesis. (docksci.com)

Bone tissue engineering is the study of how the intersection of cells, biomaterials, and bioactive factors can restore normal bone function after surgical, degenerative, or traumatic bone loss. (confex.com)
Chen F, Liu X. Advancing biomaterials of human origin for tissue engineering. (scielo.br)
 Integrating Native and Engineered Tissue  Coordinating Cell-Material Interaction  Smart Biomaterials 1. (slideshare.net)
Choosing the correct biomaterials for bone scaffolds is crucial to ensure compatibility and effectiveness. (boydbiomedical.com)
Cruz Perez B, Tang J, Morris HJ, Palko JR, Pan X, Hart RT, Liu J. Scaffold download drawing made easy dragons fantasy unleash your creative beast as you conjure up biomaterials presence giving, hiringContact, and siehe coverage. (it-dresden.net)

Biodegradable metal scaffolds have showed interesting mechanical property that was close to that of human bone with tailored degradation behaviour. (hindawi.com)
A biodegradable scaffold allows the replacement of biological tissues via physiological extracellular components without leaving toxic degradation products. (hindawi.com)
Mechanically, the major challenge is to achieve adequate initial strength and stiffness and to maintain them during the stage of healing or neotissues generation throughout the scaffold degradation process [ 3 , 7 , 8 ]. (hindawi.com)
Polymers, such as polycaprolactone or poly(lactic-co-glycolic acid), offer flexibility in scaffold design and degradation rates. (boydbiomedical.com)

It is essential for maintaining the structural integrity of the skin and other connective tissues, as well as for repairing and healing damaged tissues. (senzuhealth.com)

Scaffolds demonstrated controlled hierarchical structure within each region and structural variation along the length with structural integrity and mechanical properties within the range of trabecular bone. (programmaster.org)

Another group engineered tendon constructs by rolling tenocyte-seeded SIS scaffolds into tubular constructs that could be mounted into custom loading frames for static or dynamic loading within an incubator. (researchgate.net)
Ultimately this approach would serve as a strategy for 3D printed tissue constructs to provide sufficient oxygenation to support cells while vasculature in formed after in vivo implantation. (umd.edu)
Implanting pieces of tissue or scaffolding material into the mammalian central nervous system (CNS) is wrought with difficulties surrounding the size of tools needed to conduct such implants and the ability to maintain the orientation and integrity of the constructs during and after their transplantation. (hindawi.com)
Here, novel technology has been developed that allows for the implantation of neural constructs or intact pieces of neural tissue into the CNS with low trauma. (hindawi.com)
By "laying out" (instead of forcibly expelling) the implantable material from a thin walled glass capillary, this technology has the potential to enhance neural transplantation procedures by reducing trauma to the host brain during implantation and allowing for the implantation of engineered/dissected tissues or constructs in such a way that their orientation and integrity are maintained in the host. (hindawi.com)
7.1 Pluronic F127 hydrogel characterization and biofabrication in cellularized constructs for tissue engineering applications  Emilia Gioffredi et. (slideshare.net)
The junction between the epithelium and the underlying connective tissue undulates, constituting of rete ridges, which lack currently available soft tissue constructs. (tissueandcells.com)

Many bone tissue engineering therapies involve the use full-length proteins as bioactive agents. (confex.com)
Incorporating bioactive molecules and growth factors within the scaffold provides a favorable microenvironment that promotes the recruitment and attachment of bone-forming cells, such as osteoblasts. (boydbiomedical.com)
By mimicking the structure and composition of natural bone tissue and incorporating bioactive molecules, bioactive scaffolds provide a favorable environment for new bone growth and accelerate the healing process. (boydbiomedical.com)

Using a self-stimulated neural conductive channel to create a suitable scaffold for the growth and differentiation of neural-like cells can be desirable20. (yjxinhua.com)
For stem cells to be used in tissue engineering a scaffold is essential to provide the necessary support for the transport of nutrients, oxygen and the elimination of metabolic waste 30 , promoting a conducive environment for cell growth and differentiation. (bvsalud.org)

The present hydrogel can form an ECM mimic and can form a potent candidate for various tissue engineering applications. (docksci.com)
These scaffolds are made from materials such as ceramics, polymers, or composites and mimic the structure and composition of natural bone to provide a framework for new bone growth. (boydbiomedical.com)

The research themes rank around molecular mechanisms matrix proteins and fibers exert in disorders affecting blood vessels, bone, skin and adipose tissue. (mcgill.ca)
2022). Fibrillin-1 regulates white adipose tissue development, homeostasis, and function. (mcgill.ca)

3D scaffolds were created by sintering loaded microspheres in a 10 x 5 mm cylindrical stainless steel mold. (confex.com)
Scaffold Imaging: Composite microspheres were analyzed qualitatively for surface integrity using a scanning electron microscope (SEM). (confex.com)
In this study, we overcome these challenges by coupling tissue engineering toolsets with microfluidics technologies to create engineered cancer microspheres. (nsf.gov)

The new approach was developed to ensure a relatively uniform apatite coating on the interior pore surfaces deep inside a scaffold, even for a relatively thick scaffold with small pores. (manchester.ac.uk)
The scaffold and apatite coating were characterized using thermogravimetry analysis, scanning electron microscopy, energy dispersive X-ray spectroscopy, and X-ray diffractometry. (manchester.ac.uk)

26 ] has shown that osteoblast survival and growth were significantly enhanced in the PLLA/HA composite scaffolds compared to the plain PLLA scaffolds. (hindawi.com)
This study attempted to assess VEGF and BMP-2 reflecting the effect of hybrid bio-composite scaffold on bone healing in dogs and evaluate the quality of the healing process radiologically. (springeropen.com)

Polycaprolactone (PCL) as a biocompatible polymer with semi-crystalline nature provides structural integrity and mechanical stability of the scaffold in tissue engineering8,11. (yjxinhua.com)

The absorbable synthetic sutures are Polyglycolic acid (dexon) which has the advantages of tensile strength, very little tissue reactivity, knots well. (swicofil.com)

Electrospun nanofiber materials have emerged as promising scaffolds for cell culture and tissue engineering applications. (unh.edu)

One of the critical advantages of biomaterial scaffolds for bone repair is their ability to guide and stimulate cell proliferation and differentiation. (boydbiomedical.com)

Finally, as a mechanical support, a scaffold must possess adequate mechanical stability to withstand both the implantation procedure and the mechanical forces that are typically experienced at the scaffold-tissue interface and does not collapse during patient's normal activities [ 3 ]. (hindawi.com)

Metals that can degrade in physiological environment, namely, biodegradable metals, are proposed as potential materials for hard tissue scaffolding where biodegradable polymers are often considered as having poor mechanical properties. (hindawi.com)
The ECM integrates molecular signals that synchronize the specific function of the tissues on responding to the physiological demands. (docksci.com)

Could companies eventually print functional cancerous tissue in the lab to hasten the development of oncology drugs? (advfn.com)
An ECM substitute should act as a scaffold to carry the cells until a functional tissue is reestablished (Finosh and Jayabalan 2012). (docksci.com)
Three-dimensional bio-printing is a rapidly growing field attempting to recreate functional tissues for medical and pharmaceutical purposes. (unh.edu)

Such a scaffold can be made from synthetic and natural molecules or a combination of both, which can be effectively used for the ex vivo engineering of various organ parts. (docksci.com)

incorporated PAG nanocomposite within gelatin nanofibers to endow the scaffold with conductive properties, which resemble the conductive behavior of axons19. (yjxinhua.com)

Mesenchymal Stem Cells (MSCs) can be isolated from several body tissues, including dental tissues. (bvsalud.org)
The ability to restore cells and tissue function without the need of immunosuppressive drugs and without the concern for tissue compatibility makes Mesenchymal Stem Cells (MSCs, usual acronym) a strong promise for the future. (bvsalud.org)

Cartilage is a good tissue to target for scale-up bioprinting because it is made up of only one cell type and has no blood vessels within the tissue. (carbomer.com)

The selection of the suture will depend on physical and chemical characteristics and the biological culture of the tissue in which it is placed. (swicofil.com)
2013). Incorporation of physiochemical, biological and mechanical cues along with these scaffolds improves the quality and durability of the ECM substitutes. (docksci.com)

The applications of biomaterial scaffolds for bone repair are wide-ranging. (boydbiomedical.com)
By working with the rheological, mechanical, and microstructural properties of different compositions, a set of biomaterial compositions was identified to have high structural integrity and shape fidelity without needing a harmful amount of pressure to extrude. (unh.edu)

This review critically focuses on opportunities to employ protein-graphene oxide structures either as nanocomposites or as biocomplexes and highlights the effects of carbonaceous nanostructures on protein conformation and structural stability for applications in tissue engineering and regenerative medicine. (mdpi.com)
The findings will contribute to the development of novel nanofiber-based scaffolds for cell culture applications, particularly in regenerative medicine and tissue engineering. (unh.edu)

The robustness and efficacy of the retrodifferentiation process in generating unprecedented quantities of stem cells belonging to the three germ layers will enable organ and tissue reconstruction ex vivo, using bio-printing and various scaffold materials. (eurekaselect.com)
Melek LN. Tissue engineering in oral and maxillofacial reconstruction. (scielo.br)

Scaffolds alone do not usually completely heal the defects due to the lack of sufficient osteoinduction. (springeropen.com)
The association of scaffolds to repair extensive bone defects can contribute to their evolution and morphophysiological recomposition. (scielo.br)
The first suggests that disruption of the inner nuclear membrane and the nuclear lamina causes disorganization of nuclear chromatin and gene expression, while the second proposes that the mechanical strength of the cell nucleus is disrupted when the nuclear lamina is weakened leading to structural and signaling defects in mechanically stressed tissue such as muscle and heart. (medscape.com)

Three different scaffold architectures were analysed. (upc.edu)

Biodegradable polymers degrade through hydrolysis process and are gradually absorbed by the human body thus allowing the supported tissue to gradually recover its functionality [ 8 , 17 ]. (hindawi.com)

The scaffolds were hemocompatible and were able to adsorb appreciable plasma proteins on to the surface. (docksci.com)
[ 1 ] Even though these proteins are ubiquitously expressed, disease manifestations are tissue specific for as yet unclear reasons. (medscape.com)
Emerin is a ubiquitous inner nuclear membraneprotein, presentin nearly all cell types, although its highest expression is in skeletal and cardiacmuscle.Emerin binds to many nuclear proteins, including several gene-regulatory proteins (eg, barrier-to-autointegration factor, germ cell-less, Btf), nesprins (proteins that act as molecular scaffolds), F-actin, and lamins. (medscape.com)

This interaction improves structural integrity to tissue scaffolds. (wikipedia.org)

It is also desirable for a scaffold to have high interconnectivities between pores for uniform cell seeding and distribution, and for the nutrients and metabolites exchange at the cell/scaffold construct [ 4 - 6 ]. (hindawi.com)
43 Therefore, cell sheets with enhanced thickness and mechanical properties obtained through appropriate cyclic mechanical stimulation possess great potential for bone tissue engineering applications. (researchgate.net)
Cell sheet-based scaffold-free technology holds promise for tissue engineering applications and has been extensively explored during the past decades. (researchgate.net)
Findings from this study reveal that thermo-responsive elastomer, together with mechanical conditioning, can potentially be applied to prepare high-quality cell sheets for bone tissue engineering. (researchgate.net)
Bioprocess considerations covering the cell isolation step starting from different tissue sources (i.e., stem/progenitor cells vs. more committed precursors), as well as the need for robust and cost-effective protocols featuring easy scalability envisioning clinical applications, which are approached herein. (mdpi.com)
Overall, the ultimate goal would be to obtain clinically relevant cell numbers, while maintaining cell/tissue identity and functionality. (mdpi.com)
Scaffolds were also developed with regional compositional organization through co-deposition of polymeric framework and a cell-laden hydrogel demonstrating selective homogenous distribution of the required cell population. (programmaster.org)
Researchers suggest that a shortage of caveolae impairs the structural integrity of muscle cells, interferes with cell signaling, and causes the self-destruction of cells (apoptosis). (medlineplus.gov)
The classical tissue engineering paradigm integrates a cell source, support structure, and suitable chemical and physical factors to functionally regenerate lost tissue. (umd.edu)
Recent research has shown that pieces of fetal nigral tissue placed in the striatum of 6-OHDA lesioned rats offer greater cell survival and predictability of graft function (in comparison to dissociated nigral cells) in the animal model of Parkinson's disease [ 20 ]. (hindawi.com)
As such, preserving the integrity of sensitive samples is a daily challenge for cell culture laboratories in their search for innovative new therapies. (ddw-online.com)
During this process, leukocytes lose lineage-associated markers home and undergo homocytic aggregation, upregulate expression of stem cell antigens, and subsequently redifferentiate to give rise original tissue or, transdifferentiate into a different tissue altogether. (eurekaselect.com)
The hydrogel scaffolds were then used for dermal fibroblast cell culture to evaluate cell growth patterns and behavior on the scaffolding material. (unh.edu)
As a result of being capable of differentiating into a variety of cell types, it can be presumed that stem cell therapy has an advantage when compared to other tissue repair methods. (bvsalud.org)
Stem cells derived from dental tissues are isolated from specialized tissues and have a strong ability to give rise to other cell lines, but with a different potential of bone marrow stem cells 16 . (bvsalud.org)
Cell therapy is a therapy where cellular material is injected systemically or directly into the injured tissue, to promote local repair or to restore systemic health. (bvsalud.org)

Bone is a highly vascularized tissue in which blood vessels and bone cells interact to maintain skeletal integrity (Gemini et al. (springeropen.com)

Histologic evaluation of a tissue-engineered oral mucosa showed the topographical microstructures of grid-type were well-preserved, rather than pillar-type, a well-stratified epithelial layer was regenerated on all scaffolds and the epithelial rete ridge-like structure was developed. (tissueandcells.com)

An Effort to Fabricate Clinically Relevant Scaffold Using 3D Bioprinti" by Cartwright Nelson, Slesha Tuladhar et al. (unh.edu)

Present replacement strategies have limitations ranging from availability of the same type of tissue to long-term stability. (unibs.it)

Until now, several progenitor cells derived from dental tissues have been isolated and characterized ( table I ). (bvsalud.org)

The repair process begins with the formation of the clot, accompanied by an inflammatory process with proliferation of granulation tissue. (scielo.br)

Elastin is a resilient connective tissue protein found in the ECM of most vertebrate tissues, and it is an important part in the interstitium of tissues that undergo repeated physical deformations in the human body (Swee et al. (github.io)

however, critical problems still remain to be resolved for advancing tissue engineering into clinical application. (umd.edu)
MSCs have a clinical attractiveness because they are easy to expand, they have the ability to differentiate into various types of tissues 5 , and can be directed to become osteocytes, chondrocytes or adipocytes. (bvsalud.org)
It can occur in almost all tissues and it is a major contributor to clinical diseases, leading to organ failure and accounting for approximately one third of deaths worldwide [1,2]. (omicsonline.org)

Not only do microfibrils provide structural integrity of specific organ systems, but they also provide a scaffold for elastogenesis in elastic tissues. (github.io)

b) Computer-controlled application of a vacuum uniaxially strains the membranes, driving the loading pins apart to stretch the growth channel, and apply controlled dynamic strain to developing scaffold-free tendon fibers, emulating tensile strains seen in tendon development in vivo [90]. (researchgate.net)
The aim of this study was to evaluate the sealing capability and tissue interaction of mussel-mimetic tissue adhesive (mussel glue) in comparison to fibrin glue on punctured fetal membranes in vivo. (researchgate.net)

The researchers put the patch in nutrient media to allow it to further integrate into a single piece of tissue. (carbomer.com)

The aim of this paper is to provide a review about current and future materials for scaffolds to carry stem cells in tissue engineering in Dentistry, especially for bone tissue repair. (bvsalud.org)

Chemicals and Drugs11

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes2

Technology, Industry, Agriculture10

Regeneration22

Vitro7

Collagen19

Hydrogels6

Porosity7

Organs6

Acts as a scaffold1

Biocompatibility5

Biomimetic5

PLGA6

Extracellular matrix5

Porous3

Hydrogel scaffold1

Fabrication4

Abstract1

Biomaterials5

Degradation4

Connective tissues1

Trabecular bone1

Constructs7

Bioactive3

Growth and differentiation2

Mimic2

Adipose tissue2

Microspheres3

Apatite2

Composite2

Biocompatible1

Tensile strength1

Electrospun1

Differentiation1

Mechanical stability1

Physiological2

Functional3

Molecules1

Nanocomposite1

Mesenchymal stem2

Bioprinting1

Biological2

Biomaterial2

Regenerative2

Reconstruction2

Defects3

Architectures1

Biodegradable1

Proteins3

Improves1

Cell16

Blood vessels1

Epithelial1

Fabricate1

Stability1

Progenitor cells1

Granulation tissue1

Protein1

Clinical3

Organ1

Vivo2

Researchers1

Materials1