• humans
  • However, adiponectin production and release in obese humans and animals are thought to be downregulated by feedback inhibition by as-yet-unidentified serum humoral components, resulting in decreased serum adiponectin, with insulin or tumor necrosis factor-α playing a possible role in this mechanism ( 9 ). (diabetesjournals.org)
  • levels
  • This insulin release further decreases insulin receptors due to elevated hormonal levels, and thus a vicious cycle begins of excessive appetite with weight gain. (health.am)