• receptor
  • The reason for this is that the highest concentration of insulin receptors is located in the abdominal rectus muscles and the increased layer of fat appears to impair insulin receptor sensitivity. (health.am)
  • Secondary diabetes is carbohydrate intolerance secondary to pancreatic disease, excess production of certain hormones (eg, growth hormone), use of certain drugs (eg, corticosteroids), insulin receptor abnormalities, and certain genetic disorders. (health.am)
  • in part through PKC epsilon-mediated downregulation of insulin receptor (IR) gene. (ahajournals.org)
  • 3-10 Recent studies have demonstrated that free fatty acids lead to activation of the innate immune receptor, Toll-like receptor 4 (TLR-4), and the downstream proinflammatory transcription factor NF-κB which may play an important role in mediating inflammation and insulin resistance. (ahajournals.org)
  • diabetes
  • 1,2 Excess body weight and obesity are associated with the development of metabolic syndrome and type II diabetes, both of which are associated with insulin resistance and increased risk of cardiovascular complications. (ahajournals.org)
  • The authors further demonstrate that brief in vitro exposure to palmitic acid, one of the free fatty acids that is elevated in obesity, in concentrations that are modestly higher than those observed in obesity and type II diabetes, could induce insulin resistance in aortic tissue taken from nonobese wild-type C57BL6 mice fed a normal chow but not in aortic tissue of nonobese TLR-4-null mice fed a normal chow. (ahajournals.org)
  • The test is usually used to test for diabetes, insulin resistance, impaired beta cell function, and sometimes reactive hypoglycemia and acromegaly, or rarer disorders of carbohydrate metabolism. (wikipedia.org)