• Patients may develop diabetes mellitus secondary to insulin resistance. (wikipedia.org)
  • These SNPs are associated with increased risk of type 2 diabetes mellitus, diabetic nephropathy, inflammation, high blood pressure and abnormal plasma osmolality, indicating that variation in TONEBP expression might contribute to these phenotypes. (nature.com)
  • In addition, functional studies have shown that TonEBP is involved in the pathogenesis of rheumatoid arthritis, atherosclerosis, diabetic nephropathy, acute kidney injury, hyperlipidaemia and insulin resistance, autoimmune diseases (including type 1 diabetes mellitus and multiple sclerosis), salt-sensitive hypertension and hepatocellular carcinoma. (nature.com)
  • Type 2 Diabetes is associated with chronic hyperglycemia due to metabolic disorders caused by insulin resistance [ 1 ]. (longdom.org)
  • Obesity being major contributor of enhanced type II diabetes and is also cause of high morbidity and mortality. (longdom.org)
  • Many researchers reported that dietary modification play significant and major role in management of diabetes and hyperlipidemia [ 5 ]. (longdom.org)
  • Diabetes Mellitus: Insulin resistance or insulin deficient, leading to hyperglycemia, or too much glucose, a type of sugar, in the blood. (horizonhealthcare.org)
  • Patients with diabetes mellitus are at high risk of cardiovascular events because of abnormal lipid levels status. (heraldopenaccess.us)
  • High prevalence of dyslipidemia among type 2 diabetes mellitus in Mukalla city were observed and so the common patterns of dyslipidemia is LDL-C followed by cholesterol. (heraldopenaccess.us)
  • Type 2 Diabetes Mellitus is a heterogeneous condition characterized by the presence of both impaired insulin secretion and insulin resistance [3]. (heraldopenaccess.us)
  • Six countries in the Middle East are rated among the top 10 countries in the world with the highest prevalence of diabetes [5]. (heraldopenaccess.us)
  • Diabetes mellitus is a common secondary cause of hyperlipidemia, particularly if glycemic control is poor, which in-turn is an important risk factor for atherosclerosis and coronary heart disease [12,13]. (heraldopenaccess.us)
  • [6-9] Individuals with obesity, metabolic syndrome, and type 2 diabetes have a much higher incidence of persistently acidic urine and uric acid nephrolithiasis. (bladeresearchinc.com)
  • Consuming them can shield diabetics from oxidative harm, which can make diabetes worse. (oohk.net)
  • Generally, diabetic nephropathy is considered after a routine urinalysis and screening for microalbuminuria in the setting of diabetes. (medscape.com)
  • Elevated blood fatty-acid concentrations (associated with insulin resistance and diabetes mellitus Type 2), reduced muscle glucose uptake, and increased liver glucose production all contribute to elevated blood glucose levels. (thediabeticpharmacist.com)
  • Then we summarized the mechanisms of these alkaloid components of Rhizoma coptidis on cardiovascular and cerebrovascular diseases, diabetes and diabetic complications. (springer.com)
  • Also disruption of this signaling pathway may account for the lowered β-cell GIP-R expression and resulting GIP resistance in type 2 diabetes. (diabetesjournals.org)
  • Although dysregulated lipid metabolism results in diabetic nephropathy (DN) development in patients with type 2 diabetes mellitus (T2DM), it is not understood whether betatrophin is associated with urinary albumin excretion and renal function. (biomedcentral.com)
  • Insulin resistance underlies a constellation of adverse metabolic and physiological changes (the insulin resistance syndrome) which is a strong risk factor for development of type 2 diabetes and CHD. (cambridge.org)
  • 5 The aetiological risk factors leading to the onset of CVD are well recognised and include hyperlipidaemia, hypertension, diabetes, obesity, smoking and lack of physical activity. (uk.com)
  • OLETF (Otsuka Long-Evans Tokushima Fatty) rats from 20 weeks of age are characterized by obesity, hyperglycemia, hyperlipidemia and insulin resistance, which is phenotypes of type 2 diabetes. (dsmc.or.kr)
  • Metabolic effects of diuretic and beta-blocker treatment of hypertension in patients with non-insulin-dependent diabetes mellitus. (nhri.edu.tw)
  • Type 2 diabetes mellitus (T2DM) is a progressive metabolic disease characterized by pancreatic β-cell dysfunction and peripheral insulin resistance, leading to defects in glucose metabolism and chronic low-grade inflammation. (frontiersin.org)
  • Does Eating High-Glycemic-Index Foods Lead to Obesity, Diabetes, and Heart Disease? (acsh.org)
  • 1998), by H. Leighton Steward and associates diets high in carbohydrate (CHO) are responsible for insulin increases that inhibit fat-burning and lead to obesity, type 2 diabetes (non-insulin-dependent diabetes mellitus), and atherosclerosis (specifically, coronary heart disease, or CHD). (acsh.org)
  • In any case, the relationship of high-GI foods and/or a high-CHO diet to the development of obesity, type 2 diabetes, and cardiovascular disease (CVD) remains to be puzzled out. (acsh.org)
  • Epidemiological studies have not lent much credence to the notion that high-CHO diets in general, or those consisting mostly of high-GI foods, lead to obesity, diabetes, and CVD. (acsh.org)
  • The contention that the quantity or percentage of CHO in a diet, or the relative ability of individual foods or diets to increase plasma glucose concentrations, is the primary determinant in the development of obesity, insulin resistance,* and type 2 diabetes is inconsistent with some observations of human populations. (acsh.org)
  • In the Japanese population, more than 20% of the population shows insulin resistance and in the adult population with diabetes mellitus type 2 the prevalence of metabolic syndrome ranges from 38 to 53%, depending on the gender and the criterion used 16 . (bvsalud.org)
  • According to a past review of studies, curcumin may help treat and prevent diabetes, as well as associated disorders like diabetic nephropathy (also called diabetic kidney disease), which affects people with type 1 diabetes and type 2 diabetes. (mightynutra.com)
  • For example, one study found that feeding 80 mg of tetrahydrocurcumin (one of the main substances of curcumin) per kg body weight to rats with type 2 diabetes for 45 days led to a significant decrease in blood sugar, as well as an increase in plasma insulin. (mightynutra.com)
  • A study in type 2 diabetes published in the July 2019 issue of Nutrition & Metabolism reveals that curcumin supplements helped lower blood insulin levels after 16 weeks. (mightynutra.com)
  • The results suggest the probable active participation of higher concentrations of C-peptide in the intensification of inflammatory and atherogenic processes in obese patients with type 2 diabetes. (medsci.org)
  • In patients with obesity and type 2 diabetes, altered serum concentrations of Il-10 seems to be dependent on the degree of insulin resistance and proinflammatory status. (medsci.org)
  • Both, obesity which is a major risk factor for the insulin resistance development and type 2 diabetes (T2DM), and the chronic hyperglycemia itself play an important role in its pathogenesis. (medsci.org)
  • People develop type 1 diabetes when their bodies make antibodies that destroy the body's own insulin-making beta cells. (diabetes.org)
  • Human investigations suggest that fenugreek can be beneficial as an adjunct in controlling high blood glucose and lipid levels in people with diabetes. (lww.com)
  • By studying diabetic dyslipid- in diabetes mellitus because insulin resist- aemia among a group of our patients we ance or deficiency affects key enzymes hoped to draw attention of the medical com- and pathways in lipid metabolism [ 1 ]. (who.int)
  • All manuscripts are subjected to a RAPID peer review process, and those of high quality (which have not previously been published and are not under consideration for publication by another journal) would be published without any delay in subsequent issues of the Diabetes journal after approval. (diabetesjournal.in)
  • Diabetic neuropathy is one of the most common microvascular complications of diabetes. (cobfoundation.org)
  • Diabetes itself does not cause changes in personality or psychiatric illness, but particular subgroups of the diabetic population appear to be at risk for developing psychosocial problems. (cdc.gov)
  • Young people with insulin- dependent diabetes mellitus (IDDM) may have a higher prevalence of eating disorders, such as anorexia nervosa and bulimia, and adults with longstanding diabetes and major medical complications have a higher prevalence of symptoms of depression and anxiety. (cdc.gov)
  • Elderly persons who have non-insulin-dependent diabetes mellitus (NIDDM) and other symptomatic medical conditions may also have a higher risk of developing psychological problems. (cdc.gov)
  • The patient's comorbidities of past organ transplant and insulin-dependent diabetes required delicate consideration of those health conditions to guide treatment. (cdc.gov)
  • We report a complicated case of M. senegalense infection in a patient with a previous kidney transplant and insulin-dependent diabetes mellitus in Memphis, Tennessee, USA. (cdc.gov)
  • The patient's past diagnoses at the time of infection included type 2 diabetes mellitus, lupus, hypertension, hyperlipidemia, sleep apnea, and coronary artery disease. (cdc.gov)
  • Several individuals with diabetes lose n I sensitivity and may present foot deformities, resulting in diabetic foot. (bvsalud.org)
  • Muchos individuos con diabetes pierden sensibilidad y pueden desarrollar deformidades en los pies, dando lugar al pie diabético. (bvsalud.org)
  • High glucose affected the expression level of cell-bound perlecan, angiogenesis-associated cytokines, and the matrix degradation on the cells, implying that hyperglycemia influences vessel formation during placentation. (hindawi.com)
  • Factors that may contribute to this greater platelet reactivity are not completely elucidated and include metabolic abnormalities as hyperglycemia, hyperlipidemia, insulin resistance, and conditions as oxidative stress, inflammation, and endothelial dysfunction [ 3 ]. (hindawi.com)
  • It is defined as group of metabolic disorder that is characterized by hyperglycemia resulting from defect in insulin secretion, insulin action or both, which leads to alteration in carbohydrate, fat and protein metabolism [1]. (heraldopenaccess.us)
  • The failure of β-cells compensates for ambient insulin resistance that leads to uncontrolled hyperglycemia resulted in renal glomerular hyperfiltration with microalbuminuria [ 6 ]. (biomedcentral.com)
  • Obesity is associated with insulin resistance. (cambridge.org)
  • Adipose tissue in obesity becomes refractory to suppression of fat mobilization by insulin, and also to the normal acute stimulatory effect of insulin on activation of lipoprotein lipase (involved in fat storage). (cambridge.org)
  • Metabolic Syndrome (MS) is the denomination proposed by the World Health Organization (WHO) 42 , which designates a set of risk factors for cardiovascular diseases (CVDs), such as visceral obesity, dyslipidemia, high hypertension, glucose intolerance and insulin resistance 32 , which frequently are presented together. (bvsalud.org)
  • The relatively high prevalence of the metabolic syndrome is a worldwide phenomenon that seems to be increasing in parallel with the obesity prevalence 16 . (bvsalud.org)
  • Dyslipidaemia obesity and insulin changes highly acceler- encompasses changes in HDL-cholesterol ate the progression to atherosclerosis [ 2 ]. (who.int)
  • Currently, diabetic nephropathy is the leading cause of chronic kidney disease in the United States and other Western societies. (medscape.com)
  • Good evidence suggests that early treatment delays or prevents the onset of diabetic nephropathy or diabetic kidney disease. (medscape.com)
  • Regular outpatient follow-up is key in managing diabetic nephropathy successfully. (medscape.com)
  • Recently, attention has been called to atypical presentations of diabetic nephropathy with dissociation of proteinuria from reduced kidney function. (medscape.com)
  • Also noted is that microalbuminuria is not always predictive of diabetic nephropathy. (medscape.com)
  • [ 3 ] Nevertheless, a majority of the cases of diabetic nephropathy present with proteinuria, which progressively gets worse as the disease progresses, and is almost uniformly associated with hypertension. (medscape.com)
  • Several issues are key in the medical care of patients with diabetic nephropathy. (medscape.com)
  • Three major histologic changes occur in the glomeruli of persons with diabetic nephropathy. (medscape.com)
  • The earliest morphologic abnormality in diabetic nephropathy is the thickening of the GBM and expansion of the mesangium due to accumulation of extracellular matrix. (medscape.com)
  • The image below is a simple schema for the pathogenesis of diabetic nephropathy. (medscape.com)
  • Atherosclerosis accounts for up to 80% of cholesterol (LDL-C) and the total choles- deaths in diabetic patients due to coronary terol/HDL-C ratio (TC/HDL-C) [ 1 ]. (who.int)
  • The renal vasculature typically displays evidence of atherosclerosis, usually due to concomitant hyperlipidemia and hypertensive arteriosclerosis. (medscape.com)
  • Metabolic complications include insulin resistance, high metabolic rate, and uncontrolled lipid levels such as hypertriglyceridemia, low HDL, and high LDL. (wikipedia.org)
  • Platelets have a "key role" in atherogenesis and its thrombotic complications in subjects with DM [ 3 ], and the concomitant presence of multiple "classical" cardiovascular risk factors (arterial hypertension, cigarette smoking, and hyperlipidemia) in diabetic subjects contributes to enhanced atherothrombotic risk. (hindawi.com)
  • In this review, we introduce the characteristics of the gut microbiota in T2DM population, T2DM animal models, and diabetic complications. (frontiersin.org)
  • Here, we summarize the characteristics of the gut microbiota in T2DM population, T2DM animal models, and diabetic complications, as well as the molecular mechanisms linking host and the gut microbiota in T2DM, which may provide new ideas for the treatment of T2DM. (frontiersin.org)
  • This paper aimed to measure miR-222-3p expression in sera of PCOS patients and to explore its clinical value on PCOS diagnosis and prediction of diabetic and cardiovascular complications. (biomedcentral.com)
  • Correlations between miR-222-3p and glycolipid metabolic indicators and diabetic and cardiovascular complications in PCOS were analyzed. (biomedcentral.com)
  • High expression of miR-222-3p predicted high risks of diabetic and cardiovascular complications in PCOS. (biomedcentral.com)
  • The prevalence of dyslipidemia in type 2 diabetic patients was 85%, prevalence of dyslipidemia in males was 86% while in females was 84% but the difference was not significant (P-value 0.4). (heraldopenaccess.us)
  • About half of the studied T2DM patients have high serum cholesterol level (52.5%), while 22.5% had low serum HDL- C levels and 39.2% had high serum triglyceride level, most of patients had serum LDL-C levels above normal range (67.5%), so the common patterns of dyslipidemia in this study were LDL-C followed by cholesterol. (heraldopenaccess.us)
  • excess abdominal fat, insulin resistance, dyslipidemia, and hypertension) is greater with SGAs than with conventional antipsychotics. (msdmanuals.com)
  • Its best-known actions in β-cells are to augment meal-related insulin secretion and over the long-term to increase proinsulin synthesis and β-cell proliferation and survival ( 3 , 4 ). (diabetesjournals.org)
  • Insulin stimulates albumin gene expression and albumin secretion from hepatocyte in both healthy subjects and diabetic patients. (biomedcentral.com)
  • Moreover, the concomitant presence of multiple "classical" cardiovascular risk factors in diabetic subjects contributes to enhanced atherothrombotic risk. (hindawi.com)
  • Although, currently, treatment has proven useful in reducing vascular events, diabetic patients continue to have a higher risk of adverse cardiovascular events compared with those in nondiabetic patients. (hindawi.com)
  • Cardiovascular (CV) diseases are the leading cause of morbidity and mortality in diabetic patients. (hindawi.com)
  • A wealth of published data documents the ability of carnitine to improve insulin sensitivity, mitochondrial function, and cardiovascular health. (lifeextension.com)
  • Its most common forms are Diabetic Peripheral Neuropathy (DPN), Diabetic autonomic neuropathy (DAN), and the most commonly diagnosed form is cardiovascular autonomic neuropathy neuropathy (CAN)) and painful diabetic neuropathy (PDN). (cobfoundation.org)
  • In the present study, three drugs were tested whether they affect parameters representing peripheral insulin sensitivity in OLETF rats. (dsmc.or.kr)
  • Sheu WH , Hou JC, Jeng CY, Fuh MM. Reproducibility of the measurement of insulin sensitivity by the modified insulin suppression test. (nhri.edu.tw)
  • one type of hyperlipidemia is characterized by high levels of LDL, or "bad," cholesterol). (mightynutra.com)
  • The hallmark characteristics are widespread loss of subcutaneous fat, ectopic fat deposition, leptin deficiency, and severe metabolic abnormalities such as insulin resistance. (wikipedia.org)
  • ing of metabolic abnormalities which hospital in the capital city of Jordan, Am- Data collection includes hyperlipidaemia [elevated tri- man), and is the primary teaching clinic glycerides (TG), low serum high-den- for the family medicine programme. (who.int)
  • [19] Countries such as Japan, Israel, and Pakistan have a much higher prevalence of uric acid stones at 16%, 22%, and 28%, respectively. (bladeresearchinc.com)
  • The prevalence increases with age and with higher serum uric acid levels. (shinseungkeon.com)
  • Björntorp , P ( 1994 ) Fatty acids, hyperinsulinemia, and insulin resistance: which comes first? (cambridge.org)
  • High density lipoprotein turnover in patients with hypertension. (nhri.edu.tw)
  • After 40 weeks type 1 diabetic symptoms follow, such as polyphasia, polydipsia, and polyurea. (dsmc.or.kr)
  • However, even hyperuricemia without symptoms may accompany hyperlipidemia, high blood pressure , and arteriosclerosis, so careful observation is required. (shinseungkeon.com)
  • A meta-analysis (6 randomized controlled trials of 669 people with diabetic neuropathy) suggested that vitamin B12 alone or in combination with other drugs reduced neuropathic symptoms and improved pain compared with placebo. (cobfoundation.org)
  • Alternanthera sessilis red ethyl acetate fraction exhibits antidiabetic potential on obese type 2 diabetic rats ") report that, despite their inability to identify active compounds, they observed that ethyl acetate fraction of Alternanthera sessilis ameliorated T2D via increased insulin content and decreased insulin resistance. (hindawi.com)
  • Eat the right type of oils to promote healthy insulin action. (water-for-health.co.uk)
  • ABSTRACT This study investigated the patterns and determinants of lipid disorders among a group of 250 type 2 adult diabetic patients and 60 age- and sex-matched healthy controls in Sudan. (who.int)
  • The chy- among type 2 diabetic patients [ 6 ]. (who.int)
  • Soy is also high in isoflavones, found in tests to help thin the blood and promote arterial flexibility by lowering inflammation! (oohk.net)
  • Expression of insulin receptor β-subunit in liver and adipocytes also decreased in OLETF rats than in LETO rats. (dsmc.or.kr)
  • 인슐린 수용체 아단위인 insulin receptor β-subunit의 발현은 LETO 쥐에 비해 OLETF 쥐의 지방세포와 간세포에서 현저히 감소하였으며, gliclazide와 glimepiride 처치군에서는 상당히 회복되었으나, repaglinide 처치군에서는 회복되지 않았다. (dsmc.or.kr)
  • Receptor binding studies, as well as studies in animals, have shown that etonogestrel, the biologically active metabolite of desogestrel, combines high progestational activity with minimal intrinsic androgenicity (91,92). (nih.gov)
  • Colorectal cancer (CRC) is a disease with high incidence worldwide. (scielo.br)
  • The heart disease (CHD) and cerbrovascular or term diabetic dyslipidaemia comprises a peripheral vascular disease [ 2,3 ]. (who.int)
  • Recent studies in human autopsy and in a mouse model of induced insulin resistance have also suggested that patients with T2DM cause insulin resistance due to a decrease in β-cell mass by apoptosis [ 4 ]. (biomedcentral.com)
  • However, increased levels of betatrophin in T1DM is in contradiction with the initial finding in an insulin-deficient mouse model by Meltons group [ 11 ] and there are mixed data regarding betatrophin levels in T2DM. (biomedcentral.com)
  • Conclusion: Vitamin B12 may provide positive help for diabetic neuropathy, but limited by small sample sizes, more research is needed to confirm these data. (cobfoundation.org)
  • Following 12 weeks of study and a subsequent wash-out period of 21 days, 12 patients were randomly selected from each arm of the 2 diabetic patient groups and were crossed over to receive the other study oil and evaluated every 4 weeks for another 12 weeks in a similar manner as before. (longdom.org)
  • There was reduction in FBS and PPBS across all RBSO groups, but was significant only in the diabetic patients (p=0.010). (longdom.org)
  • The role of chronic administration of antiplatelet drugs in primary prevention of arterial vascular events is known to be less clear than in secondary prevention, and, also in diabetic patients, the decision to give primary prophylaxis should be taken on an individual-patient basis, after a careful evaluation of the balance between the expected benefits and the risk of major bleedings. (hindawi.com)
  • This paper reviews the role of currently available antiplatelet drugs in primary and secondary prevention of vascular events in diabetic patients and the limitations of these drugs, and it discusses the role of novel and more potent antiplatelets and of new agents currently under clinical development. (hindawi.com)
  • However, although the currently available treatments have proven to be useful in reducing ischemic events, diabetic patients continue to have a higher risk of adverse events compared with those in non-diabetic patients. (hindawi.com)
  • The role of novel and more potent antiplatelet strategies, currently under clinical development, seems attractive in diabetic patients. (hindawi.com)
  • A Cross-sectional study was conducted in a randomly selected eligible patients from the diabetic registry of the AL Noor Charity Center (ACC), Mukalla city in eastern Yemen during the period from May-July 2017. (heraldopenaccess.us)
  • Insulin resistance and abnormal electrocardiograms in patients with high blood pressure. (nhri.edu.tw)
  • RÉSUMÉ La présente étude a évalué la prévalence du syndrome métabolique et ses composantes selon les critères de l' Adult Treatment Panel III chez des patients jordaniens consultant dans un établissement de soins en médecine familiale pour la prise en charge des facteurs de risque cardio-vasculaires. (who.int)
  • From these results, sulfonylurea drugs may have ability to ameliorate insulin resistance and the effect is greater in glimepiride than in gliclazide. (dsmc.or.kr)
  • Scientific findings have positively associated (1) diets high in fat (especially saturated fat) and in refined CHOs (particularly sugars) and (2) the development of insulin resistance. (acsh.org)
  • An upregulation of IR expression and its activation is significantly associated with higher downstream G protein signaling cascades. (mdpi.com)
  • Soybean is a plant protein high in lipids. (oohk.net)
  • Eat fish, particularly oily fish due to its beneficial effects on lipoproteins and reduction of CHD risk, not to mention its high protein content. (water-for-health.co.uk)
  • They further contend that diets relatively high in protein and/or fat are the key to reducing blood insulin, losing weight, and improving health. (acsh.org)
  • For example, although the diet of the Pima Indians living in northern Mexico consists largely of potatoes and corn tortillas both high-CHO, high-GI foods these Pimas weigh 60 to 65 lbs less than the Pima residents of Arizona, who consume much more protein and fat than do their Mexican cousins. (acsh.org)
  • Foods high in protein and/or fat tend to have GIs below those of high-CHO foods. (acsh.org)
  • High-potency antipsychotics have a higher affinity for dopamine receptors and less for alpha-adrenergic and muscarinic receptors. (msdmanuals.com)
  • Al lomicrons, low-density lipoproteins (LDL), Muhtaseb's study of Arab women indi- very-low-density lipoproteins (VLDL) and cated an incidence of 50% of lipid disorders high-density lipoproteins (HDL). (who.int)
  • A small molecule swertisin from Enicostemma littorale differentiates NIH3T3 cells into islet-like clusters and restores normoglycemia upon transplantation in diabetic Balb/c mice ") showed that swertisin could promote the differentiation of NIH3T3 cells into pancreatic islet-like cell mass, which restored hypoglycemic status to normal. (hindawi.com)