Loading...




Warning: preg_replace(): Compilation failed: unmatched parentheses at offset 8 in /home/lookformedical/www/faq.php on line 154
  • subcutaneous
  • A traditional pump includes: the pump (including controls, processing module, and batteries) a disposable reservoir for insulin (inside the pump) a disposable infusion set, including a cannula for subcutaneous insertion (under the skin) and a tubing system to interface the insulin reservoir to the cannula. (wikipedia.org)
  • An insulin port functions as a medication delivery channel directly into the subcutaneous tissue (the tissue layer located just beneath the skin). (wikipedia.org)
  • In general inhaled insulins have been more rapidly absorbed than subcutaneous injected insulin, with faster peak concentration in serum and more rapid metabolism. (wikipedia.org)
  • In the neutral subcutaneous space, higher-order aggregates form, resulting in a slow, peakless dissolution and absorption of insulin from the site of injection. (wikipedia.org)
  • After subcutaneous injection of the acidic solute (which can cause discomfort and a stinging sensation), when a physiologic pH (approximately 7.4) is achieved the increase in pH causes the insulin to come out of solution resulting in the formation of higher order aggregates of insulin hexamers. (wikipedia.org)
  • amino
  • It passes through the endoplasmic reticulum and 24 amino acids ('the signal peptide') are removed by enzyme action from one end of the chain, leaving another form (pro-insulin) behind. (news-medical.net)
  • Through genetic engineering of the underlying DNA, the amino acid sequence of insulin can be changed to alter its ADME (absorption, distribution, metabolism, and excretion) characteristics. (wikipedia.org)
  • Novolog
  • Novolog allows for a flexible dosing schedule, which allows patients to adjust their insulin according to any changes in their eating habits. (wikipedia.org)
  • Therefore, Novolog® given by injection should normally be used in a regimen with long-acting or intermediate insulin. (wikipedia.org)
  • Novolog® can also be used with external insulin pumps. (wikipedia.org)
  • The NovoLog® FlexPen® is a way to take NovoLog® via a prefilled, disposable insulin pen delivery system. (wikipedia.org)
  • NovoLog® is also supplied in 3-mL PenFill® cartridges and can be used in the NovoPen® 3 insulin delivery system. (wikipedia.org)
  • diabetic
  • Manufactured insulin' has proved to be a boon for diabetic patients. (buzzle.com)
  • Insulin formulated for diabetic patients is available in different types. (buzzle.com)
  • Another disadvantage of insulin pump use is a higher risk of developing diabetic ketoacidosis if the pump malfunctions. (wikipedia.org)
  • Insulin is used to treat a number of diseases including diabetes and its acute complications such as diabetic ketoacidosis and hyperosmolar hyperglycemic states. (wikipedia.org)
  • It would therefore be advantageous to administer insulin to diabetic patients in a manner mimicking the natural oscillations. (wikipedia.org)
  • Pulsatile insulin delivery to the portal vein or islet cell transplantation to the liver of diabetic patients are therefore attractive therapeutic alternatives. (wikipedia.org)
  • Regular insulin is the treatment of choice for the two diabetic emergencies diabetic ketoacidosis and hyperosmolar hyperglycemic states. (wikipedia.org)
  • zinc
  • Allergy to Insulin products is rare with a prevalence of about 2%, of which most reactions are not due to the insulin itself but to preservatives added to insulin such as zinc, protamine, and meta-cresol. (wikipedia.org)
  • Humulin R consists of zinc-insulin crystals dissolved in a clear fluid. (wikipedia.org)
  • NPH insulin is made by mixing regular insulin and protamine in exact proportions with zinc and phenol such that a neutral-pH is maintained and crystals form. (wikipedia.org)
  • University of Toronto, Canada later licensed protamine zinc insulin (PZI), to several manufacturers. (wikipedia.org)
  • 1926 Nordisk receives Danish charter to produce insulin 1936 Hagedorn discovers that adding protamine to insulin prolongs the effect of insulin 1936 Canadians D.M. Scott and A.M. Fisher formulate zinc insulin mixture and license to Novo 1946 Nordisk crystallizes a protamine and insulin mixture 1950 Nordisk markets NPH insulin 1953 Nordisk markets "Lente" zinc insulin mixtures. (wikipedia.org)
  • Levemir
  • Regarding weight gain compared to NPH insulin, the Levemir package insert states the following disclaimer: "LEVEMIR was associated with somewhat less weight gain than NPH (Table 4). (wikipedia.org)
  • Whether these observed differences represent true differences in the effects of LEVEMIR and NPH insulin is not known, since these trials were not blinded and the protocols (e.g., diet and exercise instructions and monitoring) were not specifically directed at exploring hypotheses related to weight effects of the treatments compared. (wikipedia.org)
  • On June 13, 2009, the U.S. Food and Drug Administration (FDA) issued a public health advisory for Levemir insulin after learning that 129,000 stolen vials reappeared and were being sold in the U.S. market. (wikipedia.org)
  • serum
  • We investigated anthropometric indices, insulin sensitivity, levels of serum adipokines, and inflammatory markers in overweight Korean women before and after clinical intervention trial. (nih.gov)
  • This insulin has a high affinity for serum albumin, increasing its duration of action. (wikipedia.org)
  • proteins
  • Insulin acts to regulate the metabolism of glucose and the process necessary for the intermediary metabolism of fats, carbohydrates and proteins. (healthcentral.com)
  • Circulating insulin also affects the synthesis of proteins in a wide variety of tissues. (wikipedia.org)
  • Apart from animals, insulin-like proteins are also known to exist in the Fungi and Protista kingdoms. (wikipedia.org)
  • These changes facilitate the recruitment of specific adapter proteins such as the insulin receptor substrate proteins (IRS) in addition to SH2-B (Src Homology 2 - B ), APS and protein phosphatases, such as PTP1B, eventually promoting downstream processes involving blood glucose homeostasis. (wikipedia.org)
  • The Insulin Index can be more useful than either the Glycemic Index or the Glycemic Load because certain foods (e.g., lean meats and proteins) cause an insulin response despite there being no carbohydrates present, and some foods cause a disproportionate insulin response relative to their carbohydrate load. (wikipedia.org)
  • Onset
  • It has a shortened delay of onset, allowing slightly more flexibility than regular insulin, which requires a longer waiting period before starting a meal after injection. (wikipedia.org)
  • NPH insulin is cloudy and has an onset of 1-4 hours. (wikipedia.org)
  • NPH insulin has the advantage that it can be mixed with an insulin that has a faster onset to complement its longer lasting action, which is the primary reason NPH remains on the market today, because manufacturers sell a variety of premixed insulin formulations. (wikipedia.org)
  • syringes
  • In the United States, Regular and NPH insulin types are available without a prescription (as are syringes). (diabetesdaily.com)
  • Insulin pens offer several significant advantages over insulin syringes: ease of handling, accuracy, and they are more discreet to use and easier to transport. (wikipedia.org)