ResistanceCentral adipositySecretionVisceral adiposityDiabetesLipidLeptin and insulinAdiposeHyperinsulinemiaDemonstrating that both basSensitivity and beta-cell functionHormonesObeseAdiponectinPancreasHOMA-IRMetabolismHomeostasisAltering insulin sensitivityPeripheral insulin sensitivityReceptorsBlood GlucoseFood intakeMiceLevels of insulinNegatively associatedBodyExcessHypothalamicModifiesHumansBrainAlleviateOverweightPancreaticMechanismsConcentrationsResistant
Resistance89
- Intramyocellular lipid is associated with visceral adiposity, markers of insulin resistance, and cardiovascular risk in prepubertal children: the EPOCH study. (cuanschutz.edu)
- Here we investigated the roles of ghrelin in HFCS- and SUC-induced adiposity and insulin resistance. (tamu.edu)
- Interestingly, we also found that ghrelin deletion exacerbates HFCS-induced adiposity and inflammation in adipose tissues, as well as whole-body insulin resistance. (tamu.edu)
- Our findings suggest that HFCS and SUC have differential effects on lipid metabolism: while sucrose promotes obesogenesis, HFCS primarily enhances inflammation and insulin resistance, and ghrelin confers protective effects for these metabolic dysfunctions. (tamu.edu)
- This study aims to compare the differences in circulating adiponectin levels and their relationships to regional adiposity , insulin resistance , serum lipid , and inflammatory factors in young, healthy Japanese women with different physical activity statuses. (bvsalud.org)
- Obesity is considered a risk factor for both asthma and insulin resistance in adults. (londonmet.ac.uk)
- Insulin resistance(IR) also influences the pulmonary function in the non-obese population. (londonmet.ac.uk)
- To investigate the modifying effect of insulin resistance on the predictive role of anthropometric measures in the estimation of impaired lung function among asthmatic adults. (londonmet.ac.uk)
- Clinical studies suggest that type 2 diabetes mellitus (T2DM) is a risk factor for cognitive decline and dementia, and have found evidence that insulin resistance (IR) occurs in the brain of patients with T2DM and Alzheimer disease (AD). (nature.com)
- Clinical studies suggest a link between type 2 diabetes mellitus (T2DM) and insulin resistance (IR) and cognitive dysfunction, but there are significant gaps in our knowledge of the mechanisms underlying this relationship. (nature.com)
- One CLA isomer has increased insulin resistance in men with metabolic syndrome , or a series of risk factors which increase their risk for heart disease. (webmd.com)
- Patients suffering from lipodystrophies experience reduced body fat, severe insulin resistance, hypertriglyceridemia, and hypoleptinemia, and nonalcoholic fatty liver disease. (medscape.com)
- Obesity is characterized by increased body adiposity and leads to insulin resistance. (medscape.com)
- Although young PTG heterozygous mice initially demonstrate normal glucose tolerance, progressive glucose intolerance, hyperinsulinemia, and insulin resistance develop with aging. (jci.org)
- Insulin resistance in older PTG heterozygous mice correlates with a significant increase in muscle triglyceride content, with a corresponding attenuation of insulin receptor signaling. (jci.org)
- It is recognized that there exists a link between hyperandrogenicity and insulin resistance. (nel.edu)
- Our study strongly supports the hypothesis that development of insulin resistance seems to be dependent on early hyperandrogenicity. (nel.edu)
- Insulin resistance ( IR ) is a pathological condition in which cells either fail to respond normally to the hormone insulin or downregulate insulin receptors in response to hyperinsulinemia . (wikipedia.org)
- In states of insulin resistance, the same amount of insulin does not have the same effect on glucose transport and blood sugar levels. (wikipedia.org)
- There are many causes of insulin resistance and the underlying process is still not completely understood. (wikipedia.org)
- Risk factors for insulin resistance include obesity , sedentary lifestyle , family history of diabetes, various health conditions, and certain medications. (wikipedia.org)
- Insulin resistance is considered a component of the metabolic syndrome . (wikipedia.org)
- There are multiple ways to measure insulin resistance such as fasting insulin levels or glucose tolerance tests, but these are not often used in clinical practice. (wikipedia.org)
- Insulin resistance can be improved or reversed with lifestyle approaches, such as exercise and dietary changes. (wikipedia.org)
- There are a number of risk factors for insulin resistance, including being overweight or obese or having a sedentary lifestyle . (wikipedia.org)
- [1] Various genetic factors can increase risk, such as a family history of diabetes, and there are some specific medical conditions associated with insulin resistance, such as polycystic ovary syndrome . (wikipedia.org)
- Dietary factors are likely to contribute to insulin resistance. (wikipedia.org)
- Foods that have independently been linked to insulin resistance include those high in sugar with high glycemic indices , low in omega-3 and fiber, and which are hyperpalatable which increases risk of overeating. (wikipedia.org)
- The percentage of polyunsaturated fatty acids (PUFAs) is inversely correlated with insulin resistance. (wikipedia.org)
- [3] It is hypothesized that increasing cell membrane fluidity by increasing PUFA concentration might result in an enhanced number of insulin receptors, an increased affinity of insulin to its receptors, and reduced insulin resistance. (wikipedia.org)
- Vitamin D deficiency has also been associated with insulin resistance. (wikipedia.org)
- Sedentary lifestyle increases the likelihood of development of insulin resistance. (wikipedia.org)
- Studies have consistently shown that there is a link between insulin resistance and circadian rhythm, with insulin sensitivity being higher in the morning and lower in the evening. (wikipedia.org)
- A mismatch between the circadian rhythm and the meals schedule, such as in circadian rhythm disorders , may increase insulin resistance. (wikipedia.org)
- Some medications are associated with insulin resistance including corticosteroids , protease inhibitors (type of HIV medication), [11] and atypical antipsychotics . (wikipedia.org)
- Being exposed to light during sleep has been shown to cause insulin resistance and increase heart rate. (wikipedia.org)
- Many hormones can induce insulin resistance including cortisol , [14] growth hormone , and human placental lactogen . (wikipedia.org)
- Cortisol counteracts insulin and can lead to increased hepatic gluconeogenesis , reduced peripheral utilization of glucose, and increased insulin resistance. (wikipedia.org)
- Mood disorders associated with insulin resistance and obesity. (continuingeducation.net)
- Previous clinical studies and randomized controlled trials have revealed that low serum vitamin D levels are associated with the risk of developing insulin resistance. (frontiersin.org)
- Magnesium has been reported to be a protective factor for insulin resistance, and magnesium has been considered an important co-factor for vitamin D activation. (frontiersin.org)
- However, the effect of dietary magnesium intake on the relationship between vitamin D and the risk of developing insulin resistance has not been comprehensively investigated. (frontiersin.org)
- Therefore, we designed this cross-sectional analysis to assess whether dietary magnesium intake modifies the association of vitamin D and insulin resistance. (frontiersin.org)
- We assessed differences between serum vitamin D levels and the risk of developing insulin resistance (interaction test), using a weighted multivariate logistic regression to analyze differences between participants with low and high magnesium intake levels. (frontiersin.org)
- Among adults in the United States, we found an independent association between vitamin D level and insulin resistance, and this association was modified according to different levels of magnesium intake. (frontiersin.org)
- Insulin resistance (IR) refers to an efficiency decline in the performance of insulin to promote glucose uptake and utilization in tissues or cells ( 1 , 2 ). (frontiersin.org)
- HFD-fed MHCII(-/-) mice developed less adipose inflammation and insulin resistance than did wild-type mice, despite developing similar adiposity. (nih.gov)
- Heterogeneity analysis revealed that an increasing index of insulin resistance was independently associated with improving the performance of adiponectin upon metabolic syndrome diagnosis (ratio of diagnostic odds ratio = 3.89, 95% CI: 1.13-13.9). (frontiersin.org)
- Further Mendelian randomization analysis identified that the amplified risk could be attributed to increased susceptibility (up to 7%) to insulin resistance compared with women. (frontiersin.org)
- Factors that affect insulin resistance should be considered for adjustment in future assessments. (frontiersin.org)
- Lee S, Bacha F, Hannon T, Kuk JL, Boesch C, Arslanian S " Effects of aerobic versus resistance exercise without caloric restriction on abdominal fat, intrahepatic lipid, and insulin sensitivity in obese adolescent boys: a randomized, controlled trial. . (bcm.edu)
- Lee S, Bacha F, Gungor N, Arslanian S " Comparison of different definitions of pediatric metabolic syndrome: relation to abdominal adiposity, insulin resistance, adiponectin, and inflammatory biomarkers. . (bcm.edu)
- Bacha F, Saad R, Gungor N, Arslanian SA " Are obesity-related metabolic risk factors modulated by the degree of insulin resistance in adolescents? . (bcm.edu)
- A new study, published last month in The American Journal of Psychiatry , demonstrated a link between insulin resistance and the risk of developing depression. (dietdoctor.com)
- Further, the researchers discovered that the evidence for a link between depression and new-onset cases of insulin resistance was strongest for participants who developed prediabetes. (dietdoctor.com)
- Insulin resistance is a common metabolic condition where your body struggles to use insulin effectively. (dietdoctor.com)
- All three markers of insulin resistance were associated with greater risk of depression. (dietdoctor.com)
- Fortunately, a low-carb lifestyle can help treat and prevent insulin resistance . (dietdoctor.com)
- Hyperthyroidism is often linked to insulin resistance. (globalrph.com)
- Insulin resistance and other features of the metabolic syndrome have been causally linked to adipose tissue macrophages (ATMs) in mice with diet-induced obesity. (diabetesjournals.org)
- We aimed to characterize macrophage phenotype and function in human subcutaneous and omental adipose tissue in relation to insulin resistance in obesity. (diabetesjournals.org)
- In obese women, CD11c + ATM density was greater in subcutaneous than omental adipose tissue and correlated with markers of insulin resistance. (diabetesjournals.org)
- These findings identify proinflammatory CD11c + ATMs as markers of insulin resistance in human obesity. (diabetesjournals.org)
- Background: Alström Syndrome (AS) is a rare autosomal recessive disease featuring highly accelerated insulin resistance, fatty liver, diabetes and heart failure among other syndromic features. (endocrine-abstracts.org)
- They can improve glucose uptake by cells but sometimes cause insulin resistance . (medicinenet.com)
- tension,glucoseintolerance,insulin afterful explanationoftheobjectives resistance[3]andhyperlipidaemia[4]. (who.int)
- Studies have investigated the role of leptin in obesity, anorexia nervosa, insulin resistance, and hypertension. (thermofisher.com)
- Metabolic syndrome is a combination of conditions that include insulin resistance/Type II diabetes, HTN, hyperlipidemia, and obesity. (nursingcenter.com)
- The primary risk factors of NASH include obesity (body mass index [BMI] >30), insulin resistance, Type II diabetes, "central adiposity" ( Paskos & Paletas, 2009 , para. (nursingcenter.com)
- They come together as a symbiotic relationship, such as obesity coupled with insulin resistance, and with these come HTN and hyperlipidemia. (nursingcenter.com)
- Perhaps, the strongest risk factors for the development of NASH syndrome are obesity and insulin resistance. (nursingcenter.com)
- Insulin resistance, when diagnosed, is almost exclusively found in those who are clinically obese. (nursingcenter.com)
- Type 2 diabetes mellitus consists of an array of dysfunctions characterized by hyperglycemia and resulting from the combination of resistance to insulin action, inadequate insulin secretion, and excessive or inappropriate glucagon secretion. (medscape.com)
- According to the 2005-2006 insulin resistance, and employment status. (cdc.gov)
- Among men, Canadian Community Health Survey, the prevalence of factors were age, apolipoprotein A1 level, apolipoprotein B obesity among people who self-identified as Aboriginal level, and insulin resistance. (cdc.gov)
- Metabolic syndrome is characterized by a large waist circumference (due to excess abdominal adipose tissue), hypertension, abnormal fasting plasma glucose or insulin resistance, and dyslipidemia. (msdmanuals.com)
- Some experts think that chronic stress causes hormonal changes that contribute to abdominal obesity, insulin resistance, and low blood lipid (HDL) levels. (msdmanuals.com)
- Metabolic changes include the increase of serum lipids and peripheral insulin resistance resulting in DM 9,12 . (bvsalud.org)
- Insulin resistance (IR) is common in HIV-seropositive patients, particularly among those receiving protease inhibitor (PI) and is more prevalent among those with lipoatrophy or fat accumulation in the visceral region. (bvsalud.org)
- Insulin resistance is inversely and independently associated with bone size in young, nondiabetic men, according to a new study. (medscape.com)
- The authors suggest that insulin resistance itself may alter bone accrual and thus partially explain the elevated fracture risk seen among patients with type 2 diabetes despite normal bone densities. (medscape.com)
- Specifically, the investigators found that trabecular and cortical bone size was reduced in individuals with insulin resistance, even after researchers controlled for body composition, muscle size, and sex steroid levels, implying that diabetic bone fragility is an early consequence of the underlying pathophysiology. (medscape.com)
- The team suggests several direct and indirect pathways by which insulin resistance could affect bone size, such as impaired insulin signaling, fat-mass- or adiposity-associated pathways, and modulation of the muscle-bone relationship at weight-bearing sites. (medscape.com)
- She told Medscape Medical News that "the relationship between insulin resistance and bone geometry most likely results from a combination of factors, including direct effects of insulin resistance on bone as well as nondirect factors such as fat mass and physical activity. (medscape.com)
- Regardless of the potential explanations for the association, the findings reinforce the importance of identifying the development of insulin resistance and diabetes early, as well as that of monitoring the bone health of individuals with diabetes. (medscape.com)
- Dr Verroken noted, however, that further research will be needed to determine whether preventing the progression of insulin resistance and, in turn, type 2 diabetes "also prevents the development or progression of bone fragility. (medscape.com)
- She said: "Maintaining a healthy lifestyle with adequate physical activity is already important from a young age, given that not only might it prevent the development of insulin resistance, it also benefits bone health. (medscape.com)
- Fasting serum samples were used to determine insulin resistance via the homeostasis model assessment of insulin resistance (HOMA-IR), while bone geometry was determined with peripheral quantitative computed tomography at the distal radius and the radial and tibial shaft. (medscape.com)
- Compared with non-insulin-resistant participants, men with insulin resistance had a significantly smaller trabecular area at the distal radius, a smaller cortical thickness, and increased endosteal expansion at the radial shaft, and, at the radial and tibial shafts, a smaller cortical area and smaller periosteal and endosteal circumferences, as well as lower bone strength. (medscape.com)
Central adiposity4
- Metabolic syndrome (MetS) is defined as a panel of endocrine disorders, including central adiposity, dyslipidemia, hyperglycemia and hypertension ( Kaur, 2014 ). (frontiersin.org)
- and high central adiposity, assessed by waist circumference. (dietdoctor.com)
- Values of volume to the central adiposity, sports, zhen wang et al. (lorenzopetrantoni.com)
- Excess central adiposity (called apple shape), particularly when it results in a high waist-to-hip ratio (reflecting a relatively low muscle-to-fat mass ratio), increases risk. (msdmanuals.com)
Secretion5
- The brain modulates various aspects of metabolism, such as food intake, energy expenditure, insulin secretion, hepatic glucose production and glucose/fatty acid metabolism in adipose tissue and skeletal muscle. (nature.com)
- They're known to increase insulin secretion, but excessive intake leads to prevention of insulin release. (medicinenet.com)
- Risk of circadian cortisol secretion and insulin-like growth hormone, the efficacy and 2 dm or isoproterenol. (lorenzopetrantoni.com)
- An OGTT was performed on participants without diabetes, and peripheral insulin sensitivity (Matsuda index), HOMA-IR, basal insulin clearance, insulin secretion (C-peptide index) and beta cell function (disposition index) were estimated. (lu.se)
- In contrast, most of the associations between IGFBP2 and insulin dynamics, except for insulin secretion, were mediated by either fat mass index or visceral adipose tissue in men and women. (lu.se)
Visceral adiposity1
- We found that neonatal androgenization induced adult animals displaying higher visceral adiposity mass, body weight and leptinemia than CT rats. (nel.edu)
Diabetes3
- Conclusions/interpretation: We validated 34 proteins that were associated with type 2 diabetes, of which 11 were associated with measures of type 2 diabetes pathophysiology such as peripheral insulin sensitivity and beta cell function. (lu.se)
- We established that a loss of central leptin action during obesity leads to impaired insulin action, which might explain the striking correlation of obesity and type 2 diabetes. (otago.ac.nz)
- According to the American Diabetes Association 17 , DM is a disease in which the body does not produce insulin or does not produce it correctly. (bvsalud.org)
Lipid1
- Physical activity can be a protective factor for NCDs, helping to prevent and treat diseases and functional disability, by reducing body adiposity and blood pressure, improving lipid profile and insulin sensitivity, among other benefits. (bvsalud.org)
Leptin and insulin2
- In contrast, adiposity signals such as leptin and insulin are implicated in both short- and long-term energy homeostasis. (hindawi.com)
- In particular we are interested in the central interaction of the adiposity hormones leptin and insulin, which appears crucial for the maintenance of energy and glucose homeostasis. (otago.ac.nz)
Adipose2
- Those who are insulin resistant have an abundance of adipose tissue in their abdominal area. (nursingcenter.com)
- Dual-energy x-ray absorptiometry was used to determine fat mass and visceral adipose tissue, and fasting venous blood samples were collected for analysis of glucose, insulin and C-peptide and for targeted proteomics, measuring a total of 184. (lu.se)
Hyperinsulinemia1
- Bacha F, Saad R, Gungor N, Arslanian SA " Does adiponectin explain the lower insulin sensitivity and hyperinsulinemia of African-American children? . (bcm.edu)
Demonstrating that both bas1
- An important clue came from Porte's work demonstrating that both basal insulin levels and glucose-stimulated insulin responses are directly proportional to body weight [7]. (ssib.org)
Sensitivity and beta-cell function1
Hormones2
- The brain integrates multiple metabolic inputs from the periphery through nutrients, gut-derived satiety signals and adiposity-related hormones. (nature.com)
- These neurons are the first-order neurons on which peripheral metabolic hormones, including leptin, insulin, ghrelin and nutrients, primarily act. (nature.com)
Obese2
- In the context of calorie-restricted diets, adding nuts produces a more lasting and greater magnitude of weight loss among obese subjects while improving insulin sensitivity. (cambridge.org)
- The exact actions of PPARbeta/delta are still being researched, though in obese animals it appears to decrease adiposity. (bodybuilding.com)
Adiponectin6
- Relationships of adiponectin to regional adiposity, insulin sensitivity, serum lipids, and inflammatory markers in sedentary and endurance-trained Japanese young women. (bvsalud.org)
- However, no significant correlation between adiponectin and insulin sensitivity was detected in both groups. (bvsalud.org)
- These findings suggest that adiponectin is primarily associated with regional adiposity and HDL-C regardless of insulin sensitivity and physical activity status in young, healthy women . (bvsalud.org)
- De Las Heras J, Lee S, Bacha F, Tfayli H, Arslanian S " Cross-Sectional Association between Blood Pressure, in vivo Insulin Sensitivity and Adiponectin in Overweight Adolescents. . (bcm.edu)
- ABSTRACT Adiponectin has profound insulin-sensitizing, anti-inflammatory and anti-atherogenic effects. (who.int)
- The results support the theory that adiponectin might be part of a feedback mechanism improving insulin sensitivity and cardiovascular health in pre-eclamptic patients. (who.int)
Pancreas2
HOMA-IR2
Metabolism1
- The BCAAs have variable effects on glucose metabolism, insulin levels, and response. (medicinenet.com)
Homeostasis1
- The resemblance between the metabolic abnormalities of these extreme states of adiposity underscores the importance of fat tissue in energy homeostasis. (medscape.com)
Altering insulin sensitivity1
- Further studies are needed to clarify the effect of long-term (≥ year) consumption of nuts on body weight and their role in altering insulin sensitivity both in normal and type-2 diabetics. (cambridge.org)
Peripheral insulin sensitivity3
- Neonatal hypothalamic androgenization in the female rat induces changes in peripheral insulin sensitivity and adiposity function at adulthood. (nel.edu)
- By using the neonatally androgenized female rat we explored whether this treatment modifies peripheral insulin sensitivity and visceral fat function at adulthood. (nel.edu)
- Perelló M, Castrogiovanni D, Moreno G, Gaillard R, Spinedi E. Neonatal hypothalamic androgenization in the female rat induces changes in peripheral insulin sensitivity and adiposity function at adulthood. (nel.edu)
Receptors4
- Based on that, we reasoned that any cell expressing insulin receptors might respond to a change of insulin level as if there had been a change of adiposity. (ssib.org)
- This, in turn, suggested the hypothesis that an experimentally-induced increase of brain insulin would be perceived as an increase of body fat when detected by brain cells expressing insulin receptors, and this would lead to decreased food intake. (ssib.org)
- We, as well as many other labs, systematically identified the distribution of brain insulin receptors and the mechanism by which insulin enters the brain from the blood. (ssib.org)
- Leptin is involved in regulating food intake, energy expenditure, and adiposity through hypothalamic leptin receptors. (thermofisher.com)
Blood Glucose2
- Using multiple linear regression analysis (MLRA) the interdependence of brain activity, plasma insulin and blood glucose was investigated. (frontiersin.org)
- Insulin is a hormone that facilitates the transport of glucose from blood into cells, thereby reducing blood glucose (blood sugar). (wikipedia.org)
Food intake4
- Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons. (ssib.org)
- Insulin infusion led to significant, dose-related reductions in food intake and body weight in comparison to baseline periods during which artificial CSF was infused. (ssib.org)
- Furthermore, infusion of pancreatic glucagon in the same molar dose as the largest insulin dose had no significant effect on food intake or body weight. (ssib.org)
- Over the next couple of decades, Dan Porte and myself and our colleagues developed optimal parameters for administering insulin into the brain and assessing its effects using rodent models, as well as the controls necessary to rule out illness or other alternative explanations for the altered food intake. (ssib.org)
Mice1
- Comparing to SUC-fed mice, HFCS-fed mice showed lower body weight but higher circulating glucose and insulin levels. (tamu.edu)
Levels of insulin2
- additionally circulating levels of insulin, leptin, ACTH and B were measured. (nel.edu)
- At first, this leads to chronically elevated levels of insulin, and eventually - as your cells become "immune" to the constant presence of insulin - even these high levels of insulin fail to control blood sugar, leading to the high blood sugar levels that result in a prediabetes diagnosis. (dietdoctor.com)
Negatively associated1
- using MRI-cerebral blood flow (CBF) during rest: here, changes of insulin levels were negatively associated with changes of CBF signals in the caudate and the putamen in response to glucose administration. (frontiersin.org)
Body7
- Regional adiposity [trunk fat mass (TFM), lower- body fat mass (LFM), and arm fat mass (AFM)] was evaluated using the dual-energy X-ray absorptiometry method . (bvsalud.org)
- It should be noted that although several other groups found that administering insulin into the ventricles or directly into brain neuropil elicited hypophagia and loss of body fat, insulin action in the brain remained a somewhat controversial topic to many. (ssib.org)
- Figure 2: Complex relationships between insulin signalling in the brain and elsewhere in the body in health and disease. (nature.com)
- Traditionally, nuts have been considered a staple food, but because of their high energy and fat content are not considered good for body weight control or insulin sensitivity. (cambridge.org)
- It can be caused by a variety of reasons and pushes the body to compensate by producing too much insulin to keep the blood sugar within a normal range. (frontiersin.org)
- C-reactive protein level had a significant association with body mass index ( r = 0.18), adiposity ( r = 0.23), smoking ( r = 0.20), carbohydrate intake ( r = 0.19) and saturated fatty acid ( r = 0.20). (who.int)
- DHEA can affect how insulin works in the body. (medlineplus.gov)
Excess2
- Mechanisms linking excess adiposity to metabolic dysregulation. (continuingeducation.net)
- Describe how excess adiposity is linked to metabolic dysregulation. (continuingeducation.net)
Hypothalamic3
- Glucocorticoid-dependency of increased adiposity in a model of hypothalamic obesity. (nel.edu)
- It is known that rats treated, at neonatal age, with monosodium L-glutamate (MSG) develop neuroendocrine and metabolic abnormalities, resulting in a phenotype of hypothalamic obesity, characterized by increased adiposity, corticosteronemia and leptinemia. (nel.edu)
- Perelló M, Moreno G, Gaillard R, Spinedi E. Glucocorticoid-dependency of increased adiposity in a model of hypothalamic obesity. (nel.edu)
Modifies1
- IR also modifies the association between excessive adiposity and respiratory function in asthmatic adult. (londonmet.ac.uk)
Humans1
Brain7
- Strikingly, differences in plasma insulin levels between hunger and satiety states after glucose administration at the time of the scan were negatively related to brain activity in the posterior insula and superior frontal gyrus (SFG), while plasma glucose levels were positively associated with activity changes in the fusiform gyrus. (frontiersin.org)
- Our results indicate that hormonal signals like insulin alleviate an acute hemostatic energy deficit by modifying the homeostatic and frontal circuitry of the human brain. (frontiersin.org)
- Metabolic state, insulin levels and glucose administration interact in their effects on brain activation patterns. (frontiersin.org)
- To avoid these disadvantages in the present investigation, we used resting-state fMRI in order to reveal potential links between whole brain activity and insulin and glucose levels in different metabolic states. (frontiersin.org)
- Several studies using rs-fMRI revealed associations of insulin or glucose levels with the functional connectivity (FC) of particular brain networks or brain sites that are related to homeostatic regulation but not without contradictions. (frontiersin.org)
- A dahlia flower extract has anti-diabetic properties by improving insulin function in the brain. (otago.ac.nz)
- In A. Kleinridders (Ed.), Physiological consequences of brain insulin action . (otago.ac.nz)
Alleviate2
- Importantly, both lifestyle (diet and exercise) and pharmacological interventions that are known to alleviate peripheral IR effectively restore hippocampal neuroplasticity in rodent models of T2DM and AD, and this effect may be due to restoration of insulin signalling in the hippocampus. (nature.com)
- This Review highlights these observations and discusses intervention studies which suggest that the restoration of insulin activity in the hippocampus may be an effective strategy to alleviate the cognitive decline associated with T2DM and AD. (nature.com)
Overweight1
- Burns SF, Bacha F, Lee SJ, Tfayli H, Gungor N, Arslanian SA " Declining {beta}-Cell Function Relative to Insulin Sensitivity With Escalating OGTT 2-h Glucose Concentrations in the Nondiabetic Through the Diabetic Range in Overweight Youth. . (bcm.edu)
Pancreatic1
Mechanisms1
- Insulin produces the dephosphorylation of only a small subset of proteins at discrete locations, whereas PP1 is ubiquitously expressed and is found in virtually all cellular compartments, suggesting that mechanisms exist for the targeted regulation of PP1 in insulin-responsive cells that selectively permit activation of the enzyme only at these sites. (jci.org)
Concentrations2
- Immediately after sacrifice, freshly dissected visceral fat pads were used for isolation of adipocytes, these cells were then incubated with medium alone or containing different concentrations of insulin in order to determine leptin secreted into the medium. (nel.edu)
- The results of the high glucose load 90-min test indicated that TP and CT rats developed similar glycemia but this accounted because of an early significantly higher peak values of circulating insulin in TP than in CT rats, regardless of similar enhancement in circulating glucocorticoid concentrations in both groups. (nel.edu)
Resistant1
- 0.01) only in the insulin resistant asthmatics. (londonmet.ac.uk)