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  • Lipids
  • Among different inositol lipids, the importance in transmembrane signaling and regulation of cell functions are best documented for PtdIns(4,5)P2 and PtdIns(3,4,5)P3. (springer.com)
  • There are several ways in which these low-abundance inositol lipids (less than 1 % of membrane phospholipids) could provide a signaling link or fulfill other roles in different cellular processes. (springer.com)
  • Katan M. (2015) Inositol Lipids. (springer.com)
  • moiety
  • The inositol moiety can be phosphorylated at several different positions giving rise to a number of other molecular species. (springer.com)
  • Proteins
  • scyllo-Inositol also reversed memory deficits, reduced the formation of Aβ plaques, and alleviated other symptoms that are associated with the accumulation of Aβ proteins in these mice. (wikipedia.org)
  • polyols
  • Depletion of MIOX and accumulation of polyols, such as inositol and xylitol, have been cited as contributing factors in complications associated with diabetes. (wikipedia.org)
  • sugar alcohol
  • Inositol is a sugar alcohol with half the sweetness of sucrose (table sugar). (wikipedia.org)
  • scyllo-Inositol is a naturally occurring plant sugar alcohol found most abundantly in the coconut palm. (wikipedia.org)
  • While classed as a sugar-alcohol for historical reasons, muco-inositol is more properly described as a sweet-alcohol due its perception by the mammal as sweet. (wikipedia.org)
  • MIOX
  • ENDOR spectroscopy was used to determine that the substrate directly binds to the Fe(II)/Fe(III) di-iron center of MIOX most likely through the O1 atom of myo-inositol. (wikipedia.org)
  • Hence, MIOX enables the conversion and catabolism of inositol to generate NADPH and other pentose sugars. (wikipedia.org)
  • Due to its exclusive expression in the kidney, research has focused on understanding the potential role of both myo-inositol levels and MIOX activity on metabolic diseases like diabetes mellitus and obesity. (wikipedia.org)
  • depletion
  • It is thought that lithium acts according to the inositol depletion hypothesis: lithium produces its therapeutic effect by inhibiting IMPase and therefore decreasing levels of myo-inositol. (wikipedia.org)
  • putative
  • A series of crystallization, spectroscopy and density functional theory experiments have revealed a putative mechanism (shown right) for the oxidation of myo-inositol. (wikipedia.org)
  • Myo-inositol trispyrophosphate (ITPP) is an inositol phosphate, a pyrophosphate, a drug candidate, and a putative performance-enhancing substance, which exerts its biological effects by increasing tissue oxygenation. (wikipedia.org)
  • therapeutic
  • scyllo-Inositol is undergoing clinical investigation as an orally-administered therapeutic agent for the treatment of mild to moderate Alzheimer's disease. (wikipedia.org)
  • Catalytic
  • This binding step positions the myo-inositol prior to the catalytic steps which involve attack of an iron center by diatomic oxygen followed by abstraction of a myo-inositol hydrogen atom. (wikipedia.org)
  • generate
  • Next, the hydrogen atom from C1 of myo-inositol is abstracted to generate a radical that can be attacked by an oxygen radical. (wikipedia.org)
  • bound
  • It is composed of an inositol ring with three phosphate groups bound at the 1, 4, and 5 carbon positions, and three hydroxyl groups bound at positions 2, 3, and 6. (wikipedia.org)