Development of heterotopic ossificationNeurologicalDeep vein thromFracturesTraumaMyositisSpasticityBurnsSpinal Cord InjAmputationNeurogenicBurn injuriesFibrodysplasiaComplicationsSymptomaticPatientsRehabilitationLamellar boneAmputationsEndochondralPeriarticularTraumatic Brain InEtidronatePosteriorExtensiveGeneticDiagnosisPatient'sSymptomsPreventionIncidenceNerveFormation of boneSoft tissuesStiffnessBrain and spinalArthroplastyDisordersBone growthSkeletonSeverityTypicallyInsultsMolecularAdultKnee
Development of heterotopic ossification2
- The records of 3,693 adult burn patients were analyzed for potential predictors of the development of heterotopic ossification (HO). (spauldingrehab.org)
- Banovac K, The effect of etidronate on late development of heterotopic ossification after spinal cord injury. (scireproject.com)
Neurological6
- Patients with traumatic neurological injuries, severe neurologic disorders or severe burns who develop heterotopic ossification experience limitation of motion in the areas affected. (wikipedia.org)
- Neurological heterotopic ossification: Current understanding and future directions. (trdizin.gov.tr)
- Neurological heterotopic ossification (NHO) involves the formation of bone in soft tissue following a neurological condition, of which the most common are brain and spinal cord injuries. (monash.edu)
- Neurological consequences result from the injury itself, following interruption and decentralization of the nervous system, and may be regarded as sequelae to the injury (6). (medicaljournals.se)
- Arduini M, Mancini F, Farsetti P, Piperno A, Ippolito E. A new classification of peri-articular heterotopic ossification of the hip associated with neurological injury: 3D CT scan assessment and intra-operative findings. (scireproject.com)
- Brady D, Shultz S, McDonald S, O'Brien T. Neurological heterotopic ossification: Current understanding and future directions. (scireproject.com)
Deep vein throm1
- During postoperative follow-up, all patients recovered well, with no fat liquefaction, infection, femoral nerve or iliac blood vessels injury, deep vein thrombosis, heterotopic ossification, or any and other complications. (medscimonit.com)
Fractures1
- To simulate blast-induced complex injuries, researchers exposed anesthetized rats to blast in a shock tube, then produced femoral fractures in a controlled apparatus and simulated a crush injury with controlled pressure for 1 minute. (health.mil)
Trauma6
- citation needed] Heterotopic ossification of varying severity can be caused by surgery or trauma to the hips and legs. (wikipedia.org)
- Sullivan MP, Torres SJ, Mehta S, Ahn J. Heterotopic ossification after central nervous system trauma: A current review. (trdizin.gov.tr)
- Heterotopic ossification may occur for no known reason as in myositis ossificans progressiva or may follow a wide variety of surgical, occupational, and sports trauma (e.g., hip arthroplasty, spinal cord injury, head injury, burns, and severe thigh bruises). (nih.gov)
- Specifically, the focus is on the occurrence of bony tissue in soft tissues as a result of injuries or skeletal trauma. (stevenson.edu)
- Most cases remain in the non-athlete population, the vast majority of these involving falls on the outstretched hand, but also from lifting injuries or blunt trauma. (radsource.us)
- The treatment of cartilage defects in trauma injuries and degenerative diseases represents a challenge for orthopedists. (bvsalud.org)
Myositis2
- In traumatic heterotopic ossification (traumatic myositis ossificans), the patient may complain of a warm, tender, firm swelling in a muscle and decreased range of motion in the joint served by the muscle involved. (wikipedia.org)
- Myositis ossificans is a misnomer, although the term myositis ossificans circumscripta continues to be used to describe nonhereditary forms of heterotopic ossification. (medscape.com)
Spasticity4
- After being discharged home, people with spinal cord injuries need to watch out for some common medical complications such as blood clots and spasticity. (mossrehab.com)
- The patient may experience deep venous thrombosis - also known as DVT, spasticity, heterotopic ossification - also named as HO, and contractures. (mossrehab.com)
- Sometimes the muscle tightness created by spasticity can actually help you to move and reposition yourself, an important activity to prevent you from getting pressure injuries. (mossrehab.com)
- If they have anything that is going wrong below their level of injuries in areas that they are not feeling as well or they have decreased sensation, such as a urinary tract infection or a pressure injury, their spasticity may exacerbate or become worse or more intense. (mossrehab.com)
Burns3
- citation needed] Heterotopic ossification often develops in patients with traumatic brain or spinal cord injuries, other severe neurologic disorders or severe burns, most commonly around the hips. (wikipedia.org)
- aur A, Sinclair M, Caruso E, Peretti G, Zaleske D. Heterotopic ossification around the elbow followHeterotopic ing burns in children: results after excision. (trdizin.gov.tr)
- Such injuries can take several forms, including electric current burns, flash burns, and contact burns. (medscape.com)
Spinal Cord Inj2
- See also Spinal Cord Injuries , Autonomic Dysreflexia in Spinal Cord Injury , Functional Outcomes per level of Spinal Cord Injury , Hypercalcemia in Spinal Cord Injury , Osteoporosis and Spinal Cord Injury , Prevention of Thromboembolism in Spinal Cord Injury , Rehabilitation of Persons with Spinal Cord Injuries , and Spinal Cord Injury and Aging . (medscape.com)
- Resection of heterotopic ossification in patients with spinal cord injuries. (scireproject.com)
Amputation3
- This study uses an established animal model for heterotopic ossification due to traumatic blast-related amputation. (health.mil)
- Relative to immediate amputation groups, the groups with simulated tourniquets had more heterotopic bone, a heightened and prolonged systemic inflammatory response, and increased evidence of injury to the kidneys, liver, and lungs. (health.mil)
- Tourniquet use following blast-associated complex lower limb injury and traumatic amputation promotes end organ dysfunction and amplified heterotopic ossification formation. (health.mil)
Neurogenic2
- Neurogenic heterotopic ossification - This condition is the one that comes to mind when the generic phrase heterotopic ossification is used. (medscape.com)
- Despite many investigations, the etiology and pathogenesis of neurogenic heterotopic ossification remain unknown. (medscape.com)
Burn injuries3
- HO is also seen after other neurologic insults, such as traumatic brain injury (TBI), stroke, Guillain-Barré syndrome (GBS), and after burn injuries and orthopedic procedures (eg, total hip replacement). (medscape.com)
- Heterotopic ossification (HO), the development of abnormal bone in the soft tissue, is a rare but severely debilitating complication of burn injuries. (spauldingrehab.org)
- Predicting Heterotopic Ossification Early After Burn Injuries: A Risk Scoring System. (spauldingrehab.org)
Fibrodysplasia8
- Excess inflammation and canonical BMP receptor (BMPR) signaling are coinciding hallmarks of the early stages of injury-induced endochondral heterotopic ossification (EHO), especially in the rare genetic disease fibrodysplasia ossificans progressiva (FOP). (ozgene.com)
- There are also rare genetic disorders causing heterotopic ossification such as fibrodysplasia ossificans progressiva (FOP), a condition that causes injured bodily tissues to be replaced by heterotopic bone. (wikipedia.org)
- Fibrodysplasia ossificans progressiva (FOP) is a rare and disabling genetic condition characterized by congenital malformations of the great toes and progressive heterotopic ossification (HO) in specific anatomic patterns. (medscape.com)
- Extensive heterotopic ossification on the back of a patient with fibrodysplasia ossificans progressiva. (medscape.com)
- Fibrodysplasia ossificans progressiva is the most catastrophic disorder of heterotopic ossification in humans. (medscape.com)
- Progressive postnatal heterotopic ossification in fibrodysplasia ossificans progressiva usually appears within the first decade of life as spontaneous or injury-induced exacerbations. (medscape.com)
- The natural history of heterotopic ossification in patients who have fibrodysplasia ossificans progressiva. (medscape.com)
- Age- and joint-specific risk of initial heterotopic ossification in patients who have fibrodysplasia ossificans progressiva. (medscape.com)
Complications10
- In addition, the tissue damage from these injuries can cause systemic complications and must be considered for the optimal treatment of wounded personnel. (health.mil)
- To assess the occurrence and risk factors for complications following spinal cord injury during and after inpatient rehabilitation. (medicaljournals.se)
- Multi-level random coefficient analyses revealed that complications were common following spinal cord injury. (medicaljournals.se)
- Complications are common following spinal cord injury. (medicaljournals.se)
- Spinal cord injury (SCI) is often followed by complications, which add to the detrimental effect that loss of motor, sensory and autonomic function have on a person's health, social participation and quality of life (1-4). (medicaljournals.se)
- What complications can brain injuries cause? (halelawfirm.com)
- According to Brainline , there are a wide range of complications associated with serious injuries to the brain and head. (halelawfirm.com)
- Because some of these complications are life-threatening, immediate medical attention is recommended for all brain injury victims. (halelawfirm.com)
- In this installment of the Living With a Spinal Cord Injury series, we review signs and symptoms and prevention strategies for these potential medical complications. (mossrehab.com)
- Also their body will continue to change, they will continue to make progress and, in addition to that, they may experience common medical complications that are long-term for the spinal cord injury population. (mossrehab.com)
Symptomatic3
- About every third patient who has total hip arthroplasty (joint replacement) or a severe fracture of the long bones of the lower leg will develop heterotopic ossification, but is uncommonly symptomatic. (wikipedia.org)
- Symptomatic heterotopic ossification after very severe traumatic brain injury in 114 patients: incidence and risk factors. (trdizin.gov.tr)
- Etidronate disodium tablets, USP are indicated for the treatment of symptomatic Paget's disease of bone and in the prevention and treatment of heterotopic ossification following total hip replacement or due to spinal cord injury. (nih.gov)
Patients15
- Between 50% and 90% of patients who developed heterotopic ossification following a previous hip arthroplasty will develop additional heterotopic ossification. (wikipedia.org)
- It is not clear exactly what this means, because these patients do not develop heterotopic bone formation. (wikipedia.org)
- The aim of this study was to examine the characteristics and long-term results of treatment of HO in pediatric patients with severe traumatic brain injury (TBI). (trdizin.gov.tr)
- Results: Of 78 patients with TBI, HO was diagnosed in six patients at an average of four months after the injury. (trdizin.gov.tr)
- Intravenous disodium etidronate therapy in spinal cord injury patients with heterotopic ossification. (scireproject.com)
- Banovac K, Gonzalez F, Evaluation and management of heterotopic ossification in patients with spinal cord injury. (scireproject.com)
- Risk factors for heterotopic ossification in patients with spinal cord injury: A case-control study of 264 patients. (scireproject.com)
- Durovic A, Miljkovic D, Brdareski Z, Plavsic A, Jevtic M. Pulse low intensity electromagnetic field as prophylaxis of heterotopic ossification in patients with traumatic spinal cord injury. (scireproject.com)
- Diphosphonate treatment for heterotopic ossification in spinal cord injury patients. (scireproject.com)
- Genet F, Jourdan C, Lautridou C, Chehensse C, Minooee K, Denormandie P, Schnitzler A. The Impact of Preoperative Hip Heterotopic Ossification Extent on Recurrence in Patients with Head and Spinal Cord Injury: A Case Control Study. (scireproject.com)
- In 1918, Dejerine and Ceilier first described HO in patients with spinal cord injury (SCI) from the First World War. (medscape.com)
- Guo Y, Pattavana F, Siangco C, Ngo-Huang A, Fu J, Hui D, Bruera E . Overall Survival Among Patients with Cancer and Pressure Injury and its Association with Braden Scale Score. (mdanderson.org)
- Even in patients with higher grade injuries, the clinical diagnosis of a triceps tear can be difficult. (radsource.us)
- He therefore advocated adding to the clinical exam of patients with suspected triceps injuries an assessment of extension strength while in full flexion. (radsource.us)
- The study is designed to develop a gene therapy that empowers the patients' cells to express an inhibitor of Activin A. The hope is that, upon injury, a patient's own cells could automatically protect against the development of FOP lesions. (ifopa.org)
Rehabilitation3
- The overall focus is to serve as a guide for post-injury therapy and rehabilitation spanning the phases of care and considering evidence-based approaches, prevention, and treatment with an ultimate goal of aiding in the functional recovery and long-term quality of life for burn survivors. (nih.gov)
- A total of 212 persons with a spinal cord injury admitted to specialized rehabilitation centres. (medicaljournals.se)
- Covers tumors of the hip, hip instability and displacement in infants and young children, traumatic injuries, degenerative joint disorders, and rehabilitation considerations-all from both a basic science and practical clinical perspective . (elsevierhealth.com)
Lamellar bone3
- The ossification process involves the formation of mature lamellar bone, which is indistinguishable from normal bone, in soft tissues surrounding paralyzed joints (see the following image). (medscape.com)
- Heterotopic ossification (HO) refers to the formation of mature lamellar bone in nonosseous tissue. (usuhs.edu)
- Heterotopic ossification (HO) is the formation of ectopic lamellar bone in atypical, extraskeletal tissues. (postgraduateorthopaedics.co.uk)
Amputations2
- Blast-associated traumatic amputations are life-threatening, complex injuries that often result in severe bleeding. (health.mil)
- Some amputations can result in heterotopic ossification - bone growth in the soft tissues outside the normal skeleton. (dralexjimenez.com)
Endochondral1
- Although the inciting events and the definitive cell(s) of origin continue to remain elusive, animal models and human histology samples suggest that HO formation follows a predictable sequence of events culminating in endochondral ossification. (usuhs.edu)
Periarticular1
- Periarticular heterotopic ossification in head-injured adults. (trdizin.gov.tr)
Traumatic Brain In2
- See Pediatric Concussion and Other Traumatic Brain Injuries , a Critical Images slideshow, to help identify the signs and symptoms of TBI, determine the type and severity of injury, and initiate appropriate treatment. (medscape.com)
- This may account for the clinical impression that traumatic brain injuries cause accelerated fracture healing. (wikipedia.org)
Etidronate4
- Clinical trials have demonstrated the efficacy of etidronate disodium in heterotopic ossification following total hip replacement or due to spinal cord injury. (nih.gov)
- This is thought to be the mechanism by which etidronate disodium prevents or retards heterotopic ossification. (nih.gov)
- There is no evidence etidronate disodium affects mature heterotopic bone. (nih.gov)
- If you are taking etidronate to treat Paget's disease of bone or to prevent or treat heterotopic ossification, it may take some time for your condition to improve. (medlineplus.gov)
Posterior1
- A 45 year old male complains of pain and swelling at the posterior elbow following a lifting injury three days ago. (radsource.us)
Extensive2
- Extensive heterotopic ossification at the medial aspect of the left knee. (medscape.com)
- Unfortunately, Skip's injury had caused extensive damage to the muscle and soft tissue. (orthoinfo.org)
Genetic2
- Heterotopic ossification (HO) is the abnormal growth of bone in soft connective tissues that occurs as a frequent complication in individuals with traumatic brain injury (TBI) and in rare genetic disorders. (mdpi.com)
- citation needed] Another rare genetic disorder causing heterotopic ossification is progressive osseous heteroplasia (POH), is a condition characterized by cutaneous or subcutaneous ossification. (wikipedia.org)
Diagnosis2
- Freed JH, Hahn H, Menter R, Dillon T. The use of the three-phase bone scan in the early diagnosis of heterotopic ossification (HO) and in the evaluation of didronel therapy. (scireproject.com)
- MRI is beneficial for confirming the diagnosis and evaluating the extent of injury. (radsource.us)
Patient's2
- This Calculator is intended to be used at time of admission to determine an adult burn patient's risk of developing heterotopic ossification. (spauldingrehab.org)
- In a recent study, researchers showed that extended tourniquet use in a blast-related complex lower limb injury can affect the patient's response in ways that should be considered for subsequent treatment. (health.mil)
Symptoms1
- If heterotopic ossification is causing symptoms, it is not recommended to run and talk to your physician and prosthetist about options. (dralexjimenez.com)
Prevention3
- Prophylactic radiation therapy for the prevention of heterotopic ossification has been employed since the 1970s. (wikipedia.org)
- Prevention of heterotopic ossification after spinal cord injury with indomethacin. (scireproject.com)
- Banovac K, Williams JM, Patrick LD, Levi A. Prevention of heterotopic ossification after spinal cord injury with COX-2 selective inhibitor (rofecoxib). (scireproject.com)
Incidence1
- Inan M, Chan G, Dabney K, Miller F. Heterotopic ossification following hip osteotomies in cerebral palsy: incidence and risk factors. (trdizin.gov.tr)
Nerve1
- Implant failure, and nerve injury. (caringmedical.com)
Formation of bone1
- A known local response is "heterotopic ossification," defined as the formation of bone tissue in damaged soft tissue and muscle. (health.mil)
Soft tissues1
- Studies have shown that AlkP may have an important role in ectopic calcification and ossification of soft tissues. (medscape.com)
Stiffness1
- Some degree of stiffness is not uncommon following injury and surgery. (armdocs.com)
Brain and spinal1
- A comparison of heterotopic ossification treatment within the traumatic brain and spinal cord injured population: An evidence based systematic review. (scireproject.com)
Arthroplasty1
- Significant heterotopic ossification (HO) was found in 21 hips following total hip arthroplasty (THA) rated as class I (7), class II (5), class III (7) and class IV (2). (postgraduateorthopaedics.co.uk)
Disorders2
- Hip disorders in children who have spinal cord injury. (trdizin.gov.tr)
- An A to Z listing of words and phrased commonly associated with spinal cord injury and disorders. (unitedspinal.org)
Bone growth1
- Up to 20% of brain injury victims experience abnormal bone growth after their injuries, often in the hips or shoulders. (halelawfirm.com)
Skeleton2
- Heterotopic ossification (HO) is the process by which bone tissue forms outside of the skeleton in muscles and soft tissue. (wikipedia.org)
- Characteristically exhibiting in the big toe at birth, it causes the formation of heterotopic bone throughout the body over the course of the sufferer's life, causing chronic pain and eventually leading to the immobilisation and fusion of most of the skeleton by abnormal growths of bone. (wikipedia.org)
Severity1
- This project will determine whether introducing specific anti-inflammatory bacteria to the gut microbiota can regulate the severity of injury-induced flares in FOP mice . (ifopa.org)
Typically3
- Heterotopic ossification complicating total hip replacement typically develops radiographically 3 to 8 weeks postoperatively in the pericapsular area of the affected hip joint. (nih.gov)
- Heterotopic ossification due to spinal cord injury typically develops radiographically 1 to 4 months after injury. (nih.gov)
- This syndrome, known as heterotopic ossification is typically diagnosed with x-rays, but is difficult to visualize in its early stages. (stevenson.edu)
Insults1
- Garland DE, Shimoyama ST, Lugo C, Barras D, Gilgoff I. Spinal cord insults and heterotopic ossification in the pediatric population. (trdizin.gov.tr)
Molecular1
- Legosz P, Drela K, Pulik L, Sarzynska S, Maldyk P. Challenges of Heterotopic Ossification - molecular background and current treatment strategies. (trdizin.gov.tr)
Adult1
- Therapeutic time window of multipotent adult progenitor therapy after traumatic brain injury. (uthsc.edu)
Knee1
- In the months after his surgery, Skip developed heterotopic ossification (HO) around his knee joint. (orthoinfo.org)