• Cycle
  • One important gene family involved in such control is the p21/p27/p57 class of negative cell cycle regulators. (biologists.org)
  • This mutant, called rr31 , is a fully dominant, maternal-effect, gain-of-function mutation in the cdc-25.1 cell cycle phosphatase that sensitizes the intestinal lineage to an extra cell division. (biologists.org)
  • This coordination is executed through regulating both positive and negative regulatory components of the basal cell cycle machinery. (biologists.org)
  • The cell cycle machinery is well conserved among eukaryotes and complex mechanisms ensure that cell cycle progression occurs in a timely and precise sequence. (biologists.org)
  • Cyclin-dependent kinases (Cdks) drive progression through the different cell cycle phases (reviewed by Nigg, 2001 ). (biologists.org)
  • These developmental signals converge on many of the same key cell cycle components described above. (biologists.org)
  • In addition to cell cycle regulators that act globally, the activity of some regulators is important for the proper proliferation of cells in tissues at specific times during development. (biologists.org)