Phosphodiesterase-5 (PDE5) inhibitors are suggested to have anti-tumor effects and to inhibit surgery-induced immunosuppression. (nature.com)
Current activation was unaffected by inhibitors of protein kinase (A (H-89) and tyrosine kinase (tyrphostin A25), and could not be mimicked by elevation of intracellular Ca2+ or activation of protein kinase C. Similarly, disruption of actin filaments by dihydrocytochalsin B, or generation of membrane tension by dipyridamole failed to elicit significant increases in cell chloride permeability. (aston.ac.uk)
The currents were effectively inhibited by the chloride channel inhibitors NPPB and DIDS but resistant to DPC. (aston.ac.uk)
Thromboxane inhibitors are broadly classified as either those that inhibit the synthesis of thromboxane, or those that inhibit the target effect of it. (wikimili.com)
Thromboxane synthase inhibitors inhibit the final enzyme ( thromboxane synthase ) in the synthesis of thromboxane. (wikimili.com)
HN - 2016 MH - Adenylyl Cyclase Inhibitors UI - D000067956 MN - D27.505.519.389.108 MS - Compounds that bind to and inhibit the action of ADENYLYL CYCLASES. (nih.gov)
Adenosine8
The diagnostic sensitivity of pharmacologic stress testing with adenosine and dipyridamole is thought to range from 83% to 97%, while the specificity is thought to be between 38% and 94%.3,4 The utility of these agents has expanded from simply identifying the presence of ischemia to estimation of the burden and location of the ischemic area. (uic.edu)
The nonselective adenosine agonists commonly used in pharmacologic stress testing are adenosine and dipyridamole.4 The administration of adenosine directly causes increases in the amount of adenosine at the site of the receptor. (uic.edu)
Normally adenosine is transported back into the cell via facilitated transport.3 Dipyridamole works by inhibiting this cellular reuptake mechanism causing an increase in endogenous adenosine at the adenosine receptor. (uic.edu)
Adenosine has a very short half-life (approximately 12 seconds) while dipyridamole has a longer half-life of approximately 90 minutes.2 Both agents are rapid-acting. (uic.edu)
It is believed that it holds 68% of the market compared to 15% held by adenosine, 13% by dipyridamole, and 4% by dobutamine.1 The onset of regadenoson is generally seen in less than 1 minute, and the peak effect lasts from 2 to 3 minutes. (uic.edu)
The poorly metabolized adenosine analog 2-chloroadenosine (100 µM) potentiated release approximately 2-fold whereas dipyridamole, an inhibitor of mast cell uptake of adenosine, did not inhibit adenosine potentiation suggesting that adenosine actions on mast cells may be mediated by direct activation of cell-surface receptors. (aai.org)
Adenosine increases calcium currents and exerts antiarrhythmic activity by decreasing AV nodal refractoriness and by inhibiting delayed afterdepolarizations caused by sympathetic activity. (pharmacology2000.com)
These highlights do not include all the information needed to use ASPIRIN AND EXTENDED-RELEASE DIPYRIDAMOLE CAPSULES safely and effectively. (nih.gov)
The recommended dose of aspirin and extended-release dipyridamole capsules is one capsule given orally twice daily, one in the morning and one in the evening. (nih.gov)
Aspirin and extended-release dipyridamole capsules can be administered with or without food. (nih.gov)
25 mg/200 mg capsules with a red opaque cap and a yellow opaque body, filled with light yellow to yellow extended-release dipyridamole pellets and a white to off-white, round, film-coated, biconvex, unscored, plain aspirin tablet. (nih.gov)
Results from Cochrane systematic review, pooled data analysis and meta-analysis are discussed.Single-antiplatelet therapy (SAPT) with aspirin, aspirin/extended-release dipyridamole or clopidogrel reduces the risk of recurrent ischaemic stroke in patients with non-cardioembolic ischaemic stroke or transient ischaemic attack (TIA). (nih.gov)
Clopidogrel2
Anticoagulant medications, including aspirin , warfarin ( Coumadin ), clopidogrel ( Plavix ), and dipyridamole ( Persantine ) may be associated with blood clots . (emedicinehealth.com)
Aspirin is also available in combination products with other medicines, e.g. codeine, clopidogrel and dipyridamole. (mydr.com.au)
Aspirin and dipyridamole1
This research study will evaluate the effects of aspirin and dipyridamole alone and in combination on the blood flow in the vessels of the legs. (drugpatentwatch.com)
Phosphodiesterase4
The different forms or subtypes of phosphodiesterase were initially isolated from rat brains in the early 1970s and were soon afterward shown to be selectively inhibited in the brain and in other tissues by a variety of drugs. (wikipedia.org)
PDE3 is sometimes referred to as cGMP-inhibited phosphodiesterase. (wikipedia.org)
It inhibits PDE4 to the greatest extent, but also shows significant inhibition of other PDE subtypes, and so acts as a selective PDE4 inhibitor or a non-selective phosphodiesterase inhibitor, depending on the dose. (wikipedia.org)
Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP. (lookformedical.com)
Platelet4
Conditions characterized by a reduction in platelet survival and where dipyridamole has been used include heart valve replacement, arterial grafting, cerebrovascular disorders, and disorders of peripheral circulation. (nih.gov)
The in vivo effect of dipyridamole on platelet aggregation has not been well defined and may depend on additional factors. (nih.gov)
Aspirin and other platelet-aggregation inhibiting drugs. (nih.gov)
Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (lookformedical.com)
Enzyme4
In obstructive jaundice and hepatitis with biliary obstruction, there is a rise in free cholesterol and lecithin within the plasma due to the bile salts that inhibit the activity of the enzyme lecithin-ldl cholesterol acyl transferase, which normally esterifies ldl cholesterol. (ehd.org)
The widely used drug aspirin acts by inhibiting the ability of the COX enzyme to synthesize the precursors of thromboxane within platelets. (wikimili.com)
Aspirin stops pain-producing prostaglandins being made by inhibiting the enzyme cyclooxygenase (COX), which is involved in their production. (mydr.com.au)
Eliquis is an anticoagulant medication that functions by inhibiting an enzyme within the body that contributes to blood clotting. (insulin-store.com)
PDE53
Sildenafil, tadalafil, vardenafil, and the newer udenafil and avanafil selectively inhibit PDE5, which is cGMP-specific and responsible for the degradation of cGMP in the corpus cavernosum. (wikipedia.org)
Sildenafil Citrate, m 1 hlas, tadalafil and sildenafil and vardenafil inhibits PDE5. (ultimateunderground.com)
Inhibition3
In addition, an experiment conducted in vitro using human CRC cell observed that sildenafil could inhibit metastases by restoring the cytotoxicity of MDSCs-dependent inhibition of NK cell 22 . (nature.com)
It displays a mechanism of action like many β lactam antibiotics through inhibition of cell wall synthesis by competitively inhibiting penicillin binding protein (PBP). (agscientific.com)
Most importantly, inhibition of PDE4 by roflumilast or dipyridamole could alleviate dextran sulfate sodium-induced colitis in mice and in a pilot clinical study confirmed by IF. (qxmd.com)
Mechanism3
These data suggest that the multi-target mechanism of low-dose prednisolone and dipyridamole creates a dissociated activity profile with an increased therapeutic window through cellular network selective amplification of glucocorticoid-mediated anti-inflammatory signaling. (biomedcentral.com)
However, the mechanism of action for dipyridamole is slightly different. (uic.edu)
Studies have found that sodium dehydroacetate (SD) can effectively inhibit the growth of Penicillium digitatum but its inhibitory mechanism remains unclear. (spkx.net.cn)
Sildenafil1
Sildenafil could inhibit colonic tumorigenesis via blocking the recruitment of MDSCs as shown by a recent study based on DSS-induced inflammation mice model 17 . (nature.com)
Mast cell2
They Dipyridamole only complete maturation in resident cells which hinders accurate lineage tracing research in traditional mammalian models greatly.1 We've been utilizing the zebrafish magic size to review mast cell advancement and specifically the transcriptional regulation of mast cell lineage commitment. (immune-source.com)
We harnessed the opportunities provided by the zebrafish model system and our prior characterization and validation of as a mast cell specific marker Dipyridamole to conduct a comprehensive series of embryonic in vivo studies to assess the role of genes in vertebrate mast cell development. (immune-source.com)
Prostacyclin2
Dipyridamole also potentiates the antiaggregating action of prostacyclin. (lookformedical.com)
8 ] It has been suggested that low-dose acetylsalicylic acid therapy inhibits thromboxane more than prostacyclin production and thereby protects against vasoconstriction and pathological blood coagulation in the placenta. (thieme-connect.com)
Receptor2
[10] Dipyridamole antagonizes this receptor too, but has various other mechanisms of antiplatelet activity as well. (wikimili.com)
[3] It works by irreversibly inhibiting a receptor called P2Y 12 on platelets . (mdwiki.org)
Derivative1
HN - 2016 (2002) MH - Abiraterone Acetate UI - D000069501 MN - D4.808.54.79.65 MS - An androstene derivative that inhibits STEROID 17-ALPHA-HYDROXYLASE and is used as an ANTINEOPLASTIC AGENT in the treatment of metastatic castration-resistant PROSTATE CANCER. (nih.gov)
Effectively1
Intervention experiments showed that SD treatment effectively inhibited the incidence of green mold of inoculated kumquat fruit in a concentration-dependent manner. (spkx.net.cn)
Vivo2
The combination of prednisolone and the antithrombotic drug dipyridamole was profiled using in vitro and in vivo models of anti-inflammatory activity and glucocorticoid-induced adverse effects to demonstrate a dissociated activity profile. (biomedcentral.com)
The immune-specific amplification of prednisolone anti-inflammatory activity by dipyridamole did not extend to glucocorticoid-mediated adverse effects, including corticosterone suppression or increased expression of tyrosine aminotransferase, in vivo after repeat dosing in rats. (biomedcentral.com)
PDE41
Further analysis showed that VTN triggered phosphorylation of PDE4, leading to inhibit PKA/CREB activation and CREB nuclear translocation, which further reduced GPX4 transactivation. (qxmd.com)
Medications1
We will examine how these medications are able to inhibit the clotting of platelets in the vessels of patients with PAD, and thereby affect the blood flow in the legs. (drugpatentwatch.com)
Synergistic1
Dipyridamole usually is combined with aspirin for synergistic anti-aggregatory purposes. (nih.gov)
Release3
They suppress the release of cytokines and other inflammatory signals, and inhibit the production of reactive oxygen species. (wikipedia.org)
The thrombin-induced release reaction is inhibited almost completely by the reagents hirudin and dipyridamole, and only partially by indomethacin. (nih.gov)
25 mg/200 mg capsules with a red cap and an ivory-colored body, containing yellow extended-release pellets incorporating dipyridamole and a round white tablet incorporating immediate-release aspirin. (nih.gov)
Drug1
14. Flavonoids inhibit breast cancer resistance protein-mediated drug resistance: transporter specificity and structure-activity relationship. (nih.gov)
Cell1
It functions as a T-cell co-stimulation blocker that inhibits TNF-ALPHA and prevents the activation of T-LYMPHOCYTES. (nih.gov)
See precautions, but, belimumab is a major site of cyp enzymes ginger zingiber ofcinale inhibits production of the repro ductive period. (ultimateunderground.com)
Search1
These images are a random sampling from a Bing search on the term "Dipyridamole. (fpnotebook.com)
Plasma2
Sulfhydryl analog of INOSINE that inhibits nucleoside transport across erythrocyte plasma membranes, and has immunosuppressive properties. (lookformedical.com)
This preferential effect is not absolute, however, and at higher plasma concentrations, metoprolol also inhibits beta 2 adrenoreceptors, chiefly located in the bronchial and vascular musculature. (nih.gov)
Studies2
However, the nature of the interaction has not been elucidated and benefit from the addition of dipyridamole has not been demonstrated in clinical studies. (nih.gov)
A review of clinical studies using dipyridamole indicates that it currently has limited value. (nih.gov)