AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
LipaseLipoprotein LipaseMonoacylglycerol LipasesSterol EsteraseColipasesLipolysisTrioleinTriglyceridesRhizopusGeotrichumHyperlipoproteinemia Type IPancreasCarboxylic Ester HydrolasesApolipoprotein C-IIHeparinGlyceridesChylomicronsAdipose TissueHydrolysisEnzymes, ImmobilizedCarboxylesteraseLiverAmylasesLipid MetabolismMolecular Sequence DataApolipoproteins CLipoproteinsLipoproteins, VLDLSubstrate SpecificityEsterasesRhizomucorWolman DiseaseLipidsAmino Acid SequencePhospholipases A1HypertriglyceridemiaFatty AcidsEnzyme StabilityKineticsPancreatitisEsterificationEmulsionsHydrogen-Ion ConcentrationCandidaLactonesCyclohexanonesEncyclopedias as TopicAnti-Obesity Agents
OrlistatMonoacylglycerol lipaseHormone-sensitHydrolysisPancreatic lipaseMicrobial lipasesLipoprotein lipasePotentGastricFatsInhibitionObesityEnzymeEnzymesBloodstreamIntestinalAmylaseEsterasesXanthineTriglyceridesCompoundSubstrateActivityIntestineMetabolismPharmaceuticalCompoundsVitaminDevelopmentShownActiveReleaseTypeSpecificResearchRequest
Orlistat8
  • An example of a lipase inhibitor is orlistat. (wikipedia.org)
  • The most active fraction showed a mixed mode of pancreatic lipase inhibition, as determined by Lineweaver-Burk plot analysis , and exhibited a cumulative effect with orlistat . (bvsalud.org)
  • Orlistat is in a class of medications called lipase inhibitors. (medlineplus.gov)
  • Orlistat works by inhibiting pancreatic and gastric lipases, pancreatic and gastric enzymes breakdown triglycerides in the intestine. (openpr.com)
  • Orlistat, a gut lipase inhibitor, is used to reduce the absorption of dietary fats. (medgadget.com)
  • Orlistat-Akrikhin is a lipid-lowering drug, an inhibitor of lipases of the gastrointestinal tract. (abchealthonline.com)
  • Orlistat belongs to long-acting specific inhibitors of gastrointestinal lipases. (abchealthonline.com)
  • A lipase inhibitor called orlistat is used to treat obesity because it decreases the body's absorption of fat. (reportsanddata.com)
Monoacylglycerol lipase5
  • Additionally, in a second project, novel reversible monoacylglycerol lipase (MAGL) inhibitors have been synthesized and pharmacologically evaluated. (logos-verlag.de)
  • The short form is expressed in adipose tissue where it in concert with two other lipase, adipose triglyceride lipase (ATGL) and monoacylglycerol lipase (MGL), is involved in the hydrolysis triacylglycerols to free fatty acids and (FFAs) and glycerol. (novonordisk.com)
  • JJKK 048 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor (IC 50 = 0.4 nM). (tocris.com)
  • Monoacylglycerol lipase protects the presynaptic cannabinoid 1 receptor from desensitization by endocannabinoids after persistent inflammation. (iasp-pain.org)
  • Inhibiting 2-AG degradation with the monoacylglycerol lipase (MAGL) inhibitor JZL184 during inflammation results in desensitization of CB1Rs by eCBs that is reversed with Cmp101. (iasp-pain.org)
Hormone-sensit2
Hydrolysis2
Pancreatic lipase6
  • Proanthocyanidins as the main pancreatic lipase inhibitors in chokeberry fruits. (bvsalud.org)
  • Pancreatic lipase inhibitors are recognized as important in strategies for the management of overweight and obesity . (bvsalud.org)
  • The aims of this study were to fractionate and identify the phenolic compounds of chokeberry fruit phenolic-rich extract that are active as pancreatic lipase inhibitors. (bvsalud.org)
  • Among the six fractions isolated from extract, two fractions rich in highly polymerized proanthocyanidins showed the greatest ability to inhibit pancreatic lipase activity. (bvsalud.org)
  • This study shows that black chokeberry polyphenols , particularly highly polymerized procyanidins , can effectively inhibit pancreatic lipase activity determined by in vitro methods . (bvsalud.org)
  • Pancreatic Lipase " has 1 results in Products. (rndsystems.com)
Microbial lipases1
Lipoprotein lipase2
Potent1
  • Ritonavir is a potent inhibitor of CYP3A4- and CYP2D6- mediated drug metabolism. (who.int)
Gastric1
  • This substance manifests its effect in the lumen of the stomach and small intestine by forming a covalent bond with the active serine center of gastric and pancreatic lipases. (abchealthonline.com)
Fats2
  • The primary role of lipase inhibitors is to decrease the gastrointestinal absorption of fats. (wikipedia.org)
  • It prevents absorption of fats by acting as lipase inhibitors, which eventually reduce the calorie intake. (openpr.com)
Inhibition1
  • We know that uncontrolled activation of the complement pathway is responsible for many devastating diseases, and through the development of the first two complement inhibitors - SOLIRIS and ULTOMIRIS - we have shown the transformative impact of C5 inhibition on several of these diseases," said John Orloff, M.D., Executive Vice President and Head of Research & Development at Alexion. (businesswire.com)
Obesity3
  • These inhibitors could be used for the treatment of obesity, which can subsequently lead to Type 2 diabetes and cardiovascular diseases if not managed. (wikipedia.org)
  • In patients with type 2 diabetes mellitus who are overweight or obese, antidiabetic medications that have additional actions to promote weight loss (such as glucagonlike peptide-1 [GLP-1] analogs or sodium-glucose-linked transporter-2 [SGLT-2] inhibitors) are suggested, in addition to the first-line agent for type 2 diabetes mellitus and obesity, metformin. (medscape.com)
  • CenterWatch has identified a pipeline of 21 drugs in development for obesity such as lipase inhibitors, which reduce fat absorption. (centerwatch.com)
Enzyme3
  • Angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and calcium channel blockers, rather than beta-adrenergic blockers, should be considered as first-line therapy for hypertension in patients with type 2 diabetes mellitus who are obese. (medscape.com)
  • The HSL inhibitor NNC0076-0079 blocks the activity of HSL by interfering with its active site in a non-covalently fashion - the activation of HSL is regained as the enzyme hydrolyses the ester bond of the inhibitor. (novonordisk.com)
  • First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the leishmania topoisomerase IB enzyme. (usp.br)
Enzymes1
Bloodstream1
Intestinal1
  • In Sweden, as well as many other countries, acylglycerol lipase inhibitor that works in the intestinal lumen to occupational exposure limits (OELs) are presented as an impor- reduce dietary fat absorption produces gastrointestinal side effects tant tool for managing chemical risks. (cdc.gov)
Amylase1
Esterases2
  • The suicide inhibitors are developed for active site titration experiments and may be used for the quantitative determination of active lipases and esterases in complex protein mixtures. (pharma-industry-review.com)
  • The phosphonate-based molecules are available with either chromogenic (p-nitrophenyl derivatives) or fluorogenic (4-methyl-umbelliferyl derivative) groups for sensitive detection of hydrolytic activity of lipases and esterases. (pharma-industry-review.com)
Xanthine1
  • Hyperuricemia can reach levels that require use of xanthine oxidase inhibitors to prevent nephrolithiasis. (medscape.com)
Triglycerides1
Compound1
  • After 5-7 days of inflammation, the effects of exogenous cannabinoids are significantly reduced due to CB1R desensitization via GRK2/3, as function is recovered in the presence of the GRK2/3 inhibitor, Compound 101 (Cmp101). (iasp-pain.org)
Substrate2
Activity2
  • Lipase inhibitors are substances used to reduce the activity of lipases found in the intestine. (wikipedia.org)
  • Loss-of-function variants have been shown to increase lipase activity, leading to a reduction in lipid levels and in risk for atherosclerotic cardiovascular disease (ASCVD), with no apparent adverse effects. (medscape.com)
Intestine1
  • Since lipase inhibitors are not absorbed in the intestine, and consequently not circulating in the blood, information about alternative side effects such as the modulation[clarification needed] of the gastrointestinal tract is unobtainable. (wikipedia.org)
Metabolism1
  • ANGPTL3 regulates lipoprotein metabolism by inhibiting lipoprotein and endothelial lipases. (medscape.com)
Pharmaceutical2
  • Lipase inhibitors can be found naturally in plants and can also be produced as pharmaceutical drugs. (wikipedia.org)
  • EUCODIS has a collection of over 70 advanced lipases of microbial origin, which are specifically chosen and developed for applications in the pharmaceutical industry, as well as the cosmetics and fine chemical industries. (pharma-industry-review.com)
Compounds1
  • Some active compounds with chalcone scaffold found in Glycyrrhiza glabra, Cassia mimosoides, Glycyrrhiza uralensis, Boesenbergia rotunda, apples and Morus alba also had strong effect against lipase. (wikipedia.org)
Vitamin2
  • It is recommended that multi-vitamins are taken along with lipase inhibitors, so vitamin deficiency doesn't occur. (wikipedia.org)
  • Poultry PM (1.0 mg/ml) caused a significant activation of PLA2 in a time-dependent manner (15-60 min), which was significantly attenuated by the calcium-chelating agents, cPLA2-specific inhibitor (AACOCF3) and antioxidant (vitamin C) in A549 cells. (cdc.gov)
Development1
Shown1
  • Studies have shown that lipase inhibitors work optimally when 40% of an individual's daily caloric intake is obtained from fat. (wikipedia.org)
Active1
  • Lipase inhibitors covalently bond to the active serine site on lipases. (wikipedia.org)
Release1
  • Poultry PM also significantly induced release of IL-8 by the cells in a dose- and time-dependent manner, which was significantly attenuated by the calcium chelating agents, antioxidants and COX- and LOX-specific inhibitors. (cdc.gov)
Type1
  • Lipase inhibitors may affect the amount of fat absorbed, yet they do not block the absorption of a particular type of fat. (wikipedia.org)
Specific1
  • The Lipase immo Kit is a screening kit of 6 different immobilized lipases and custom-made immobilized CalBs, tailored for specific applications. (pharma-industry-review.com)
Research1
  • 2S*,5S*,6Z)-2,5-epoxydocosan-6-en-21-ynoic acid, new fatty acid from the marine sponge Haliclona fascigera Natural Products Chemistry & Research, 6(5), 19-22. (usp.br)
Request2