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  • expression
  • Pan-JAK inhibitor revealed marked reduction in IL-4 stimulated MUC4 levels and JAK3 selective inhibitor down-regulated MUC4 mRNA expression in a concentration-dependent fashion. (biomedcentral.com)
  • 15-LO-1 was considered initially to be the reticulocyte LO that can react with mitochondrial membrane lipids, 6 but subsequently, a constitutive expression of 15-LO-1 has been reported in various types of cells, such as immature red blood cells, eosinophils, and airway epithelial cells. (ahajournals.org)
  • The biological relevance of 15-LO-1 in the vascular system has been widely explored and supported by its expression in vascular cells and the results from functional studies. (ahajournals.org)
  • Specifically, expression and function of 15-LO-1 have been studied in endothelial cells (ECs), smooth muscle cells, and monocytes as well as atherosclerotic animal models, and 15-LO-1 has been shown to play active roles in vascular remodeling and the progression of atherosclerosis. (ahajournals.org)
  • This study examined whether phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), affects the clinical symptoms of experimental autoimmune encephalomyelitis (EAE) in the rat, and the expression of both COX-1/-2 and 5-LOX in EAE spinal cords. (thisisms.com)
  • human
  • 15-LOX-1 is expressed in normal human colorectal tissue ( 16 , 17 ) and suppressed in colorectal cancer in vitro and in vivo ( 17 ). (aacrjournals.org)
  • The PC-3 human prostate cancer cell line, which overexpresses 15-LO-1, secretes high levels of VEGF and enhances tumor growth and angiogenesis as compared with the parental PC-3 cell lines. (ahajournals.org)
  • known
  • LY293111 was also known to have inhibitory effects on 5-lipoxygenase, which is upstream of the production of leukotrienes. (hindawi.com)
  • Role
  • 2,3,5,7,8 Although the directly relevant data are limited, 15-LO-1 has also been implicated for its role in angiogenesis. (ahajournals.org)
  • In this issue of Circulation Research , Viita et al assign a new role for 15-LO-1 as a regulator of angiogenesis by demonstrating its antiangiogenic action in rabbit skeletal muscle system. (ahajournals.org)
  • However, the role of 15-LO-1 in angiogenesis still remains controversial and requires careful scrutiny. (ahajournals.org)