• mechanisms
  • This result has important implications for the study of 5-Azadc and other MTIs in the prevention and therapy of colorectal cancer and supports future investigations of the mechanisms by which MTIs up-regulate 15-LOX-1. (aacrjournals.org)
  • The potential anticancer activities of DNA methyltransferase inhibitors (MTI) have been studied extensively in recent years, because DNA hypomethylation induces the reactivation of tumor suppressor genes silenced by methylation-mediated mechanisms. (aacrjournals.org)
  • However, the evidence to date is controversial if not contradictory, and the underlying molecular mechanisms of 15-LO-1 in certain disease processes remain far from clear. (ahajournals.org)
  • metabolites
  • Although most attention has focused on PGs 2 and other COX-derived metabolites, mounting evidence suggests that LO-catalyzed products, LTs, and HETEs also exert profound biological effects on the development and progression of human cancers. (aacrjournals.org)
  • Carcinogenesis
  • 4 Such expression profiles in a wide variety of cells, together with its enzymatic potential to produce reactive oxygen species and lipid hydroperoxides, have raised the possibility that 15-LO-1 and its products may be crucially involved in many pathological conditions, such as asthma, inflammation, atherogenesis, and carcinogenesis. (ahajournals.org)
  • protein
  • 3 In addition, the eicosanoid products of 12/15-LO have been detected in vascular cells, and 15-LO-1 protein has been shown to be localized to aortic atherosclerotic lesions in rabbits and in humans. (ahajournals.org)
  • subsequently
  • 15-LO-1 was considered initially to be the reticulocyte LO that can react with mitochondrial membrane lipids, 6 but subsequently, a constitutive expression of 15-LO-1 has been reported in various types of cells, such as immature red blood cells, eosinophils, and airway epithelial cells. (ahajournals.org)
  • expression
  • The present study shows that low micromolar concentrations of 5-Azadc induce the expression of 15-lipoxygenase-1 (15-LOX-1) in human colorectal cancer cells. (aacrjournals.org)
  • The biological relevance of 15-LO-1 in the vascular system has been widely explored and supported by its expression in vascular cells and the results from functional studies. (ahajournals.org)
  • Specifically, expression and function of 15-LO-1 have been studied in endothelial cells (ECs), smooth muscle cells, and monocytes as well as atherosclerotic animal models, and 15-LO-1 has been shown to play active roles in vascular remodeling and the progression of atherosclerosis. (ahajournals.org)
  • tumor
  • 3 The level of 15-LO-1 appears to be altered during the tumor development. (ahajournals.org)
  • The PC-3 human prostate cancer cell line, which overexpresses 15-LO-1, secretes high levels of VEGF and enhances tumor growth and angiogenesis as compared with the parental PC-3 cell lines. (ahajournals.org)
  • growth
  • The adhesion site effect seems partially independent of the actin cytoskeleton because growth cones treated with Sema3A and 12/15-LO inhibitor remain spread despite actin cytoskeleton loss. (jneurosci.org)
  • human
  • 15-LOX-1 is expressed in normal human colorectal tissue ( 16 , 17 ) and suppressed in colorectal cancer in vitro and in vivo ( 17 ). (aacrjournals.org)
  • Mounting evidence suggests that lipoxygenase (LO)-catalyzed products have a profound influence on the development and progression of human cancers. (aacrjournals.org)
  • directly
  • 2,3,5,7,8 Although the directly relevant data are limited, 15-LO-1 has also been implicated for its role in angiogenesis. (ahajournals.org)
  • Research
  • In this issue of Circulation Research , Viita et al assign a new role for 15-LO-1 as a regulator of angiogenesis by demonstrating its antiangiogenic action in rabbit skeletal muscle system. (ahajournals.org)