• 3 Given its homology and comparable transcription profile with known leukocyte protease inhibitors in the WFDC family of proteins, HE4 also presumably has a role in natural immunity. (nature.com)
  • that is, precursor lesions to prostatic carcinoma . (medscape.com)
  • 1 In the United States alone, it is estimated that 238,590 new cases of prostatic carcinoma were diagnosed and more than 29,720 men died from this disease in 2013. (basicmedicalkey.com)
  • Plasma selenoprotein P protects endothelial cells against damage, and epithelial selenoprotein protects prostratic secretory cells from developing carcinoma. (tahomaclinicblog.com)
  • In earlier kinetic studies we identified the existence of a unique Na+-dependent high-affinity L-aspartate transport process in rat prostate secretory epithelial cells. (biomedcentral.com)
  • Another striking effect of clorgyline was the induction of androgen receptor (AR) and classic AR target genes such as prostate-specific antigen together with other secretory epithelial cell-specific genes, suggesting that clorgyline promotes differentiation of cancer cells. (biomedcentral.com)
  • PSA is organ specific, being produced primarily by prostatic secretory epithelium, but has long been known to be elevated in non malignant conditions such as benign prostatic hyperplasia (BPH). (redituslabs.com)
  • Human epididymis protein 4 (HE4) was first identified in the epithelium of the distal epididymis and originally predicted to be a protease inhibitor involved in sperm maturation. (nature.com)
  • Monoamine oxidase A (MAO-A), a mitochondrial enzyme that degrades monoamines including neurotransmitters, is highly expressed in basal cells of the normal human prostatic epithelium and in poorly differentiated (Gleason grades 4 and 5), aggressive prostate cancer (PCa). (biomedcentral.com)
  • MAO-A is also highly expressed in basal cells of the normal prostatic epithelium. (biomedcentral.com)
  • It is extremely important for the epithelium of the oral cavity, respiratory tract, urinary tract, and ducts of the secretory glands. (ndhealthfacts.org)
  • In addition, we observed that NT5E was extensively co-localized with Prostatic acid phosphatase (PAP, also known as ACPP, Fluoride-resistant acid phosphatase or thiamine monophosphatase) in nociceptive neurons. (biomedcentral.com)
  • Major seminal plasma proteins are secretory proteins from the male sex accessory glands, such as the SEMINAL VESICLES and the PROSTATE. (bvsalud.org)
  • This ratio is useful when used in conjunction with the Elecsys total PSA test as an aid in distinguishing prostate cancer from benign prostatic conditions in men aged 50 years or older who have a digital rectal examination (DRE) that is not suspicious for prostate cancer and an Elecsys total PSA value in the range 4.00 ng/mL to 10.0 ng/mL. (redituslabs.com)
  • HGPIN is characterized by architecturally benign prostatic acini and ducts lined with atypical cells whose morphologic, histochemical, immunohistochemical, and genetic changes are similar to those of prostate cancer. (medscape.com)
  • Management of Benign Prostatic Hyperplasia: Could Dietary Polyphenols Be an Alternative to Existing Therapies? (frontiersin.org)
  • The incidence of benign prostatic hyperplasia (BPH) is gradually on the increase. (frontiersin.org)
  • Benign prostatic hyperplasia (BPH) is the most common urological condition among elderly men, affecting approximately half of men over 80 years of age. (frontiersin.org)
  • [ 2 ] However, HGPIN does not invade the basement membrane of the prostatic glands. (medscape.com)
  • The features of the senescence phenotype usually consist of the activation of a chronic DNA damage response, the involvement of various cyclin-dependent kinase inhibitors, increased secretion of proinflammatory and tissue-remodeling factors, induction of antiapoptotic genes, altered metabolic rates, and endoplasmic reticulum stress [ 13 ]. (biomedcentral.com)
  • CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. (thermofisher.com)
  • Endogenous D-cysteine plays a role in neural development by inhibiting proliferation of neural progenitor cells (NPCs) via protein kinase B (AKT) signaling mediated by the FoxO family of transcription factors. (d-aminoacids.com)
  • Bound to cysteine in place of sulfur and called the "21st amino acid," selenocysteine is the active site in some 35 proteins. (tahomaclinicblog.com)
  • PIN refers to the precancerous end of a morphologic spectrum involving cellular proliferation within prostatic ducts, ductules, and acini. (medscape.com)
  • While conventional drugs such as the α1-adrenergic receptor antagonists and 5α-reductase inhibitors have been found to be useful in the treatment of BPH, the adverse side effects associated with their usage, have led to increased search for alternative means of managing this disease. (frontiersin.org)
  • The STAT3 Inhibitor Galiellalactone Effectively Reduces Tumor Growth and Metastatic Spread in an Orthotopic Xenograft Mouse Model of Prostate Cancer. (lu.se)
  • This review describes recent advances in the role of human HMGB proteins and other proteins interacting with them, in cancerous processes related to oxidative stress, with special reference to ovarian and prostate cancer. (hindawi.com)
  • Lycopene is also speculated to have a role in preventing prostate cancer, can lower PSA levels, and reduce DNA damage in white blood cells and prostatic tissue. (ndhealthfacts.org)
  • Senescent cells have been identified in the aging prostate, and the senescence-associated secretory phenotype might be linked to prostate cancer (PCa). (biomedcentral.com)
  • LncRNAs are a class of ncRNAs that are more than 200 nucleotides in length, and although lncRNAs do not possess protein-coding capability, they play vital roles in modulating protein-coding genes at the transcriptional or posttranscriptional level [ 10 , 11 ]. (biomedcentral.com)
  • Addition of tamsulosin to the LVX regimen was beneficial for patients with bacterial prostatitis because tamsulosin could increase the maximal concentration of LVX in prostatic tissue. (dovepress.com)
  • Here, we examined the expression of the HE4 gene and protein in a large series of normal and malignant adult tissues by oligonucleotide microarray and tissue microarray, respectively. (nature.com)
  • Here, we used oligonucleotide and tissue microarrays to survey HE4 gene and protein expression in a large group of malignant and normal tissues from adults. (nature.com)
  • renin-c) encoding a cytosolic renin isoform have been discovered that may in contrast to the commonly known secretory renin (renin-a) exert protective effects Here, we analyzed the effect of renin-a and renin-b overexpression in H9c2 cardiomyoblasts on apoptosis and necrosis as well as on potential mechanisms involved in cell death processes. (bvsalud.org)
  • 7 It has been shown that proteins that belong to the transforming growth factor (TGF) superfamily, such as bone morphogenetic proteins (BMPs), also exert signals to maintain the capacity of DPCs to induce HF growing in vivo and in vitro. (benitonovas.com)
  • It carboxylates the glutamate residues in matrix Gla protein, which enables it to bind and remove calcium from blood vessels and thus prevent the formation atherosclerotic calcific plaques. (tahomaclinicblog.com)
  • The proteolytic activity of PSA in blood is inhibited by the irreversible formation of complexes with proteinase inhibitors such as alpha 1 antichymotrypsin, alpha 2 macroglobulin and other acute phase proteins. (redituslabs.com)
  • Its major function in vivo is to activate the major in-gel proteins, seminogelin I, II, and fibronectin, in freshly ejaculated semen, which then liquefies semen through proteolytic fragmentation and releases progressively motile sperm. (mlo-online.com)
  • Proteínas que se encuentran en el SEMEN. (bvsalud.org)
  • Proteins found in SEMEN. (bvsalud.org)
  • XPS indicated that CC220 mouse ex lover situ treating the debris results in the organization associated with CuO.Qualifications: Improvements in high-throughput molecular chemistry, genomics along with selleck inhibitor epigenetics, along with exponential raises throughout processing energy files storage space, have got generated a whole new period inside neurological study and knowledge. (bcrpreceptor.com)
  • Thus, inhibitors of the RAS are protective and markedly increasing the life span of patients. (bvsalud.org)
  • Given that protein aggregates in liver cells are closely linked to alcoholic liver disease, these findings suggest that quercetin could be a useful treatment for patients with this condition. (qualitycounts.com)
  • To overcome these toxicity concerns, we purified and characterized ( in vitro and in vivo ) a secretory version of recombinant mouse NT5E. (biomedcentral.com)
  • the corresponding variant proteins were produced in E.coli (BL21) cells and characterized. (d-aminoacids.com)
  • Changes in the redox state of cells affect proteins, lipids, and nucleic acids in different ways. (hindawi.com)
  • Molecular 'switch' reverses chronic inflammation and aging - Science Daily, 2/6/20 - 'By studying mice and immune cells called macrophages, the team found that a protein called SIRT2 is responsible for deacetylating the NLRP3 inflammasome. (qualitycounts.com)
  • Clorgyline, an MAO-A inhibitor, induces secretory differentiation of normal prostate cells. (biomedcentral.com)
  • [1] The immune systems of vertebrates such as humans consist of many types of proteins , cells, organs , and tissues, which interact in an elaborate and dynamic network. (wikidoc.org)
  • In particular, the present invention provides methods for enhancing the effectiveness of chemotherapy by inducing differential stress resistance in normal cells and cancer cells via short-term starvation, cell growth inhibitors, or reduced caloric or glucose intake. (justia.com)
  • Activator of protein kinase A (cyclic AMP agonist). (biolog.de)
  • Vitamins D and K2 work together in this regard because vitamin D expresses the gene that makes matrix Gla protein. (tahomaclinicblog.com)
  • This conversion depends on protein status , thyroid hormones, zinc , and vitamin C . Conversion will only occur when the body is in need of vitamin A. (ndhealthfacts.org)
  • Transporters such as organic anion-transporting polypeptide 1A2, P-glycoprotein, human organic cation transporter 1, and multidrug and toxin extrusion protein 1 are involved in the pharmacokinetics of LVX. (dovepress.com)
  • These organs and tissues were fixed en block in 10% formalin and cut coronally into four to six slices of 3-mm thickness, depending on the age of the rat, and embedded together in one block for each rat. (shengsci.com)
  • Chromogranins (Cgs) constitute a family of acidic glycopro- teins encompassing chromogranin A (CgA), chromogranin B (CgB) and secretograninII (SgII) that arewidely distributedin neuroendocrine tissues where they are packaged in secretory gran- ules. (123dok.net)
  • The HE4 (WFDC2) gene encodes a WAP-type four disulphide core domain-containing protein with a presumptive role in natural immunity. (nature.com)
  • Mitochondrial DNA (mt-DNA) disorders and abnormal regulation of nuclear-derived proteins devoted to the cross-talk between the two cellular genomes have recently interested researchers in the field of neuromuscular diseases. (shengsci.com)
  • Ecto-5'-nucleotidase (NT5E) is a glycosyl phosphatidylinositol (GPI)-anchored membrane protein that catalyzes the hydrolysis of extracellular AMP to adenosine [ 1 ]. (biomedcentral.com)
  • Our results suggest that inhibitors of MAO-A, already in clinical use to treat depression, may have potential application as therapeutic PCa drugs by inhibiting oncogenic pathway activity and promoting differentiation. (biomedcentral.com)
  • Drugs such as cocaine and methylphenidate act as reuptake inhibitors of norepinephrine, as do some antidepressants, such as those in the SNRI class. (wikipedia.org)
  • One of the more notable drugs in the stimulant class is amphetamine , which acts as a dopamine and norepinephrine analog, reuptake inhibitor, as well as an agent that increases the amount of global catecholamine signaling throughout the nervous system by reversing transporters in the synapses. (wikipedia.org)
  • K2 activates osteocalcin, a protein secreted by osteoblasts that plays a role in bone mineralization and calcium ion hemostasis. (tahomaclinicblog.com)
  • These data suggested that spinal delivery of PAP protein could be used therapeutically to generate adenosine and activate A 1 R over an extended time period. (biomedcentral.com)
  • Synaptotagmin-like protein 1 is a protein that in humans is encoded by the SYTL1 gene. (wikipedia.org)
  • Subsequent to our kinetic identification of the transport process, significant advances have been achieved in the genetic and protein identification and characterization of the X AG - transporter class as EAATs (excitatory amino acid transporters). (biomedcentral.com)
  • As emphasized in a recent review by Colgan and colleagues, this lack of a reliable source of purified protein has hindered studies with NT5E [ 2 ]. (biomedcentral.com)
  • 1 The physiologicalrole of these proteins is unclear but a number of potential biological functions have been postulated, including regulationof secretory granule formation and produc- tion ofbioactivepeptidesthroughproteolyticprocessing. (123dok.net)
  • With the final aim to increase N-methyl-D-aspartate (NMDA) receptor function in schizophrenia, luvadaxistat, a D-amino acid oxidase (DAAO) inhibitor, has been evaluated. (d-aminoacids.com)
  • however, possible toxicity from venom contaminants remains a concern--especially if this venom-derived protein were to be used in the nervous system. (biomedcentral.com)
  • The protein HMGB1 behaves as a redox sensor and its structural changes, which are conditioned by the oxidative environment, are associated with different functions of the protein. (hindawi.com)
  • By immunohistochemistry assay, studies showed that loss of Rb occurred almost universally in prostatic small cell carcinomas. (healthyprostateclub.com)
  • Considering that both PAP and NT5E generate adenosine, we hypothesized that NT5E protein might also have A 1 R-dependent antinociceptive effects. (biomedcentral.com)
  • and the 5α-reductase inhibitors [which inhibit the development of BPH through a reduction in dihydrotestosterone (DHT) production]. (frontiersin.org)
  • This invention relates to methods of inducing differential stress resistance in a subject with cancer by starving the subject for a short term, administering a cell growth inhibitor to the subject, or reducing the caloric or glucose intake by the subject. (justia.com)
  • CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. (thermofisher.com)