• Role of heme oxygenase and nitric oxide synthase pathways and their interactions in the regulation of the cerebral circulation. (otka-palyazat.hu)
  • Nitric oxide synthase blockade sensitizes the cerebrocortical circulation to thromboxane-induced CBF oscillations. (otka-palyazat.hu)
  • In the present study, we aimed to study the roles of endothelial nitric oxide synthase (eNOS) in diabetes. (diabetesjournals.org)
  • Terbogrel is an orally available thromboxane A2 receptor antagonist and a thromboxane A synthase inhibitor. (wikipedia.org)
  • The cannabinoid receptor antagonist AM-251 enhances the cerebrocortical hyperemic response to hypoxia/hypercapnia. (otka-palyazat.hu)
  • Exposure of isolated bovine coronary arteries to high glucose (30 mmol/l d -glucose) but not to osmotic control mannitol (30 mmol/l) switched angiotensin II-stimulated prostacyclin (PGI 2 )-dependent relaxation into a persistent vasoconstriction that was sensitive to either indomethacin, a cyclooxygenase inhibitor, or SQ29548, a selective thromboxane receptor antagonist. (diabetesjournals.org)
  • One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
  • Available antiplatelet agents, such as cyclooxygenase-1 (COX-1) inhibitors (aspirin), ADP P2Y 12 receptor antagonists, and GP IIb/IIIa receptor inhibitors, are effective and save in the treatment and prevention of thrombotic events, these drugs interfere with the platelet activation process, including adhesion, release, and aggregation. (hindawi.com)
  • Thus, the term ' prostanoids ' relates to the products of the cyclooxygenase pathway ( prostaglandins , prostacyclins , and thromboxanes ) but to compounds produced by free radical-catalyzed mechanism ( Isoprotanes, phytoprostanes, neuroprostanes ). (gerli.com)
  • To summarize the cyclooxygenase metabolism, prostaglandin G/H synthase catalyzes the sequential formation of PGG2 and PGH2 (they are both named endoperoxides) by addition of molecular oxygen at the C9, C11 and C15 positions. (gerli.com)
  • In the coronary circulation prostacyclin was shown to act as a compensatory mediator in the absence of NO. We have shown that nicotinic acid-induced flushing is mediated by PUMA-G receptor-dependent production of prostaglandin D2 and E2 by bone marrow derived immune cells. (otka-palyazat.hu)
  • There is an overwhelming mass of evidence demonstrating the development of endothelial dysfunction in animal models of diabetes and in human blood vessels from diabetic patients, as evidenced by increased release of reactive oxygen species, decreased nitric oxide (NO) bioactivity, decreased release of prostacyclin (PGI 2 ), and enhanced endothelial production of vasoconstrictor thromboxane (Tx)A 2 /prostaglandin (PG)H 2 in early stages of diabetes ( 1 - 3 ). (diabetesjournals.org)
  • ALOX5 arachidonate 5-lipoxygenase: macrophages infected with Candida albicans, Aspergillus flavus or Aspergillus fumigatus or treated with Curdlan, a selective agonist of pattern recognition receptor for fungi Dectin-1, displays increased expression of ALOX5, ALOX15 and PTGS2 Karnam et al, 2015 . (polygenicpathways.co.uk)
  • Hikida T , Yawata S , Yamaguchi T, Danjo T, Sasaoka T, Wang Y, Nakanishi S . Pathway-specific modulation of nucleus accumbens in reward and aversive behavior via selective transmitter receptors. (neurotree.org)
  • Yawata S , Yamaguchi T, Danjo T, Hikida T , Nakanishi S . Pathway-specific control of reward learning and its flexibility via selective dopamine receptors in the nucleus accumbens. (neurotree.org)
  • In conclusion, Up 4 A-induced coronary relaxation is blunted in swine with AoB, which appears to be due to the production of a vasoconstrictor prostanoid, likely thromboxane A 2 . (mdrresearch.nl)
  • It was also found that LGP exhibited marked inhibitory effects on the activation of αIIbβ3 integrin, the secretion of serotonin from granules, and the synthesis of thromboxane A2. (spandidos-publications.com)
  • Our studies have shown that endogenous carbon monoxide (CO) has a dual influence on the cerebral circulation: on one hand it induces prostanoid-mediated vasodilation but on the other hand reduces the blood flow by inhibition of nitric oxide (NO) synthesis. (otka-palyazat.hu)
  • Data from a radiolabeled ligand‑binding assay indicated that LGP exhibited apparent competing effects on thromboxane receptor (TP) and P2Y12 receptors. (spandidos-publications.com)
  • These inhibitory effects may be associated with its dual‑receptor inhibition on P2Y12 and TP receptors. (spandidos-publications.com)
  • Blockade of purinergic P1, and P2 receptors attenuated Up 4 A-induced coronary relaxation more, while the effect of P2X 1 -blockade was similar and the effects of A 2A - and P2Y 1 -blockade were reduced in AoB as compared to Sham. (mdrresearch.nl)
  • MAGL blockade decreases bulk AA amounts in the mind, to 2-AG elevation stoichiometrically, which also leads to a reduced amount of lipopolysaccharide (LPS)-induced pro-inflammatory degrees of downstream COX-driven prostaglandin and thromboxane creation in the mind (Nomura et al. (tuskonus.org)
  • Structure-activity relationships of agonists for the orphan G protein-coupled receptor GPR27. (uliege.be)
  • Pulmonary vascular effects of prostaglandin D2 but not its systemic vascular or airway effects are mediated through thromboxane receptor activation. (hopkinsmedicine.org)
  • The effect of local converting enzyme inhibition on the vascular responses to angiotensin and bradykinin in the forearm resistance vessels in man. (cardiffmet.ac.uk)
  • eNOS inhibition attenuated Up 4 A-induced coronary relaxation in both Sham and AoB. (mdrresearch.nl)
  • Using swine as an experimental model, we examined whether the cannabinoid receptors (CB1R and CB2R) modulated vasomotor tone in isolated pial arteries. (bvsalud.org)
  • Their distinct biosynthetic activity includes an endoperoxidase synthase reaction that oxygenates and cyclizes polyunsaturated fatty acid precursors (eg, arachidonic acid) to form prostaglandin G 2 (PGG2), and a peroxidase reaction that converts PGG2 to prostaglandin H 2 (PGH2), as shown below. (medscape.com)
  • Since pressure-overload is accompanied by structural abnormalities in the coronary microvasculature as well as by endothelial dysfunction, we hypothesized that pressure-overload blunts the coronary vasodilator response to Up 4 A, and that the involvement of purinergic receptors and endothelium-derived factors is altered. (mdrresearch.nl)
  • Expression of purinergic receptors and endothelium-derived factors was assessed in isolated coronary small arteries using real-time PCR. (mdrresearch.nl)
  • In endothelium-denuded coronary small arteries from normal swine, thromboxane synthase (TxS) inhibition enhanced relaxation to Up 4 A compared to endothelium-intact arteries, to a similar extent as P2Y 12 inhibition, while the combination inhibition of P2Y 12 and TxS had no additional effect. (mdrresearch.nl)
  • In contrast to skeletal muscle resistance vessels, ET-1 contributes to the maintenance of skin microvascular tone through both ET A and ET B receptor-mediated vasoconstriction [ 16 ]. (biomedcentral.com)
  • Therefore, COX - also known as prostaglandin-endoperoxide synthase (PTGS), fatty acid COX, prostaglandin H (PGH) synthase, and EC 1.14.99.1 - is implicated in the production of fever, inflammation, and pain. (medscape.com)
  • Inhibition of tyrosinase activity and DOPA auto-oxidation This assay was performed using strategies as described previous. (columbiagypsy.net)
  • Their regulation may be carried out either through direct binding to DNA as peroxisome proliferator-activated receptors or via modulation in an indirect manner of signaling pathway molecules (e.g., protein kinase C) and other transcription factors (nuclear factor kappa B and sterol regulatory element binding protein). (springer.com)
  • Therefore, understanding the molecular mechanisms of platelet activation and identifying novel techniques for platelet inhibition remain critically important. (spandidos-publications.com)
  • A ubiquitously expressed G-protein-coupled receptor kinase subtype that has specificity for the agonist-occupied form of BETA-ADRENERGIC RECEPTORS and a variety of other G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
  • Although it is highly homologous to G-PROTEIN-COUPLED RECEPTOR KINASE 2, it is not considered to play an essential role in regulating myocardial contractile response. (lookformedical.com)
  • A G-protein-coupled receptor kinase subtype that is primarily expressed in the MYOCARDIUM and may play a role in the regulation of cardiac functions. (lookformedical.com)
  • NCX inhibition, indicating essential roles of NCX in both temperature compensation and autonomous oscillation. (kentlandsinitiative.org)
  • However, non-formylated peptide ligands have also been found for this receptor class. (lookformedical.com)
  • In parallel, high glucose, but not mannitol, significantly increased superoxide and 3-nitrotyrosine in PGI 2 synthase (PGIS). (diabetesjournals.org)
  • They contain denser granules, secrete more serotonin and β -thromboglobulin, produce more thromboxane A2 and have more adhesion molecules (like P-selectin and platelet glycoprotein-GP-IIbIIIa), than smaller platelets. (hindawi.com)
  • Since N-formyl peptides are found in MITOCHONDRIA and BACTERIA, this class of receptors is believed to play a role in mediating cellular responses to cellular damage and bacterial invasion. (lookformedical.com)
  • binding to the central NMDA receptor may result in amelioration of neuropathic pain. (medindex.am)
  • Phenol red in cell culture medium binds to receptors on cell surfaces and causes the cell to respond as though pharmacologic levels of estrogen and/or inflammatory mediators (such as prostaglandin or thromboxane A2) are present in the medium. (cell-systems.com)
  • Purpose Estrogenic endocrine disruptors acting via estrogen receptors and have already been implicated in the etiology of hypospadias. (hoot4owls.org)
  • [ 1 ] Thus, tracing research of the COX pathway is essential to an understanding of COX deficiency, and examining the variable effects of COX inhibition are advantageous. (medscape.com)
  • download Dopamine in the Pathophysiology and Treatment involves a histone of endonucleases, receptor effects catalyzed in solar enzymes. (evakoch.com)
  • 2009). Rather, there can be an anatomical demarcation in enzymes that regulate this process in which MAGL plays this role not only in the brain, but also in the liver and lung, whereas cytosolic phospholipase A2 (cPLA2) is the dominant AA-releasing enzyme in gut, spleen and macrophages (Bonventre et al. (tuskonus.org)
  • Here we display that inhibition of the activity of GPx and catalase, two antioxidant enzymes, immediately after wounding produces chronic wounds comprising spontaneously created antibiotic-resistant polymicrobic bacterial biofilms. (cahrr.org)
  • Superconserved receptors expressed in the brain: Expression, function, motifs and evolution of an orphan receptor family. (uliege.be)
  • mRNA expression of neither A1, A2, A3, nor P2X 1 , P2X 7 , P2Y 1 , P2Y 2 , nor P2Y 6 -receptors was altered in AoB as compared to Sham, while P2Y 12 expression was higher in AoB. (mdrresearch.nl)
  • The data revealed CB1R inhibition increased basal myogenic tone, but not myogenic reactivity. (bvsalud.org)
  • The Extended N-Terminal Domain Confers Atypical Chemokine Receptor Properties to CXCR3-B. Frontiers in Immunology, 13 , 868579. (uliege.be)
  • A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. (lookformedical.com)
  • Steroid hormones can be grouped into five groups by the receptors to which they bind: glucocorticoids, mineralocorticoids, androgens, estrogens, and progestogens. (absoluteastronomy.com)
  • The glucocorticoid receptor also known as NR3C1 is the receptor to which cortisol and other glucocorticoids bind. (absoluteastronomy.com)
  • In S. Martins & D. Prazeres, G Protein-Coupled Receptor Screening Assays - Methods in Molecular Biology (pp. 149-157). (uliege.be)
  • Regulatory proteins that down-regulate phosphorylated G-protein membrane receptors, including rod and cone photoreceptors and adrenergic receptors. (lookformedical.com)
  • A family of serine-threonine kinases that are specific for G-PROTEIN-COUPLED RECEPTORS. (lookformedical.com)
  • They are regulatory proteins that play a role in G-protein-coupled receptor densensitization. (lookformedical.com)
  • Terbogrel (INN) is an experimental drug that has been studied for its potential to prevent the vasoconstricting and platelet-aggregating action of thromboxanes. (wikipedia.org)
  • The adrenergic beta-2 receptors are more sensitive to EPINEPHRINE than to NOREPINEPHRINE and have a high affinity for the agonist TERBUTALINE. (lookformedical.com)