In addition, they play important roles in gene transcription (via activation of mitogen activated protein (MAP) kinase pathways and, in higher eukaryotes, the transcription factor NFκB), generation of reactive oxygen species, apoptosis, and cell-cycle progression. (biomedcentral.com)
These regulatory inputs involve not only the conserved Rim101/PacC pathway, but also the calcium-activated phosphatase calcineurin, the Wsc1-Pkc1-Slt2 MAP kinase, the Snf1 and PKA kinases and oxidative stress-response pathways. (microbialcell.com)
The Abelson tyrosine kinase (Abl) plays a crucial role in multiple Drosophila axon guidance pathways during development, though the mechanism by which Abl elicits a diverse set of guidance outputs is currently unknown. (silverchair.com)
Moreover, we find that Abl exerts its diverse activities through at least two different mechanisms: (1) a partly kinase-independent, structural function in midline attraction through its C-terminal F-actin binding domain (FABD) and (2) a kinase-dependent inhibition of repulsive guidance pathways that does not require the Abl C terminus. (silverchair.com)
Additional examination of GC16 and GC19 exposed en richment for more pathways broadly linked with cancer and EMT, the majority of which overlap or crosstalk with TNF, MAPK, or EGFR signaling. (pka-signal.com)
Tyrosine kinase2
Paraptosis-like phenotype has also been described in human colorectal cancer cells following overactivation of the non-receptor tyrosine kinase c-Src suggesting potential involvement of Src-signalling in paraptosis. (wikipedia.org)
Next-generation sequencing identified two de novo truncating variants in the Src-family tyrosine kinase, LYN , p.Y508*, p.Q507* and a de novo missense variant, p.Y508F, that result in constitutive activation of Lyn kinase. (nature.com)
Scaffold protein2
This motif is found in Cdc42/Rac-associated proteins such as the protein kinases Pak, MRCK and Ack, the adaptor proteins Spec and WASP, and, in degenerate form, in the kinases MLK, Mekk4, adaptor Par6, scaffold protein IRSp53, and the Borg proteins. (biomedcentral.com)
Torc1 consists of either the Tor1 or the Tor2 kinase, a putative scaffold protein Kog1, Lst8, and Tco89 [4, 5]. (researchsquare.com)
Inhibitor4
Additionally, research found that caspase inhibitors (zVAD.fmk, p53, BAF), x-chromosome-linked inhibitor (xiap), and Bcl-xL( from the Bcl-2 family) did not prevent cell death in 293T cells when induced by IGFIR-IC. (wikipedia.org)
The human trabecular meshwork cells were treated with t BHP for 1 or 2 h with or without pretreatment of SB203580, an inhibitor of MAP kinase homologs. (molvis.org)
and liver fibrosis resolved on treatment with the Src kinase inhibitor dasatinib. (nature.com)
Two patients with truncating mutations had liver fibrosis that in one patient resolved on treatment with the Src kinase inhibitor dasatinib. (nature.com)
Mitogen2
This study is to investigate the role of p38 mitogen-activated protein kinase (p38MAPK) in tert -butyl hydroperoxide ( t BHP)-induced apoptosis of human trabecular meshwork (iHTM) cells. (molvis.org)
Mitogen-activated protein kinases (MAPKs) comprise a large family of proteins activated by a wide range of proinflammatory cytokines and environmental stress. (molvis.org)
Phosphatase1
We uncovered that GO terms for MAP kinase phosphatase exercise and inactivation of MAPK ac tivity had been enriched in GC16. (pka-signal.com)
Inflammatory11
Over 500 kinases have now been identified in human cells and they activate many processes in the cells, including the production of inflammatory mediators. (atlasofscience.org)
Inflammatory stimuli activate a cascade of kinases within the cell resulting in the activation of inflammatory genes which further amplify inflammation. (atlasofscience.org)
There is a need to find new anti-inflammatory treatments for patients with severe asthma that cannot be controlled with currently used drugs and for all patients with COPD. (atlasofscience.org)
Because many different kinases are involved in activating the inflammation of asthma and COPD, this has led to the development of kinase blockers as potential new anti-inflammatory treatments. (atlasofscience.org)
Kinase inhibitors have been found to be useful in the treatment of other long-term inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel diseases, but so far none have been approved for use in asthma and COPD. (atlasofscience.org)
Currently increasing importance is attributed to the inflammatory process as a crucial factor responsible for the progressive damage to vascular walls and progression of atherosclerosis in obese people. (medsci.org)
Hyperglycemia contributes to glycosylation of proteins and lipids, increases the production of reactive oxygen species, stimulates the synthesis and secretion of pro-inflammatory cytokines and acute phase proteins in various tissues, promoting thus inflammation processes in the vascular wall [ 2 , 3 ]. (medsci.org)
Atherosclerotic plaque develops in response to a localized inflammatory reaction in the vessel wall ( Ross, 1999 ). (rupress.org)
In the tracheobronchial (airway) vasculature, these include the inhibition of inflammatory hyperperfusion, microvascular hyperpermeability, mucosal oedema formation, and the formation of new blood vessels (angiogenesis). (ersjournals.com)
In addition to inflammatory cell infiltration in the bronchial wall 1 , histological analysis of endobronchial biopsy specimens and new methods of blood flow measurements have revealed prominent alterations of the tracheobronchial (airway) vasculature in patients with asthma. (ersjournals.com)
Our findings reveal a critical role for Lyn kinase in modulating inflammatory signals, regulating microvascular permeability and neutrophil recruitment, and in promoting hepatic fibrosis. (nature.com)
Homologs1
Cdc42 and/or Rac homologs are found in fruit flies, round-worms and budding yeast. (biomedcentral.com)
19971
1997. Inhibition of L-aromatic amino acid decarboxylase by polychlorinated biphenyls. (cdc.gov)
Proteins3
Some cell wall polysaccharide synthesis and cytoskeleton formation-related proteins were up-regulated by JA to promote tuber cell expansion. (biomedcentral.com)
Kinases are enzymes that phosphorylate proteins, leading to their activation within cells. (atlasofscience.org)
The inhibition of Torc1 by rapamycin mimics nutrient starvation and causes an array of physiological changes that include global changes in gene expression, phosphorylation/dephosphorylation of various factors, decreased cell growth, degradation of proteins, and ultimately cell cycle arrest in the G 1 phase [4, 9-11]. (researchsquare.com)
Protein1
Rapid and transient activation of myelin basic protein kinase in tobacco leaves treated with hairpin from Erwinia amylovora . (springer.com)
Inhibits1
In yeast, rapamycin inhibits the TORC1 kinase signaling pathway causing rapid alteration in gene expression and ultimately cell cycle arrest in G 1 through mechanisms that are not fully understood. (researchsquare.com)
Clinical2
Several inhaled kinase inhibitors have been developed and work well in experimental models of asthma and COPD, but so far none have been found to be useful in patients in clinical studies. (atlasofscience.org)
Although many different kinases have been found to be activated in asthma and COPD, so far very few have been inhibited in clinical studies. (atlasofscience.org)
Microvascular1
The major structural and functional changes related to the airway circulation include the proliferation of blood vessels (angiogenesis) 2 - 4 , increased blood flow 5 , 6 , increased microvascular permeability 7 , 8 , and oedema formation in the airway wall 9 . (ersjournals.com)
Inflammation2
Kinase inhibitors block individual kinases in this cascade, resulting in reduced inflammation. (atlasofscience.org)
A role of Src family kinase members in causing sterile inflammation and human disease is only recently recognized. (nature.com)
Complex1
In Saccharomyces cerevisiae , rapamycin binds to the peptidyl-prolyl isomerase Fpr1 leading to the inhibition of the Target of Rapamycin (TOR) kinase that forms the TOR Complex 1 (Torc1) [4, 5]. (researchsquare.com)
Structural2
In addition, corticosteroids seem to reverse components of the asthma-induced structural changes (airway remodelling), including the increased vascularity of the bronchial wall 24 . (ersjournals.com)
These results highlight how a multifunctional kinase can trigger diverse axon guidance outcomes through the use of distinct structural motifs. (silverchair.com)
Cell2
Paraptosis has been found in some developmental and neurodegenerative cell deaths, as well as induced by several cancer drugs. (wikipedia.org)
We characterize the role of increased Lyn kinase activity in neutrophils, endothelial cells and lesional liver biopsies and utilized an iPSC-derived endothelial cell platform for disease modeling of neutrophilic vasculitis and to screen and evaluate drug efficacy. (nature.com)
Asthma3
Many different kinases have been found to be activated in cells from the lungs of patients with asthma and chronic obstructive pulmonary disease (COPD, which includes chronic bronchitis and emphysema). (atlasofscience.org)
The most promising kinases for inhibition in asthma and COPD are p38 MAP kinases, JAK kinases and Syk kinases. (atlasofscience.org)
Kinases as Novel Therapeutic Targets in Asthma and Chronic Obstructive Pulmonary Disease. (atlasofscience.org)
Activation1
The defining features of paraptosis are cytoplasmic vacuolation, independent of caspase activation and inhibition, and lack of apoptotic morphology. (wikipedia.org)
Specific1
Find support for a specific problem in the support section of our website. (mdpi.com)
Activity1
Kinases often activated other kinases in a cascade of activity and also one kinase cascade may interact with another, making them complicated to study. (atlasofscience.org)
Processes1
Neuropeptide-encoding messenger RNAs (mRNAs) can be found in neuronal processes beyond the perikaryon. (niepokorny.org)
Members1
We focus on six 'core' effectors that operate in almost all these species - members of the Pak, WASP/WAVE, formin, lipid-kinase, IQGAP and NADPH oxidase families. (biomedcentral.com)
Small1
Interestingly, small GTPases related to Rac are found even in organisms that lack Ras, such as plants. (biomedcentral.com)
Beneficial1
Some lactobacilli, considered beneficial commensals, are found in the gastrointestinal tract of humans and animals. (nature.com)
Development1
Physiological results indicated that low JA concentration (especially 5 μM) promoted tuber development, whereas higher JA concentration (50 μM) showed inhibition effect. (biomedcentral.com)
Significant1
Significant relationships were found between levels of glucose and sICAM-1and also E-selectin and HOMA-IR. (medsci.org)
Cells1
Our data provide a new insight whereby rapamycin signaling via the Torc1 kinase may exploit the pheromone pathway to arrest cells in the G 1 phase. (researchsquare.com)
Drug1
One away around this is to develop kinases inhibitors that are inhaled directly into the lungs, to reduce the amount of drug that gets in to the body. (atlasofscience.org)