• PCR using primers specific for 20beta-hydroxysteroid dehydrogenase (20beta-HSD) which is involved in DHP production, follicle stimulating hormone receptor (FSHR), luteinizing hormone receptor (LHR), the two forms of membrane progestin receptor: mPR-alpha and mPR-beta, as well as GAPDH (control), were performed. (biomedcentral.com)
  • On the other hand, TGF-beta1 had no effect on mPR-alpha mRNA expression and increased FSHR mRNA levels. (biomedcentral.com)
  • Two human beta-defensins, HBD-1 and HBD-2, were discovered in 1995 and 1997, respectively. (lookformedical.com)
  • Rational design, optimization, and biological evaluation of novel alpha-Phosphonopropionic acids as covalent inhibitors of Rab geranylgeranyl transferase. (medchem.fi)
  • Metrizamide showed reversible, non-specific inhibition of testosterone metabolism and reduction of the MI. (nih.gov)
  • It upregulated the declined level of serum testosterone and the expression of steroidogenic genes such as CYP11A1 and 17β3-HSD with an obvious histologic improvement of the testes with re-establishment of the normal spermatogenic series, Sertoli and Leydig cells. (biomedcentral.com)
  • In 1995, 11α-OHP, along with its epimer 11β-hydroxyprogesterone, was identified as a very potent competitive inhibitor of both isoforms (1 and 2) of 11β-hydroxysteroid dehydrogenase (11β-HSD). (wikipedia.org)
  • 11 alpha-Hydroxyprogesterone (11 alpha OH-P) was an order of magnitude more potent a competitive inhibitor of the 11 beta HSD-2 than was glycyrrhetinic acid (GA) (approximate IC50 = 0.9 vs. 15 nM). (wikipedia.org)
  • Inhibition of human CYP1 enzymes by a classical inhibitor α-naphthoflavone and a novel inhibitor N-(3, 5- dichlorophenyl)cyclopropanecarboxamide - an in vitro and in silico study. (medchem.fi)
  • Fickert, P., Karpen, S. J., and Trauner, M. Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation. (fairpeel.com)
  • Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands. (lookformedical.com)
  • beta-Defensins are cationic peptides with broad-spectrum antimicrobial activity that are produced by epithelia at mucosal surfaces. (lookformedical.com)
  • In this study, we characterized the expression of HBD-1 and HBD-2 mRNAs within the major salivary glands, tongue, gingiva, and buccal mucosa and detected beta-defensin peptides in salivary secretions. (lookformedical.com)
  • beta-Defensins are cationic peptides with broad-spectrum antimicrobial activity that may play a role in mucosal defenses of several organs. (lookformedical.com)
  • The aggregation of both amyloid beta (Abeta) peptides extracellularly and Tau proteins intracellularly plays key roles in the pathological consequences of AD, which lead to cholinergic neurodegeneration and eventually death. (inra.fr)
  • Zinc binding to the peptide replica and analogs to residues 93-115 of horse liver alcohol dehydrogenase (ADH) was examined by competition of the peptides and the chromophoric chelator 4-(2- pyridylazo)resorcinol for zinc and X-ray absorption fine structure analysis of the zinc ligands. (researchgate.net)
  • Sarma, L., and Kesavan, P. C. Protecting results of chlorogenic acid, curcumin and beta-carotene in opposition to gamma-radiation-induced in vivo chromosomal injury. (fairpeel.com)
  • In this minireview, we chronicle the research that led to the recent discovery of forkhead box L2 (FOXL2) as an essential mediator of activin-regulated FSH beta subunit ( Fshb ) transcription in vitro and in vivo. (bioone.org)
  • Molecular cloning and characterization of rat genes encoding homologues of human beta-defensins. (lookformedical.com)
  • Here, we report the identification of two genes encoding beta-defensin homologues in the rat. (lookformedical.com)
  • The beta-defensin genes mapped closely on rat chromosome 16 and were closely linked to the alpha-defensins genes, suggesting that they are part of a gene cluster, similar to the organization reported for humans. (lookformedical.com)
  • Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acids), d-alpha-Tocopherol is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production. (medindex.am)
  • Human beta-defensins may play an important role in the innate defenses against oral microorganisms. (lookformedical.com)
  • One gene was highly similar to the human beta-defensin-1 (HBD-1) gene and mouse beta-defensin-1 gene at both the nucleic acid and amino acid levels and was termed rat beta-defensin-1 (RBD-1). (lookformedical.com)
  • The purpose of this study is to evaluate the inhibition effects of apatinib on human and rat cytochrome P450, including CYP3A2/4, CYP2B1/6, CYP2C9/11, CYP2D1/6, and CYP2E1. (bvsalud.org)
  • In this population, mean hydroxysteroid 5 alpha-reductase and 17 beta-hydroxysteroid dehydrogenase activities were 3.8 and 2.3 nmol/10(6) cells per 2h respectively, more than 100-fold greater than in the densest population, comprised of undifferentiated and early differentiating cells. (nih.gov)
  • TGF-beta is a multifunctional growth factor involved in regulating a variety of cellular activities. (biomedcentral.com)
  • The inhibition of antioxidant activity in plasmodium may contribute to killing the malaria causing parasites. (ncats.io)
  • Furthermore, hCG upregulated 20beta-HSD, LHR and mPR-beta mRNA levels, but this stimulatory effect was blocked by TGF-beta1. (biomedcentral.com)
  • During oocyte growth, follicle stimulating hormone (FSH) stimulates production of estradiol-17β from the ovary. (biomedcentral.com)
  • LH stimulates a number of signaling cascades culminating in the production of 17α-hydroxyprogesterone (17α-HP). (biomedcentral.com)
  • LPS-binding protein transports LPS to soluble CD14 or membrane-bound CD14 on monocytes and cells macrophages, resulting in an effector phase characterized by the production of IL-1 and tumor necrosis element alpha (TNF-) and then the production of IL-6 and IL-8 (7, 29). (institutopsicofarmacologia.com)
  • In the granulosa cells, under the action of 20β-hydroxysteroid dehydrogenase (20β-HSD), 17α-HP is converted to 17α, 20β-dihydroxyprogesterone (DHP), the maturation inducing hormone (MIH) in cyprinids, such as zebrafish and goldfish. (biomedcentral.com)
  • Most effector cells of the innate immune system, such as monocytes and endothelial cells, communicate TLR-2 and TLR-4 on their membranes (13, 17). (institutopsicofarmacologia.com)
  • Short-chain dehydrogenases/reductases (SDRs) constitute a large family of NAD(P)(H)-dependent oxidoreductases, sharing sequence motifs and displaying similar mechanisms. (researchgate.net)
  • To test whether beta-defensin expression was inducible, gingival keratinocyte cell cultures were treated with interleukin-1beta (IL-1beta) or bacterial lipopolysaccharide (LPS) for 24 h. (lookformedical.com)
  • Because beta-defensins are salt-sensitive epithelial products, we looked for pulmonary beta-defensin expression. (lookformedical.com)
  • Treatment with TGF-beta1 caused a dose and time-dependent decrease in mRNA levels of 20beta-HSD, LHR and mPR-beta in follicles. (biomedcentral.com)
  • Licorice constituents reduce or reverse drug resistance in MRSA when combined with beta-lactam antibiotics. (interactionsguide.com)
  • However, we have used our mouse model of HIT to demonstrate that inhibition of Syk can safely and effectively prevent HIT [30]. (immune-source.com)
  • Inhibition of transforming growth factor beta-activated kinase 1 confers neuroprotection after traumatic brain injury in rats. (shengsci.com)
  • The transforming growth factor beta-activated kinase 1 (TAK1), a member of the Mitogen-activated protein kinase kinase kinase family, is characterized as a key regulator in inflammatory and apoptosis signaling pathways. (shengsci.com)