Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. (justia.com)
The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved. (justia.com)
The invention is also directed to pharmaceutical compositions which include a therapeutically effective amount of a compound of formula (I), or pharmaceutically acceptable salts thereof, and a pharmaceutically acceptable carrier. (justia.com)
The invention is also directed to methods of treating mammals for diseases in which the β-secretase enzyme is involved, such as Alzheimer's disease, and the use of the compounds and pharmaceutical compositions of the invention in the treatment of such diseases. (justia.com)
Pharmaceutically acceptable2
Provided is a composition comprising a polyglycolized glyceride and a compound having the following structure (I): or a pharmaceutically acceptable salt thereof. (justia.com)
Also provided are crystalline forms of the compound of structure (I), or a pharmaceutically acceptable salt thereof. (justia.com)
Present invention2
The present invention is directed to 2-aminoimidazole compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. (justia.com)
The compounds of the present invention are useful for treating Alzheimer's disease by inhibiting the activity of β-secretase or BACE, thus preventing the formation of insoluble Aβ and arresting the production of Aβ. (justia.com)
Diseases1
The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer. (justia.com)
Present invention relates1
The present invention relates to a pyrazine derivative, an application thereof in inhibiting SHP2, and a compound of formula (I) or pharmaceutically acceptable salts, esters, isomers, solvates, prodrugs or isotope labels thereof. (justia.com)
Compositions1
and (V-A). Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein. (justia.com)
Activity2
Synthesis and anti-leishmanial activity of heterocyclic betulin derivatives. (forda-mof.org)
Chemical composition and antimicrobial activity of the essential oils from the gum of Turkish Pistachio (Pistacia vera L.). Journal of Agricultural and Food Chemistry, 52(12), 3911-3914. (forda-mof.org)
Journal1
Oxadiazoles: Part XV-Synthesis and Biological Activities of Substituted 1, 3, 4-Oxadiazole Derivatives Kartik Ladva, Pankaj Patel, Paresh Upadhyay, Hansa Parekh Indian journal of chemistry. (edu.in)
Methods1
The present disclosure provides methods of preparing compounds of Formulae (I-A), (II? (justia.com)