Harmine and harmaline are reversible inhibitors of monoamine oxidase A (RIMAs). (wikipedia.org)
Harmine and harmaline are selective and reversible inhibitors of monoamine oxidase A (MAO-A), while tetrahydroharmine is a weak serotonin reuptake inhibitor (SRI). (psychonautwiki.org)
Harmaline5
Harmine, once known as telepathine and banisterine, is a naturally occurring beta-carboline alkaloid that is structurally related to harmaline, and also found in the vine Banisteriopsis caapi. (wikipedia.org)
Harmala alkaloids are also found in the Banisteriopsis caapi vine, the key plant ingredient in the sacramental beverage ayahuasca, in concentrations that range between 0.31 and 8.43% for harmine, 0.03-0.83% for harmaline and 0.05-2.94% for tetrahydroharmine. (wikipedia.org)
Unlike MAOIs such as phenelzine, harmine and harmaline are reversible and selective meaning they do not have nearly as high a risk for "cheese syndrome" caused by consuming tyramine-containing foods, which is a risk associated with monoamine oxidase A inhibitors, but not monoamine oxidase B inhibitors. (wikipedia.org)
Of these, it most commonly consists of a DMT -containing plant source in combination with one that contains an MAOI or RIMA (typically sources like B. caapi vine or syrian rue ) to produce uniquely potent, sometimes medicinal, psychedelic effects. (psychonautwiki.org)
The brew contains two main ingredients - ayahuasca vine ( Banisteriopsis caapi ) and chacruna leaves ( Psychotria viridis ) - both of which contain psychoactive compounds that produce powerful hallucinations and vivid imagery. (ayahuascaretreatsusa.org)
Ayahuasca1
He said since he met ayahuasca his life has been shaped by the vine "I am just following the vine in as many ways as possible. (erowid.org)
Syrian Rue1
It was assumed to be a newly discovered chemical at the time, however, it was soon realized that telepathine was already more widely known as "harmine" from its previous discovery in Peganum harmala (Syrian Rue). (wikipedia.org)