• dermal exposure
  • Breath MeOH concentration peaked 15min after cessation of dermal exposure, then declined rapidly between 15 and 30 after exposure, followed by a slower decrease thereafter. (cdc.gov)
  • The authors conclude that breath monitoring of MeOH exposure would require a 2hr waiting period after dermal exposure, representing a drawback in this method of monitoring. (cdc.gov)
  • For sunscreens, health risk from dermal exposure on intact skin are considered extremely low, and is outweighed by the risk of ultraviolet radiation damage including cancer from not wearing sunscreen. (wikipedia.org)
  • Humans
  • Biological monitoring tests were conducted in humans experimentally exposed to methyl-ethyl-ketone (78933) (MEK) and toluene (108883), both alone and in combination, by inhalation. (cdc.gov)
  • Devlin RB, McDonnell WF, Mann R, Becker S, House DE, Schreinemachers D, Koren HS (1991a) Exposure of humans to ambient levels of ozone for 6.6 hours causes cellular and biochemical changes in the lung. (springer.com)
  • For humans, the main source of toxaphene exposure is through ingested seafood. (wikipedia.org)
  • Industrial applications also are quite wide ranging, from preservative and sanitizing uses to antimicrobial agents, energy production, metalworking fluids, mining, paint manufacturing, and paper manufacturing, many of which increase potential exposure to it by humans as well as organisms, both terrestrial and marine. (wikipedia.org)
  • nasal
  • Bascom R, Naclerio RM, Fitzgerald TK, Kagey-Sobotka A, Proud D (1990) Effect of ozone inhalation on the response to nasal challenge with antigen of allergic subjects. (springer.com)
  • conclude
  • The authors note that these levels do not exceed those for single exposures, and conclude that the OSHA mixtures formula, which assumes additivity, is conservative in relation to the exposure conditions studied. (cdc.gov)
  • organisms
  • When such data does not exist, estimates are made by comparison to known similar toxic things, or to similar exposures in similar organisms. (wikipedia.org)
  • study
  • The investigators did not observe a general performance deterioration over the course of the study, and they suggest that the effective MAK doses might have been much greater if the animals had received an extended course of exposure. (cdc.gov)
  • In the present study we explored the effects of repeated inhalation exposure in asthmatic and healthy mice to two different sizes of TiO 2 . (biomedcentral.com)
  • One study considers release of airborne engineered nanoparticles at workplaces, and associated worker exposure from various production and handling activities, to be very probable. (wikipedia.org)
  • The study estimated that considerable years of exposure are necessary for significant pathology to occur. (wikipedia.org)
  • oral
  • Oral exposure to ricin is far less toxic as some of the poison is inactivated in the stomach. (wikipedia.org)
  • The EPA defines an oral reference dose (abbreviated RfD) as: [A]n estimate, with uncertainty spanning perhaps an order of magnitude, of a daily oral exposure to the human population (including sensitive subgroups) that is likely to be without an appreciable risk of deleterious effects during a lifetime. (wikipedia.org)
  • human
  • A new report published by the National Academies Press (NAP) focuses on EPA's controlled human inhalation exposure (CHIE) studies, which are also referred to as human clinical studies or human challenge studies. (aiha.org)
  • A free PDF download of Controlled Human Inhalation-Exposure Studies at EPA is available on NAP's website . (aiha.org)
  • Becker S, Madden M, Newman SL, Devlin RB, Koren HS (1991b) Modulation of human alveolar macrophage properties by ozone exposure in vitro. (springer.com)
  • Under the Clean Air Act, the U.S. Environmental Protection Agency (EPA) conducts a range of studies to evaluate exposure to, and effects of, air pollutants on human health. (nas.edu)
  • environmental
  • Recent evidence suggests that exposure to environmental particulate matter exacerbates symptoms of asthma. (biomedcentral.com)
  • The five-page 2003 letter also states that the Weinberg Group "has helped numerous companies manage issues allegedly related to environmental exposures. (wikipedia.org)
  • chronic
  • The EPA also determined a chronic RfD for chlorpyrifos exposure based on studies in which animals were administered low doses of the pesticide for two years. (wikipedia.org)
  • hours
  • Subjects were exposed in a 2 cubic meter exposure chamber for 4 hours to 200 parts per million (ppm) MEK (20 subjects), 100ppm toluene (30 subjects), 100ppm MEK plus 50ppm toluene (16 subjects) or, as a positive control, 0.8 milliliters ethanol per kilogram of body weight (18 subjects). (cdc.gov)
  • levels
  • Significant increases in blood and breath MeOH levels were seen after 6 and 8hr sedentary exposure to 400ppm MeOH. (cdc.gov)
  • Exposure of one hand in MeOH for 8min gave peak blood MeOH levels equivalent to inhalation exposure at the threshold limit value of 200ppm. (cdc.gov)
  • Levels of exposure to inhalable and respirable CB dust were estimated to be 6.2±1.7 and 2.3±0.29 mg/m 3 , respectively. (ac.ir)
  • Exposure to high levels of toxaphene can cause damage to the lungs, nervous system, liver, kidneys, and in extreme cases, may even cause death. (wikipedia.org)
  • health
  • A large part of the population has impaired health conditions that will make them more susceptible to develop health problems from particulate exposure. (biomedcentral.com)
  • airborne
  • The system allows you to vary the concentration of airborne pathogens, the rate of air flow, and the length of exposure, so experiments can be reproduced accurately and adjusted easily. (glascol.com)
  • Exposure is commonly understood to be the concentration of the airborne pollutant in the air at the mouth and nose boundary. (wikipedia.org)
  • adult
  • The median lethal dose (LD50) of ricin is around 22 micrograms per kilogram of body weight if the exposure is from injection or inhalation (1.78 milligrams for an average adult). (wikipedia.org)
  • harmful
  • But detection of cases of excessive exposure of harmful agents on those workers who properly used and maintained approved respirators (with high efficiency filters), has prompted experts to change their opinions. (wikipedia.org)
  • concentration
  • Exposures occurred at each concentration while at rest or while performing light exercise on a bicycle ergometer. (cdc.gov)
  • The mean breath MeOH concentration dropped to about 10ppm 5min after end of exposure. (cdc.gov)
  • Blood MeOH concentration increased up to 45min after exposure, remained constant between 1 and 2hr after exposure before declining. (cdc.gov)