• Concurrent initial therapy with other antimicrobial agents and aztreonam for injection is recommended before the causative organism(s) is known in seriously ill patients who are also at risk of having an infection due to Gram-positive aerobic pathogens. (pfizermedicalinformation.com)
  • It is given by intravenous or intramuscular injection or by inhalation. (wikipedia.org)
  • Aztreonam is poorly absorbed when given orally, so it must be administered as an intravenous or intramuscular injection (trade name Azactam), or inhaled (trade name Cayston) using an ultrasonic nebulizer. (wikipedia.org)
  • Aztreonam for Injection may be administered intravenously or by intramuscular injection. (pfizermedicalinformation.com)
  • Aztreonam, which is relatively β-lactamase resistant, is the only available monobactam. (antiinfectivemeds.com)
  • Because of the unfused beta-lactam ring there is somewhat lower cross-reactivity between aztreonam and many other beta-lactam antibiotics, and it may be safe to administer aztreonam to many patients with hypersensitivity (allergies) to penicillins and nearly all cephalosporins. (wikipedia.org)
  • There is a much lower risk of cross-sensitivity between aztreonam and other beta-lactam antibiotics than within other beta-lactam antibiotics. (wikipedia.org)
  • Certain antibiotics (eg, cefoxitin, imipenem) may induce high levels of beta-lactamase in vitro in some Gram-negative aerobes such as Enterobacter and Pseudomonas species, resulting in antagonism to many beta-lactam antibiotics including aztreonam. (pfizermedicalinformation.com)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of Aztreonam for Injection, USP and other antibacterial drugs, aztreonam for injection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. (pfizermedicalinformation.com)
  • Aztreonam for Injection is indicated for adjunctive therapy to surgery in the management of infections caused by susceptible organisms, including abscesses, infections complicating hollow viscus perforations, cutaneous infections, and infections of serous surfaces. (pfizermedicalinformation.com)
  • Aztreonam for Injection is effective against most of the commonly encountered Gram-negative aerobic pathogens seen in general surgery. (pfizermedicalinformation.com)
  • aztreonam decreases effects of BCG vaccine live by pharmacodynamic antagonism. (medscape.com)
  • aztreonam decreases effects of microbiota oral by pharmacodynamic antagonism. (medscape.com)
  • aztreonam decreases effects of typhoid vaccine live by pharmacodynamic antagonism. (medscape.com)
  • These in vitro findings suggest that such beta-lactamase inducing antibiotics not be used concurrently with aztreonam. (pfizermedicalinformation.com)
  • Aztreonam inhibits cell wall synthesis by blocking peptidoglycan crosslinking to cause bacterial death. (wikipedia.org)
  • Aztreonam can be safely used in patients with a penicillin or cephalosporin allergy (except for patients with a ceftazidime allergy as ceftazidime and aztreonam share a similar side chain). (wikipedia.org)
  • The combination of aztreonam and avibactam has demonstrated to be active against 80% of MBL isolates reaching a clinical infection resolution in 80% of MBL-infected patients. (wikipedia.org)
  • In the United States, the Food and Drug Administration (FDA) approved the inhalation form on 22 February 2010, for the suppression of P. aeruginosa infections in patients with cystic fibrosis. (wikipedia.org)
  • Vitamin deficiency may result from an inadequate diet, increased requirements (eg, pregnancy, lactation), or secondary to disease or drug use. (medscape.com)
  • Aztreonam was approved for medical use in the United States in 1986. (wikipedia.org)
  • When aztreonam pharmacokinetics were assessed for adult and pediatric patients, they were found to be comparable (down to 9 months old). (nih.gov)
  • Because of the unfused beta-lactam ring there is somewhat lower cross-reactivity between aztreonam and many other beta-lactam antibiotics, and it may be safe to administer aztreonam to many patients with hypersensitivity (allergies) to penicillins and nearly all cephalosporins. (wikipedia.org)
  • however, systemic absorption of aztreonam following inhaled administration is expected to be minimal. (rxlist.com)
  • [ 27 ] The white blood cell counts, platelet counts, and neutrophil counts (all markers of systemic inflammation) of patients receiving inhaled aztreonam remained within the reference range more often than values reported for patients receiving placebo. (medscape.com)
  • [ 18 ] Despite the fact that the systemic concentration of aztreonam after administration of inhaled aztreonam (75 mg three times daily) is only 1% of the concentration after a 500-mg injection of aztreonam, it is still recommended that inhaled aztreonam be used in pregnant patients only when the potential benefit outweighs the risk. (medscape.com)
  • It is given by intravenous or intramuscular injection or by inhalation. (wikipedia.org)
  • After identical single intravenous or intramuscular doses of aztreonam for injection, the serum concentrations of aztreonam are comparable at 1 hour (1.5 hours from start of intravenous infusion) with similar slopes of serum concentrations thereafter. (nih.gov)
  • Aztreonam has been shown to enter fetal circulation by crossing the placenta after i.v. administration. (medscape.com)
  • The serum half-life of aztreonam averaged 1.7 hours (1.5 to 2) in subjects with normal renal function, independent of the dose and route of administration. (nih.gov)
  • In elderly patients, the mean serum half-life of aztreonam increased and the renal clearance decreased, consistent with the age-related decrease in creatinine clearance. (nih.gov)
  • According to the results of AIR-CF1, patients receiving inhaled aztreonam had a reduced frequency of productive cough compared with those receiving placebo (12.5% versus 25%, p = 0.047). (medscape.com)
  • After receiving up to nine repeated courses of inhaled aztreonam, the most common adverse events experienced by patients with CF were cough (89.4%) and productive cough (80.3%), which may have been attributable to their underlying disease. (medscape.com)
  • aztreonam will decrease the level or effect of bazedoxifene/conjugated estrogens by altering intestinal flora. (medscape.com)
  • What Are the Side Effects Associated with Using Aztreonam Inhalation? (rxlist.com)
  • aztreonam decreases effects of BCG vaccine live by pharmacodynamic antagonism. (medscape.com)
  • aztreonam decreases effects of typhoid vaccine live by pharmacodynamic antagonism. (medscape.com)
  • cefoxitin decreases effects of aztreonam by pharmacodynamic antagonism. (medscape.com)
  • There is a much lower risk of cross-sensitivity between aztreonam and other beta-lactam antibiotics than within other beta-lactam antibiotics. (wikipedia.org)